2025
Tsuchiya H, Hanaki T, Sakabe T, Tokuyasu N, Nagahara T, Umekita Y, Isomoto H, Fujiwara Y, Nanba D. Immune evasion from macrophages by NEAT1-induced CD24 in liver cancer. Oncogene, 2025, 44: 3652-3664.
2024
Minato H, Endo R, Kurata Y, Notsu T, Kinugasa Y, Wakimizu T, Tsuneto M, Shirayoshi Y, Ninomiya H, Yamamoto K, Hisatome I, Otsuki A. Azelnidipine protects HL-1 cardiomyocytes from hypoxia/reoxygenation injury by enhancement of NO production independently of effects on gene expression. Heart Vessels, 2024, 39: 899-908.
Priyono AK, Miake J, Sawano T, Ichihara Y, Nagata K, Okamura A, Tomomori T, Takami A, Notsu T, Yamamoto K, Imamura T. Mitochondrial Responses to Sublethal Doxorubicin in H9c2 Cardiomyocytes: The Role of Phosphorylated CaMKII. Yonago Acta Med, 2024, 67: 41-51.
これまでの主要な業績
難波 (Nanba D)
Nanba D*, Sakabe J, Mosig J, Brouard M, Toki F, Shimokawa M, Kamiya M, Braschler T, Azzabi F, Droz-Georget Lathion S, Johnsson K, Roy K, Schmid CD, Bureau JB, Rochat A, Barrandon Y. Low temperature and mTOR inhibition favor stem cell maintenance in human keratinocyte cultures. EMBO Rep, 2023, 24: e55439. (*: corresponding author)
Nanba D*, Toki F, Asakawa K, Matsumura H, Shiraishi K, Sayama K, Matsuzaki K, Toki H, Nishimura EK*. EGFR-mediated epidermal stem cell motility drives skin regeneration through COL17A1 proteolysis. J Cell Biol, 2021, 220: e202012073. (*: corresponding authors)
Hirose T, Kotoku J*, Toki F, Nishimura EK, Nanba D*. Label-free quality control and identification of human keratinocyte stem cells by deep learning-based automated cell tracking. Stem Cells, 2021, 39: 1091-1100. (*: corresponding authors)
Liu N, Matsumura H, Kato T, Ichinose S, Takada A, Namiki T, Asakawa K, Morinaga H, Mohri Y, De Arcangelis A, Geroges-Labouesse E, Nanba D, Nishimura, EK. Stem cell competition orchestrates skin homeostasis and ageing. Nature, 2019, 568: 344-350.
Nanba D*, Toki F, Tate S, Imai M, Matsushita N, Shiraishi K, Sayama K, Toki H, Higashiyama S, Barrandon Y*. (2015). Cell motion predicts human epidermal stemness. J Cell Biol, 2015, 209: 305-315. (*: corresponding authors)
Nanba D*, Toki F, Matsushita N, Matsushita S, Higashiyama S, Barrandon Y*. Actin filament dynamics impacts keratinocyte stem cell maintenance. EMBO Mol Med, 2013, 5: 640-653. (*: corresponding authors)
Nanba D, Mammoto A, Hashimoto K, Higashiyama, S. Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF. J Cell Biol, 2003, 163: 489-502.
Nanba D, Hieda Y, Nakanishi Y. Remodeling of desmosomal and hemidesmosomal adhesion systems during early morphogenesis of mouse pelage hair follicles. J Invest Dermatol, 2000, 114: 171-177.
土谷 (Tsuchiya H)
Tsuchiya H*, Shinonaga R, Sakaguchi H, Kitagawa Y, Yoshida K. NEAT1–SOD2 Axis Confers Sorafenib and Lenvatinib Resistance by Activating AKT in Liver Cancer Cell Lines. Curr Issues Mol Biol, 2023, 45: 1073–1085. (*: corresponding author)
Tsuchiya H*, Shinonaga R, Sakaguchi H, Kitagawa Y, Yoshida K, Shiota G. NEAT1 Confers Radioresistance to Hepatocellular Carcinoma Cells by Inducing PINK1/Parkin-Mediated Mitophagy. Int J Mol Sci, 2022, 23: 14397–14397. (*: corresponding author)
Sakaguchi H, Tsuchiya H*, Kitagawa Y, Tanino T, Yoshida K, Uchida N, Shiota G. NEAT1 Confers Radioresistance to Hepatocellular Carcinoma Cells by Inducing Autophagy through GABARAP. Int J Mol Sci. 2022, 23: 711–711. (*: corresponding author)
Koyama S, Tsuchiya H*, Amisaki M, Sakaguchi H, Honjo S, Fujiwara Y, Shiota G. NEAT1 is Required for the Expression of the Liver Cancer Stem Cell Marker CD44. Int J Mol Sci. 2020, 21: 1927–1927. (*: corresponding author)
Tsuchiya H*, Amisaki M, Takenaga A, Honjo S, Fujiwara Y, Shiota G. HBx and c-MYC Cooperate to Induce URI1 Expression in HBV-Related Hepatocellular Carcinoma. Int J Mol Sci. 2019, 20: 5714–5714. (*: corresponding author)
Tsuchiya H, da Costa KA, Lee S, Renga B, Jaeschke H, Yang Z, Orena SJ, Goedken MJ, Zhang Y, Kong B, Lebofsky M, Rudraiah S, Smalling R, Guo G, Fiorucci S, Zeisel SH, Wang L. Interactions Between Nuclear Receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice. Gastroenterology. 2015, 148: 1012–1023.e14.
Lee SM§, Zhang Y§, Tsuchiya H§, Smalling R, Jetten AM, Wang L. Small Heterodimer Partner/Neuronal PAS Domain Protein 2 Axis Regulates the Oscillation of Liver Lipid Metabolism. Hepatology. 2015, 61: 497–505. (§: equal contributors)
Tsuchiya H*, Ebata Y, Sakabe T, Hama S, Kogure K, Shiota G. High-fat, high-fructose diet induces hepatic iron overload via a hepcidin-independent mechanism prior to the onset of liver steatosis and insulin resistance in mice.Metabolism. 2013, 62: 62–69. (*: corresponding author)
Tsuchiya H*, Ikeda Y, Ebata Y, Kojima C, Katsuma R, Tsuruyama T, Sakabe T, Shomori K, Komeda N, Oshiro S, Okamoto H, Takubo K, Hama S, Shudo K, Kogure K, Shiota G. Retinoids ameliorate insulin resistance in a leptin-dependent manner in mice. Hepatology. 2012, 56: 1319–1330. (*: corresponding author)
Tsuchiya H*, Akechi Y, Ikeda R, Nishio R, Sakabe T, Terabayashi K, Matsumi Y, Ashla AA, Hoshikawa Y, Kurimasa A, Suzuki T, Ishibashi N, Yanagida S, Shiota G. Suppressive Effects of Retinoids on Iron-Induced Oxidative Stress in the Liver. Gastroenterology. 2009, 136: 341–350. (*: corresponding author)
經遠 (Tsuneto M)
Wakimizu T, Morikawa K, Fukumura K, Yuki T, Adachi T, Kurata Y, Miake J, Hisatome I, Tsuneto M*, Shirayoshi Y. SHOX2 refines the identification of human sinoatrial nodal cell population in the in vitro cardiac differentiation. Regen Ther, 2022, 21:239-249. (*: corresponding authors)
Tornack J, Kawano Y, Garbi N, Hämmerling GJ, Melchers F, Tsuneto M*. Flt3 ligand-eGFP-reporter expression characterizes functionally distinct subpopulations of CD150+ long-term repopulating murine hematopoietic stem cells. Eur J Immunol, 2017, 47:1477-1487. (*: corresponding authors)
Kajikhina K, Melchers F, Tsuneto M*. Chemokine polyreactivity of IL7Rα+CSF-1R+ lympho-myeloid progenitors in the developing fetal liver. Sci Rep, 2015, 5:12817. (*: corresponding authors)
Tsuneto M*, Tokoyoda K, Kajikhina E, Hauser AE, Hara T, Tani-Ichi S, Ikuta K, Melchers F. B-cell progenitors and precursors change their microenvironment in fetal liver during early development. Stem Cells, 2013, 31:2800-12. (*: corresponding authors)
Tornack J, Seiler K, Grützkau A, Grün JR, Onodera M, Melchers F, Tsuneto M*. Ectopic Runx1 expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis. PLoS One, 2013, 8:e70116. (*: corresponding authors)
Tsuneto M*, Yamazaki H, Yoshino M, Yamada T, Hayashi S., Ascorbic acid promotes osteoclastogenesis from embryonic stem cells. Biochem Biophys Res Commun, 2005, 335:1239-46. (*: corresponding authors)
Tsuneto M*, Tominaga A, Yamazaki H, Yoshino M, Orkin SH, Hayashi S. Enforced expression of PU.1 rescues osteoclastogenesis from embryonic stem cells lacking Tal-1. Stem Cells, 2005, 23:134-43. (*: corresponding authors)
板場 (Itaba N)
Fukushima K, Itaba N, Kono Y, Okazaki S, Enokida S, Kuranobu N, Murakami J, Enokida M, Nagashima H, Kanzaki S, Namba N, Shiota G*. Secreted matrix metalloproteinase-14 is a predictor for antifibroticeffect of IC-2-engineered mesenchymal stem cell sheets on liverfibrosis in mice. Regen Ther, 2021, 18: 292-301. (*: corresponding author)
Sakaguchi T, Kono Y, Itaba N, Morimoto M, Isomoto H, Shiota G*. Identification of a Novel Deactivating Small-molecule Compound for Fibrogenic Hepatic Stellate Cells. Yonago Acta Med, 2020, 63: 79-87. (*: corresponding author)
Hoi S, Tsuchiya H, Itaba N, Suzuki K, Oka H, Morimoto M, Takata T, Isomoto H, Shiota G*. WNT/β-catenin Signal Inhibitor IC-2-derived Small-Molecule Compounds Suppress TGF-β1-induced Fibrogenic Response of Renal Epithelial Cells by Inhibiting SMAD2/3 Signalling. Clin Exp Pharmacol Physiol, 2020, 47: 940-946. (*: corresponding author)
Itaba N, Kono Y, Watanabe K, Yokobata T, Oka H, Osaki M, Kakuta H, Morimoto M, and Shiota G*. Reversal of established liver fibrosis by IC-2-engineered mesenchymal stem cell sheets. Sci Rep, 2019, 9: 6841. (*: corresponding author)
Itaba N, Noda I, Oka H, Kono Y, Okinaka K, Yokobata T, Okazaki S, Morimoto M, Shiota G*. Hepatic cell sheets engineered from human mesenchymal stem cells with a single small molecule compound IC-2 ameliorate acute liver injury in mice. Regen Ther, 2018, 24: 45-57. (*: corresponding author)
Seto K§, Sakabe T§, Itaba N, Azumi J, Oka H, Morimoto M, Umekita Y, Shiota G*. A Novel Small-molecule WNT Inhibitor, IC-2, Has the Potential to Suppress Liver Cancer Stem Cells. Anticancer Res, 2017, 37: 3569-3579. (§: equal contributors; *: corresponding author)
Yokogi S, Tsubota T*, Kanki K, Azumi J, Itaba N, Oka H, Morimoto M, Ryoke K, Shiota G. Wnt/β-Catenin Signal Inhibitor HC-1 Sensitizes Oral Squamous Cell Carcinoma Cells to 5-Fluorouracil through Reduction of CD44-Positive Population. Yonago Acta Med, 2016, 59: 93-99. (*: corresponding author)
Itaba N, Sakabe T, Kanki K, Azumi J, Shimizu H, Yohei K, Yoshiaki M, Ken-ichiro A, Takayuki T, Hiroyuki O, Toshihiko S, Hiroyuki S, Minoru M, Yo M, Yumi M, Goshi S*. Identification of the small molecule compound which induces hepatic differentiation of human mesenchymal stem cells. Regen Ther, 2015, 2: 32-41. (*: corresponding author)
Itaba N§, Matsumi Y§, Okinaka K, Ashla AA, Kono Y, Osaki M, Morimoto M, Sugiyama N, Ohashi K, Okano T, Shiota G*. Human mesenchymal stem cell-engineered hepatic cell sheets accelerate liver regeneration in mice. Sci Rep, 2015, 5: 16169. (§: equal contributors; *: corresponding author)
Itaba N§, Wairagu PM§, Aramaki N§, Yasui T§, Matsumi Y, Kono Y, Phan AN, Otsu M, Kunisada T, Nakamura Y, Okano H, Jeong Y*, Shiota G*. Nuclear receptor gene alteration in human induced pluripotent stem cells with hepatic differentiation propensity. Hepatol Res, 2014, 44: E408-19. (§: equal contributors; *: corresponding authors)