AlF1 Clinical Significance

Activated macrophages contain Allograft Inflammatory Factor 1. Activated macrophages are seen in inflammatory tissues. AIF1 levels have been observed to link positively with metabolic markers such as BMI, lipids, and fasting plasma glucose levels in healthy humans. Obese patients' excess adipose tissue is linked to persistent inflammation and an increase in the number of activated macrophages. As a result, AIF1 could be a good predictor of macrophage activation in the body. When found in serum, AIF1 has also been shown to be a marker for diabetic nephropathy. Diabetic nephropathy is a complication of long-term type 1 and types 2 diabetes, and research suggests that AIF1 (AIF1 antibody)may be linked to other elements of diabetes. It's located in the pancreatic islets' activated macrophages and has been demonstrated to reduce insulin secretion while affecting glucose elimination.

The notion of AIF-1 playing a role in cancer development has been discussed in recent years. In hepatocarcinoma cell lines and tissue, AIF-1 expression was shown to be much higher than in healthy samples. AIF-1's participation in the proliferation and migration of tumor cells is one way in which it could contribute to the development of disease. Other diseases include diabetes, kidney disease, and rheumatoid arthritis.