ACE LAB
Animal Cell Engineering Lab
Graduate School of Engineering Biology, KAISTProf. Gyun Min LeeEmbedded Files
Welcome to Animal Cell Engineering Lab!
Welcome to Animal Cell Engineering Lab!
For the production of recombinant proteins, Chinese hamster ovary (CHO) cells have been the most popular hosts in industry since the first product, human tPA, was approved for marketing in the mid 1980's. As of 2002, more than 50 recombinant proteins produced from CHO cells are approved for marketing. Our research group focus on the research and development of therapeutic protein production using recombinant CHO cells. The topics range from molecular biology to bioprocess engineering.
“CRISPR/Cas9 Screening Reveals TM9SF2 Knockout as a Solution to HEK293 Cell Aggregation for Improved AAV Production”, S. Park, S. Shin, G. Han, Y. Won, S. Y. Lee, D. Razafsky, H. George, G. M. Lee, Mol. Ther. Adv. (2026).
“Genome-Wide CRISPR Screening Identifies Genes in Recombinant Human Embryonic Kidney 293 Cells for Increased Ammonia Resistance”, S. Y. Lee, H. S. Kim, Y. G. Kim, S. Shin, S. Kweon , J. J. Lee, G. M. Lee, Metabolic Eng. (2026).
“Product-Stabilized Filamentation by Human Glutamine Synthetase Allosterically Tunes Metabolic Activity”, E. Greene, R. Muniz, H.Yamamura, S. Hoff, P. Bajaj, D. J. Lee, E. M.Thompson, A. Arada, G. M. Lee, M. Bonomi, J. M. Kollman, J. S. Fraser, eLife 14:RP108336 (2025).
“Genome-Wide CRISPR Screening Identifies Genes in Recombinant Human Embryonic Kidney 293 Cells for Increased Ammonia Resistance”, S. Y. Lee, H. S. Kim, Y. G. Kim, S. Shin, S. Kweon , J. J. Lee, G. M. Lee, Metabolic Eng. (2025).
“Recombinase-Mediated Cassette Exchange-Based CRISPR Activation Screening Identifies Hyperosmotic Stress-Resistant Genes in Chinese Hamster Ovary Cells”, M. Baek, S. Kweon, Y. Kim, N. E. Lewis, J. S. Lee, G. M. Lee, ACS Synth. Biol. (2025).
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