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Neurohormonal regulation of metabolism and ageing in the heart and brain
The X-Signaling lab
The X-Signaling lab
We are a part of the UCLA Cardiovascular theme and metabolic theme. Dr. Xiang is a member of the UCLA MCIP and Neuroscience Gratudate Program.
Our lab investigates diabetes and metabolic disorders in the settings of obesity and ageing, focusing on the links to cardiovascular and neurodegenerative diseases. Using tools ranging from stem cells, single-molecule imaging, genomics and proteomics, to whole-animal genetic models, we aim to uncover mechanisms and develop innovative therapies for conditions such as diabetes, heart failure, and Alzheimer’s disease.
Key discoveries:
Identifying the critical roles of the CNS beta2 adrenergic receptor in Alzheimer's disease and Parkinson disease. PMC2923357: PMC5761666
Developing SiMPull for studying single biomolecules on TIRF microscope. PMC3103084: PMC3654178
Characterizing the insulin/beta2 adrenergic receptor signaling complex in diabetic hearts. PMC5302024: PMC4113065
Defining two functional subpopulations of a GPCR in a single hippocampal neuron. PMC5849717: PMC10404024
Characterizing an intracellular pool of beta1 adrenergic receptor in SERCA2a regulation in the heart. PMC7856104: PMC8556367: PMC9288959
2026 News
Welcome new postdoc, Madhuri to join us!
Welcome new postdoc, Madhuri to join us!
August 2026, Madhuri joined us as a postdoctoral fellow.
Welcome Jing to join us as a postdoc!
Welcome Jing to join us as a postdoc!
July 2026, Jing joined us as a postdoctoral fellow.
We recevied a NHLBI R01 grant!
We recevied a NHLBI R01 grant!
June 2026, we received an new R01. We will work with Dr. Hank Granzier at the University of Arizona to study signaling regulation of myofilament stiffness in HFpEF
Welcome Martin join us from UCLA MCIP program!
Welcome Martin join us from UCLA MCIP program!
June 2026, Martin joined us as a Ph.D. student. He has extensive experimece in cardiac inflammation.
Robert M. Berne Distinguished Lectureship award!
Robert M. Berne Distinguished Lectureship award!
April 2026, Dr. Xiang received the prestigous American Physiology Society Robert M. Berne Distingushed Lectureship award.
2025 News
Rita won YIA oral competition in 2025 AHA presymposium!
Rita won YIA oral competition in 2025 AHA presymposium!
Rita won the oral competition in the YIA award in the ACRE AHA presymposium , New Orleans, Nov 2025
Amr presented in ENDO2025
Amr presented in ENDO2025
Amr was selected to present the novel role of thyroid hormone in septic hearts in ENDO2025, San Francisco, Oct 2025.
Sherif recognized in ASPET!
Sherif recognized in ASPET!
Sherif won the oral competition in Young invesitgator session in May 2025 ASPET, Portland.
Join the team
Join the team
At UCLA, we are excited to recriut talented postdocs, PhDs, and professional researchers.
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