Kevin Xiang Lab

Neurohormonal regulation of metabolism and ageing in the heart and brain

Mission of the X-lab

We are a part of the UCLA Cardiovascular theme and metabolic theme. Dr. Xiang is a member of the UCLA MCIP graduate program and neuroscience Program.

Our lab investigates diabetes and metabolic disorders in obesity and ageing, focusing on their links to cardiovascular and neurodegenerative diseases. Using tools ranging from stem cells, single-molecule imaging, genomics and proteomics, to whole-animal genetic models, we aim to uncover mechanisms and develop innovative therapies for conditions such as diabetes, heart failure, and Alzheimer’s disease.

Key discoveries:

Identifying the critical roles of the CNS beta2 adrenergic receptor in Alzheimer's disease and Parkinson disease. PMC2923357: PMC5761666
Developing SiMPull for studying single biomolecules on TIRF microscope. PMC3103084: PMC3654178
Characterizing the insulin/beta2 adrenergic receptor signaling complex in diabetic hearts. PMC5302024: PMC4113065
Defining two functional subpopulations of a GPCR in a single hippocampal neuron. PMC5849717: PMC10404024
Characterizing an intracellular pool of beta1 adrenergic receptor in SERCA2a regulation in the heart. PMC7856104: PMC8556367: PMC9288959

Learn More

News

B2AR controls CaMKII for CTGF expression!

Chaoqun's paper accepted in Function in July 2025. [link]

Sherif recognized in ASPET!

Sherif won the oral competition in Young invesitgator session in May 2025 ASPET, Portland.

Amr presented in ENDO2025

Amr was selected to present the novel role of thyroid hormone in septic hearts in ENDO2025, San Francisco, Oct 2025.

Rita won in 2025 AHA presymposium!

Rita won the oral competition in the YIA award in the ACRE AHA presymposium , New Orleans, Nov 2025

Join the team

As a new lab in UCLA, we are excited to recriut talented postdocs, PhDs, and professional researchers.

Apply: ykxiang@mednet.ucla.edu

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