Motohashi Lab
Department of Medical Biochemsitry,
Tohoku University Graduate School of Medicine
Redox metabolism underlying gene expression regulation
Life is nothing but an electron looking for a place to rest. These are the words of Albert St. Gerge, the Hungarian biochemist who won the 1937 Nobel Prize for the discovery of vitamin C. He expressed that the movement of electrons, or redox reactions (redox reactions), is the most fundamental activity of life. Disturbance of redox homeostasis causes stress in the organism and induces a response to it. Recognizing that extending healthspan is an extremely important issue for medicine in today's rapidly aging society, our laboratory aims to understand the stress response mechanisms of living organisms to determine how they adapt to their environment and maintain life.
Overcoming NRF2-activated cancer
To overcome intractable cancers in which the transcription factor NRF2 is abnormally activated, we are analyzing it by focusing on metabolic activity.
Understanding the Biological Functions of Supersulfides
We aim to understand the pathological basis of inflammation and cancer by elucidating the roles of supersulfides, which have recently been identified as new biomolecules, in the body.
Stress sensing, response, and adaptation by metabolism
Focusing on stress-sensing mechanisms as metabolic changes and functional modifications of cells brought about by metabolites, we are pursuing new mechanisms to regulate cell differentiation and inflammatory responses.
Toward the discovery of new pathways
We aim to discover new regulatory axes of life through CRISPR screening based on genome editing technology.
What's new?
2024.4.22.~4.26 Taking an entire week, our lab moved from the 2nd floor of Institute to Development, Aging and Cancer to the 3rd floor of Building 1 in Graduate School of Medicine.
2024.4.18. A paper with Associate Professor Hiroki Sekine as the first author has been accepted for publication in Nature Metabolism.
2024.3.30-4.1. Associate Professor Hiroki Sekine and Assistant Professor Shohei Murakami gave lectures at the Kickoff Symposium of the International Leading Research Program on Redox Supramolecules (G-ReXS 2024).
2024.3.27. Hideya Iwaki, Doctoral Course, Graduate School of Medicine, Kento Iida, Master's Course, Graduate School of Medicine, and Xuan Wang, Master's Course, Graduate School of Life Sciences, have completed their respective courses and received their degree certificates. Congratulations to them!
2024.3.24. JSPS RPD researcher Madoka Kawaguchi gave an invited lecture at the 1st International Cancer Immunology Symposium of the Japanese Association for Cancer Immunology.
2024.3.14. Haruna Takeda, a third-year doctoral student at Tohoku University Graduate School of Medicine, has been selected for Sasagawa Science Research Grant.
2024.3.8. Haruna Takeda, a third-year doctoral student at Tohoku University Graduate School of Medicine, was selected as the winner of the top prize of Tohoku University Graduate School of Medicine's Female Graduate Student Encouragement Award (Nanase Award).
Let's work together!
2-1 Seiryocho, Aoba-ku, Sendai-shi, Miyagi 980-8575
Tohoku University School of Medicine Bldg.1, 3F
Department of Medical Chemistry, Tohoku University Graduate School of Medicine
Hozumi Motohashi
Phone: 022-717-8089
FAX: 022-717-8090
email:hozumi.motohashi.a7[at]tohoku.ac.jp