READING 1: THE DISCOVERY OF PENICILLIN
Q1: results of animal experiments
Answer: D
Key word(s): animal experiments, mice, penicillin
Cited Sentence: "They experimented on mice infected with streptococcus. Those untreated died, while those injected with penicillin survived."
Explanation: The results of animal experiments are described here, where mice infected with streptococcus showed different outcomes depending on whether they were treated with penicillin or not.
Q2: recognition of the scientists’ valuable work
Answer: G
Key word(s): recognition, valuable work, awards
Cited Sentence: "Fleming and Florey received knighthoods in 1944 and they, together with Chain, were awarded the Nobel Prize in Physiology or Medicine in 1945."
Explanation: This paragraph discusses the recognition of the scientists' work through prestigious awards such as knighthoods and the Nobel Prize.
Q3: a statement about the beginning of mass production
Answer: E
Key word(s): mass production, making large quantities, Penicillium chrysogeum
Cited Sentence: "It became obvious that Penicillium notatum would never generate enough penicillin for effective treatments so they began to look for a more productive species."
Explanation: This marks the beginning of large-scale production efforts as the scientists sought more efficient species of mould to produce penicillin.
Q4: Fleming’s cautionary advice
Answer: H
Key word(s): caution, resistance, overuse
Cited Sentence: "Fleming was mindful of the dangers of resistance to penicillin early on and he expressly warned on many occasions against overuse of the drug, because this would lead to bacterial resistance."
Explanation: In this section, Fleming is quoted giving advice about the dangers of bacterial resistance due to the overuse of penicillin.
Q5: examples of uses for penicillin
Answer: F
Key word(s): uses, penicillin, treatment
Cited Sentence: "Penicillin proved to be very effective in the treatment of pneumococcal pneumonia – the death rate in WWII was 1% compared to 18% in WWI."
Explanation: This paragraph provides an example of penicillin's use in treating pneumonia during WWII and highlights its effectiveness.
Q6: the starting point for Fleming’s original research
Answer: B
Key word(s): starting point, research, staphylococcus bacteria
Cited Sentence: "Fleming was cultivating staphylococcus bacteria in Petri dishes containing agar."
Explanation: This sentence describes the beginning of Fleming's research, where he was studying staphylococcus bacteria.
Q7: holiday
Answer: holiday
Key word(s): holiday, return, mould
Cited Sentence: "Before going on holiday in the summer of 1928, he piled up the agar plates... When he returned to work two weeks later, Fleming noticed mould growing..."
Explanation: Fleming noticed the mould after returning from his holiday, which was the trigger for his discovery.
Q8: mycologist
Answer: mycologist
Key word(s): consulted, mycologist, identification
Cited Sentence: "Fleming consulted a mycologist called C J La Touche..."
Explanation: Fleming sought the expertise of a mycologist (a fungal scientist) to identify the mould.
Q9: (pathogenic) bacteria
Answer: (pathogenic) bacteria
Key word(s): active against, bacteria
Cited Sentence: "Fleming found that it was active against several different pathogenic bacteria..."
Explanation: The mould was found to be effective against various types of pathogenic bacteria.
Q10: non-toxic
Answer: non-toxic
Key word(s): safe, non-toxic, use in humans
Cited Sentence: "It was also non-toxic, so here was a bacteria-destroying agent that could be used as an antiseptic in wounds without damaging the human body."
Explanation: The mould was safe for human use because it was non-toxic, which made it an ideal antiseptic.
Q11: (eventually) died
Answer: (eventually) died
Key word(s): first human subject, died
Cited Sentence: "Their first case in 1940, an Oxford police officer... rallied after five days of treatment but, when the supply of penicillin ran out, he eventually died."
Explanation: The first human test subject, an Oxford police officer, initially recovered but died when the supply of penicillin was exhausted.
Q12: American scientists
Answer: American scientists
Key word(s): collaboration, United States
Cited Sentence: "In 1941, Florey and biochemist Dr Norman Heatley went to the United States to team up with American scientists..."
Explanation: The collaboration between Florey, Heatley, and American scientists is described here.
Q13: Nobel Prize
Answer: Nobel Prize
Key word(s): Nobel Prize, awarded
Cited Sentence: "... together with Chain, were awarded the Nobel Prize in Physiology or Medicine in 1945."
Explanation: This sentence reveals that Fleming, Florey, and Chain were awarded the Nobel Prize in 1945 for their contributions to the discovery of penicillin.