TP53 Functions

TP53 Functions

The TP53 gene gives instructions for producing the tumor protein p53 (or p53). This protein functions as a tumor suppressor, meaning it controls cell division by preventing cells from growing and dividing (proliferating) too quickly or uncontrollably. The p53 protein is found in the nuclei of cells all across the body, where it binds to DNA directly. When a cell's DNA is damaged by harmful chemicals, radiation, or ultraviolet (UV) rays from the sun, this protein is crucial in determining whether the DNA will be repaired or the injured cell will self-destruct (undergo apoptosis). If the damage to the DNA can be repaired, p53 activates other genes to repair it. This protein blocks the cell from dividing and signals it to go into apoptosis if the DNA can't be repaired.p53 helps to prevent cancers by preventing cells with mutant or damaged DNA from proliferating. Because it regulates DNA repair and cell division, p53 has earned the moniker "guardian of the genome."

Tp53 (TP53 Antibody)has a tissue-level anticancer impact that operates by blocking angiogenesis, in addition to its cellular and molecular effects. As tumors grow, they require new blood vessels to supply them, and p53 prevents this by I interfering with tumor hypoxia regulators like HIF1 and HIF2, (ii) inhibiting the production of angiogenic promoting factors, and (iii) directly increasing the production of angiogenesis inhibitors like arrestin.