DelveInsight's comprehensive report on "Alopecia Areata Market Insight, Epidemiology, and Market Forecast - 2034" delivers extensive understanding of alopecia areata, encompassing historical and projected epidemiology alongside market dynamics in the United States, EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan.

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Key Highlights from the Market Report

• In 2023, the United States documented the highest alopecia areata prevalence with approximately 764 thousand cases, projected to increase by 2034 at a CAGR of 1.4%.

• In 2023, the UK registered the highest diagnosed prevalent case numbers of alopecia areata among the EU4 and the UK, with approximately 323 thousand cases. Spain followed with around 170 thousand cases, while Italy documented the lowest diagnosed prevalence, with nearly 100 thousand cases.

• In 2023, Japan documented approximately 167 thousand diagnosed prevalent cases of alopecia areata in females and 107 thousand cases in males, with case numbers projected to escalate by 2034.

• In 2023, females represented 63% of alopecia areata cases in the EU4 and the UK, while males accounted for 37%. These gender-specific distributions are anticipated to evolve, with overall prevalence projected to increase by 2034.

• In Germany, approximately 89% of alopecia areata cases in 2023 manifested in individuals before 40 years of age, while 11% were documented in those above 40 years of age, indicating heightened susceptibility among the younger age demographic.

• In 2023, around 14% of alopecia areata cases in the EU4 and the UK were classified as mild, 45% moderate, and 41% severe. These severity distributions are expected to persist, with overall prevalence anticipated to increase by 2034.

• Key pharmaceutical developers include Eli Lilly and Company, Pfizer, Incyte Corporation, Sun Pharmaceuticals, and others.

• Notable therapies comprise OLUMIANT (baricitinib), LITFULO (ritlecitinib), Etrasimod, Coacillium (LH-8), PF-06651600, ADX-914, Upadacitinib, Daxdilimab, CTP-543, Deucravacitinib, SHR0302, IMG-007, Jaktinib, Rezpegaldesleukin, Rosnilimab, LEO 124249, Baricitinib, and others.

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Epidemiological Segmentation in the 7MM

• Total Prevalence of Alopecia Areata

• Prevalent Cases of Alopecia Areata by severity

• Gender-specific Prevalence of Alopecia Areata

• Diagnosed Cases of Episodic and Chronic Alopecia Areata

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Marketed Alopecia Areata Therapeutics

OLUMIANT (Baricitinib): Eli Lilly and Company/Incyte Corporation OLUMIANT represents a selective and reversible JAK inhibitor that targets the cytokine signaling pathway associated with alopecia areata. It functions by inhibiting ATPase activation on JAK, blocking signal transmission to cells via the Signal Transducer and Activator of Transcription (STAT) pathway. This mechanism interrupts inflammation and immune responses involved in the condition. OLUMIANT, functioning as a JAK inhibitor, has obtained regulatory approval in the US, EU, and Japan for treating severe alopecia areata.

LITFULO (Ritlecitinib): Pfizer LITFULO (ritlecitinib), developed by Pfizer, represents an innovative FDA-approved oral treatment for severe alopecia areata, an autoimmune disorder causing substantial hair loss. It functions by targeting JAK3 and TEC inhibitors to interrupt immune pathways responsible for hair follicle destruction. LITFULO has received approval for use in the US, EU, and Japan, addressing the needs of individuals aged 12 and older with severe forms of the condition. It also received breakthrough designation, highlighting its potential to transform alopecia areata therapeutic management.

LEQSELVI (Deuruxolitinib, CTP 543): Sun Pharmaceuticals LEQSELVI (Deuruxolitinib), developed by Sun Pharmaceutical Industries, represents an FDA-approved oral treatment for severe alopecia areata in adults. It functions by inhibiting JAK1 and JAK2, targeting immune pathways that contribute to hair loss in the condition. LEQSELVI is administered once daily and has received breakthrough and fast track designation for alopecia areata. This approval provides a new therapeutic option for individuals with severe alopecia areata, offering hope for those affected by this autoimmune disorder.

Emerging Alopecia Areata Therapeutics

RINVOQ (Upadacitinib): AbbVie RINVOQ (upadacitinib), a JAK1-specific oral inhibitor, demonstrates promise for alopecia areata treatment, despite being primarily approved for rheumatoid arthritis and atopic dermatitis. Clinical studies indicate substantial hair regrowth and improved quality of life. Currently advancing through Phase III, RINVOQ is projected for alopecia areata approval by 2027.

Bempikibart (ADX-914): Q32 Bio Bempikibart (ADX-914) represents a fully human antibody that targets the IL-7 Receptor Alpha subunit (IL-7Ra) and Thymic Stromal Lymphopoietin (TSLP), aiming to regulate immune function in autoimmune diseases. Currently in Phase II trials for alopecia areata, both IL-7 and TSLP pathways are linked to T-cell-mediated processes in autoimmune conditions. Q32 Bio has completed enrollment for the Phase II trial.

Amlitelimab (SAR-445229): Sanofi Amlitelimab (SAR-445229) represents a monoclonal antibody targeting OX40L, a molecule that activates T cells driving autoimmune responses. By blocking the OX40-OX40L pathway, it reduces inflammation and regulates the immune system without widespread immunosuppression. Currently in Phase II trials for alopecia areata, it shows potential as a targeted, effective alternative to traditional immunosuppressive therapies.

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Market Forecast Outlook

Alopecia areata represents a chronic autoimmune disorder causing non-scarring hair loss, often initiating as patchy bald spots on the scalp but potentially affecting other hair-bearing areas. The immune system attacks hair follicles, disrupting growth cycles. The condition can range from localized patches to complete hair loss (alopecia totalis or universalis). Genetic and environmental factors contribute to its onset. Besides physical manifestations, alopecia areata significantly impacts emotional well-being and quality of life.

Treatment Market Landscape

The Alopecia Areata Treatment Market has evolved to incorporate a comprehensive approach, combining medications with supportive care. The market offers a range of therapies, including corticosteroids, immunosuppressants, immunomodulators, and topical sensitizers or irritants. Corticosteroids remain central for their anti-inflammatory properties, reducing immune attacks on hair follicles, while immunosuppressants and immunomodulators are utilized in more severe or resistant cases to regulate the immune system and prevent further hair loss.

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Report Scope

• Geographic Coverage: 7MM

• Study Period: 2020-2034

• Featured Companies: Eli Lilly and Company, Pfizer, Incyte Corporation, Sun Pharmaceuticals, and others

• Pipeline Therapies: OLUMIANT (baricitinib), LITFULO (ritlecitinib), Etrasimod, Coacillium (LH-8), PF-06651600, ADX-914, Upadacitinib, Daxdilimab, CTP-543, Deucravacitinib, SHR0302, IMG-007, Jaktinib, Rezpegaldesleukin, Rosnilimab, LEO 124249, Baricitinib, and others

• Market Dynamics: Alopecia Areata Market Drivers and Barriers

• Additional Coverage: Market Access and Reimbursement, Unmet Needs and Future Perspectives

Table of Contents

1. Key Insights

2. Alopecia Areata Market Report Introduction

3. Alopecia Areata Executive Summary

4. Key Events

5. Alopecia Areata Epidemiology and Market Forecast Methodology

6. Alopecia Areata Market Overview at a Glance

7. Alopecia Areata Market Disease Background and Overview

8. Guidelines

9. Epidemiology and Patient Population of Alopecia Areata in the 7MM

10. Alopecia Areata Patient Journey

11. Alopecia Areata Marketed Drugs

12. Alopecia Areata Emerging Drugs

13. Alopecia Areata: 7MM Analysis

14. Alopecia Areata Unmet Needs

15. Alopecia Areata SWOT Analysis

16. Alopecia Areata KOL Views

17. Alopecia Areata Market Access and Reimbursement

18. Appendix

19. DelveInsight Capabilities

20. Disclaimer

21. About DelveInsight

About DelveInsight

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