Comprehensive Therapeutic Development Pipeline for Small Lymphocytic 

DelveInsight's latest analysis of the "Small Lymphocytic Lymphoma Pipeline Intelligence, 2025" delivers extensive insights on more than 80 organizations and over 80 developmental compounds in the Small Lymphocytic Lymphoma therapeutic landscape. The analysis encompasses drug candidate profiles across both clinical and preclinical development phases. Additionally, it includes evaluation of Small Lymphocytic Lymphoma investigational treatments by formulation type, developmental phase, administration method, and molecular classification. The report also identifies dormant pipeline candidates in this therapeutic area.

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Essential Highlights from the Small Lymphocytic Lymphoma Pipeline Analysis

On December 05, Dana-Farber Cancer Institute initiated an investigation to test the effectiveness of zanubrutinib in combination with venetoclax in participants with previously treated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).

On December 04, Eli Lilly and Company revealed a Study J2N-MC-JZ01 (JZ01) representing an individual-study appendix (ISA) under master protocol J2N-MC-JZNY, and represents participants from the completed originator investigation, clinical study LOXO-BTK-18001/J2N-OX-JZNA. Participants in the originator investigation will have the opportunity to continue their assigned study intervention or continue their follow-up visits by transitioning to this investigation. This investigation will assess the long-term safety and efficacy of pirtobrutinib.

DelveInsight's Small Lymphocytic Lymphoma Pipeline analysis reveals a dynamic field with over 80 active organizations advancing more than 80 pipeline treatment candidates.

The prominent Small Lymphocytic Lymphoma Companies include Loxo Oncology, Chia Tai Tianqing Pharmaceutical Group, Iovance Biotherapeutics, Ascentage Pharma, NovalGen, Pfizer, MingSight Pharmaceuticals, Jiangsu MingSight-Relin Pharmaceutical, TG Therapeutics, and additional organizations.

Notable Small Lymphocytic Lymphoma Pipeline Therapies include Pirtobrutinib, Bendamustine, Rituximab, Venetoclax, LOXO-305, ABT-199, ofatumumab, TG02 citrate, and additional candidates.

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Small Lymphocytic Lymphoma Background

SLL represents an indolent (slow growing) non-Hodgkin lymphoma that impacts B cells. B cells (also known as B lymphocytes) are specialized white blood cells. Under normal conditions they produce immunoglobulins (also called antibodies) that help protect our bodies against infection and disease. Small lymphocytic lymphoma is considered part of the same disease process as CLL; however, the disease is known as SLL when it involves a lymph node, and CLL when it involves the peripheral blood. SLL that accumulates in the bone marrow and the spleen can deplete the amount of healthy blood cells in the circulating blood (blood that flows throughout the body). This indolent B-cell malignancy presents unique therapeutic challenges due to its chronic nature, variable clinical course, and tendency for transformation to more aggressive lymphoma subtypes. While patients may experience prolonged periods of stable disease, the condition typically follows a relapsing-remitting pattern requiring multiple lines of therapy over time. Current treatment approaches focus on delaying disease progression, managing symptoms, and preserving quality of life while balancing treatment-related toxicities.

Small Lymphocytic Lymphoma Emerging Drug Profiles

TQ-B3525: Chia Tai Tianqing Pharmaceutical Group

TQ-B3525 represents a novel and selective oral PI3K α/δ inhibitor with activity 41 and 138 folds higher than Buparlisib against PI3K α and PI3K δ in pre-clinical research. TQ-B3525 is well-tolerated in Chinese patients with advanced malignancies, and demonstrated high promising antitumor activity in R/R lymphoma patients. Presently, the compound is advancing through Phase I/II stage of Clinical investigation evaluation for the treatment of SLL.

LOXO-305: Loxo Oncology

Pirtobrutinib (LOXO-305), represents an investigational, oral, highly-selective non-covalent Bruton's tyrosine kinase (BTK) inhibitor. BTK serves a key role in the B-cell antigen receptor signaling pathway, which is required for the development, activation and survival of normal white blood cells, known as B-cells, and malignant B-cells. BTK represents a validated molecular target found across numerous B-cell leukemias and lymphomas including chronic lymphocytic leukemia, mantle cell lymphoma, Waldenstrom's macroglobulinemia, and marginal zone lymphoma. Currently available BTK inhibitors irreversibly inhibit BTK and the long-term efficacy of these therapies can be limited by acquired resistance. Pirtobrutinib was engineered to reversibly bind BTK, deliver consistently high target coverage regardless of BTK turnover rate, preserve activity in the presence of the C481 acquired resistance mutations, and avoid off-target kinases that have complicated the development of both covalent and investigational non-covalent BTK inhibitors. Pirtobrutinib is currently undergoing evaluation in multiple clinical investigations. Safety and efficacy have not been established for the uses being investigated.

IOV 2001: Iovance Biotherapeutics

IOV 2001 represents an adoptive cell therapy consisting of autologous peripheral blood lymphocytes (PBL) being created by Iovance Biotherapeutics. Presently, the compound is advancing through Phase I/II stage of Clinical investigation evaluation for the treatment of SLL.

The Small Lymphocytic Lymphoma Pipeline Analysis Delivers Intelligence Into

The analysis delivers comprehensive intelligence about organizations that are creating therapies for the treatment of Small Lymphocytic Lymphoma with aggregate therapies created by each organization for the same indication.

It evaluates various therapeutic candidates categorized into early-phase, mid-phase, and late-phase of development for Small Lymphocytic Lymphoma Treatment.

Small Lymphocytic Lymphoma Companies are engaged in targeted therapeutics development with corresponding active and inactive (dormant or terminated) projects.

Small Lymphocytic Lymphoma Drugs in development classified by developmental phase, administration route, target receptor, monotherapy or combination therapy, various mechanisms of action, and molecular classification.

Comprehensive analysis of partnerships (company-company partnerships and company-academia partnerships), licensing agreements and financial arrangements for future progression of the Small Lymphocytic Lymphoma market.

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Small Lymphocytic Lymphoma Companies

Loxo Oncology, Chia Tai Tianqing Pharmaceutical Group, Iovance Biotherapeutics, Ascentage Pharma, NovalGen, Pfizer, MingSight Pharmaceuticals, Jiangsu MingSight-Relin Pharmaceutical, TG Therapeutics, and additional organizations.

Small Lymphocytic Lymphoma Pipeline Analysis Delivers Therapeutic Evaluation

The pipeline analysis delivers therapeutic evaluation of developmental drugs by Administration Route. Products have been organized under various administration routes including:

• Intra-articular

• Intraocular

• Intrathecal

• Intravenous

• Ophthalmic

• Oral

• Parenteral

• Subcutaneous

• Topical

• Transdermal

Small Lymphocytic Lymphoma Products Organized by Molecular Classification

Products have been organized under various molecular types including:

• Oligonucleotide

• Peptide

• Small molecule

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Parameters of the Small Lymphocytic Lymphoma Pipeline Analysis

Coverage: Global

Small Lymphocytic Lymphoma Companies: Loxo Oncology, Chia Tai Tianqing Pharmaceutical Group, Iovance Biotherapeutics, Ascentage Pharma, NovalGen, Pfizer, MingSight Pharmaceuticals, Jiangsu MingSight-Relin Pharmaceutical, TG Therapeutics, and additional organizations.

Small Lymphocytic Lymphoma Pipeline Therapies: Pirtobrutinib, Bendamustine, Rituximab, Venetoclax, LOXO-305, ABT-199, ofatumumab, TG02 citrate, and additional candidates.

Small Lymphocytic Lymphoma Therapeutic Evaluation by Product Type: Mono, Combination, Mono/Combination

Small Lymphocytic Lymphoma Therapeutic Evaluation by Clinical Phases: Discovery, Pre-clinical, Phase I, Phase II, Phase III

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Contents Overview

1. Introduction

2. Executive Summary

3. Small Lymphocytic Lymphoma: Overview

4. Pipeline Therapeutics

5. Therapeutic Assessment

6. Small Lymphocytic Lymphoma– DelveInsight’s Analytical Perspective

7. Late Stage Products (Pre-Registration)

8. Drug Name : Company Name

9. Drug profiles in the detailed report…..

10. Last Stage Products (Phase III)

11. LOXO-305: Loxo Oncology

12. Drug profiles in the detailed report…..

13. Mid Stage Products (Phase I/II)

14. TQ-B3525: Chia Tai Tianqing Pharmaceutical Group

15. Drug profiles in the detailed report…..

16. Preclinical and Discovery Stage Products

17. Drug name : Company name

18. Drug profiles in the detailed report…..

19. Inactive Products

20. Small Lymphocytic Lymphoma Key Companies

21. Small Lymphocytic Lymphoma Key Products

22. Small Lymphocytic Lymphoma - Unmet Needs

23. Small Lymphocytic Lymphoma - Market Drivers and Barriers

24. Small Lymphocytic Lymphoma - Future Perspectives and Conclusion

25. Small Lymphocytic Lymphoma Analyst Views

26. Small Lymphocytic Lymphoma Key Companies

27. Appendix

Conclusion

The Small Lymphocytic Lymphoma pipeline demonstrates substantial advancement with diverse therapeutic approaches addressing critical unmet needs in this indolent B-cell malignancy. With over 80 organizations developing more than 80 pipeline candidates, the therapeutic landscape is experiencing unprecedented innovation driven by enhanced understanding of B-cell receptor signaling pathways, BTK biology, and mechanisms of acquired resistance to existing therapies. The remarkable diversity of therapeutic modalities under investigation—spanning novel BTK inhibitors, PI3K inhibitors, BCL-2 antagonists, adoptive cell therapies, and combination regimens—reflects the multifaceted approach being pursued to address disease heterogeneity and overcome resistance mechanisms that limit durability of current treatments.

malignancy.

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