The Matrisome Portal is an open-access resource that aims to support and facilitate ECM research by sharing detailed protocols, tools, and datasets with the scientific community.

The resources deployed through the Matrisome Portal are the results of the Matrisome Project, an effort initiated by Dr. Alexandra Naba during her postdoctoral training in the laboratory of Dr. Richard Hynes at MIT. This work was done in collaboration with members of the Bioinformatics & Computing Facility at the Koch Institute for Integrative Cancer Research at MIT, and Karl Clauser and Dr. Steve Carr at the Proteomics Platform of the Broad Institute. 

This website is now maintained by the Naba lab at the University of Illinois Chicago, with support from many contributors.

Recent developments include:

• The in-silico prediction of the matrisomes of new model organisms, including the zebrafish, Drosophila, and C. elegans, using de-novo sequence analysis.

• The deployment of MatrisomeDB, a searchable database that integrates proteomic data on the ECM of healthy and diseased tissues (Shao et al., Nucleic Acids Research, 2020; Shao et al., Nucleic Acids Research, 2023).

• The integration of quantitative proteomic data from the ECM Atlas in MatrixDB (Clerc et al., Nucleic Acids Research, 2019; Samarasinghe et al., Nucleic Acids Research, 2024).

• The building of MatriCom, a web application devised to mine scRNA sequencing datasets to infer ECM-ECM and cell-ECM communication systems in the context of the diverse cell populations that constitute any tissue or organ (Lamba et al., Journal of Cell Science, 2025).