About The Matrisome Project
The Matrisome Project is an effort initiated by Dr. Alexandra Naba during her postdoctoral training in the laboratory of Dr. Richard Hynes at MIT, in collaboration with members of the Bioinformatics & Computing Facility at the Koch Institute for Integrative Cancer Research at MIT, and Karl Clauser and Dr. Steve Carr at the Proteomics Platform of the Broad Institute.
The Matrisome Project is an open access resource which aims to support and facilitate ECM research by sharing detailed protocols, tools, and datasets with the scientific community.
Recent developments include:
The in-silico prediction of the matrisomes of new model organisms including the zebrafish, Drosophila, and C. elegans, using de-novo sequence analysis.
The deployment of MatrisomeDB, a searchable database that provides live cross-referencing to gene and protein databases for every ECM and ECM-associated gene and integrates experimental data of the ECM atlas (Shao et al., Nucleic Acids Research, 2020 and Shao et al., Nucleic Acids Research, 2023).