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We employ a broad range of approaches, including stem cell models, single-molecule manipulation, live-cell and super-resolution imaging, molecular and biochemical techniques, proteomics and genomics, and transgenic models, to investigate membrane receptors and ion channels involved in cardiovascular and neurological diseases associated with metabolic disorders and aging.
We employ a broad range of approaches, including stem cell models, single-molecule manipulation, live-cell and super-resolution imaging, molecular and biochemical techniques, proteomics and genomics, and transgenic models, to investigate membrane receptors and ion channels involved in cardiovascular and neurological diseases associated with metabolic disorders and aging.
We develop and apply advanced biosensors to monitor signaling molecules—including second messengers (cAMP, cGMP, IP₃, and Ca²⁺), protein kinases (PKA, Akt, and CaMKII), and neurotransmitters (norepinephrine and ATP)—in neurons and cardiac myocytes. By combining these tools with live-cell imaging, we investigate pathological signaling remodeling underlying diabetes, heart failure, and Alzheimer’s disease.
We develop and apply advanced biosensors to monitor signaling molecules—including second messengers (cAMP, cGMP, IP₃, and Ca²⁺), protein kinases (PKA, Akt, and CaMKII), and neurotransmitters (norepinephrine and ATP)—in neurons and cardiac myocytes. By combining these tools with live-cell imaging, we investigate pathological signaling remodeling underlying diabetes, heart failure, and Alzheimer’s disease.
Leica FRET microscope
Leica FRET microscope
Zeiss FRET microscope
Zeiss FRET microscope
cAMP in single adult ventriclar myocytes
cAMP in single adult ventriclar myocytes
cAMP in the whole heart, Collaboration with Dr. Ripplinger
cAMP in the whole heart, Collaboration with Dr. Ripplinger
We developed a SiMPull method to study single DNA, protein, or chemicals on TIRF microscope.
We developed a SiMPull method to study single DNA, protein, or chemicals on TIRF microscope.
Single Molecule Pulldown (SiMPull) assay
Single Molecule Pulldown (SiMPull) assay
Olympus SiMPull microscope
Olympus SiMPull microscope
We apply super resolution imaging to study membrane receptors and channels in the heart and brain.
We apply super resolution imaging to study membrane receptors and channels in the heart and brain.
Super-resolution images of two populations of a GPCR in HEK293 cells
Super-resolution images of two populations of a GPCR in HEK293 cells
Leica Stelaris STED super-resolution imaging microscope
Leica Stelaris STED super-resolution imaging microscope
We develop and apply animal models of diseases using behavioral, surgical, and transgenic approaches, including HFpEF and Alzheimer's diseases.
We develop and apply animal models of diseases using behavioral, surgical, and transgenic approaches, including HFpEF and Alzheimer's diseases.
5X FAD Alzheimer's disease
5X FAD Alzheimer's disease
Diastolic function measured by echocardigram in HFpEF
Diastolic function measured by echocardigram in HFpEF
We apply electrophysiology and behavioral tests.
We apply electrophysiology and behavioral tests.
Patch-clamp and electrophysiology
Patch-clamp and electrophysiology
Behavioral tests, including MWM, FST, novel object, elevated plus, open field, fear-conditioning, etc.
Behavioral tests, including MWM, FST, novel object, elevated plus, open field, fear-conditioning, etc.
Other resources
Other resources
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Lab meetings
Lab meetings
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Lab Ordering
Lab Ordering
[coming....]
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