Motohashi Lab - Publications (2023~)

Motohashi Lab

2026

Cao TLD, Okita Y, Yahatabara R, Elhinnawi MA, Azmi NU, Poullikkas T, Motohashi H, Kato M. Importance of SUMOylation Consensus Sequence of MAFK in Regulating EMT, Tumor Growth, Stemness, and Drug Resistance. Cancer Sci. 2026 Feb;117(2):445-455. doi: 10.1111/cas.70282.
Pan S, Kawaguchi M, Akaike T, Motohashi H. Unveiling the Role of Supersulfides in Cancer Progression: From Maligmancy to Therapeutic Horizons. Ferroptosis Oxid Stress 2, 202511, 2026. doi: 10.70401/fos.2026.0018.
Hayashi H, Hamada S, Matsumoto R, Takikawa T, Xu Y, Jie R, Nakasuji H, Abe T, Kikuta K, Motohashi H, Ohmuraya M, Masamune A. Spink1 promotes the survival of Kras-mutant pancreatic acinar cells. Pancreatology. 2026 Mar 19:S1424-3903(26)00134-1. doi: 10.1016/j.pan.2026.03.014.
Lamb RJ, Ibrahim FS, Khodade VS, Davies SP, Griffiths K, Takata T, Gu J, Matsunaga T, Grand RJ, Nichols FM, Barton AJ, Aubdool AA, Morita M, Motohashi H, Xian M, Akaike T, Toscano JP, Madhani M. Hydropersulfides promote angiogenesis and preserve vascular function. Redox Biol. 2026 Jul;94:104192. doi: 10.1016/j.redox.2026.104192.
Sakata N, Akaike T, Motohashi H. Lysosomes and Supersulfides: Emerging Links in Cellular Metabolism and Homeostasis. J Biochem. 2026 Jul 24:mvag058. doi: 10.1093/jb/mvag058.
Barayeu U, Ogata S, Takata T, Jung M, Matsunaga T, Morita M, Ida T, Lange M, Unno Y, Boushehri S, Greicius P, Nishimura A, Catti L, Pan Y, Zhang T, Shimizu T, Ushioda R, Nakabayashi T, Asamitsu S, Fusegawa K, Suzuki T, Ishida T, Tanda N, Watanabe Y, Tsuchiya Y, Yamaguchi R, Noguchi S, Mishima E, Yano F, Arisawa M, Stuehr DJ, Xia N, Li H, Moosmann B, Gräter F, Aponte-Santamaría C, Olzmann JA, Conrad M, van der Vliet A, Dick TP, Motohashi H, Yoshizawa M, Akaike T. Mammals produce cyclo-octasulfur to suppress lipid peroxidation and ferroptosis. Science. 2026 Sep 24;393(6818):eaec5473. doi: 10.1126/science.aec5473.

2025

Cao TLD, Okita Y, Yahatabara R, Elhinnawi MA, Azmi NU, Poullikkas T, Motohashi H, Kato M. Importance of SUMOylation Consensus Sequence of MAFK in Regulating EMT, Tumor Growth, Stemness, and Drug Resistance. Cancer Sci. 2025 Nov 29. doi: 10.1111/cas.70282.
Sung E, Murakami S, Morita M, Ida T, Akaike T, Motohashi H. Mitochondria regulate the cell fate decisions of megakaryocyte-erythroid progenitors. Stem Cell Reports. 2025 Nov 20:102720. doi: 10.1016/j.stemcr.2025.102720.
Okazaki K, Kawaguchi M, Murakami S, Takeda H, Sekine H, Takeuchi O, Motohashi H. Regnase-1 Promotes Tumor-Initiating Activity in Non-Small Cell Lung Cancer. J Biochem. 2025 Oct 23:mvaf061. doi: 10.1093/jb/mvaf061. Epub ahead of print. PMID: 41128304.
Braunstein I, Motohashi H, Dallenga T, Schaible UE, Benhar M. Redox signaling in innate immunity and inflammation: focus on macrophages and neutrophils. Free Radic Biol Med. 2025 Sep;237:427-454. doi: 10.1016/j.freeradbiomed.2025.06.006. Epub 2025 Jun 6. PMID: 40484207.
Sekine H, Akaike T, Motohashi H. Oxygen needs sulfur, sulfur needs oxygen: a relationship of interdependence. EMBO J. 2025 May 20. doi: 10.1038/s44318-025-00464-7.
Asamitsu S, Ozawa Y, Okamoto H, Ogata S, Matsunaga T, Yoshitake J, Fusegawa K, Taniyama Y, Sato C, Ishida H, Abe T, Motohashi H, Akaike T, Kamei T. Supersulfide metabolome of exhaled breath condensate applied as diagnostic biomarkers for esophageal cancer. Cancer Sci. 2025 Apr;116(4):1023-1033. doi: 10.1111/cas.16430.
Cuadrado A, Cazalla E, Bach A, Bathish B, Naidu SD, DeNicola GM, Dinkova-Kostova AT, Fernández-Ginés R, Grochot-Przeczek A, Hayes JD, Kensler TW, León R, Liby KT, López MG, Manda G, Shivakumar AK, Hakomäki H, Moerland JA, Motohashi H, Rojo AI, Sykiotis GP, Taguchi K, Valverde ÁM, Yamamoto M, Levonen AL. Health position paper and redox perspectives - Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases. Redox Biol. 2025 Apr;81:103569. doi: 10.1016/j.redox.2025.103569.

2024

Himori K, Yamada M, Onoki T, Matsumaru D, Motohashi H, Okutsu M. Nrf2 deficiency in muscle attenuates experimental autoimmune myositis-induced muscle weakness. J Physiol. 2024 Oct 21. doi: 10.1113/JP286534. Epub ahead of print. PMID: 39429109.
Akaike T, Morita M, Ogata S, Yoshitake J, Jung M, Sekine H, Motohashi H, Barayeu U, Matsunaga T. New aspects of redox signaling mediated by supersulfides in health and disease. Free Radic Biol Med. 2024 Jul 9;222:539-551. doi: 10.1016/j.freeradbiomed.2024.07.007. Epub ahead of print. PMID: 38992395.
Berndt C, Alborzinia H, Amen VS, Ayton S, Barayeu U, Bartelt A, Bayir H, Bebber CM, Birsoy K, Böttcher JP, Brabletz S, Brabletz T, Brown AR, Brüne B, Bulli G, Bruneau A, Chen Q, DeNicola GM, Dick TP, Distéfano A, Dixon SJ, Engler JB, Esser-von Bieren J, Fedorova M, Friedmann Angeli JP, Friese MA, Fuhrmann DC, García-Sáez AJ, Garbowicz K, Götz M, Gu W, Hammerich L, Hassannia B, Jiang X, Jeridi A, Kang YP, Kagan VE, Konrad DB, Kotschi S, Lei P, Le Tertre M, Lev S, Liang D, Linkermann A, Lohr C, Lorenz S, Luedde T, Methner A, Michalke B, Milton AV, Min J, Mishima E, Müller S, Motohashi H, Muckenthaler MU, Murakami S, Olzmann JA, Pagnussat G, Pan Z, Papagiannakopoulos T, Pedrera Puentes L, Pratt DA, Proneth B, Ramsauer L, Rodriguez R, Saito Y, Schmidt F, Schmitt C, Schulze A, Schwab A, Schwantes A, Soula M, Spitzlberger B, Stockwell BR, Thewes L, Thorn-Seshold O, Toyokuni S, Tonnus W, Trumpp A, Vandenabeele P, Vanden Berghe T, Venkataramani V, Vogel FCE, von Karstedt S, Wang F, Westermann F, Wientjens C, Wilhelm C, Wölk M, Wu K, Yang X, Yu F, Zou Y, Conrad M. Ferroptosis in health and disease. Redox Biol. 2024 May 30;75:103211. doi: 10.1016/j.redox.2024.103211. Epub ahead of print. PMID: 38908072.
Sekine H, Takeda H, Takeda N, Kishino A, Anzawa H, Isagawa T, Ohta N, Murakami S, Iwaki H, Kato N, Kimura S, Liu Z, Kato K, Katsuoka F, Yamamoto M, Miura F, Ito T, Takahashi M, Izumi Y, Fujita H, Yamagata H, Bamba T, Akaike T, Suzuki N, Kinoshita K, Motohashi H. PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity. Nat Metab. 2024 Jun;6(6):1108-1127. doi: 10.1038/s42255-024-01053-4.
Hayashi M, Okazaki K, Papagiannakopoulos T*, Motohashi H*. The complex roles of redox and antioxidant biology in cancer. Cold Spring Harb Perspect Med. 2024 May 21:a041546. doi: 10.1101/cshperspect.a041546. Epub ahead of print. PMID: 38772703.
Sekine H, Motohashi H. Unique and overlapping roles of NRF2 and NRF1 in transcriptional regulation. J Clin Biochem Nutr. 2024 Mar;74(2):91-96. doi: 10.3164/jcbn.23-106.
Nishimura A, Yoon S, Matsunaga T, Ida T, Jung M, Ogata S, Morita M, Yoshitake J, Unno Y, Barayeu U, Takata T, Takagi H, Motohashi H, van der Vliet A, Akaike T. Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality. Redox Biol. 2024 Feb;69:103018. doi: 10.1016/j.redox.2023.103018.
Hayasaka K, Takeda H, Sakurada A, Matsumura Y, Abe J, Shiono S, Notsuda H, Suzuki H, Endo M, Motohashi H, Okada Y. Clinical, Genomic, and Transcriptomic Featurses of Lung Adenocarcinoma With Uncommon EGFR Mutation. Clin Lung Cancer. 2024 Jan;25(1):e43-e51. doi: 10.1016/j.cllc.2023.10.006.

2023

Alam MM, Kishino A, Sung E, Sekine H, Abe T, Murakami S, Akaike T*, Motohashi H*. Contribution of NRF2 to Sulfur Metabolism and Mitochondrial Activity. Redox Biol 60, 102624, 2023. doi: 10.1016/j.redox.2023.102624. (*co-correspondence)

Takeda H, Nakajima Y, Yamaguchi T, Watanabe I, Miyoshi S, Nagashio K, Sekine H, Motohashi H, Yano H, Tanaka J. The anti-inflammatory and anti-oxidative effect of a classical hypnotic bromovalerylurea mediated by the activation of NRF2. J Biochem mvad030, 2023. doi: 10.1093/jb/mvad030.

Zainol Abidin QH, Ida T, Morita M, Matsunaga T, Nishimura A, Jung M, Hassan N, Takata T, Ishii I, Kruger W, Wang R, Motohashi H, Tsutsui M, Akaike T. Synthesis of Sulfides and Persulfides Is Not Impeded by Disruption of Three Canonical Enzymes in Sulfur Metabolism. Antioxidants (Basel) 12(4), 868, 2023. doi: 10.3390/antiox12040868.

Ikeda R, Noshiro D, Morishita H, Takada S, Kageyama S, Fujioka Y, Funakoshi T, Komatsu-Hirota S, Arai R, Ryzhii E, Abe M, Koga T, Motohashi H, Nakao M, Sakimura K, Horii A, Waguri S, Ichimura Y, Noda NN, Komatsu M. Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response. EMBO J. 2023 Jul 17;42(14):e113349. doi: 10.15252/embj.2022113349.

Matsunaga T, Sano H, Takita K, Morita M, Yamanaka S, Ichikawa T, Numakura T, Ida T, Jung M, Ogata S, Yoon S, Fujino N, Kyogoku Y, Sasaki Y, Koarai A, Tamada T, Toyama A, Nakabayashi T, Kageyama L, Kyuwa S, Inaba K, Watanabe S, Nagy P, Sawa T, Oshiumi H, Ichinose M, Yamada M, Sugiura H, Wei FY, Motohashi H*, Akaike T*. Supersulphides provide airway protection in viral and chronic lung diseases. Nat Commun. 2023 Jul 25;14(1):4476. doi: 10.1038/s41467-023-40182-4. (*co-correspondence)

Takeda H, Murakami S, Liu Z, Sawa T, Takahashi M, Izumi Y, Bamba T, Sato H, Akaike T, Sekine H, Motohashi H*. Sulfur metabolic response in macrophage limits excessive inflammatory response by creating a negative feedback loop. Redox Biol. 2023 Jul 29;65:102834. doi: 10.1016/j.redox.2023.102834.

Kasamatsu S, Nishimura A, Alam MM, Morita M, Shimoda K, Matsunaga T, Jung M, Ogata S, Barayeu U, Ida T, Nishida M, Nishimura A, Motohashi H*, Akaike T*. Supersulfide catalysis for nitric oxide and aldehyde metabolism. Sci Adv. 2023 Aug 18;9(33):eadg8631. doi: 10.1126/sciadv.adg8631. (*co-correspondence)

Hayasaka K, Ohkouchi S, Saito-Koyama R, Suzuki Y, Okazaki K, Sekine H, Watanabe T, Motohashi H*, Okada Y*. Aging exacerbates murine lung ischemia-reperfusion injury by excessive inflammation and impaired tissue repair response. Am J Transplant. 2023 Sep 19:S1600-6135(23)00692-5. (*co-correspondence)

Murakami S, Kusano Y, Okazaki K, Akaike T, Motohashi H. NRF2 signalling in cytoprotection and metabolism. Br J Pharmacol. 2023 Sep 15. doi: 10.1111/bph.16246. Epub ahead of print. PMID: 37715470.

Barayeu U, Sawa T, Nishida M, Wei FY, Motohashi H, Akaike T. Supersulfide biology and translational medicine for disease control. Br J Pharmacol. 2023 Oct 23. doi: 10.1111/bph.16271. Epub ahead of print. PMID: 37872133.

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