IL1B ELISA

IL1B (IL1B ELISA) is a cytokine that belongs to the interleukin 1 family. This cytokine is produced as a proprotein by activated macrophages and is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is a key mediator of the inflammatory response and is involved in a number of cellular activities such as cell proliferation, differentiation, and apoptosis. This cytokine's induction of cyclooxygenase-2 (PTGS2/COX2) in the central nervous system (CNS) has been linked to inflammatory pain hypersensitivity. On chromosome 2, this gene and eight other interleukin 1 family genes form a cytokine gene cluster.

T cells were stimulated to produce IL-17, IL-21, and IL-22 when IL-1 was combined with IL-23. This expression induction occurs in the absence of additional signals. This suggests that IL-1 plays a role in the modulation of autoimmune inflammation.