Phylogenetic tree of SARS-CoV-2 sequences isolated from patients living in different countries; the tree shows that there is so much diversity within a single Coronavirus species. This major diversity can help people hypothesize why the rate of transmission, pathogenesis, and virulence of SARS-CoV-2 varies in different parts of the world, and how environment and ethnicity plays a big role in triggering diversity and evolution within a virus species.
(1) Accession number, (2) geographic location, and (3) collection date, subsequently, is specified for each SARS-Cov-2 sequence on the tree.
Phylogenetic tree of SARS-CoV-2 sequences isolated from patients living in different states within the U.S.; the tree shows that there is so much diversity within a single Coronavirus species. This major diversity can help people hypothesize why the rate of transmission, pathogenesis, and virulence of SARS-CoV-2 varies in different parts of the U.S., and how environment and ethnicity plays a big role in triggering diversity and evolution within a virus species.
(1) Accession number, (2) geographic location, and (3) collection date, subsequently, are specified for each SARS-Cov-2 sequence on the tree. One Coronavirus from 45/50 U.S. states are presented on the phylogenetic tree. SARS-CoV-2 sequences from Delaware, Montana, North Dakota, South Dakota, and West Virginia were not found in NCBI Virus and are therefore not on the tree.
ViralZone = source
SUMMARY: Close contact with people via mouth or nose secretions (rephrase in own words - sentence is from WHO) promotes COVID-19 transmission. The virus can spread via saliva, respiratory secretions, or other secretion droplets. (rephrase in own words - sentence is from WHO). When an individual coughs, sneezes, talks, shouts, or sings, their secretion droplets can reach other people within 1-2 meters. Respiratory droplets enter via the eyes, nose, and mouth, and cause infection.
AEROSOLS: Some medical procedures produce aerosols - small droplets that have the ability to stay suspended in the air for some time. These aerosols can also contain SARS-CoV-2; individuals that inhale aerosols are prone to COVID-19 infection. Aerosol transmission of COVID-19 has been reported in closed areas like restaurants and nightclubs, where people talk a lot, secreting heavy amounts of respiratory droplets.
SPEECH DROPLETS: Speech droplets are considered to be a likely method of transmission. Loud speech can emit thousands of fluid droplets per second. In closed environments, the fluid speech droplets disappear within 8-14 minutes. This study shows that even normal speech promotes airborne transmission of COVID-19.
SAFETY MEASURES: To avoid COVID-19 infection from human respiratory droplets, individuals must keep a 6 feet distance from others, always wear a mask, avoid touching their nose, mouth, and eyes when in public, and frequently wash their hands with soap. Healthcare workers should always wear personal and medical protective equipment when working at the hospital in order to avoid infection by aerosols.
SUMMARY: Individuals infected with COVID-19 may leave infected respiratory droplets on surfaces and objects like tables, doorknobs, and handrails. Others who contact these infected surfaces or objects and touch their nose, mouth, or eyes without washing their hands, may get infected.
FOOD CONTAINERS, FOOD PACKAGING, and FOOD: There is currently no evidence of anyone contracting COVID-19 after touching food containers or packaging. However, it is possible for virus particles to linger on fruits and vegetables. Therefore, it is best to take safety precautions when handling food containers, food packaging, and food itself.
HOUSEHOLD SURFACES: According to a study by the National Institute of Health (NIH), COVID-19 can live up to 4 hours on copper, up to 24 hours on cardboard, and up to 3 days on stainless steel and plastic surfaces.
STOOL, URINE, and OTHER BODILY FLUIDS: SARS-CoV-2 has been detected in the stool of some people. Though it is still unclear whether the virus spreads through bodily fluids like urine, vomit, breast milk, or semen, it has potential to do so.
SAFETY MEASURES: To avoid indirect COVID-19 infection, individuals must always wash and fully sanitize their hands before touching their nose, mouth, and eyes. It is also crucial to regularly cleanse and disinfect frequently touched surfaces, objects, or things, both in public and in the household. In addition, individuals must follow the food safety guidelines when handling food from outside, including groceries. An important food safety guideline is to wash food containers, food packaging, and food items, to avoid contracting COVID-19 through touching virus particles that could be lingering on these containers or foods. When grocery shopping, individuals must wear gloves and masks, and maintain proper social distancing.
The picture above is just a rough idea of how far pathogen-bearing droplets can travel based on the data provide by the article “Transmission of COVID-19 virus by droplets and aerosols: A critical review on the unresolved dichotomy,” published in the Elsevier Public Health Emergency Collection. Many factors affect how far and at what velocity respiratory droplets can travel including: (1) droplet size and aerodynamic diameter, (2) expiration event (e.g., sneezing, coughing, talking), (3) what kind/type of mask the exhaler is wearing, (4) air velocity from the point of source, (4) environmental conditions (e.g., radiation (sunlight), temperature, wind speed, humidity, air pressure), and (6) setting cirumstances (e.g., open setting, closed setting, number of objects or people, ventilation, area, structure).
The following were observations from a study conducted to explore the characteristics of droplets and aerosol from human expiratory activities with chest infections:
95% of droplet particles were smaller than 100 μm.
Most droplet particles were between 4 μm and 8 μm.
The following were the human expiratory activities explored:
5 minutes of normal breathing
Single strong nasal expiration
Talking loudly (counting)
A single cough with mouth open
A single cough with mouth closed
Single sneeze
Sources (for all of above information):
Video by the "Kurzgesagt - In a Nutshell" youtube channel, https://www.youtube.com/watch?v=BtN-goy9VOY
World Health Organization, https://www.who.int/news-room/q-a-detail/q-a-coronaviruses#:~:text=symptoms
Habibzadeh P, Stoneman EK. The novel coronavirus: A bird's eye view. Int J Occup Environ Med 2020;11:65-71. doi: 10.15171/ijoem.2020.1921
Andersen, K.G., Rambaut, A., Lipkin, W.I. et al. The proximal origin of SARS-CoV-2. Nat Med (2020). https://doi.org/10.1038/s41591-020-0820-9.