Principal Investigators

Satoshi Kashiwagi, M.D., Ph.D.

Assistant Professor of Radiology, Harvard Medical School (HMS)

Assistant Investigator, Department of Radiology, Mass General Brigham (MGB)

Academic & Professional Experience

Assistant Professor, Department of Radiology, Harvard Medical School, Boston, MA (2018 - Present)
Assistant Professor, Department of Medicine, Harvard Medical School, Boston, MA (2016 - 2018)
Assistant Investigator, Department of Radiology, MGB, Boston, MA (2017 - Present)
Assistant Investigator, Department of Medicine, MGH, Boston, MA (2016 - 2018)
Instructor, Department of Radiology, Harvard Medical School, Boston, MA (2009 - 2015)

Education

M.D. 1997, Keio University School of Medicine, Tokyo, Japan
Ph.D. 2004, Keio University, Graduate School of Medicine, Tokyo, Japan

CONTACT INFORMATION

149 13th St., Rm 5.213

Charlestown, MA 02129

p: 1-(617)-726-6265

WEBSITES

MGB Profile

CII profile

Translational Molecular Imaging Scientist

Researcher advancing near-infrared probe technologies for precision imaging, image-guided intervention, and targeted therapy.

My research focuses on the design and translational development of near-infrared probes for precision imaging and intervention. I investigate the molecular and biological mechanisms that govern probe targeting to specific cells, tissues, and organs, and use these insights to develop imaging-guided therapeutic strategies. My work also includes the development of multichannel near-infrared platforms for intraoperative imaging and the characterization of probe pharmacology, including ADME properties, to support clinical translation. In addition, I pioneered the therapeutic application of NIR-II light, or NIR-II photobiomodulation, for immunomodulation and disorders of the central nervous system. Through this integrated approach, I aim to advance next-generation optical technologies for disease detection, surgical guidance, and targeted treatment.

Featured Publications (full list ->📚)

Yokomizo S, Kopp T, Roessing M, Morita A, Lee S, Cho S, Ogawa E, Komai E, Inoue K, Fukushi M, Feil S, Kim HH, Bragin DE, Gerashchenko D, Huang PL, Kashiwagi S,* Atochin DN.* Near-Infrared II Photobiomodulation Preconditioning Ameliorates Stroke Injury via Phosphorylation of eNOS. Stroke, 2024; 55(6):1641-1649.

https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.045358

Park HS, Yokomizo S, Wang H, Manganiello S, Monaco H, McDonnell R, Kim HJ, Rho J, Gladstone J, Ahn S, Jung H, Kang H, Bao K, Kashiwagi S,* Choi HS*. Bifunctional Tumor-Targeted Bioprobe for Phototheranosis. Biomater Res. 2024; 28:0002.

https://spj.science.org/doi/10.34133/bmr.0002

Hwang DW, Ser J, Ziabrev K, Park GK, Jo MJ, Yokomizo S, Bao K, Yamashita A, Cho H, Henary M, Kashiwagi S,* Choi HS*. Image-Guided Monitoring of Mitochondria and Blood-Brain Barrier Dysfunction in Amyotrophic Lateral Sclerosis Mice. Biomater Res. 2025; 29:0162.

https://spj.science.org/doi/10.34133/bmr.0162

Fukuda T, Yokomizo S, Casa S, Monaco H, Manganiello S, Wang H, Lv X, Ulumben AD, Yang C, Kang MW, Inoue K, Fukushi M, Sumi T, Wang C, Kang H, Bao K, Henary M,* Kashiwagi S,* Choi HS*. Fast and Durable Intraoperative Near-infrared Imaging of Ovarian Cancer Using Ultrabright Squaraine Fluorophores. Angew Chem Int Ed Engl. 2022 04 19; 61(17):e202117330.

https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202117330

Yokomizo S, Henary M, Buabeng ER, Fukuda T, Monaco H, Baek Y, Manganiello S, Wang H, Kubota J, Ulumben AD, Lv X, Wang C, Inoue K, Fukushi M, Kang H, Bao K, Kashiwagi S,* Choi HS*. Topical pH Sensing NIR Fluorophores for Intraoperative Imaging and Surgery of Disseminated Ovarian Cancer. Adv Sci. 2022 07; 9(20):e2201416.

https://advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202201416

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