Cholestatic Pruritus Treatment Pipeline Analysis 2025

DelveInsight's "Cholestatic Pruritus Pipeline Analysis 2025" delivers extensive intelligence on over 6 pharmaceutical firms and more than 6 investigational medications within the Cholestatic Pruritus development arena. The analysis encompasses profiles of Cholestatic Pruritus therapeutic candidates, spanning both clinical and preclinical phases. Additionally, it includes evaluation of Cholestatic Pruritus investigational treatments by product category, developmental phase, administration method, and molecular classification. The report also spotlights dormant development programs in this therapeutic area.

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Primary Highlights from the Cholestatic Pruritus Pipeline Analysis

• On October 9, 2025, Mirum Pharmaceuticals Inc. revealed that a clinical research investigation aims to examine the application of the investigational medication, volixibat, for managing pruritus (itching) linked with Primary Biliary Cholangitis (PBC), and to evaluate the potential influence on PBC disease advancement.

• DelveInsight's Cholestatic Pruritus Pipeline analysis reveals a dynamic field featuring more than 6 engaged entities advancing over 6 investigational treatments for Cholestatic Pruritus management.

• Major Cholestatic Pruritus pharmaceutical firms include Escient Pharmaceuticals, Cara Therapeutics, GlaxoSmithKline, CymaBay Therapeutics, Mirum Pharmaceuticals, and additional organizations.

• Notable Cholestatic Pruritus investigational medications include EP547, Linerixibat, Maralixibat, LUM001, A4250, among others.

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Cholestatic Pruritus Background

Cholestasis represents impaired bile secretion. Pruritus is a complication arising from cholestasis, including cases associated with genetic mutations affecting hepatocyte transporter coding and inflammatory hepatic diseases. Pruritus is a debilitating manifestation observed in 80% to 100% of individuals with cholestatic hepatic conditions, encompassing primary biliary cholangitis, primary sclerosing cholangitis, and intrahepatic cholestasis of pregnancy. Cholestatic pruritus exhibits severe characteristics.

Cholestatic Pruritus Investigational Drug Profiles

Volixibat: Mirum Pharmaceuticals

Volixibat is an orally administered, minimally absorbed compound engineered to selectively inhibit the apical sodium dependent bile acid transporter (ASBT). Volixibat may provide a novel therapeutic strategy for adult cholestatic conditions by preventing bile acid recycling through ASBT inhibition, consequently reducing bile acid levels systemically and hepatically. Phase 1 and Phase 2 investigations of volixibat demonstrated targeted fecal bile acid elimination, a pharmacodynamic indicator of ASBT inhibition, alongside reductions in LDL cholesterol and elevations in 7C4, which serve as markers of bile acid synthesis. Volixibat has undergone evaluation in more than 400 subjects throughout numerous clinical investigations. The most frequently reported adverse events were mild to moderate gastrointestinal occurrences observed in the volixibat treatment groups. Presently, the medication is undergoing Phase II clinical trial assessment for Cholestatic Pruritus management.

Linerixibat: GlaxoSmithKline

Linerixibat is an experimental therapeutic agent for managing cholestatic pruritus in individuals with PBC and remains unapproved for clinical use globally. In 2019, FDA conferred orphan drug designation for linerixibat in managing PBC and related cholestatic pruritus. Linerixibat is a minimally absorbed small molecule IBAT inhibitor delivered as an oral tablet formulation. Through blocking bile acid reabsorption within the small intestine, linerixibat decreases pruritic bile acids in systemic circulation. Presently, the medication is undergoing Phase III clinical trial assessment for Cholestatic Pruritus management.

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Cholestatic Pruritus Pharmaceutical Firms

Escient Pharmaceuticals, Cara Therapeutics, GlaxoSmithKline, CymaBay Therapeutics, Mirum Pharmaceuticals, and additional organizations.

The Cholestatic Pruritus Pipeline Analysis Offers Intelligence On:

• The analysis delivers detailed intelligence regarding pharmaceutical companies developing therapeutics for Cholestatic Pruritus management, including cumulative therapies created by each organization for this indication.

• It evaluates various therapeutic candidates categorized into early-phase, mid-phase, and late-phase development for Cholestatic Pruritus Treatment.

• Cholestatic Pruritus pharmaceutical firms engaged in targeted therapeutic development with corresponding active and inactive (dormant or terminated) initiatives.

• Cholestatic Pruritus investigational medications classified by developmental phase, administration method, target receptor, monotherapy or combination therapy, distinct mechanism of action, and molecular classification.

• Comprehensive analysis of partnerships (company-to-company collaborations and company-to-academia partnerships), licensing arrangements, and funding particulars for future progression of the Cholestatic Pruritus Market.

The Cholestatic Pruritus Pipeline analysis presents therapeutic evaluation of investigational medications by Administration Method. Products are classified under multiple administration routes including:

• Intra-articular

• Intraocular

• Intrathecal

• Intravenous

• Ophthalmic

• Oral

• Parenteral

• Subcutaneous

• Topical

• Transdermal

Cholestatic Pruritus products are classified under various molecular categories including:

• Oligonucleotide

• Peptide

• Small molecule

From investigational drug candidates to competitive intelligence, the Cholestatic Pruritus Pipeline Analysis encompasses comprehensive insights - review it today @ Cholestatic Pruritus Market Drivers and Barriers, and Future Perspectives

Scope of the Cholestatic Pruritus Pipeline Analysis

• Coverage: Global

• Cholestatic Pruritus Pharmaceutical Firms: Escient Pharmaceuticals, Cara Therapeutics, GlaxoSmithKline, CymaBay Therapeutics, Mirum Pharmaceuticals, and additional organizations.

• Cholestatic Pruritus Investigational Treatments: EP547, Linerixibat, Maralixibat, LUM001, A4250, among others.

• Cholestatic Pruritus Therapeutic Evaluation by Product Category: Monotherapy, Combination, Mono/Combination

• Cholestatic Pruritus Therapeutic Evaluation by Clinical Phases: Discovery, Preclinical, Phase I, Phase II, Phase III

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Table of Contents

* Introduction

* Executive Summary

* Cholestatic Pruritus: Overview

* Pipeline Therapeutics

* Therapeutic Assessment

* Cholestatic Pruritus- DelveInsight's Analytical Perspective

* Late Stage Products (Phase III)

* Linerixibat: GlaxoSmithKline

* Drug profiles in the detailed report.....

* Mid Stage Products (Phase II)

* Volixibat: Mirum Pharmaceuticals

* Drug profiles in the detailed report.....

* Early Stage Products (Phase I)

* Drug profiles in the detailed report.....

* Preclinical and Discovery Stage Products

* Drug name: Company Name

* Drug profiles in the detailed report.....

* Inactive Products

* Cholestatic Pruritus Key Companies

* Cholestatic Pruritus Key Products

* Cholestatic Pruritus- Unmet Needs

* Cholestatic Pruritus- Market Drivers and Barriers

* Cholestatic Pruritus- Future Perspectives and Conclusion

* Cholestatic Pruritus Analyst Views

* Cholestatic Pruritus Key Companies

* Appendix

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