Recent Publications

2025

Haines KL, Li R, Grey S, Kim HE, Gann E, Almond C, Rouse M, Joshi MB, Schobel SA, Agarwal S, Kirk A, Elster EA, Fernandez-Moure JS. Exploratory Cluster Analysis of IL2RA and Associated Biomarkers and Complications After Blunt Chest Trauma, JTACS 98(6) 899-906, June 2025. https://journals.lww.com/jtrauma/abstract/2025/06000/exploratory_cluster_analysis_of_il2ra_and.10.aspx.

Rindler RS, Robertson H, Yampert LD, Khatri V, Texakalidis P, Eshraghi S, Grey S, Schobel SA, Elster EA, Boulis N, Grossberg JA. Predicting Vasospasm and Early Mortality in Severe TBI: A Model Using Serum, Cytokines, Neuronal Proteins, and Clinical Data, Neurosurgery 96(5) 1133-1145, May 2025. https://journals.lww.com/neurosurgery/abstract/9900/predicting_vasospasm_and_early_mortality_in_severe.1390.aspx.

Upadhyaya P, Wang J, Mathew DT, Ali A, Tallowin S, Gann E, Lisboa FA, Schobel SA, Elster EA, Buchman TG, Dente CJ, Kamaleswaran R. Predicting Sepsis Induced Hypotension Patient Attributes for Restrictive vs Liberal Fluid Strategy, Shock 63(3) 399-405, March 2025. https://journals.lww.com/shockjournal/abstract/2025/03000/predicting_sepsis_induced_hypotension_patient.9.aspx.

Rouse M, Gann ER, Brandsma J, Sugiharto VA, Robertson H, Genzor P, Chen HW, Simons MP, Schobel SA, Chenoweth JG, Jenkins SA, Clark DV, DellaVolpe J, Chitty S, Rivera I, Lewis M, Park C, Parikh A, Vir P, Stewart IJ, Pratt K. Seraph-100 hemoperfusion for management of severe COVID-19: Assessment of serum and plasma analytes pre- and post-filtration, Blood Purif (2025) 54(3): 200-210. https://doi.org/10.1159/000542995.

2024

Choudhary T, Upadhyaya P, Davis CM, Yang P, Tallowin S, Lisboa FA, Schobel SA, Coopersmith CM, Elster EA, Buchman TG, Dente CJ, Kamaleswaran R. Derivation and Validation of Generalized Sepsis-induced Acute Respiratory Failure Phenotypes Among Critically Ill Patients: A Retrospective Study, BMC Critical Care (2024) 28:321. https://doi.org/10.1186/s13054-024-05061-4.

Rowe CJ, Nwaolu U, Martin L, Huang BJ, Mang J, Salinas D, Schlaff CD, Ghenbot S, Lansford JL, Potter BK, Schobel SA, Gann ER, Davis TA. Systemic inflammation following traumatic injury and its impact on neuroinflammatory gene expression in the rodent brain, Journal of Neuroinflammation 21, 211 (2024). https://doi.org/10.1186/s12974-024-03205-5.

Schobel SA, Gann ER, Unselt D, Grey SF, Lisboa FA, Upadhyay MM, Rouse M, Tallowin S, Be NA, Zhang X, Dalgard CL, Wilkerson MD, Hauskrecht M, Badylak SF, Zamora R, Vodovotz Y, Potter BK, Davis TA, Elster EA. The influence of microbial colonization on inflammatory versus pro-healing trajectories in combat extremity wounds. Sci Rep. 2024 Mar 4;14(1):5006. doi: 10.1038/s41598-024-52479-5. PMID: 38438404; PMCID: PMC10912443.

2023

Wang, J., de Vale, J.S., Gupta, S., Upadhyaya, P., Lisboa, F.A., Schobel, S.A., Elster, E.A., Dente, C.J., Buchman, T.G. and Kamaleswaran, R. ClotCatcher: A Novel Natural Language Model to Accurately Adjudicate Venous Thromboembolism from Radiology Reports, BMC Medical Informatics and Decision Making 23, Article number: 262 (2023). https://doi.org/10.1186/s12911-023-02369-z.

Li R, Rouse M, Pace BT, Grey SF, Mclaughlin K, Schobel SA, Simons MP. Host CD3+ T-cells can significantly modulate phage treatment effects on bacterial bioburden in mouse models. Frontiers in Microbiology. 2023;14. doi: 10.3389/fmicb.2023.1240176.

Rowe CJ, Mang J, Huang B, Dommaraju K, Potter BK, Schobel SA, Gann ER, Davis TA. Systemic inflammation induced from remote extremity trauma is a critical driver of secondary brain injury. Mol Cell Neurosci. 2023 Jul 12;126:103878. doi: 10.1016/j.mcn.2023.103878. Epub ahead of print. PMID: 37451414.

Zamora R, Forsberg JA, Shah AM, Unselt D, Grey S, Lisboa FA, Billiar TR, Schobel SA, Potter BK, Elster EA, Vodovotz Y. Central role for neurally dysregulated IL-17A in dynamic networks of systemic and local inflammation in combat casualties. Sci Rep. 2023 Apr 24;13(1):6618. doi: 10.1038/s41598-023-33623-z. Epub 2023 April 24. PMID: 37095162; PMCID: PMC10126120.

Gelbard RB, Hensman H, Schobel S, Stempora L, Gann E, Moris D, Dente CJ, Buchman TG, Kirk AD, Elster E. A random forest model using flow cytometry data identifies pulmonary infection after thoracic injury. J Trauma Acute Care Surg. 2023 Jul 1;95(1):39-46. doi: 10.1097/TA.0000000000003937. Epub 2023 Apr 11. PMID: 37038251.

Larson JL, Robertson HT, Grey SF, Schobel SA, Potter BK, Elster EA. Acute respiratory distress syndrome and acute lung injury in a trauma population with and without long bone fractures. Front Syst Biol. 2023 Jan;2. doi: 10.3389/fsysb.2022.1058603. 

2022

Vicente DA, Schobel SA, Anfossi S, Hensman H, Lisboa F, Robertson H, Khatri V, Bradley MJ, Shimizu M, Buchman TG, Davis TA, Dente CJ, Kirk AD, Calin GA, Elster EA. Cellular microRNAs correlate with clinical parameters in multiple injury patients. J Trauma Acute Care Surg. 2022 Oct 1;93(4):427-438. doi: 10.1097/TA.0000000000003708. Epub 2022 Jul 7. PMID: 35797620; PMCID: PMC9488942.

Avila-Herrera A, Thissen JB, Mulakken N, Schobel SA, Morrison MD, Zhou X, Grey SF, Lisboa FA, Unselt D, Mabery S, Upadhyay MM, Jaing CJ, Elster EA, Be NA. Metagenomic features of bioburden serve as outcome indicators in combat extremity wounds. Sci Rep. 2022 Aug 15;12(1):13816. doi: 10.1038/s41598-022-16170-x. Epub 2022 August 15. PMID: 35970993; PMCID: PMC9378645.

McKinley TO, Gaski GE, Billiar TR, Vodovotz Y, Brown KM, Elster EA, Constantine GM, Schobel SA, Robertson HT, Meagher AD, Firoozabadi R, Gary JL, O'Toole RV, Aneja A, Trochez KM, Kempton LB, Steenburg SD, Collins SC, Frey KP, Castillo RC; METRC. Patient-specific precision injury signatures to optimize orthopaedic interventions in multiply injured patients (precise study). J Orthop Trauma. 2022 Jan 1;36(Suppl 1):S14-S20. doi: 10.1097/BOT.0000000000002289. PMID: 34924514.

Vicente D, Schobel SA, Anfossi S, Hensman H, Lisboa F, Robertson H, Khatri V, Bradley MJ, Shimizu M, Buchman TG, Davis TA, Dente CJ, Kirk AD, Calin GA, Elster EA. Viral micro-RNAs are detected in the early systemic response to injury and are associated with outcomes in polytrauma patients. Crit Care Med. 2022 Feb 1;50(2):296-306. doi: 10.1097/CCM.0000000000005181. PMID: 34259445.

2021

Gunasingha RMKD, Grey SF, Munoz B, Schobel S, Lee J, Erwin C, Irons T, McMillan E, Unselt D, Elster E, Bradley M. To scan or not to scan: development of a clinical decision support tool to determine if imaging would aid in the diagnosis of appendicitis. World J Surg. 2021 Oct;45(10):3056-3064. doi: 10.1007/s00268-021-06246-6. Epub 2021 Aug 9. PMID: 34370058.

 Breslin AW, Limkakeng AT, Silvius E, Staton CA, Almond C, Joshi MB, Adams B, Johnston B, McGowan L, Kirk AD, Elster E. Immune response profiling in patients with traumatic injuries associated with alcohol ingestion. Clin Transl Sci. 2021 Sep;14(5):1791-1798. doi: 10.1111/cts.13022. Epub 2021 May 1. PMID: 33932089; PMCID: PMC8504819.

Gelbard RB, Hensman H, Schobel S, Stempora LL, Moris D, Dente CJ, Buchman TG, Kirk AD, Elster E. An integrative model using flow cytometry identifies nosocomial infection after trauma. J Trauma Acute Care Surg. 2021 Jul 1;91(1):47-53. doi: 10.1097/TA.0000000000003148. PMID: 33660689.

Ronaldi AE, Polcz JE, Robertson HT, Walker PF, Bozzay JD, Dubose JJ, White PW, Rasmussen TE, White JM. A multi-registry analysis of military and civilian penetrating cervical carotid artery injury. J Trauma Acute Care Surg. 2021 Aug 1;91(2S Suppl 2):S226-S232. doi: 10.1097/TA.0000000000003296. Epub 2021 May 28. PMID: 34039922.

Gerardo CJ, Silvius E, Schobel S, Eppensteiner JC, McGowan LM, Elster EA, Kirk AD, Limkakeng AT. Association of a network of immunologic response and clinical features with the functional recovery from crotalinae snakebite envenoming. Front Immunol. 2021 Mar 15;12:628113. doi: 10.3389/fimmu.2021.628113. PMID: 33790901; PMCID: PMC8006329.

Dente CJ, Mina MJ, Morse BC, Hensman H, Schobel S, Gelbard RB, Belard A, Buchman TG, Kirk AD, Elster EA. Predicting the need for massive transfusion: prospective validation of a smartphone-based clinical decision support tool. Surgery. 2021 Nov;170(5):1574-1580. doi: 10.1016/j.surg.2021.04.034. Epub 2021 Jun 8. PMID: 34112517.

Hoyt BW, Baird MD, Schobel S, Robertson H, Sanka R, Potter BK, Bradley M, Oh J, Elster EA. Tranexamic acid administration and pulmonary embolism in combat casualties with orthopaedic injuries. OTA Int. 2021 Oct 19;4(4):e143. doi: 10.1097/OI9.0000000000000143. Epub 2021 October 19. PMID: 34765896; PMCID: PMC8575417.

Matthews JB, Blair PG, Ellison EC, Andrew Elster E, Nagler A, Schwaitzberg SD, Shabahang MM, Sidawy AN, Spanknebel K, Stain SC, Britt LD, Sachdeva AK. Checklist Framework for Surgical Education Disaster Plans. J Am Coll Surg. 2021 Oct;233(4):557-563. doi: 10.1016/j.jamcollsurg.2021.06.015. Epub 2021 Jul 12. PMID: 34265427; PMCID: PMC8273374.
Bradley M, Shi A, Khatri V, Schobel S, Silvius E, Kirk A, Buchman T, Oh J, Elster E. Prediction of venous thromboembolism using clinical and serum biomarker data from a military cohort of trauma patients. BMJ Mil Health. 2021 Dec;167(6):402-407. doi: 10.1136/bmjmilitary-2019-001393. Epub 2020 Mar 5. PMID: 32139417.

Shashikumar SP, Josef CS, Sharma A, Nemati S. DeepAISE - An interpretable and recurrent neural survival model for early prediction of sepsis. Artif Intell Med. 2021 Mar;113:102036. doi: 10.1016/j.artmed.2021.102036. Epub 2021 Feb 13. PMID: 33685592; PMCID: PMC8029104.

2020

Walker PF, Bozzay JD, Johnston LR, Elster EA, Rodriguez CJ, Bradley MJ. Outcomes of tranexamic acid administration in military trauma patients with intracranial hemorrhage: a cohort study. BMC Emerg Med. 2020 May 14;20(1):39. doi: 10.1186/s12873-020-00335-w. PMID: 32410581; PMCID: PMC7222426.

Dente CJ, Styrmisdottir E, Shi A, Schobel S, Khatri V, Potter BK, Forsberg JA, Buchman T, Kirk AD, Elster E. Driving biology: the effect of standardized wound management on wound biomarker profiles. J Trauma Acute Care Surg. 2020 Mar;88(3):379-389. doi: 10.1097/TA.0000000000002568. PMID: 32107353.

Bradley M, Dente C, Khatri V, Schobel S, Lisboa F, Shi A, Hensman H, Kirk A, Buchman TG, Elster E. Advanced modeling to predict pneumonia in combat trauma patients. World J Surg. 2020 Jul;44(7):2255-2262. doi: 10.1007/s00268-019-05294-3. Erratum in: World J Surg. 2020 Apr 19;: Epub 2019 November 22. PMID: 31748888.

 Reyna MA, Josef CS, Jeter R, Shashikumar SP, Westover MB, Nemati S, Clifford GD, Sharma A. Early prediction of sepsis from clinical data: the physionet/computing in cardiology challenge 2019. Crit Care Med. 2020 Feb;48(2):210-217. doi: 10.1097/CCM.0000000000004145. PMID: 31939789; PMCID: PMC6964870.