Publications

2025 publications

1. Cardiac ß2 adrenergic receptor deletion drives calmodulin kinase II upregulation to induce connection tissue growth factor in cardiac fibrosis and diastolic dysfunction. Function (Oxf). 2025 Aug 12. Zhu C, Zhao M, Zhao L, Wu M, Xiang YK. . PMID: 40796320.
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2. Signaling by intracellular ß2-adrenergic receptors regulates AMPA receptor trafficking and synaptic plasticity. Cell Rep. 2025 Jul 17; 44(8):116011. Lee B, Xing X, Hammes EA, Zeng Z, Estrada-Tobar ZM, Kim K, Ireton KE, Mimi Man KN, Jacobi AA, Berumen RA, Weiner JC, Shen A, Xu B, Wang J, Gasser PJ, Navedo MF, Xiang YK, Díaz E, Chen CY, Horne MC, Hell JW. PMID: 40679912.
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3. Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia. Circ Res. 2025 Aug 15; 137(5):646-663. Hong J, Martín-Aragón Baudel M, Niloy SI, Taylor J, Mohabbat Y, Moustafa Y, Pereira Da Silva E, O'Donnell BL, Zhu Z, Daghbouche-Rubio N, Reddy GR, Sasse KC, Ward SM, Xiang YK, Isakson BE, Nieves-Cintrón M, Navedo MF. PMID: 40636957; PMCID: PMC12252251.
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4. Mealtime alters daily rhythm in nuclear O-GlcNAc proteome to regulate hepatic gene expression. Cell Rep. 2025 Jun 19. Liu X, Cai YD, Hou C, Liu X, Luo Y, Mendiola AJP, Xu X, Luo Y, Zheng H, Zhao C, Chen CH, Zhang Y, Xiang YK, Ma J, Chiu JC. PMID: 40666963; PMCID: PMC12262729.
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5. Habitual Exercise Modulates Neuroimmune Interaction to Mitigate Aortic Stiffness. Circ Res. 2025 Jun 06; 136(12):1579-1594. Cho JM, Vu K, Park SK, Zhu E, Li YR, Zhao P, Yokota T, Yang L, Lu R, Xiang YK, Shen YH, Chapleau MW, Hsiai TK. PMID: 40304034; PMCID: PMC12140871.
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6. Structure and dynamics determine G protein coupling specificity at a class A GPCR. Sci Adv. 2025 Mar 21; 11(12):eadq3971. Casiraghi M, Wang H, Brennan PC, Habrian C, Hübner H, Schmidt MF, Maul L, Pani B, Bahriz SMFM, Xu B, Staffen N, Assafa TE, Chen B, White E, Sunahara RK, Inoue A, Xiang YK, Lefkowitz RJ, Isacoff EY, Nucci N, Gmeiner P, Lerch MT, Kobilka BK. PMID: 40106559; PMCID: PMC12101717.
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7. Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein. iScience. 2025 Feb 21; 28(2):111741. Han Y, Dawson JRD, DeMarco KR, Rouen KC, Ngo K, Bekker S, Yarov-Yarovoy V, Clancy CE, Xiang YK, Ahn SH, Vorobyov I. PMID: 39898043; PMCID: PMC11787599.
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8. Inhibition of the upregulated phosphodiesterase 4D isoforms improves SERCA2a function in diabetic cardiomyopathy. Br J Pharmacol. 2025 Apr; 182(7):1487-1507. Zhu Z, Guan Q, Xu B, Bahriz S, Shen A, West TM, Zhang Y, Deng B, Wei W, Han Y, Wang Q, Xiang YK. PMID: 39662482.
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Additional publications

1. 1. An activity-regulated transcriptional program directly drives synaptogenesis. Nat Neurosci. 2024 Sep; 27(9):1695-1707. Yee C, Xiao Y, Chen H, Reddy AR, Xu B, Medwig-Kinney TN, Zhang W, Boyle AP, Herbst WA, Xiang YK, Matus DQ, Shen K. PMID: 39103556; PMCID: PMC11374667.
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   2. Phosphodiesterase in heart and vessels: from physiology to diseases. Physiol Rev. 2024 Apr 01; 104(2):765-834. Fu Q, Wang Y, Yan C, Xiang YK. PMID: 37971403; PMCID: PMC11281825. 

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1. 3. Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory. Sci Signal. 2023 03 28; 16(778):eade3380. Martinez JM, Shen A, Xu B, Jovanovic A, de Chabot J, Zhang J, Xiang YK. PMID: 36976866; PMCID: PMC10404024.
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   4. Whole-heart multiparametric optical imaging reveals sex-dependent heterogeneity in cAMP signaling and repolarization kinetics. Sci Adv. 2023 01 20; 9(3):eadd5799. Caldwell JL, Lee IJ, Ngo L, Wang L, Bahriz S, Xu B, Bers DM, Navedo MF, Bossuyt J, Xiang YK, Ripplinger CM. PMID: 36662864; PMCID: PMC9858506.
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   5. Divergent Actions of Myofibroblast and Myocyte β2-Adrenoceptor in Heart Failure and Fibrotic Remodeling. Circ Res. 2023 01 06; 132(1):106-108. Deng B, Zhang Y, Zhu C, Wang Y, Weatherford E, Xu B, Liu X, Conway SJ, Abel ED, Xiang YK. PMID: 36458552; PMCID: PMC9985902.
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   6. Monoamine Oxidases Desensitize Intracellular β1AR Signaling in Heart Failure. Circ Res. 2021 10 29; 129(10):965-967. Wang Y, Zhao M, Shi Q, Xu B, Zhu C, Li M, Mir V, Bers DM, Xiang YK. . PMID: 34530626; PMCID: PMC8556367.
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   7. Intracellular β1-Adrenergic Receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility. Circ Res. 2021 01 22; 128(2):246-261. Wang Y, Shi Q, Li M, Zhao M, Reddy Gopireddy R, Teoh JP, Xu B, Zhu C, Ireton KE, Srinivasan S, Chen S, Gasser PJ, Bossuyt J, Hell JW, Bers DM, Xiang YK. . PMID: 33183171; PMCID: PMC7856104.
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   8. GRK5 Controls SAP97-Dependent Cardiotoxic β1 Adrenergic Receptor-CaMKII Signaling in Heart Failure. Circ Res. 2020 08 28; 127(6):796-810. Xu B, Li M, Wang Y, Zhao M, Morotti S, Shi Q, Wang Q, Barbagallo F, Teoh JP, Reddy GR, Bayne EF, Liu Y, Shen A, Puglisi JL, Ge Y, Li J, Grandi E, Nieves-Cintron M, Xiang YK. . PMID: 32507058; PMCID: PMC7484403.
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   9. The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival. Cell. 2018 09 06; 174(6):1436-1449.e20. Maeder CI, Kim JI, Liang X, Kaganovsky K, Shen A, Li Q, Li Z, Wang S, Xu XZS, Li JB, Xiang YK, Ding JB, Shen K. PMID: 30146163; PMCID: PMC6542560.
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   10. Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell. Nat Commun. 2018 03 13; 9(1):1050. Shen A, Nieves-Cintron M, Deng Y, Shi Q, Chowdhury D, Qi J, Hell JW, Navedo MF, Xiang YK. . PMID: 29535304; PMCID: PMC5849717.
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   11. β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease. Science. 2017 09 01; 357(6354):891-898. Mittal S, Bjørnevik K, Im DS, Flierl A, Dong X, Locascio JJ, Abo KM, Long E, Jin M, Xu B, Xiang YK, Rochet JC, Engeland A, Rizzu P, Heutink P, Bartels T, Selkoe DJ, Caldarone BJ, Glicksman MA, Khurana V, Schüle B, Park DS, Riise T, Scherzer CR. PMID: 28860381; PMCID: PMC5761666.
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   12. Insulin and β Adrenergic Receptor Signaling: Crosstalk in Heart. Trends Endocrinol Metab. 2017 06; 28(6):416-427. Fu Q, Wang Q, Xiang YK. PMID: 28256297; PMCID: PMC5535765.
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   13. Inhibiting Insulin-Mediated β2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction. Circulation. 2017 Jan 03; 135(1):73-88. Wang Q, Liu Y, Fu Q, Xu B, Zhang Y, Kim S, Tan R, Barbagallo F, West T, Anderson E, Wei W, Abel ED, Xiang YK. PMID: 27815373; PMCID: PMC5302024.
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   14. Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure. Circ Res. 2016 Sep 30; 119(8):931-43. Barbagallo F, Xu B, Reddy GR, West T, Wang Q, Fu Q, Li M, Shi Q, Ginsburg KS, Ferrier W, Isidori AM, Naro F, Patel HH, Bossuyt J, Bers D, Xiang YK. PMID: 27576469; PMCID: PMC5307331.
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   15. Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy. Cell Stem Cell. 2015 Jul 02; 17(1):89-100. Wu H, Lee J, Vincent LG, Wang Q, Gu M, Lan F, Churko JM, Sallam KI, Matsa E, Sharma A, Gold JD, Engler AJ, Xiang YK, Bers DM, Wu JC. PMID: 26095046; PMCID: PMC4546705. 

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1. 16. Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts. Diabetes. 2014 Aug; 63(8):2676-89. Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, Zhang Y, Riehle C, Zhu Y, Rawlings T, Shi Q, Clark RB, Chen X, Abel ED, Xiang YK. PMID: 24677713; PMCID: PMC4113065.

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1. 17. Biological techniques: Wrapped around the heart. Nature. 2014 Mar 06; 507(7490):43-4. Clancy CE, Xiang YK. PMID: 24598634.

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1. 18. Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts. PNAS. 2012 Apr 24; 109(17):6578-83. Liu S, Li Y, Kim S, Fu Q, Parikh D, Sridhar B, Shi Q, Zhang X, Guan Y, Chen X, Xiang YK. PMID: 22493261; PMCID: PMC3340097.

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1. 19. Compartmentalization of beta-adrenergic signals in cardiomyocytes. Circ Res. 2011 Jul 08; 109(2):231-44. Xiang YK. PMID:21737818; PMCID: PMC3493619.
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   20. Probing cellular protein complexes using single-molecule pull-down. Nature. 2011 May 26; 473(7348):484-8. Jain A, Liu R, Ramani B, Arauz E, Ishitsuka Y, Ragunathan K, Park J, Chen J,, Xiang YK, Ha T. PMID: 21614075; PMCID: PMC3103084.
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   21. Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart. Sci Transl Med. 2011 Sep 14; 3(100):100ra88. Chakir K, Depry C, Dimaano VL, Zhu WZ, Vanderheyden M, Bartunek J, Abraham TP, Tomaselli GF, Liu SB, Xiang YK, Zhang M, Takimoto E, Dulin N, Xiao RP, Zhang J, Kass DA. PMID: 21918105; PMCID: PMC3329869.

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