연사 소개

[ 1차 온라인 심포지엄 ]

약력 

2022. 09 ~                                    울산과학기술원 바이오메디컬공학과                부교수

2017. 08 ~ 2022. 08                  울산과학기술원 바이오메디컬공학과                조교수

2015. 08 ~ 2017. 08                  하버드대학교 Wyss Institute                        박사후연구원

2015. 03 ~ 2015. 08                  서울대학교                                                          박사후연구원

2011. 03 ~ 2015. 02                   서울대학교 동물생명공학과                              박사과정

2005. 03 ~ 2011. 02                  서울대학교 동물생명공학과                               학사과정

강의 제목

Microfluidic human blood-brain barrier-on-a-chip for studying CNS drug delivery 

강의 내용

The highly specialized human microvascular brain endothelium forms a selective blood-brain barrier (BBB) with adjacent pericytes and astrocytes that restricts delivery of many pharmaceuticals with targets in the central nervous system. The BBB is of major clinical relevance because dysfunction of the BBB is observed in many neurological diseases including Alzheimer’s disease. Given the importance of BBB in medical treatment, a predictive model of the human BBB is highly required. Here, I will discuss an in vitro three dimensional models of the human BBB which recapitulates the function and architecture of the in vivo human BBB using tissue engineering and organ-on-a-chip technologies. Induced pluripotent stem cell (iPSC) derived human microfluidic BBB model provides physiological relevant signals to cells and retains in vivo like barrier function for accurate screening of human BBB shuttles. I will further discuss a new ECM hydrogel membrane, named EBM, supported by an electrospun nanofiber skeleton providing BM-like environments to the brain endothelial cells due to its in vivo-like fine fibril structure, physiological level of Young’s modulus, lower thickness and greater permeability, and BM ECM-mediated biochemical signaling. 

관련 논문

1. Park TE, Mustafaoglu N, Herland A, Hasselkus R, Mannix R, FitzGerald EA, Prantil-Baun R, Watters A, Henry O, Benz M, Sanchez H, McCrea HJ, Goumnerova LC, Song HW, Palecek SP, Shusta E, and Ingber DE*, Hypoxia-enhanced Blood-Brain Barrie9r Chip recapitulates human barrier function and shuttling of drugs and antibodies, Nature Communications, 2019, 13, 10(1):2621 

2. Choi JW, Yoon J, Kim DS*, Park TE*, Human iPS-derived blood-brain barrier model exhibiting enhanced barrier properties empowered by engineered basement membrane, Biomaterials, 2023, 293, 121983 

3. Choi B, Choi JW, Jin H, Sim HR, Park JH, Park TE*, Kang JH*, Condensed ECM-based nanofilms on highly permeable PET membranes for robust cell-to-cell communications with improved optical clarity, Biofabrication, 2021, 13, 4