Publications

2026 (Author Contribution: * corresponding) 

1. Kang H, Bao K, Yamashita A, Kashiwagi S, Choi HS. Chapter 17 - Image-guided anticancer drug delivery. In: Chen X, Zhang J, Wong S, editors. Cancer Theranostics (Second Edition): Academic Press; 2026. p. 281-96.

2. Jaiswal S, Yamashita A, Lee S, Amirfakhri S, Ser J, Kashiwagi S, Lin G, Hoffman RM, Henary M, Choi HS, Bouvet M. Sprayable pH-sensitive near-infrared fluorophore for rapid, bright, specific, and safe visualization of human thyroid cancer in orthotopic mouse models. Surgery, 2026;189:109703

2025

1. Kang H, Park SH, Ozmen GE, Hur W, Dinh J, Wang H, Nguyen V, Ahn S, Yamashita A, Stiles WR, Kashiwagi S, Bao K, Henary M, Choi HS. Cartilage-targeting fluorophores for early detection of arthritis in the NIR-II window. Chem, 2025;11(8):102481.

2. Heo D, Kim H, Katagiri W, Yoon C, Lim HG, Kim C, Choi HS*, Kashiwagi S*, Kim HH*. Enhanced Model Antigen Retention in Tissue through Topical High-Frequency Ultrasound Treatment. Biomed Eng Lett, 2025; 15(2):273-282.

3. Paranjape S, Choi, KY, Kashiwagi S*, Choi HS*. H-dots: Renal clearable zwitterionic nanocarriers for disease diagnosis and therapy. Langmuir, 2025; 41(4):2111-2123.

4. Chang H, Hur W, Kang H*, Jun B-H*. In vivo surface-enhanced Raman scattering techniques: nanoprobes, instrumentation, and applications. Light: Science & Applications, 2025;14(1):79. Selected as ESI Highly Cited Paper in November 2025 https://www.nature.com/lsa/news#12

5. Hwang DW, Ser J, Ziabrev K, Park GK, Jo MJ, Yokomizo S, Bao K, Yamashita A, Cho H, Henary M, Kashiwagi S*, Choi HS*. Image-Guided Monitoring of Mitochondria and Blood-Brain Barrier Dysfunction in Amyotrophic Lateral Sclerosis Mice. Biomater Res, 2025; 29:0162.

6. Choi KY, Park HS, Paranjape S, Dang L, Jang P, Ser J, Yamashita A, Bao K, Park CH, Kashiwagi S*, Choi HS*. Precise Detection of Surgical Margin in Head and Neck Cancer Using Dual Near-Infrared Imaging of the Tumor and Tumor Microenvironment. Biomater Res, 2025; 29:0235

7. Jun EB, Kim K, Lee JH, Park SH, Kashiwagi S, Bao K, Kim HK, Choi HS. Tumor-Embedded Nerve Surgery Using Dual-Channel Intraoperative Imaging Probes. ACS Appl Mater Interfaces, 2025; 17(31):44178-44187.

8.  Kim W, Lee JS, Choi Y-S, Yoo K, Kim M, Ham K-M, Shin M, Kim H-M, Pham X-H, Yang C-H, Lee SH, Rho W-Y, Park S-M, Kang H, Jeong DH, Kim J, Chang H, Kim D-E, Jun B-H. Synthesis of Porous Au-Shell-Coated Silica Nanoparticles (SiO2@Au@AuPS) under Mild Conditions for Photothermal Therapy and Chemotherapy of Cancer Cells. ACS Applied Nano Materials, 2025;8(5):2563-73.

9. Kim Y-H, Cho H-S, Yoo K, Yang C-H, Lee S-K, Kang H, Jun B-H. Solar-Driven Interfacial Evaporation Using Bumpy Gold Nanoshell Films with Controlled Shell Thickness. Int J Mol Sci, 2025;26(13):6160.

10. Lee H, Li Y, Bao K, Lee SS, Kang H, Choi HS, Choi Y. Zwitterionic alginate derivative as a new delivery platform for enhanced blood circulation. J Pharm Invest, 2025;55:143-54.

11. Pal R, Krishnamoorthy M, Matsui A, Kang H, Morita S, Taniguchi H, Kobayashi T, Morita A, Choi HS, Duda DG, Kumar ATN. Fluorescence Lifetime Imaging Enables In Vivo Quantification of PD-L1 Expression and Intertumoral Heterogeneity. Cancer Res. 2025;85(3):618-35.

12. Yoo K, Cho H-S, Kim J, Shin M, Chu J-S, Jang S, Bae H-J, Jung HS, Kang H, Jun B-H. Aptamer-Conjugated Multi-Quantum Dot-Embedded Silica Nanoparticles for Lateral Flow Immunoassay. Biosensors. 2025;15(1):54.

13. Baek MJ, Hur, W, Kashiwagi S, Choi HS. Design Considerations for Organ-Selective Nanoparticles. ACS Nano, 2025; 19(15):14605.

2024

1. Park HS, Yokomizo S, Wang H, Manganiello S, Monaco H, McDonnell R, Kim HJ, Rho J, Ahn S, Jung H, Kang H, Bao K, Kashiwagi S*, Choi HS*. Bifunctional Tumor-Targeted Bioprobe for Phototheranosis. Biomater Res, 2024; 28:0002.

2. Kashiwagi S*, Yokomizo S, Bragin DE, Perle SJ, Kastanenka KV, Gerashchenko D, Atochin DN. Therapeutic Potentials of Near-Infrared II Photobiomodulation to Treat Cerebrovascular Diseases via Nitric Oxide Signaling. Adv Exp Med Biol, 2024; 1463:195-200

3. Yokomizo S, Kopp T, Roessing M, Morita A, Lee S, Cho S, Ogawa E, Komai E, Inoue K, Fukushi M, Feil S, Kim HH, Bragin DE, Gerashchenko D, Huang PL, Kashiwagi S*, Atochin DN*. Near-infrared II photobiomodulation ameliorates stroke injury via phosphorylation of endothelial nitric oxide synthase. Stroke, 2024; 55(6):1641-1649.

4. Jang P, Ser J, Cardenas K, Kim HJ, Hickey M, Jang J, Gladstone J, Bailey A, Dinh J, Nguyen V, DeMarco E, Srinivas S, Kang H, Kashiwagi S, Bao K, Yamashita A, Choi HS. HSA-ZW800-PEG for Enhanced Optophysical Stability and Tumor Targeting. Int J Mol Sci, 2024; 25(1):559.

5. Cui Y, Park SH, Stiles WR, Yamashita A, Dinh J, Kim RS, Zhang Y, Yin X, Baek Y, Wang H, Bao K, Kang H*, Choi HS*. Renal Clearable H‐Dots Leveraging Ligand Complexation for Enhanced Active Tumor Targeting. Small Sci, 2024; 4(11):2400246.

6. Kim Y-H, Cho H-S, Yoo K, Ham K-M, Kang H, Pham X-H, Jun B-H. High-Throughput Synthesis of Nanogap-Rich Gold Nanoshells Using Dual-Channel Infusion System. Int J Mol Sci, 2024; 25(3):1649.

7. Yamashita A, Jang P, Bao K, Kashiwagi S, Frangioni JV, Choi HS. Indocyanine Blue (ICB) as a Functional Alternative to Indocyanine Green (ICG) for Enhanced 700 nm NIR Imaging. Int J Mol Sci, 2024; 25(24):13547.

2023

1. Kashiwagi S*, Morita A, Yokomizo S, Ogawa E, Komai E, Huang PL, Bragin DE, Atochin DN. Photobiomodulation and nitric oxide signaling. Nitric Oxide, 2023; 130:58-68.

2. Kashiwagi S*, Choi HS. Ovarian cancer-targeted near-infrared fluorophores for fluorescence-guided surgery. Ann Transl Med, 2023; 11(6):274.

3. Shamim M, Dinh J, Yang C, Nomura S, Kashiwagi S, Kang H, Choi HS, Henary M. Synthesis, Optical Properties, and In Vivo Biodistribution Performance of Polymethine Cyanine Fluorophores. ACS Pharmacol Transl Sci, 2023; 6(8):1192-1206.

4. Nomura S, Yokomizo S, Wang Z, Kang H, Bao K, Yang C, Rubin BP, Bronson R, Kashiwagi S, Choi HS. CD117-Targeted Intraoperative Imaging of Gastrointestinal Stromal Tumor Using a Stem-Cell-Factor-Labeled Fluorophore. Adv NanoBiomed Res, 2023; 2300063.

5. Bao K, Tully M, Cardenas K, Wang H, Srinivas S, Rho J, Jeon OH, Dinh J, Yokomizo S, McDonnell R, Yamashita A, Kashiwagi S, Kang H, Kim HK, Choi HS. Ultralow Background Near-Infrared Fluorophores with Dual-Channel Intraoperative Imaging Capability. Adv Healthc Mater. 2023:2203134.Hou SS, Yang J, Lee JH, Rodriguez MC, Bao K, Kashiwagi S, Kumar ATN, Bacskai BJ, Choi HS. Zwitterionic near-infrared probe enables noninvasive fluorescence lifetime imaging of amyloid-β aggregates and Tau fibrils. Nat Biomed Eng, 2023; 7(3):270-280.

6. Dinh J, Yamashita A, Kang H, Gioux S, Choi HS. Optical Tissue Phantoms for Quantitative Evaluation of Surgical Imaging Devices. Adv Photonics Res. 2023;4:2200194.

7. Chae S, Yong U, Park W, Choi Y-m, Jeon I-H, Kang H, Jang J, Choi HS, Cho D-W. 3D cell-printing of gradient multi-tissue interfaces for rotator cuff regeneration. Bioact Mater. 2023;19:611-25.

8. Hahm E, Jo A, Kang E, Yoo K, Shin M, An J, Pham X, Kim H, Kang H, Kim J, Jun B. Silica Encapsulation of Hydrophobic Optical NP-Embedded Silica Particles with Trimethoxy(2-Phenylethyl)silane. Nanomaterials. 2023;13:2145.

9. Moon H-G, Eccles JD, Kim S-j, Kim K-H, Kim Y-M, Rehman J, Lee H, Kanabar P, Christman JW, Ackerman SJ, Ascoli C, Kang H, Choi HS, Kim M, You S, Park GY. Complement C1q essential for aeroallergen sensitization via CSF1R+ conventional dendritic cells type-2. J Allergy Clin Immunol. 2023;152(5):1141-52

10. Kim Y-H, Hahm E, Pham X-H, Kang H, Jeong D-H, Chang H, Jun B-H. Mercury Ion-Responsive Coalescence of Silver Nanoparticles on a Silica Nanoparticle Core for Surface-Enhanced Raman Scattering Sensing. ACS Appl Nano Mater. 2023;6(24):23469-76.

11. Yamashita A, Park SH, Zeng L, Stiles WR, Ahn S, Bao K, Kim J, Kang H, Choi HS. H-Dot Mediated Nanotherapeutics Mitigate Systemic Toxicity of Platinum-Based Anticancer Drugs. Int J Mol Sci. 2023;24(20):15466.

2022

1. Kang H, Kang MW, Kashiwagi S*, Choi HS*. NIR fluorescence imaging and treatment for cancer immunotherapy. J Immunother Cancer, 2022; 10(7): e004936.

2. Kang H*, Shamim M, Yin X, Adluru E, Fukuda T, Yokomizo S, Chang H, Park SH, Cui Y, Moy AJ, Kashiwagi S, Henary M*, Choi HS*. Tumor-Associated Immune-Cell-Mediated Tumor Targeting Mechanism with NIR-II Fluorescence Imaging. Adv Mater, 2022; 34(8):e2106500.

3. Fukuda T, Yokomizo S, Casa S, Monaco H, Manganiello S, Wang H, Lv X, Ulumben AD, Yang C, Kang MW, Inoue K, Fukushi M, Sumi T, Wang C, Kang H, Bao K, Henary M, Kashiwagi S*, Choi HS*. Fast and Durable Intraoperative Near-infrared Imaging of Ovarian Cancer Using Ultrabright Squaraine Fluorophores. Angew Chem Int Ed Engl, 2022; 61(17): e202117330.

4. Yin X, Cui Y, Kim RS, Stiles WR, Park SH, Wang H, Ma L, Chen Lin, Baek Y, Kashiwagi S, Bao K, Ulumben A, Fukuda T, Kang H*, Choi HS*. Drug Delivery of Nanotheranostics for Personalized Lung Cancer Therapy. Theranostics, 2022; 12(9):4147-4162.

5. Yokomizo S, Henary M, Buabeng ER, Fukuda T, Monaco H, Yoonji Baek, Sophia Manganiello, Wang H, Kubota J, Ulumben AD, Lv X, Wang C, Inoue K, Fukushi M, Kang H, Bao K, Kashiwagi S*, Choi HS*. Topical pH Sensing NIR Fluorophores for Intraoperative Ovarian Cancer Imaging and Surgery. Adv Sci, 2022; 9(20):e2201416.

6. Buabeng ER, Dinh J, Fukuda T, Kang H, Kashiwagi S, Choi HS, Henary M. Microwave-assisted synthesis of red-shifted pentamethine tetrahydroxanthylium core in the NIR-II window. ACS Pharmacol Transl Sci, 2022; 5(10):963-972.

7. Yokomizo S, Roessing M, Morita A, Kopp T, Ogawa E, Katagiri W, Feil S, Huang PL, Atochin DN, Kashiwagi S*. Near-infrared II photobiomodulation augments nitric oxide bioavailability via phosphorylation of endothelial nitric oxide synthase. FASEB J, 2022 36(9):e22490.

8. Katagiri W, Yokomizo S, Ishizuka T, Yamashita K, Kopp T, Roessing M, Sato A, Iwasaki T, Sato H, Fukuda T, Monaco H, Manganiello S, Nomura S, Ng MR, Feil S, Ogawa E, Fukumura D, Atochin DN, Choi HS, Kashiwagi S*. Dual near-infrared II laser modulates the cellular redox state of T cells and augments the efficacy of cancer immunotherapy. FASEB J, 2022 36(10):e22521.

9. Park SH, Kim RS, Stiles WR, Jo M, Zeng L, Rho S, Baek Y, Kim J, Kim MS,* Kang H,* Choi HS*. Injectable thermosensitive hydrogels for a sustained release of iron nanochelators. Adv Sci. 2022;9(15):e2200872.

10. Monaco H, Yokomizo S, Choi HS, Kashiwagi S*. Quickly Evolving Near-Infrared Photoimmunotherapy Provides Multifaceted Approach to Modern Cancer Treatment. View, 2022; 3:20200110.

11. Yin X, Cheng Y, Feng Y, Stiles WR, Park SH, Kang H*, Choi HS*. Phototheranostics for Multifunctional Treatment of Cancer with Fluorescence Imaging. Adv Drug Deliv Rev. 2022;189:114483.

12. Wang H, Kang H, Dinh J, Yokomizo S, Stiles WR, Tully M, Cardenas K, Srinivas S, Ingerick J, Ahn S, Bao K, Choi HS. P800SO3-PEG: a renal clearable bone-targeted fluorophore for theranostic imaging. Biomater Res. 2022;26(1):51.

13. Jones G, Zeng L, Stiles WR, Park SH, Kang H, Choi HS, Kim J. Pharmacokinetics and tissue distribution of deferoxamine-based nanochelator in rats. Nanomedicine. 2022;17(22):1649

14. Hahm E, Jo A, Lee SH, Kang H, Pham X-H, Jun B-H. Silica Shell Thickness-Dependent Fluorescence Properties of SiO2@Ag@SiO2@QDs Nanocomposites. Int J Mol Sci. 2022;23(17):10041.

15. Bock S, Choi Y-S, Kim M, Yun Y, Pham X-H, Kim J, Seong B, Kim W, Jo A, Ham K-M, Lee SG, Lee SH, Kang H, Choi HS, Jeong DH, Chang H, Kim D-E, Jun B-H. Highly sensitive near-infrared SERS nanoprobes for in vivo imaging using gold-assembled silica nanoparticles with controllable nanogaps. J Nanobiotechnology. 2022;20(1):130.

2021

1. Yokomizo S, Katagiri W, Maki Y, Sano T, Inoue K, Fukushi M, Atochin DN, Kushibiki T, Kawana A, Kimizuka Y, Kashiwagi S*. Brief exposure of skin to near-infrared laser augments early vaccine responses. Nanophotonics, 2021, 10(12):3187-3197.

2. Kang H, Jeong S, Yang J-K, Jo A, Lee H, Heo EH, Jeong DH, Jun B-H, Chang H, Lee Y-S. Template-Assisted plasmonic nanogap shells for highly enhanced detection of cancer biomarkers. Int J Mol Sci, 2021; 22(4):1752.

3. Wu X, Daniel Ulumben A, Long S, Katagiri W, Wilks MQ, Yuan H, Cortese B, Yang C, Kashiwagi S, Choi HS, Normandin MD, El Fakhri G, Zaman RT. Near-Infrared Fluorescence Imaging of Carotid Plaques in an Atherosclerotic Murine Model. Biomolecules, 2021; 11(12).

4. Yang C, Wang H, Yokomizo S, Hickey M, Chang H, Kang H, Fukuda T, Song MY, Lee SY, Park JW, Bao K, Choi HS. ZW800-PEG: A renal clearable zwitterionic near-infrared fluorophore for potential clinical translation. Angew Chem Int Ed, 2021; 60(25):13847-52.

5. Han HH, Kang H, Kim S-J, Pal R, Kumar ATN, Choi HS, Hahn SK. Fluorescent nanodiamond-hyaluronate conjugates for target-specific molecular imaging. RSC Adv. 2021;11(37):23073-81.

6. Maki Y, Kashiwagi S, Kimizuka Y. Laser vaccine adjuvants: Light-augmented immune responses. Vaccine, 2021; 39(46):6805-6812.

2020

1. Kang H, Rho S, Stiles WR, Baek Y, Hu S, Hwang DW, Kashiwagi S, Kim MS, Choi HS. Size-Dependent EPR Effect of Polymeric Nanoparticles on Tumor Targeting. Adv Healthcare Mater, 2020; 9(1):e1901223.

2. Katagiri W, Lee G, Tanushi A, Tsukada K, Choi HS*, Kashiwagi S*. High-throughput single-cell live imaging of photobiomodulation with multispectral near-infrared lasers in cultured T cells. J Biomed Opt, 2020; 25(3):1-18.

3. Ji Y, Jones C, Baek Y, Park GK, Kashiwagi S*, Choi HS*. Near-infrared fluorescence imaging in immunotherapy. Adv Drug Deliv Rev, 2020;167:121

4. Kashiwagi S. Laser adjuvant for vaccination. FASEB J, 2020; 34(3):3485.

5. Kang H, Stiles WR, Baek Y, Nomura S, Bao K, Hu S, Park GK, Jo MJ, I H, Coll J-L, Rubin BP, Choi HS. Renal clearable theranostic nanoplatforms for gastrointestinal stromal tumors. Adv Mater, 2020; 32(6):1905899.

6. Kang H, Koh Y, Jeong S, Jeong C, Cha MG, Oh M, Yang J-K, Lee H, Jeong DH, Jun B-H, Chang H, Kim Y-K, Lee Y-S. Graphical and SERS dual-modal identifier for encoding OBOC library. Sensor Actuat B-Chem, 2020;303:127211.

7. Park GK, Lee JH, Soriano E, Choi M, Bao K, Katagiri W, Kim DY, Paik JH, Yun SH, Frangioni JV, Clancy TE, Kashiwagi S, Henary M, Choi HS. Rapid and selective targeting of heterogeneous pancreatic neuroendocrine tumors. iScience, 2020; 23(4):101006.

8. Yadav Y, Owens EA, Nomura S, Fukuda T, Yoonji B, Kashiwagi S, Choi HS, Henary M. Ultra-Bright and Serum-Stable Squaraine Dyes. J Med Chem, 2020; 63(17):9436–9445.

9. Kilian HI, Kang H, Nyayapathi N, Fukuda T, Adluru E, Zhang H, Quinn B, Xia J, Choi HS, Lovell J. Facile formulation of a long-wavelength cyanine for optical imaging in the second near-infrared window. Biomater Sci, 2020; 8:4199-205.

10. Pham X-H, Hahm E, Kim TH, Kim H-M, Lee SH, Lee SC, Kang H, Lee H-Y, Jeong DH, Choi HS, Jun B-H. Enzyme-amplified SERS immunoassay with Ag-Au bimetallic SERS hot spots. Nano Res, 2020; 13(12):3338-46.

11. Jones G, Goswami SK, Kang H, Choi HS, Kim J. Combating iron overload: a case for deferoxamine-based nanochelators. Nanomedicine, 2020;15(13):1341

2019

1. Hwang DW, Jo MJ, Lee JH, Kang H, Bao K, Hu S, Baek Y, Moon HG, Lee DS, Kashiwagi S, Henary M, Choi HS. Chemical modulation of bioengineered exosomes for tissue-specific biodistribution. Adv Ther, 2019; 2(11):1900111.

2. Ji Y, Wang Z, Bao K, Park GK, Kang H, Hu S, McDonald E, Kim MS, Kashiwagi S*, Choi HS*. Targeted molecular imaging of TLR4 in hepatocellular carcinoma using zwitterionic NIR fluorophores. Quant Imaging Med Surg, 2019; 9(9):1548-1555.

3. Katagiri W, Lee JH, Tétrault M-A, Kang H, Jeong S, Yokomizo S, Santos S, Jones C, Hu S, Tsukada K, Fakhri G, Choi HS, Kashiwagi S*. Real-time imaging of vaccine biodistribution using zwitterionic NIR nanoparticles. Adv Healthcare Mater, 2019; 8(15):e1900035.

4. Kang H, Han M, Xue J, Baek Y, Chang J, Hu S, Nam H, Jo MJ, Fakhri GE, Hutchens MP, Choi HS, Kim J. Renal clearable nanochelators for iron overload therapy. Nat Commun, 2019; 10(1):5134.

5. Park GK, Kim SH, Kim K, Das P, Kim BG, Kashiwagi S, Choi HS, Hwang NS. Dual-channel fluorescence imaging of hydrogel degradation and tissue regeneration in the brain. Theranostics, 2019; 9(9):4255-4264.

6. Miranda D, Huang H, Kang H, Zhan Y, Wang D, Zhou Y, Geng J, Kilian HI, Stiles W, Razi A, Ortega J, Xia J, Choi HS, Lovell JF. Highly-soluble cyanine j-aggregates entrapped by liposomes for in vivo optical imaging around 930 nm. Theranostics, 2019; 9(2):381-390.

7. Pal R, Kang H, Choi HS, Kumar ATN. Fluorescence lifetime-based tumor contrast enhancement using an EGFR antibody–labeled near-infrared fluorophore. Clin Cancer Res, 2019; 25(22):6653-61.

8. Jeong S, Kang H, Cha MG, Lee SG, Kim J, Chang H, Lee Y-S, Jeong DH. Two-dimensional SERS encoding method for on-bead peptide sequencing in high-throughput bioanalysis. Chem Commun, 2019;55(18):2700-4.

9. Cha MG, Kang H, Choi Y-S, Cho Y, Lee M, Lee H-Y, Lee Y-S, Jeong DH. Effect of alkylamines on morphology control of silver nanoshells for highly enhanced Raman scattering. ACS Appl Mater Interfaces, 2019;11(8):8374-81.