Overview of CXCR3 Antibody

Overview of CXCR3 Antibody

CXCR3 Antibody is a polyclonal antibody that reacts with Human, Rat. A human CXCR3 antibody is produced against a 19-amino-acid peptide near the carboxy terminus. CXCR3's immunogen is found among the last 50 amino acids. CXCR3 is a fully functional receptor involved in the chemotaxis of malignant B lymphocytes and is expressed on malignant B cells from chronic lymphoproliferative diseases, particularly in individuals with CLL. CXCR3 is discovered to be a unique target for therapeutic intervention early in type 1 diabetes in the absence of known causative factors. CXCR3 signaling has been linked to MG pathogenesis, and it has been suggested that CXCR3 could be used as a new therapeutic target to treat MG. CXCR3A and CXCR3B play a role in CXCL4L1's chemotactic and vascular actions.

CXCR3, a chemokine receptor that is very similar to the interleukine 8B receptor, has been found to mediate T-cell recruitment to sites of inflammation and T-cell retention in inflamed CNS. In multiple sclerosis and diabetes, CXCR3 has been proposed as the main inflammatory chemokine receptor implicated in intrathecal T-cell accumulation. In chronic lymphoproliferative diseases, it is expressed on malignant B cells. CXCR3 has been found in the brain, lymphoid, and other peripheral tissues, as well as in disorders such as atherosclerosis, Alzheimer's, multiple sclerosis, rheumatoid arthritis, lymphomas, asthma, neoplasms, leukemia, and inflammatory states of many organs.