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Cardiac ß2 adrenergic receptor deletion drives calmodulin kinase II upregulation to induce connection tissue growth factor in cardiac fibrosis and diastolic dysfunction. Function (Oxf). 2025 Aug 12. Zhu C, Zhao M, Zhao L, Wu M, Xiang YK. . PMID: 40796320.
View in: PubMedSignaling by intracellular ß2-adrenergic receptors regulates AMPA receptor trafficking and synaptic plasticity. Cell Rep. 2025 Jul 17; 44(8):116011. Lee B, Xing X, Hammes EA, Zeng Z, Estrada-Tobar ZM, Kim K, Ireton KE, Mimi Man KN, Jacobi AA, Berumen RA, Weiner JC, Shen A, Xu B, Wang J, Gasser PJ, Navedo MF, Xiang YK, Díaz E, Chen CY, Horne MC, Hell JW. PMID: 40679912.
View in: PubMedArterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia. Circ Res. 2025 Aug 15; 137(5):646-663. Hong J, Martín-Aragón Baudel M, Niloy SI, Taylor J, Mohabbat Y, Moustafa Y, Pereira Da Silva E, O'Donnell BL, Zhu Z, Daghbouche-Rubio N, Reddy GR, Sasse KC, Ward SM, Xiang YK, Isakson BE, Nieves-Cintrón M, Navedo MF. PMID: 40636957; PMCID: PMC12252251.
View in: PubMedMealtime alters daily rhythm in nuclear O-GlcNAc proteome to regulate hepatic gene expression. Cell Rep. 2025 Jun 19. Liu X, Cai YD, Hou C, Liu X, Luo Y, Mendiola AJP, Xu X, Luo Y, Zheng H, Zhao C, Chen CH, Zhang Y, Xiang YK, Ma J, Chiu JC. PMID: 40666963; PMCID: PMC12262729.
View in: PubMedHabitual Exercise Modulates Neuroimmune Interaction to Mitigate Aortic Stiffness. Circ Res. 2025 Jun 06; 136(12):1579-1594. Cho JM, Vu K, Park SK, Zhu E, Li YR, Zhao P, Yokota T, Yang L, Lu R, Xiang YK, Shen YH, Chapleau MW, Hsiai TK. PMID: 40304034; PMCID: PMC12140871.
View in: PubMedStructure and dynamics determine G protein coupling specificity at a class A GPCR. Sci Adv. 2025 Mar 21; 11(12):eadq3971. Casiraghi M, Wang H, Brennan PC, Habrian C, Hübner H, Schmidt MF, Maul L, Pani B, Bahriz SMFM, Xu B, Staffen N, Assafa TE, Chen B, White E, Sunahara RK, Inoue A, Xiang YK, Lefkowitz RJ, Isacoff EY, Nucci N, Gmeiner P, Lerch MT, Kobilka BK. PMID: 40106559; PMCID: PMC12101717.
View in: PubMedMolecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein. iScience. 2025 Feb 21; 28(2):111741. Han Y, Dawson JRD, DeMarco KR, Rouen KC, Ngo K, Bekker S, Yarov-Yarovoy V, Clancy CE, Xiang YK, Ahn SH, Vorobyov I. PMID: 39898043; PMCID: PMC11787599.
View in: PubMedInhibition of the upregulated phosphodiesterase 4D isoforms improves SERCA2a function in diabetic cardiomyopathy. Br J Pharmacol. 2025 Apr; 182(7):1487-1507. Zhu Z, Guan Q, Xu B, Bahriz S, Shen A, West TM, Zhang Y, Deng B, Wei W, Han Y, Wang Q, Xiang YK. . PMID: 39662482.
View in: PubMedAn activity-regulated transcriptional program directly drives synaptogenesis. Nat Neurosci. 2024 Sep; 27(9):1695-1707. Yee C, Xiao Y, Chen H, Reddy AR, Xu B, Medwig-Kinney TN, Zhang W, Boyle AP, Herbst WA, Xiang YK, Matus DQ, Shen K. PMID: 39103556; PMCID: PMC11374667.
View in: PubMedDifferential Downregulation of β1-Adrenergic Receptor Signaling in the Heart. J Am Heart Assoc. 2024 Jun 18; 13(12):e033733. Xu B, Bahriz S, Salemme VR, Wang Y, Zhu C, Zhao M, Xiang YK. . PMID: 38860414; PMCID: PMC11255761.
View in: PubMedCarvedilol Activates a Myofilament Signaling Circuitry to Restore Cardiac Contractility in Heart Failure. JACC Basic Transl Sci. 2024 Aug; 9(8):982-1001. Wang Y, Zhao M, Liu X, Xu B, Reddy GR, Jovanovic A, Wang Q, Zhu C, Xu H, Bayne EF, Xiang W, Tilley DG, Ge Y, Tate CG, Feil R, Chiu JC, Bers DM, Xiang YK. . PMID: 39297139; PMCID: PMC11405995.
View in: PubMedPhosphodiesterase in heart and vessels: from physiology to diseases. Physiol Rev. 2024 Apr 01; 104(2):765-834. Fu Q, Wang Y, Yan C, Xiang YK. . PMID: 37971403; PMCID: PMC11281825. View in: PubMed
Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory. Sci Signal. 2023 03 28; 16(778):eade3380. Martinez JM, Shen A, Xu B, Jovanovic A, de Chabot J, Zhang J, Xiang YK. . PMID: 36976866; PMCID: PMC10404024.
View in: PubMedCharacterizing Adrenergic Regulation of Glucose Transporter 4-Mediated Glucose Uptake and Metabolism in the Heart. JACC Basic Transl Sci. 2023 Jun; 8(6):638-655. Jovanovic A, Xu B, Zhu C, Ren D, Wang H, Krause-Hauch M, Abel ED, Li J, Xiang YK. . PMID: 37426525; PMCID: PMC10322917.
View in: PubMedWhole-heart multiparametric optical imaging reveals sex-dependent heterogeneity in cAMP signaling and repolarization kinetics. Sci Adv. 2023 01 20; 9(3):eadd5799. Caldwell JL, Lee IJ, Ngo L, Wang L, Bahriz S, Xu B, Bers DM, Navedo MF, Bossuyt J, Xiang YK, Ripplinger CM. PMID: 36662864; PMCID: PMC9858506.
View in: PubMedDivergent Actions of Myofibroblast and Myocyte β2-Adrenoceptor in Heart Failure and Fibrotic Remodeling. Circ Res. 2023 01 06; 132(1):106-108. Deng B, Zhang Y, Zhu C, Wang Y, Weatherford E, Xu B, Liu X, Conway SJ, Abel ED, Xiang YK. . PMID: 36458552; PMCID: PMC9985902.
View in: PubMedAdenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains. JCI Insight. 2022 11 22; 7(22). Ren L, Thai PN, Gopireddy RR, Timofeyev V, Ledford HA, Woltz RL, Park S, Puglisi JL, Moreno CM, Santana LF, Conti AC, Kotlikoff MI, Xiang YK, Yarov-Yarovoy V, Zaccolo M, Zhang XD, Yamoah EN, Navedo MF, Chiamvimonvat N. PMID: 36509290; PMCID: PMC9746826.
View in: PubMedProbing spatiotemporal PKA activity at the ryanodine receptor and SERCA2a nanodomains in cardomyocytes. Cell Commun Signal. 2022 09 14; 20(1):143. Xu B, Wang Y, Bahriz SMFM, Zhao M, Zhu C, Xiang YK. . PMID: 36104752; PMCID: PMC9472443.
View in: PubMedMonoamine oxidase A and organic cation transporter 3 coordinate intracellular β1AR signaling to calibrate cardiac contractile function. Basic Res Cardiol. 2022 07 17; 117(1):37. Wang Y, Zhao M, Xu B, Bahriz SMF, Zhu C, Jovanovic A, Ni H, Jacobi A, Kaludercic N, Di Lisa F, Hell JW, Shih JC, Paolocci N, Xiang YK. . PMID: 35842861; PMCID: PMC9288959.
View in: PubMedDeciphering cellular signals in adult mouse sinoatrial node cells. iScience. 2022 Jan 21; 25(1):103693.Reddy GR, Ren L, Thai PN, Caldwell JL, Zaccolo M, Bossuyt J, Ripplinger CM, Xiang YK, Nieves-Cintrón M, Chiamvimonvat N, Navedo MF. PMID: 35036877; PMCID: PMC8749457.
View in: PubMedMonoamine Oxidases Desensitize Intracellular β1AR Signaling in Heart Failure. Circ Res. 2021 10 29; 129(10):965-967. Wang Y, Zhao M, Shi Q, Xu B, Zhu C, Li M, Mir V, Bers DM, Xiang YK. . PMID: 34530626; PMCID: PMC8556367.
View in: PubMedCarvedilol induces biased β1 adrenergic receptor-nitric oxide synthase 3-cyclic guanylyl monophosphate signalling to promote cardiac contractility. Cardiovasc Res. 2021 08 29; 117(10):2237-2251. Wang Q, Wang Y, West TM, Liu Y, Reddy GR, Barbagallo F, Xu B, Shi Q, Deng B, Wei W, Xiang YK. . PMID: 32956449; PMCID: PMC8502477.
View in: PubMedIntracellular β1-Adrenergic Receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility. Circ Res. 2021 01 22; 128(2):246-261. Wang Y, Shi Q, Li M, Zhao M, Reddy Gopireddy R, Teoh JP, Xu B, Zhu C, Ireton KE, Srinivasan S, Chen S, Gasser PJ, Bossuyt J, Hell JW, Bers DM, Xiang YK. . PMID: 33183171; PMCID: PMC7856104.
View in: PubMedAKAP5 complex facilitates purinergic modulation of vascular L-type Ca2+ channel CaV1.2. Nat Commun. 2020 10 20; 11(1):5303. Prada MP, Syed AU, Reddy GR, Martín-Aragón Baudel M, Flores-Tamez VA, Sasse KC, Ward SM, Sirish P, Chiamvimonvat N, Bartels P, Dickson EJ, Hell JW, Scott JD, Santana LF, Xiang YK, Navedo MF, Nieves-Cintrón M. PMID: 33082339; PMCID: PMC7575592.
View in: PubMedGRK5 Controls SAP97-Dependent Cardiotoxic β1 Adrenergic Receptor-CaMKII Signaling in Heart Failure. Circ Res. 2020 08 28; 127(6):796-810. Xu B, Li M, Wang Y, Zhao M, Morotti S, Shi Q, Wang Q, Barbagallo F, Teoh JP, Reddy GR, Bayne EF, Liu Y, Shen A, Puglisi JL, Ge Y, Li J, Grandi E, Nieves-Cintron M, Xiang YK. . PMID: 32507058; PMCID: PMC7484403.
View in: PubMedEmpagliflozin Ameliorates Obesity-Related Cardiac Dysfunction by Regulating Sestrin2-Mediated AMPK-mTOR Signaling and Redox Homeostasis in High-Fat Diet-Induced Obese Mice. Diabetes. 2020 06; 69(6):1292-1305. Sun X, Han F, Lu Q, Li X, Ren D, Zhang J, Han Y, Xiang YK, Li J. PMID: 32234722.
View in: PubMedInsulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling. JCI Insight. 2020 03 26; 5(6). Riehle C, Weatherford ET, Wende AR, Jaishy BP, Seei AW, McCarty NS, Rech M, Shi Q, Reddy GR, Kutschke WJ, Oliveira K, Pires KM, Anderson JC, Diakos NA, Weiss RM, White MF, Drakos SG, Xiang YK, Abel ED. PMID: 32213702; PMCID: PMC7213803.
View in: PubMedHyperinsulinemia promotes heterologous desensitization of β2 adrenergic receptor in airway smooth muscle in obesity. FASEB J. 2020 03; 34(3):3996-4008. Xu R, Gopireddy RR, Wu Y, Wu L, Tao X, Shao J, Wang W, Li L, Jovanovic A, Xu B, Kenyon NJ, Lu Q, Xiang YK, Fu Q. PMID: 31960515.
View in: PubMedβ-blockers augment L-type Ca2+ channel activity by targeting spatially restricted β2AR signaling in neurons. Elife. 2019 10 14; 8. Shen A, Chen D, Kaur M, Bartels P, Xu B, Shi Q, Martinez JM, Man KM, Nieves-Cintron M, Hell JW, Navedo MF, Yu XY, Xiang YK. . PMID: 31609201; PMCID: PMC6813027.
View in: PubMedPhosphodiesterase 5 Associates With β2 Adrenergic Receptor to Modulate Cardiac Function in Type 2 Diabetic Hearts. J Am Heart Assoc. 2019 08 06; 8(15):e012273. West TM, Wang Q, Deng B, Zhang Y, Barbagallo F, Reddy GR, Chen D, Phan KS, Xu B, Isidori A, Xiang YK. . PMID: 31311394; PMCID: PMC6761630.
View in: PubMedWhole-Cell cAMP and PKA Activity are Epiphenomena, Nanodomain Signaling Matters. Physiology (Bethesda). 2019 07 01; 34(4):240-249. Bers DM, Xiang YK, Zaccolo M. PMID: 31165682; PMCID: PMC6863374.
View in: PubMedAdenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia. J Clin Invest. 2019 06 04; 129(8):3140-3152. Syed AU, Reddy GR, Ghosh D, Prada MP, Nystoriak MA, Morotti S, Grandi E, Sirish P, Chiamvimonvat N, Hell JW, Santana LF, Xiang YK, Nieves-Cintrón M, Navedo MF. PMID: 31162142; PMCID: PMC6668679. View in: PubMed
A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia. Elife. 2019 03 01; 8. Prada MP, Syed AU, Buonarati OR, Reddy GR, Nystoriak MA, Ghosh D, Simó S, Sato D, Sasse KC, Ward SM, Santana LF, Xiang YK, Hell JW, Nieves-Cintrón M, Navedo MF. PMID: 30821687; PMCID: PMC6397001.
View in: PubMedIlluminating cell signaling with genetically encoded FRET biosensors in adult mouse cardiomyocytes. J Gen Physiol. 2018 11 05; 150(11):1567-1582. Reddy GR, West TM, Jian Z, Jaradeh M, Shi Q, Wang Y, Chen-Izu Y, Xiang YK. . PMID: 30242036; PMCID: PMC6219686.
View in: PubMedProfiling of Differential Expression of Genes in Mice Carrying Both Mutant Presenilin 1 and Amyloid Precursor Protein Transgenes with or without Knockout of B2 Adrenergic Receptor Gene. J Appl Bioinforma Comput Biol. 2018; 7(3). Zhou Y, Chen L, Zhou X, Pei Y, Wei S, Mehmood A, Xiang YK, Wang D. PMID: 31058201; PMCID: PMC6497178.
View in: PubMedThe THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival. Cell. 2018 09 06; 174(6):1436-1449.e20. Maeder CI, Kim JI, Liang X, Kaganovsky K, Shen A, Li Q, Li Z, Wang S, Xu XZS, Li JB, Xiang YK, Ding JB, Shen K. PMID: 30146163; PMCID: PMC6542560.
View in: PubMedFunctionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell. Nat Commun. 2018 03 13; 9(1):1050. Shen A, Nieves-Cintron M, Deng Y, Shi Q, Chowdhury D, Qi J, Hell JW, Navedo MF, Xiang YK. . PMID: 29535304; PMCID: PMC5849717.
View in: PubMedβ2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease. Science. 2017 09 01; 357(6354):891-898. Mittal S, Bjørnevik K, Im DS, Flierl A, Dong X, Locascio JJ, Abo KM, Long E, Jin M, Xu B, Xiang YK, Rochet JC, Engeland A, Rizzu P, Heutink P, Bartels T, Selkoe DJ, Caldarone BJ, Glicksman MA, Khurana V, Schüle B, Park DS, Riise T, Scherzer CR. PMID: 28860381; PMCID: PMC5761666.
View in: PubMedHeterologous desensitization of cardiac β-adrenergic signal via hormone-induced βAR/arrestin/PDE4 complexes. Cardiovasc Res. 2017 May 01; 113(6):656-670. Shi Q, Li M, Mika D, Fu Q, Kim S, Phan J, Shen A, Vandecasteele G, Xiang YK. . PMID: 28339772; PMCID: PMC5852637.
View in: PubMedInsulin and β Adrenergic Receptor Signaling: Crosstalk in Heart. Trends Endocrinol Metab. 2017 06; 28(6):416-427. Fu Q, Wang Q, Xiang YK. . PMID: 28256297; PMCID: PMC5535765.
View in: PubMedHigh-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of β2 -adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts. J Physiol. 2017 03 15; 595(6):1973-1986. Fu Q, Hu Y, Wang Q, Liu Y, Li N, Xu B, Kim S, Chiamvimonvat N, Xiang YK. . PMID: 27983752; PMCID: PMC5350441.
View in: PubMedInhibiting Insulin-Mediated β2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction. Circulation. 2017 Jan 03; 135(1):73-88. Wang Q, Liu Y, Fu Q, Xu B, Zhang Y, Kim S, Tan R, Barbagallo F, West T, Anderson E, Wei W, Abel ED, Xiang YK. . PMID: 27815373; PMCID: PMC5302024.
View in: PubMedGenetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure. Circ Res. 2016 Sep 30; 119(8):931-43. Barbagallo F, Xu B, Reddy GR, West T, Wang Q, Fu Q, Li M, Shi Q, Ginsburg KS, Ferrier W, Isidori AM, Naro F, Patel HH, Bossuyt J, Bers D, Xiang YK. . PMID: 27576469; PMCID: PMC5307331.
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