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Chair and Chief Executive Officer
Dave Ricks is chair and chief executive officer of Eli Lilly and Company. Joining Lilly in 1996, Dave has held roles in marketing, sales, drug development, and international operations, becoming CEO in January 2017 and chair of the board in June 2017. Under his leadership, Lilly has delivered record R&D output and addressed significant health challenges like diabetes, Alzheimer’s disease, and cancer. He earned a Bachelor of Science degree from Purdue University and a Master of Business Administration degree from Indiana University. Dave serves on the boards of Adobe and Business Roundtable and is engaged in Central Indiana’s well-being.
董事長兼執行長
Dave Ricks 是禮來公司（Eli Lilly and Company）的董事長兼執行長。自1996年加入禮來公司以來，Dave 曾擔任行銷、銷售、藥物開發以及國際業務等多個職位，並於2017年1月出任執行長，同年6月擔任董事會主席。在他的領導下，禮來公司實現了創紀錄的研發成果，並應對了糖尿病、阿茲海默症以及癌症等重大健康挑戰。他擁有普渡大學的科學學士學位以及印第安納大學的工商管理碩士學位。此外，Dave 亦在 Adobe 和 Business Roundtable 的董事會任職，並積極參與印第安納州中部地區的社區福祉活動。
Dave Ricks
I’m Emily Wu and I play the role of Dave Ricks. So I am a Chair and Chief Executive Officer of Eli Lilly and Company. I hold a Bachelor of Science degree from Purdue University and a Master of Business Administration degree from Indiana University. I also serve on the boards of Adobe and Business Roundtable and remain actively engaged in Central Indiana’s well-being.
Dave Ricks (中文)
我是 Emily Wu，今天扮演 Dave Ricks 的角色。
我作為禮來公司（Eli Lilly and Company）的董事長兼執行長，擁有普渡大學的科學學士學位以及印第安納大學的工商管理碩士學位。此外，我也在 Adobe 和 Business Roundtable 的董事會任職，並積極參與印第安納州中部地區的社區福祉活動。
Pharmaceutical Product Life Cycle
Case Study 5: 12 principles of green chemistry in product life cycle
In this project, the stage of research and development plays an important role in our product life cycle, which is to use the 12 principles of green chemistry to evaluate potential environmental impacts.
For instance, in order to make the product as safe as possible for its use, we eliminate and reduce hazardous materials, which corresponds to the principle of designing Safer Chemicals.
案例研究 5：綠色化學12項原則在產品生命週期中的應用
在此項目中，研發階段在我們的產品生命週期中扮演了重要角色，我們利用綠色化學的12項原則來評估潛在的環境影響。
例如，為了使產品的使用盡可能安全，我們會減少或消除危險材料，這與「設計更安全化學品」的原則相符。
The chart highlights our Management Approach to the pharmaceutical product life cycle, emphasizing the different environmental considerations at each stage.
這張圖表突顯了我們對藥品生命週期的管理方法，強調了每個階段的不同環境考量。
Each stage integrates strategies like environmental risk assessments, emissions reduction, and water conservation to further reduce environmental footprint throughout the life cycle of the products.
每個階段都融合了環境風險評估、減少排放以及節約用水等策略，以在產品整個生命週期中進一步減少環境足跡。
Integrating sustainability across the value-chain to achieve the ultimate goal of having a positive impact on patients and the planet.
Research and development
Using the 12 principles of green chemistry, environmental risk assessments, packaging manufacturing reviews, and an environmental development review process.
Materials and natural resources: Water conservation
Recycling over 97% of water from 2022-2023, reducing water use in water-stressed areas.
Implementing 100% of water management plans.
All sites, partners, and manufacturers meet strict environmental standards to ensure water sustainability.
將永續性融入整個價值鏈，以實現對患者和地球產生積極影響的終極目標。
研究與開發
應用綠色化學的12項原則、環境風險評估、包裝製造審查，以及環境開發審查流程。
材料與自然資源：水資源保護
從2022年至2023年回收超過97%的用水，減少在缺水地區的用水量。
落實100%的水資源管理計畫。
確保所有場地、合作夥伴及製造商符合嚴格的環境標準，以確保水資源永續性。
Green chemistry is the design of chemical products and processes that reduce or eliminate the use or generation of hazardous substances.
綠色化學的設計是為了減少或消除有害物質的使用或產生的化學產品和製程。
These principles encourage sustainable strategies, such as using renewable resources, safer solvents, and catalysts, while promoting pollution prevention, energy efficiency, and the safe degradation of chemical products.
這些原則鼓勵永續策略，例如使用再生資源、更安全的溶劑和催化劑，同時還能促進污染預防、能源效率和化學產品的安全降解。
Green chemistry has been a focus at lily for many years.
The principle of designing Safer Chemicals:
We eliminate and reduce hazardous materials in order to make the product as safe as possible for its use.
The principle of Atom Economy:
We increase the overall efficiency of material use in order to maximize integration of all materials used into the final product.
The principle of design for degradation:
We replace hazardous pollutants with safer alternatives in order to choose substances that degrade into environmentally friendly products.
綠色化學多年來一直是禮來的重點領域。
設計更安全化學品的原則：
我們致力於消除和減少危險物質，以確保產品在使用過程中的最大安全性。
原子經濟性的原則：
我們提升材料使用的整體效率，最大限度地將所有使用的材料整合進最終產品中。為降解而設計的原則：
我們以更安全的替代品取代有害污染物，選擇能降解為對環境友善的物質。
Case Study 6: Peptide Manufacturing Processes informs Sustainability
In our research we find that we need more environmentally friendly processes in peptide production.
As you can see in the chart of the red section, current methods rely on harmful solvents like DMF and DCM, create a lot of waste, and have a high PMI, which means Process Mass Intensity and isn’t great for the environment.
Additionally, methods like intensive chromatography, batch synthesis, and the large amount of waste from SPPS make the peptide manufacturing processes less sustainable.
The green section highlights more sustainable alternatives, such as green solvents, recombinant peptide production, and crystallization, focusing on reducing PMI.
Other greener approaches include hybrid synthesis, tag-assisted LPPS, and Fmoc-amino acid alternatives, which aim to minimize waste and reduce PMI.
案例研究 6：多肽製造流程推動可持續性
在我們的研究中，我們發現多肽生產需要更環保的流程。
如圖表中的紅色部分所示，目前的方法依賴於有害溶劑，例如 DMF 和 DCM，會產生大量廢料，且具有很高的 PMI（即「過程物料強度指標」，Process Mass Intensity），對環境非常不利。
此外，像是密集色譜法、批量合成以及SPPS產生的大量廢棄物，這些方法使多肽製造過程變得不夠環保。
圖表中的綠色部分則強調了更可持續的替代方案，例如使用綠色溶劑、重組多肽生產技術和結晶法，這些方法專注於降低 PMI。
其他更環保的方法包括混合合成、標籤輔助液相多肽合成（LPPS）以及Fmoc氨基酸替代品，這些方法旨在減少浪費並降低PMI（製程質量強度）。
Source:
About the Chair and Chief Executive Officer - Dave Rick https://www.linkedin.com/in/davearicks
12 Principles of Green Chemistry
https://www.acs.org/greenchemistry/principles/12-principles-of-green-chemistry.html
2023 Sustainability Report https://downloads.ctfassets.net/1o78rkhl3da6/sOlTh4owsO65U8AIdlXFF/84a595385f83cccb79743f69cc694e65/2023ESGReport-PDF_C_20241101.pdf
Study of Process Mass Intensity (PMI): A Holistic Analysis of Current Peptide Manufacturing Processes Informs Sustainability in Peptide Synthesis https://pubs.acs.org/doi/10.1021/acs.joc.3c01494
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