1. Amang Rodriguez Memorial Medical Center, Marikina City

• Latest IRR: A.O. No. 2019-0032, August 27, 2019

• Latest Enabling Law: R.A. No. 12204, "An Act Increasing the Bed Capacity of the Amang Rodriguez Memorial Medical Center in the City of Marikina, Metro Manila, from Five Hundred (500) to One Thousand (1,000) Beds, and Appropriating Funds Therefor," May 8, 2025

• R.A. No. 11287, "An Act Increasing the Bed Capacity of the ‘Amang’ Rodriguez Memorial Medical Center from Three Hundred (300) to Five Hundred (500) Beds, Upgrading the Service Facilities and Professional Health Care Therein, and Appropriating Funds Therefor," April 12, 2019 

2. East Avenue Medical Center, Quezon City

• Latest IRR: A.O. No. 2021-0067, December 23, 2021

• Latest Enabling Law: R.A. No. 11561, "An Act Increasing the Bed Capacity of the East Avenue Medical Center in Barangay Diliman, Quezon City from Six Hundred (600) to One Thousand (1,000) Beds, and Appropriating Funds Therefor," June 24, 2021

3. Dr. Jose Fabella Memorial Hospital, Manila

• Latest Enabling Law: R.A. No. 5294, "An Act Changing the Name of the Maternity and Children's Hospital to Dr. Jose Fabella Memorial Hospital," June 15, 1968

4. Dr. Jose N. Rodriguez Memorial Hospital and Sanitarium, Caloocan City

• Latest IRR: A.O. No. 2019-0038 dated October 2, 2019

• Latest Enabling Law: R.A. No. 11286, "An Act Increasing the Bed Capacity for Tertiary General Health Care Services of the Dr. Jose N. Rodriguez Memorial Hospital and Sanitarium in Tala, Caloocan City from Two Hundred (200) to Eight Hundred (800) Beds, Reapportioning the Authorized Two Thousand (2,000) Bed Capacity of the Hospital, Amending for the Purpose Republic Act No. 9420, and Appropriating Funds Therefor," April 12, 2019

5. Jose R. Reyes Memorial Medical Center, Manila

• Latest Enabling Law: R.A. No. 4264, "An Act Changing the Name of North General Hospital to Dr. Jose R. Reyes Memorial Hospital." June 19, 1965

6. Las Piñas General Hospital and Satellite Trauma Center, Las Piñas City

• Latest IRR: A.O. No. 2021-0016 dated February 19, 2021

• Latest Enabling Law: R.A. No. 11497, "An Act Increasing the Bed Capacity of the Las Piñas General Hospital and Satellite Trauma Center in Las Piñas City, Metro Manila from Two Hundred (200) to Five Hundred (500) Beds, Upgrading its Professional Health Care Services and Facilities, and Appropriating Funds Therefor," November 13, 2020

7. National Center for Geriatric Health, Jose R. Reyes Memorial Medical Center, Manila

• Latest Enabling Policy: D.O. No. 2015-0024, "Rescission of Department Order No. 2014-0073 dated April 7, 2014 regarding Transfer of Management and Administration of the National Center for Geriatric Health from Jose R. Reyes Memorial Medical Center (JRRMMC) to the National Kidney and Transplant Institute (NKTI)," February 5, 2015

8. National Center for Mental Health, Mandaluyong City

• Latest IRR: As provided in Chapter VI, Section 30 of "Implementing Rules and Regulations of Republic Act No. 11036, Otherwise Known as the Mental Health Act," posted on February 24, 2019

• Latest Enabling Law: As provided in Chapter VI, Section 29 of R.A. No. 11036, "An Act Establishing a National Mental Health Policy for the Purpose of Enhancing the Delivery of Integrated Mental Health Services, Promoting and Protecting the Rights of Persons Utilizing Psychosocial Health Services, Appropriating Funds Therefor and Other Purposes," or "Mental Health Act," June 20, 2018

9. National Children's Hospital, Quezon City

• Latest Enabling Law: R.A. No. 1340, "An Act Amending Sections One, Two, Three, Four and Five of Republic Act Numbered Seven Hundred Thirty-one Providing for the Establishment of the National Children's Hospital and Appropriating Funds for the Purpose," June 16, 1955

10. Philippine Cancer Center, Quezon City (under DOH Central Office)

• Latest IRR: As provided in Rule III, Section 10 of the "Implementing Rules and Regulations (IRR) of the Republic Act No. 11215, otherwise known as the National Integrated Cancer Control Act," posted on August 15, 2019

• Earliest Enabling Law: As provided in Article III, Section 10 of R.A. No. 11215, "An Act Institutionalizing a National Integrated Cancer Control Program and Appropriating Funds Therefor," or "National Integrated Cancer Control Act," February 14, 2019

11. Philippine Orthopedic Center, Quezon City

• Latest Enabling Law: R.A. No. 6786, "An Act Changing the Name of the National Orthopedic Hospital and Rehabilitation Medical Center in Quezon City to Philippine Orthopedic Center," November 29, 1989

12. Quirino Memorial Medical Center, Quezon City

• Latest IRR: A.O. No. 2021-0017, February 22, 2021

• Latest Enabling Law: R.A. No. 11501, "An Act Increasing the Bed Capacity of the Quirino Memorial Medical Center in Quezon City, Metro Manila from Five Hundred (500) Beds to One Thousand (1,000) Beds, Upgrading its Professional Health Care Services and Facilities, Authorizing the Increase of Its Medical Personnel Complement and Appropriating Funds Therefor," November 13, 2020

13. Research Institute for Tropical Medicine, Muntinlupa City

• Latest Enabling Policy: E.O. No. 674, "Establishing the Research Institute for Tropical Medicine," March 25, 1981

14. Rizal Medical Center, Pasig City

• Latest IRR: A.O. No. 2019-0025, July 26, 2019

• Latest Enabling Law: R.A. No. 11208, "An Act Increasing the Bed Capacity of Rizal Medical Center in Pasig City from Three Hundred (300) to Five Hundred (500) Beds and Appropriating Funds Therefor," February 14, 2019

15. San Lazaro Hospital, Manila

• Latest Enabling Law: R.A. No. 1297, "An Act Authorizing the Appropriation of Three Million Pesos for the Construction of a Building or Buildings for the San Lazaro Hospital," June 16, 1955

16. San Lorenzo Ruiz General Hospital, Malabon City

• Latest IRR: A.O. No. 2019-0030, August 20, 2019

• Latest Enabling Law: R.A. No. 11289, "An Act Converting the San Lorenzo Ruiz Women’s Hospital in Malabon City, Metro Manila into a General Hospital to be known as the San Lorenzo Ruiz General Hospital, Increasing its Bed Capacity from Ten (10) to Two Hundred (200) Beds and Appropriating Funds Therefor," April 12, 2019

17. Senate President Neptali A. Gonzales General Hospital, Mandaluyong City

• Latest IRR: A.O. 2021-0047, October 12, 2021

• Earliest Enabling Law: R.A. No. 11557, "An Act Establishing a Three Hundred (300)-bed Capacity Tertiary Training and General Hospital in Barangay Mauway, City of Mandaluyong to be known as the Senate President Neptali A Gonzales General Hospital, and Appropriating Funds Therefor," June 24, 2021

18. Tondo Medical Center, Manila

• Latest IRR: A.O. No. 2019-0045, October 24, 2019

• Latest Enabling Law: R.A. No. 11331, "An Act Increasing the Bed Capacity of Tondo Medical Center in the City of Manila from Two Hundred (200) to Three Hundred (300) Beds, Upgrading its Professional Health Care Services and Facilities, Authorizing the Increase of its Medical Personnel, and Appropriating Funds Therefor," April 17, 2019

19. Valenzuela Medical Center, Valenzuela City

• Latest IRR: A.O. No. 2019-0042, October 23, 2019

• Latest Enabling Law: R.A. No. 11327, "An Act Increasing the Bed Capacity of Valenzuela Medical Center in the City of Valenzuela, from Two Hundred (200) to Five Hundred (500) Beds, and Appropriating Funds Therefor," April 17, 2019

1. Lung Center of the Philippines, Quezon City

• Earliest Enabling Policy: P.D. No. 1823, "Creating the Lung Center of the Philippines" dated January 16, 1981

2. National Kidney and Transplant Institute, Quezon City

• Earliest Enabling Policy: P.D. No. 1832, "Creating the National Kidney Foundation of the Philippines" dated January 16, 1981

3. Philippine Heart Center, Quezon City

• Earliest Enabling Policy: P.D. No. 673, "Creating the Philippine Heart Center for Asia" dated March 19, 1975

4. Philippine Children's Medical Center, Quezon City

• Earliest Enabling Policy: P.D. No. 1631, "Creating the Lungsod ng Kabataan" dated August 10, 1979

1. Bicutan Rehabilitation Center

2. Las Pinas Drug Abuse Treatment and Rehabilitation Center

NATIONAL REFERENCE LABORATORIES

1. East Avenue Medical Center

2. Lung Center of the Philippines

3. National Kidney and Transplant Institute

4. Philippine Health Center

5. Research Institute for Tropical Medicine

6. San Lazaro Hospital

SUB-NATIONAL REFERENCE LABORATORIES

7. San Lazaro Hospital SNL

NATIONAL BLOOD CENTER

• Philippine Blood Center