Akash focuses on the pathological signaling of β2-adrenergic receptor in Alzheimer's disease. He will take advantage of transgenic approaches to understand the GRK and PKA mediated β2-adrenergic receptor in neurodegeneration and brain inflammation in the mouse model of Alzheimer's disease with overexpression of human familial mutant APP and PSEN genes.
Yunfeng is exploring the novel signaling paradigm induced by thyroid hormone in metabolism.
Additionally, Yunfeng is working on nongenomic actions of thyroid hormones and the impacts on cardiac cAMP-PKA pathway in the heart.
Wen has traveled around the world. After finishing her BS and MS in Shanghai, she won a National Scholarship and moved to pursue her PhD training in Hannover, Germany. She then joined X-lab at UCDavis/UCLA.
Wen is taking a very challenging project to study nuclear structure and gene regulation in adult myocytes and its implications in cardiac development and regeneration in heart failure. Outside the lab, she enjoys going to the gym and traveling.
Ning is a native in Beijing. He obtained his PhD in Peking University and currently is a visiting reseracher from Beijing Friendship Hospital, Capital Medical University in Beijing, where he holds an assistant professor equivalent title. He focuses on the cardiac injury mechanisms for receptor autoantibodies. Outside of the lab, Ning enjoys the time with his family.
In X-lab, he studies the novel regulation role of SAP97 in LTCC as well as cardiac remodeling in ischemic hearts.
Damini completed her PhD in Biochemistry in India and has done postdoctoral work at UC Merced and Duke. At UCLA, she is studying GPCR-targeted PROTACs and how amyloid peptides interact with the β2-adrenergic receptor. She is excited to explore new directions in GPCR pharmacology.
Sherif Bahriz, sailing from Egypt, is investigating new mechanisms of PKA activation across the brain, heart, and adipose tissue. His research focuses on how PKA signaling influences heart failure and metabolic diseases, with the goal of identifying potential new therapeutic targets.