대한뇌혈류대사학회 제13차 온라인 심포지엄 연사 소개

주현우

한림대학교 일송생명과학연구소

hwju@hallym.ac.kr

약력

2025.09~ Assistant Professor at Ilsong Life Science Institute, Hallym University Principal Investigator

2024.02~2025.08 Assistant Professor of Research at Burke Neurological Institute, Weill Cornell Medicine Independent research (non-tenure)

2020.06~2024.01 Postdoctoral fellow at Burke Neurological Institute, Weill Cornell Medicine Postdoctoral research

2016.07~2020.05 Postdoctoral Fellow at Sidney Kimmel Comprehensive Cancer Center, Postdoctoral research

Johns Hopkins University School of Medicine

강의제목

Regulation of Efferocytosis in Monocyte-Derived Macrophages Promotes Stroke Recovery

강의내용

Ischemic stroke induces a robust inflammatory response that critically shapes secondary neurodegeneration and long-term functional recovery. Although both resident microglia and infiltrating peripheral immune cells participate in post-stroke tissue remodeling, their distinct contributions remain incompletely understood. In this presentation, we demonstrate that infiltrating monocyte-derived macrophages (M-Mφ) exhibit significantly higher efferocytic activity than microglia and play a central role in regulating chronic-phase neurodegeneration after stroke. Using a monocyte-tracking platform, we identify efferocytosis as a key reparative function of M-Mφ in the injured brain. Furthermore, we show that remote limb ischemic conditioning (RIC) induces systemic reprogramming of peripheral monocytes, characterized by enhanced CD36 expression and monocyte subset conversion. This immune reprogramming is maintained after brain infiltration, where CD36-dependent efferocytosis promotes resolution of inflammation and improves long-term functional recovery. These findings establish a CD36-mediated efferocytosis axis as a core neuro-immune mechanism of stroke recovery and suggest immune-based therapeutic strategies that mimic RIC effects.