Publication

[200] "Targeted Gene Deletion Using DNA-Free RNA-Guided Cas9 Nuclease Accelerates Adaptation of CHO Cells to Suspension Culture", N. Lee, J. O. Shin, J. Park, G. M. Lee, S. H. Cho, B. K. Cho, ACS Synth. Biol. (2016).

[199] “Heparan Sulfate Proteoglycan Synthesis in CHO DG44 and HEK293 Cells” S. Lee, M. G. Kim, N. Kim, W. D. Heo, and G. M. Lee, Biotechnol. Bioproc. Eng. (2016). 

[198] “Valeric Acid Induces Cell Cycle Arrest at G1 phase in CHO Cell Cultures and Improves Recombinant Antibody Productivity”, J. H. Park, S. M. Noh, J. R. Woo, J. W. Kim, and G. M. Lee, Biotechnol. J. 11:487 (2016).

[197] “Versatile Microscale Screening Platform for Improving Recombinant Protein Productivity in Chinese Hamster Ovary Cells”, H. G. Hansen, C. N. Nilsson, A. M. Lund, S. Kol, L. M. Grav, M. Lundqvist, J. Rockberg, G. M. Lee, M. R. Andersen, and H. F. Kildegaard, Sci. Rep. 5:18016 (2015). 

[196] “Efficient CRISPR/Cas9-Mediated Multiplex Genome Editing in CHO Cells via High-Level sgRNA-Cas9 Complex”, J. Shin, N. Lee, Y. Song, J. Park, T. J. Kang, S. C. Kim, G. M. Lee, and B. K. Cho, Biotechnol. Bioproc. Eng. 20:825 (2015). 

[195] “Effect of Bcl-xL Overexpression on Sialylation of Fc-Fusion Protein in Recombinant Chinese Hamster Ovary Cell Cultures”, J. H. Lee, Y. G Kim, and G. M. Lee, Biotechnol. Prog. 31:1133 (2015). 

[194] “Glutamine Substitution: the Role it can Play to Enhance Therapeutic Protein Production”, T. K. Ha and G. M. Lee, Pharm. Bioprocessing 3:249 (2015). 

[193] “Purification of TNFR-Fc Produced in Recombinant CHO Cells: Characterization of Product-Related Impurities”, K. H. Min and G. M. Lee, Process Biochem. 50:1313 (2015). 

[192] “One-Step Generation of Triple Knockout CHO Cell Lines Using CRISPR Cas9 and Fluorescent Enrichment”, L. M. Grav, J. S. Lee, S. Gerling S., T. B. Kallehauge, A. H. Hansen, S. Kol, G. M. Lee, L. E. Pedersen, and H. F. Kildegaard, Biotechnol. J. 10:1446 (2015). 

[191] “Understanding of Altered N-Glycosylation-Related Gene Expression in Recombinant Chinese Hamster Ovary Cells Subjected to Elevated Ammonium Concentration by Digital mRNA Counting”, T. K. Ha, Y. G. Kim, and G. M. Lee, Biotechnol. Bioeng. 112:1583 (2015). 

[190] “Novel Glycosylated VEGF Decoy Receptor Fusion Protein, VEGF-Grab, Efficiently Suppresses Tumor Angiogenesis and Progression”, J. E. Lee, C. Kim, H. Yang, I. Park, N. Oh, S. Hua, H. Jeong, H. An, S. C. Kim, G. M. Lee, G. Y. Koh, and H. M. Kim, Mol Cancer Ther. 14:470 (2015). 

[189] “Characterization and Expression of Proprotein Convertases in CHO Cells: Efficient Proteolytic Maturation of Human Bone Morphogenetic Protein-7”, M. Sathyamurthy, C. L. Kim, Y. L. Bang, Y. S. Kim, J. W. Jang, and G. M. Lee, Biotechnol. Bioeng. 112:560 (2015). 

[188] “Electrospun Chitosan/poly(vinyl alcohol) Reinforced with CaCO3 Nanoparticles with Enhanced Mechanical Properties and Biocompatibility for Cartilage Tissue Engineering”, N. S. Sambudi, M. Sathyamurthy, G. M. Lee, and S. B. Park, Composites Science and Technology.106:76 (2015). 

[187] “Effect of Lithium Choride on the Production and Sialylation of Fc-fusion Protein in Chinese Hamster Ovary Cell Culture”, T. K. Ha, Y. G. Kim, and G. M. Lee, Appl. Microbiol. Biotechnol. 98:9239 (2014).

[186] "Gadd45-Induced Cell Cycle G2/M Arrest for Improved Transient Gene Expression in Chinese Hamster Ovary Cells", W. H. Kim, Y. J. Kim, and G. M. Lee, Biotechnol. Bioproc. Eng. 19:386 (2014).

[185] “Effect of Glutamine Substitution by TCA Cycle Intermediates on the Production and Sialylation of Fc-fusion Protein in Chinese Hamster Ovary Cell Cultures”, T. K. Ha and G. M. Lee, J. Biotechnol. 180:23 (2014). 

[184] “Effect of Sodium Butyrate on the Assembly, Charge Variants, and Galactosylation of Antibody Produced in Recombinant Chinese Hamster Ovary Cells”, J. K Hong, S. M. Lee, K. Y. Kim, and G. M. Lee, Appl. Microbiol. Biotechnol. 98:5417 (2014). 

[183] “Effect of Glucose Feeding on the Glycosylation Quality of Antibody Produced by a Human Cell Line, F2N78, in Fed-Batch Culture”, J. S. Seo, B. S. Min, Y. J. Kim, J. M. Cho, E. Baek, M. S. Cho, and G. M. Lee, Appl. Microbiol. Biotechnol. 98:3509 (2014). 

[182] “Digital mRNA Profiling of N-glycosylation Gene Expression in Recombinant Chinese Hamster Ovary Cells Treated with Sodium Butyrate”, S. M. Lee, Y. G. Kim, E. G. Lee, and G. M. Lee, J. Biotechnol. 171:56 (2014). 

[181] “Double Antiangiogenic Protein, DAAP, Targeting Vascular Endothelial Growth Factor-A and Angiopoietins Attenuates Collagen-induced Arthritis”, Y. S. Hah, Y. J. Koh, H. S. Lim, H. O. Kim, Y. H. Cheon, H. S. Noh, K. Y. Jang, S. Y. Lee, G. M. Lee, G. Y. Koh, and S. I. Lee, Arthritis Res Ther. Aug 14;15(4):R85. (2013).

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