Life is nothing but an electron looking for a place to rest. These are the words of Albert St. Gerge, the Hungarian biochemist who won the 1937 Nobel Prize for the discovery of vitamin C. He expressed that the movement of electrons, or redox reactions (redox reactions), is the most fundamental activity of life. Disturbance of redox homeostasis causes stress in the organism and induces a response to it. Recognizing that extending healthspan is an extremely important issue for medicine in today's rapidly aging society, our laboratory aims to understand the stress response mechanisms of living organisms to determine how they adapt to their environment and maintain life.

• 2025.9.1.  Associate Professor Hiroki Sekine has been appointed as Professor in the Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University.

• 2025.8.7. Prof. Hozumi Motohashi gave a lecture at the 2025 Public Symposium hosted by Section III of the Science Council of Japan, the Tohoku District Meeting of the Science Council of Japan, and Tohoku University.

• 2025.7.16. Prof. Hozumi Motohashi gave a talk in the symposium at the Joint Meeting of JSCS 77th & JSDB 58th.

• 2025.6.9. Prof. Hozumi Motohashi gave an invited talk at the Gordon Research Conference "Erythropoiesis: Cellular and Molecular Mechanisms, Pathogenesis, and Clinical-Translation".

• 2025.6.5.  Prof. Hozumi Motohashi gave an invited talk at the 22nd SFRRI Biennial Meeting. 

• 2025.4.20. Dr. Eunkyu Sung, who completed her doctoral program this spring and is now working as a research fellow, received the Poster Award at Redox Week in Sendai 2025.

• 2025.4.4.  Dr. Haruna Takeda, who completed her Ph.D. this spring, has been selected as a Postdoctoral Fellow of the Human Frontier Science Program.

• 2025.3.27. Mr. Pan Shaoting, a first-year master's student (M1), has been selected as a 2025 scholarship recipient by the Toshimi Otsuka Memorial Foundation.

• 2025.3.25.  Mr. Chikara Sakai (D4), Mr. Kenji Hamada (D4), Ms. Haruna Takeda (D4), and Mr. Ryutaro Komori (M2) from the Graduate School of Medicine have completed their respective programs and were awarded their diplomas. Congratulations to all!

• 2025.3.16.  Dr. Madoka Kawaguchi, a JSPS RPD Research Fellow, received the Excellent Oral Presentation Award at the 2025 Rising Star Networking Event of the Three Cancer-Related Societies.

• 2025.3.5.  Haruna Takeda, a fourth-year doctoral student, has been awarded Tohoku University President Prize.

• 2025.2.27.  Assistant Professor Shohei Murakami gave an invited lecture at the symposium of the Interdisciplinary Hub Formation Program, "Formation of a Collective Intelligence Platform for Extending Healthy Life Expectancy."

• 2025.2.7. Kazuki Hayasaka, a former member of our laboratory and currently an active thoracic surgeon, has been awarded the Research Encouragement Award by the Institute of Development, Aging and Cancer.

• 2025.1.30. Haruna Takeda, a fourth-year doctoral student, has been awarded Ikushi Prize.

• 2025.1.9.  Associate Professor Hiroki Sekine has been awarded the Gold Medal of the Faculty of Medicine Scholarship Award.

• 2024.12.15. Yusuke Kusano, who completed the doctoral program at the Graduate School of Medicine, has been awarded the Young Investigator Award at the 97th Annual Meeting of the Japanese Biochemical Society.

• 2024.11.21. Assistant Professor Shohei Murakami gave an invited talk at the SfRBM2024. 

• 2024.11.4.   Prof. Hozumi Motohashi served as an organizer and gave an invited talk at the Cold Spring Harbor Asia "Iron, Reactive Oxygen Species & Ferroptosis in Life, Death & Disease". 

• 2024.11.1. 1st-year postgraduate PhD student Yujue Wang and Keito Iida were selected for a challenging research support project. 

• 2024.11.1. Mei Omata, a first-year Ph.D. student, and Yunosuke Yasuda, a second-year Ph.D. student, have been awarded the Excellence Prize in the 2024 Starter Research Encouragement Award, and Haruna Takeda, a fourth-year Ph.D. student, has been selected for the Grand Prize in the 2024 Booster Research Encouragement Award.

• 2024.10.25. Prof. Hozumi Motohashi gave a lecture at the Anti-Aging Research Conference.

• 2024.10.18. Prof. Hozumi Motohashi gave a lecture at the 14th Signal Network Research Conference.

• 2024.10.2.  The first-year master's student in the Graduate School of Life Science, Shaoting Pan, has been selected as a scholarship recipient of the JGC-Saneyoshi scholarship foundation.

• 2024.9.28. Prof. Hozumi Motohashi gave a special lecture at the 5th Academic Gathering of the Japanese Society for the Myocardial Protection.

• 2024.9.27.  Haruna Takeda, a fourth-year doctoral student, has been accepted into both the JSPS Overseas Fellowship and the JSPS Postdoctoral Fellowship (PD).

• 2024.9.25. Yusuke Kusano, D4, a doctoral student in the Graduate School of Medicine, has completed the process and received his degree. Congratulations!

• 2024.9.24. Prof. Hozumi Motohashi gave FAOBMB Osamu Hayaishi Lecture at BioMolecular Horizon 2024.  

• 2024.9.18. Associate Professor Hiroki Sekine's proposal has been selected as a project under the AMED-PRIME initiative, "Bridging the fundamental mechanism of aging and the effective treatment of age-related disease associated with impaired functional system". 

• 2024.9.5. Associate Professor Hiroki Sekine gave an invited lecture at Forum 2024 Hygienic Pharmacology and Environmental Toxicology.

• 2024.9.2. Assistant Professor Keito Okazaki's research proposal has been accepted for a 2024 Medical Research Grant (Research B) (Gonryo Igaku Shinko Kyokai).

• 2024.8.22. Prof. Hozumi Motohashi gave an invited lecture at the 13th International Meeting on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide.

• 2024.7.20. Associate Professor Hiroki Sekine gave an invited lecture at the 32nd Japanese Cell Death Conference.

• 2024.7.19. Research student Wang Yujue won the first prize for the best student presentation at the 162nd Colloquium of the Institute of Development, Aging and Cancer, Tohoku University.  Congratulations!

• 2024.7.18. Associate Professor Hiroki Sekine gave an invited lecture at the 45th Japanese Society for Inflammation and Regenerative Medicine.

• 2024.7.16. Prof. Hozumi Motohashi gave an invited lecture at the Gordon Research Conference "Thiol-Based Redox Regulation and Signaling".

• 2024.6.21. Prof. Hozumi Motohashi gave a special lecture at the 50th Annual Meeting of the Society for Biomolecular Sciences.

• 2024.6.15. Prof. Hozumi Motohashi gave a special lecture at the 2024 annual meeting of the Kanto Branch of the Japanese Biochemical Society.

• 2024.6.9. Associate Professor Hiroki Sekine gave an invited lecture at the 76th Congress of the Vitamin Society.

• 2024.6.5. Prof. Hozumi Motohashi gave a lecture at The 7th World Congress on Hydrogen Sulfide in Biology and Medicine. 

• 2024.5.31.  PRESS RELEASE: New oxygen-sensing mechanism discovered ~ Oxygen-dependent modulation of vitamin B6 bioactivation regulates inflammatory response of macrophages.~   （PNPO–PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity）    (rdcu.be/dJxsh )<--- Download from here!

• 2024.5.30. 1st-year postgraduate PhD student Mei Omata was selected for a challenging research support project. Congratulations!

• 2024.5.14.  We held a welcome party for lab newcomers + move-in launch.

• 2024.4.22.~4.26 Taking an entire week, our lab moved from the 2nd floor of Institute to Development, Aging and Cancer to the 3rd floor of Building 1 in Graduate School of Medicine.

• 2024.4.18. A paper with Associate Professor Hiroki Sekine as the first author has been accepted for publication in Nature Metabolism.

• 2024.3.30-4.1.  Associate Professor Hiroki Sekine and Assistant Professor Shohei Murakami gave lectures at the Kickoff Symposium of the International Leading Research Program on Redox Supramolecules (G-ReXS 2024).

• 2024.3.27.  Hideya Iwaki, Doctoral Course, Graduate School of Medicine, Kento Iida, Master's Course, Graduate School of Medicine, and Xuan Wang, Master's Course, Graduate School of Life Sciences, have completed their respective courses and received their degree certificates. Congratulations to them!

• 2024.3.24. JSPS RPD researcher Madoka Kawaguchi gave an invited lecture at the 1st International Cancer Immunology Symposium of the Japanese Association for Cancer Immunology.

• 2024.3.14. Haruna Takeda, a third-year doctoral student at Tohoku University Graduate School of Medicine, has been selected for Sasagawa Science Research Grant. 

• 2024.3.8. Haruna Takeda, a third-year doctoral student at Tohoku University Graduate School of Medicine, was selected as the winner of the top prize of Tohoku University Graduate School of Medicine's Female Graduate Student Encouragement Award (Nanase Award).