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As a leading expert in life sciences market research, I'm excited to share insights from DelveInsight’s comprehensive report on the CD40/CD40L Inhibitors market. This innovative field targets the CD40-CD40L pathway, crucial for immune regulation in autoimmune diseases, transplantation, and oncology. In this LinkedIn article, I'll explore the market dynamics, competitive landscape, and forecast to 2034 across the 7MM (US, EU4, UK, Japan).
CD40/CD40L Inhibitors Market Overview and Projections
CD40/CD40L Inhibitors Market Overview and Projections
The CD40/CD40L Inhibitors market in the 7MM is projected to grow at a significant CAGR by 2034 in leading countries (US, EU4, UK, and Japan). The CD40-CD40L Dyad, a well-characterized immune checkpoint pair, plays a key role in T cell activation, immunoglobulin isotype switching, and cytokine production; its ligand, CD40L (CD154), is a type II transmembrane protein (32–39 kDa) whose size varies due to post-translational modifications. Among several costimulatory signals, CD40-CD40L is of special interest to the transplantation community because it is vital in controlling or regulating humoral and cellular immunity. Given the central role of CD40-CD40L signaling in the regulation of inflammatory processes, this dyad is involved in the pathophysiology of many autoimmune and inflammatory diseases, including inflammatory bowel disease, systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes mellitus, and allograft.
DelveInsight’s “CD40/CD40L Inhibitors Market, Target Population, Competitive Landscape, and Market Forecast – 2034” report delivers an in-depth understanding of the CD40/CD40L inhibitors, historical and Competitive Landscape as well as the CD40/CD40L inhibitors market trends in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan.
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Some facts of the CD40/CD40L Inhibitors Market Report are:
According to DelveInsight, CD40/CD40L Inhibitors market size is expected to grow at a significant CAGR by 2034.
According to DelveInsight’s analysis, the CD40/CD40L Inhibitors Market in the 7MM was valued at approximately USD XX million in 2023. Over the forecast period from 2025 to 2034, this CD40/CD40L Inhibitors Market is projected to reach USD XX billion.
Leading CD40/CD40L Inhibitors companies working in the market are Sanofi, UCB, Amgen, Eledon Pharmaceuticals, Kiniksa Pharmaceuticals, Memgen, and others.
Key CD40/CD40L Inhibitors Therapies expected to launch in the market are Frexalimab, Dapirolizumab pegol, Dazodalibep, Tegoprubart, MEM-288, and Others.
The CD40/CD40L Inhibitors market is expected to surge due to the increasing prevalence of autoimmune and inflammatory diseases and the launch of innovative therapies during the forecast period. Furthermore, multiple-stage CD40/CD40L Inhibitors pipeline products will significantly revolutionize the CD40/CD40L Inhibitors market dynamics.
In November 2024, UCB and Biogen presented detailed results from the Phase III PHOENYCS GO study evaluating dapirolizumab pegol, demonstrating significant clinical improvement in disease activity in people living with moderate-to-severe SLE.
In June 2024, Frexalimab showed sustained lesion reduction and low relapse rates over 48 weeks in relapsing multiple sclerosis.
In February 2025, Tonix Pharmaceuticals announced the positive topline results from the Phase I trial for TNX-1500 for the prevention of kidney transplant rejection and treatment of autoimmune diseases.
CD40/CD40L Inhibitors Overview
The ligand of CD40, known as CD154 or CD40L, is a type II transmembrane protein, with a variable molecular weight between 32 and 39 kDa because of post-translation modifications. A soluble form of CD40L has been reported to express activities similar to the transmembrane form. CD40L is a member of the Tumor Necrosis Factor (TNF) superfamily and is characterized by a sandwich extracellular structure that is composed of a ß-sheet, a-helix loop, and a ß-sheet. This structure allows for the trimerization of CD40L, which is also a feature of the TNF family of ligands. CD40L is expressed primarily by activated T cells, as well as activated B cells and platelets; and under inflammatory conditions is also induced in monocytic cells, natural killer cells, mast cells, and basophils. The wide expression of this costimulatory pair indicates the pivotal roles they play in different cellular immune processes.
Do you know what will be the CD40/CD40L Inhibitors market share in 7MM by 2034 – CD40/CD40L Inhibitors Market Dynamics and Trends
CD40/CD40L Inhibitors Market
In 2023, the CD40/CD40L Inhibitors market across the 7MM was valued at USD XX billion, with the U.S. contributing significantly. The EU4 and the UK generated substantial shares, while Japan accounted for a smaller portion. Emerging therapies dominated the market, with monoclonal antibodies and fusion proteins leading. Key companies—including Sanofi, UCB, Amgen, and Eledon Pharmaceuticals—are driving innovation, supporting a projected high CAGR from 2025 to 2034.
Market growth is fueled by advancements in immune modulation aimed at autoimmune and inflammatory diseases. Current approaches include investigational inhibitors, while pipeline therapies such as Frexalimab and Dapirolizumab pegol target CD40/CD40L signaling. Combination with other immunosuppressants remains vital for enhancing outcomes.
Despite progress, gaps persist due to limited approved therapies and challenges in patient stratification. Nonetheless, ongoing research indicates strong potential for CD40/CD40L Inhibitors to transform autoimmune care.
CD40/CD40L Inhibitors Epidemiology
According to DelveInsight, the target population for CD40/CD40L Inhibitors includes patients with autoimmune diseases like SLE, multiple sclerosis, and rheumatoid arthritis. In 2024, the US accounted for ~529,300 diagnosed prevalent cases of SLE among the 7MM. Amyotrophic lateral sclerosis is most commonly diagnosed in the 70–79 age group. In 2024, the UK had observed nearly 2500 cases of kidney transplants.
CD40/CD40L Inhibitors Epidemiology Segmentation:
Total Cases in Selected Indications
Total Eligible Patient Pool in Selected Indications
Total Treated Cases in Selected Indications
Interested to know how the emerging diagnostic approaches will be contributing to the increased CD40/CD40L Inhibitors target population pool? Download report – CD40/CD40L Inhibitors Patient Pool Forecast
CD40/CD40L Inhibitors Pipeline Development Activities and Drugs Uptake
Frexalimab – Sanofi
Frexalimab is a novel monoclonal antibody that blocks the costimulatory CD40/CD40L cellular pathway necessary for adaptive and innate immune cell activation. Frexalimab’s Phase II data showed a reduction of key biomarkers of nerve cell damage in relapsing multiple sclerosis.
Dapirolizumab Pegol – UCB and Biogen
Dapirolizumab pegol inhibits CD40L signaling, reducing B cell activation and autoantibody production. It is currently in Phase III for SLE.
CD40/CD40L Inhibitors Competitive Landscape
The CD40/CD40L Inhibitors report provides insights into different therapeutic candidates in Phase III, Phase II, and Phase I stages. It also analyses CD40/CD40L Inhibitors key players involved in developing targeted therapeutics.
CD40/CD40L Inhibitors Companies and Drugs
Frexalimab: Sanofi
Dapirolizumab pegol: UCB and Biogen
Dazodalibep: Amgen
Tegoprubart (AT-1501): Eledon Pharmaceuticals
Abiprubart (KPL-404): Kiniksa Pharmaceuticals
MEM-288: Memgen
Lu AG22515: H. Lundbeck
Download report to know which TOP 3 therapies will be capturing the largest CD40/CD40L Inhibitors market share by 2034? Click here – CD40/CD40L Inhibitors Treatment Market
CD40/CD40L Inhibitors Therapeutics Assessment
Major key companies are working proactively in the CD40/CD40L Inhibitors Therapeutics market to develop novel therapies which will drive the CD40/CD40L Inhibitors treatment markets in the upcoming years are Sanofi, UCB, Amgen, Eledon Pharmaceuticals, Kiniksa Pharmaceuticals, Memgen, and others.
CD40/CD40L Inhibitors Clinical Trials
The report delves into ongoing and upcoming clinical trials for CD40/CD40L Inhibitors, highlighting trial designs, patient recruitment, endpoints, and key results from studies evaluating therapies like Frexalimab and Dapirolizumab pegol.
CD40/CD40L Inhibitors Companies
Leading entities include Sanofi, UCB, Amgen, Eledon Pharmaceuticals, Kiniksa Pharmaceuticals, Memgen, and others, each advancing targeted treatments for autoimmune and inflammatory indications.
CD40/CD40L Inhibitors Drugs
Key therapies encompass Frexalimab, Dapirolizumab pegol, Dazodalibep, Tegoprubart, MEM-288, and Others, focusing on immune modulation and pathway inhibition
Do you know how Frexalimab and Dapirolizumab pegol market launch will be impacting the CD40/CD40L Inhibitors market CAGR? Download sample report - CD40/CD40L Inhibitors Clinical Trials and Drugs Market
CD40/CD40L Inhibitors Report Key Insights
1. Key Insights
2. Report Introduction
3. Executive Summary of CD40/CD40L
4. Key Events of CD40/CD40L
5. Epidemiology and Market Forecast Methodology
6. CD40/CD40L Market Overview at a Glance in the 7MM
6.1. Market Share (%) Distribution by Therapies in 2025
6.2. Market Share (%) Distribution by Therapies in 2034
7. CD40/CD40L: Background and Overview
7.1. Introduction
7.2. Treatment
8. Target Patient Pool
8.1. Key Findings
8.2. Assumptions and Rationale: 7MM
8.3. Epidemiology Scenario in the 7MM
8.4. Total Cases in Selected Indications for CD40/CD40L in the 7MM
8.5. Total Eligible Patient Pool for CD40/CD40L in Selected Indications in the 7MM
8.6. Total Treated Cases in Selected Indications for CD40/CD40L in the 7MM
9. Emerging Therapies
9.1. Key Competitors
9.2. Dapirolizumab Pegol: UCB and Biogen
9.2.1. Product Description
9.2.2. Other developmental activities
9.2.3. Clinical development
9.2.4. Safety and efficacy
9.3. Frexalimab: Sanofi
9.3.1. Product Description
9.3.2. Other developmental activities
9.3.3. Clinical development
9.3.4. Safety and efficacy
List to be continued in the report
10. CD40/CD40L: Seven Major Market Analysis
10.1. Key Findings
10.2. Market Outlook
10.3. Conjoint Analysis
10.4. Key Market Forecast Assumptions
10.4.1. Cost Assumptions and Rebates
10.4.2. Pricing Trends
10.4.3. Analogue Assessment
10.4.4. Launch Year and Therapy Uptakes
10.5. Total Market Size of CD40/CD40L in the 7MM
10.6. Market Size of CD40/CD40L by Indications in the 7MM
10.7. Market Size of CD40/CD40L by Therapies in the 7MM
10.8. The United States Market Size
10.8.1. Market Size of CD40/CD40L by Indications in the United States
10.8.2. Market Size of CD40/CD40L by Therapies in the United States
10.9. EU4 and the UK Market Size
10.9.1. Market Size of CD40/CD40L by Indications in EU4 and the UK
10.9.2. Market Size of CD40/CD40L by Therapies in EU4 and the UK
10.10. Japan Market Size
10.10.1. Market Size of CD40/CD40L by Indications in Japan
10.10.2. Market Size of CD40/CD40L by Therapies in Japan
11. Market Access and Reimbursement
12. SWOT Analysis of CD40/CD40L
13. KOL Views of CD40/CD40L
14. Unmet Needs of CD40/CD40L
15. Appendix
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