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UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY
CURRICULUM VITAE
Peng Yao, Ph.D.
Aab Cardiovascular Research Institute
Department of Medicine, University of Rochester School of Medicine and Dentistry
The Center for RNA Biology
The Center for Biomedical Informatics
601 Elmwood Ave., Box CVRI, Rochester, NY 14642
Telephone: (585) 276-7708
E-mail: Peng_Yao@URMC.Rochester.edu
Citizenship: United States of America
CURRENT POSITIONS
Associate Professor (tenure track)
Aab Cardiovascular Research Institute, Department of Medicine, Department of Biochemistry & Biophysics (secondary affiliation), University of Rochester School of Medicine & Dentistry, Rochester, NY
EDUCATION
9/2003 –6/2008 Ph.D. in Biochemistry and Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Science, Shanghai, China
Advisor: En-Duo Wang, Ph.D. (Member of Chinese National Academy of Science)
9/1999 – 6/2003 B.S. in Biotechnology, Wuhan University, Wuhan, China
POST-DEGREE TRAINING
8/2008 – 11/2012 Postdoctoral Fellow in Cellular and Molecular Medicine
Laboratory of Paul L. Fox, Ph.D. (Robert Canova Endowed Chair in Inflammation Research), Department of Cell Biology, Lerner Research Institute (LRI), Cleveland Clinic, Cleveland, OH
FACULTY APPOINTMENTS
10/2021 – Present Associate Professor (tenure track), Aab Cardiovascular Research Institute (CVRI), Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY
Associate Professor (tenure track; Secondary affiliation), Department of Biochemistry & Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY
1/2018 – 9/2021 Assistant Professor (tenure track)
Secondary affiliation, Department of Biochemistry & Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY
9/2016 – 9/2021 Assistant Professor (tenure track)
Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY
8/2014 – 9/2016 Assistant Professor (non-tenure track)
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
11/2013 – 9/2016 Project Scientist (equivalent to instructor in universities)
Laboratory of Paul L. Fox, Ph.D., Department of Cellular and Molecular Medicine, LRI, Cleveland Clinic, Cleveland, OH
12/2012 – 11/2013 Research Associate (entry level of faculty position)
Laboratory of Paul L. Fox, Ph.D., Department of Cellular and Molecular Medicine, LRI, Cleveland Clinic, Cleveland, OH
HONORS AND AWARDS
2024 American Heart Association (AHA) Established Investigator Award (2.56%)
2023 Harold S. Geneen Charitable Trust Award
2022 LeapRx Program Award, Empire Discovery Institute & Novo Nordisk
2022 University of Research Award, University of Rochester
2022 Poster Competition Award at the 4th ACRE-APS Symposium at BCVS 2022, 1st Place, Chicago, USA
2021 Rubens Discovery Award 2021, Aab CVRI, URMC
2019 Basic Cardiovascular Sciences (BCVS) Abstract Travel Grant for AHA Scientific Session 2019
2019 ACRE-APS Junior Faculty Award at the 1st Asian Cardiovascular Symposium at BCVS 2019, 1st Place, Boston, USA
2016 Travel Award from RNA Society Meeting 2016, Kyoto, Japan
2014 Elsa Albrecht Research Associate Award, 1st Place, Department of Cellular and Molecular Medicine, LRI, Cleveland Clinic
2013 – 2017 American Heart Association, National Affiliate, Scientist Development Grant ($308,000; Role: PI)
2013 Best Poster Presentation Award, LRI Retreat, Cleveland Clinic
2013 Postdoctoral Fellow and Research Associate Award for Excellence in Research (1:300), LRI, Cleveland Clinic
2012 LRI Research Day Best Poster Award, LRI, Cleveland Clinic
2012 Elsa Albrecht Fellow Award, 1st Place, Department of Cell Biology, LRI, Cleveland Clinic
2010 – 2012 American Heart Association, Postdoctoral Fellowship ($88,000; Role: PI)
2008 Di’ao Scholarship from Chinese Academy of Sciences, 1st Place
2006 Travel Award from Shanghai-Unilever Research & Development Fund
ACADEMIC & PROFESSIONAL ORGANIZATIONS
LOCAL/REGIONAL ACADEMIC & PROFESSIONAL ORGANIZATIONS
2023 – Present, Biomedical Genetics & Genomics PhD Program, URMC, Member
2017 – Present, T32 NIH Training Grant in Cellular, Biochemical & Molecular Sciences, URMC, Member
2017 – Present, Center for Biomedical Informatics, URMC, Member
2017 – Present, Center for RNA Biology, URMC, Member
2016 – Present, Biochemistry & Molecular Biology PhD Program, URMC, Member
2016 – Present, Cellular and Molecular Pharmacology and Physiology PhD Program, URMC, Member
2016 – Present, Cell Biology of Disease PhD Program, URMC, Member
NATIONAL/INTERNATIONAL ACADEMIC &PROFESSIONAL ORGANIZATIONS
2014 – Present RNA Society
2012 – Present American Heart Association
2024 – Present International Society for Heart Research
COMMITTEES & OTHER ADMINISTRATIVE SERVICE
UR Department of Medicine (Aab Cardiovascular Research Institute)
1/2022 – Present Director of the Imaging Core of Aab CVRI
2019 – Present Co-Chair (with Dr. Douglas Anderson), CVS 401 (Cardiovascular Biology and Disease) course
2018 – Present Co-Chair (with Dr. Zhenggen Jin), CVS 402 / Aab CVRI seminar series
2023 – Present Member, Executive Committee (ExCom) for Center for Advanced Light Microscopy and Nanoscopy Resource
UR Extra-Departmental
12/2024 Chair, Ph.D. Final Oral Examination Committee (for Kejia Zhang from Dr. Dragony Fu’s lab)
2024 – Present Thesis Committee member of graduate student Belal Chowdhury from Dr. Lynne Maquat's lab, URMC
2024 – Present Thesis Committee member of graduate student Wyatt Lynn Fales from Dr. Joshua Munger's lab, URMC
2023 – Present Thesis Committee member of graduate student Megan Miaro from Dr. David Mathew's lab, URMC
2022 – Present Thesis Committee member of graduate student Rui Zhang from Dr. Yitao Yu’s lab, URMC
06/2022 Chair, Ph.D. Final Oral Examination Committee (for Jenna Lentini from Dr. Dragony Fu’s lab)
03/2019 – Present Co-Chair (with Dr. Dmitri Ermolenko), the Translation Club (Cluster)
2018 – 2022 Thesis Committee member of graduate student Li Xie from Dr. Chris Proschel's lab, URMC
3/1/2018 – 12/2022 Member, Institutional Biosafety Committee (IBC)
Local/Regional
2018 – 2019 Co-Chair, the 21st Rustbelt RNA Meeting (Cleveland, OH)
2017 – 2018 Vice Chair, the 20th Rustbelt RNA Meeting (Columbus, OH)
2013 – 2016 Member, CMM Visiting Professorship Committee, Department of CMM, LRI, Cleveland Clinic. I hosted the 2-day visit for Dr. Ira Tabas (Columbia University) in 07/2015 and organized the 2-day visit for Dr. Cathryn J. Moore (NYU School of Medicine) in 2014.
PROFESSIONAL SERVICE ASSIGNMENTS
Local/Regional
10/14/2024 Poster Judge, 2024 New York RNA Symposium in the Finger Lakes Canandaigua, NY, USA
3/16/2023 Poster Judge, the 2023 RNA Institute Annual Symposium, Albany, NY, USA
10/14/2022 Poster Judge, the 24th Annual Rustbelt RNA Meeting, Cleveland, OH, USA
10/23/2020 Poster Judge, the 22th Annual Rustbelt RNA Meeting (virtual meeting)
10/14/2016 Poster Judge, the 18th Annual Rustbelt RNA Meeting, Cleveland, OH, USA
National/International
8/19/2024 Session Chair/Moderator for Session V – Rapid Abstract Presentations, The 43rd North American Society Annual Meeting of the IHSR, ACRE-SAHR @ ISHR-NAS Pre-Conference Symposium, Long Beach, LA
5/28 – 6/1/2024 Invited mentor: Mentor/Mentee Luncheon, the 29th Annual Meeting of the RNA Society, Edinburgh, UK
7/24/2022 Session Chair/Moderator for Session II – ACRE-APS Young Investigator Award Presentation, the 4th Asian Cardiovascular Pre-Meeting Symposium of BCVS, Chicago, IL
7/9/2018 Session Chair/Moderator, Session II–MEF2 in Development and Disease, the International MADS Box Conference 2018, Lake Placid, NY, USA
5/29 – 6/3/2018 Invited mentor: Mentor/Mentee Luncheon, the 23rd Annual Meeting of the RNA Society, UC Berkeley, San Francisco, CA, USA
EDUCATIONAL CONTRIBUTIONS
Undergraduate Students (present occupation)
Andrew Flagg (Medical Student, Johns Hopkins School of Medicine; 2017)
Jordan Pappas (Undergraduate Student, University of Rochester; 2019-2020)
Virginia Aswad (Undergraduate Student, Rochester Institute of Technology; 2020-2021)
Matthew Auguste (Undergraduate Student, University of Rochester; 2020-present, AHA Institutional Award for Undergraduate Student Training during 2021-2022)
Jared Hollinger (Lab Tech III, B.S., St. John Fisher College; 2021-2024; had his first-author paper in PEP and joined OSU for PhD thesis research)
Matthew Auguste (Lab Tech III, B.S., University of Rochester; 2023-2024; currently working as clinical coordinator in Pediatric Cardiology of URMC with Dr. Geroge Porter)
Emily Bonanno (Undergraduate Student, University of Rochester; 2022-2024)
Yui Kawakami (Undergraduate Student and Lab Tech III, University of Rochester; 2024; currently working on independent animal studies)
Joseph DeTraglia (Undergraduate Student, University of Rochester; 2022-2026)
Alexander Chen (Undergraduate Student, University of Rochester; 2023-2027)
Graduate Students (present occupation)
Feng Jiang, Ph.D. (Graduate Student since 4/2018, Yao Lab; thesis defense on 12/14/2023; working as a postdoctoral fellow in Dr. Billy Jin Li’s laboratory at Stanford University from 2/1/2024 till present)
Omar Hedaya, Ph.D. (Graduate Student since 6/2018, Yao Lab; NIH T32 Fellowship awardee [T32 GM068411 PI: Lynne Maquat and Jeffery Hayes]; 26th RNA Society Annual Conference Poster Award in August 2021; thesis defense on 10/20/2023; working as a postdoctoral fellow in Dr. Kevin Weeks’ laboratory in University of North Carolina from 2/1/2024 till present)
Lindsey Wainwright (Graduate Student since 3/13/2023, Yao Lab; currently working on RNA aptamer screen for ASO delivery in cardiac myofibroblasts; received NIH T32 pre-doctoral fellowship from 7/1/2024-6/30/2025)
Jack Lawrence Schwartz (Graduate Student since 6/1/2024, Yao Lab; currently working on RNA helicases, RNA secondary structure, and uORF-mediated regulation of mRNA translation)
Jiali He (MS student from Syracuse University; joined the lab as a Research Specialist to work on independent animal studies)
Kevin Lei Pan (Rotation Graduate Student since 12/2/2024, Yao Lab; currently working on posttranslational modifications of RBPs in TGFb-activated immortalized human cardiac fibroblasts and CRISPR-Cas9-mediated knock-in HEK293T cell line construction)
Belal Chowdhury (Graduate Student since 4/15/2025, Yao Lab; currently working on RNA-binding protein function and mechanism in cardiac biology and heart disease)
Post-doctoral associates (present occupation)
Jiangbin Wu, Ph.D. (Post-doc since 9/16/2016, Yao Lab; AHA Post-doctoral Fellowship awardee [19POST34400013] and Career Development Awardee [848985]; he was promoted to Research Assistant Professor in Sep. 2020; finalist of the Outstanding Early Career Investigator Award for the BCVS2021 Scientific session; Bin published his first-author papers in EMBO MM, Circulation Research, and Cardiovascular Research and co-author papers in Circulation, Nature Communications, and Nucleic Acids Research, etc.; Professor in Cardiovascular Disease Research Institute, Soochow University, China, June 2023)
Kadiam C Venkata Subbaiah, Ph.D. (Post-doc since 12/1/2016, Yao Lab; promoted to Staff Scientist in 10/2021 and published 6 first-author papers in JCI Insight, EMBO MM, Cardiovascular Research, BBRC, CSBJ, and JCDD in Yao Lab; Staff Scientist in Scriptr Global company (Douglas Anderson’s laboratory) during 7/2022-present)
Eng-Soon Khor, Ph.D. (Post-doc during 12/19/2019-8/31/2023, Yao Lab; one manuscript reviewed in Nature Communications and the other manuscript under preparation for submission in the near future; Working in the industry on hiPSC-CM in Malaysia)
Madhuparna Pandit, Ph.D. (Post-doc during 7/5/2023-12/14/2023, Yao Lab; work on translational control of alternatively spliced mRNA isoforms in ISO-stimulated mouse hearts and eIF5A function and mechanism in regulating translation in cardiac myocytes and fibroblasts)
Debojyoti Das, Ph.D. (Post-doc since 8/17/2023, Yao Lab; currently working on eIF4G2-mediated regulation of translation initiation in cardiac fibrosis and PRRC2B function in cardiovascular development; Deb received Research Excellence of Poster Presentation Award and was selected as lighting talk in 2024 New York RNA Symposium in the Finger Lakes and University of Rochester 2024 Postdoc Association Career Enhancement Award; Deb was selected to give a talk in CSHL Translational Control meeting 2024; Deb received AHA postdoctoral fellowship from 1/1/2025-12/31/2026)
Uday Bagali, Ph.D. (Post-doc since 4/15/2024, Yao Lab; currently working on FAM210A-mediated regulation of mitochondrial translation in cardiomyocytes and Gata4 knock-in mouse models)
Liuqing Yang, Ph.D. (Post-doc since 1/10/2025, Yao Lab; currently working on RBPs during cardiomyocyte proliferation and heart regeneration, and posttranslational modification of RBPs in cardiac fibrosis and heart failure)
Aleksandr Ivanov, Ph.D. (Post-doc since 2/1/2025, Yao Lab; currently working on eIF5A function and mechanism in cardiac disease and RBPs involved in heart failure)
Fellowship, Career Development Grant, and other awards awarded to trainees
During 1/1/2019 – 12/31/2020, Dr. Jiangbin Wu was awarded AHA postdoctoral fellowship (Grant number: 19POST34400013; Priority score: 1.65; Percentile rank: 29.97%; Pay line percentile rank: 38.55%) to support his research in the EPRS project.
During 7/1/2021 – 6/30/2024, Dr. Jiangbin Wu was awarded the AHA Career Development Award (Grant number: 848985; Percentile rank: 4.4%) to support his research in the FAM210A-related project.
Dr. Jiangbin Wu was selected as the BCVS2021 Outstanding Early Career Investigator Award finalist and gave a talk on 8/24/2021.
During 7/1/2019 – 6/30/2020, Omar Hedaya was awarded an NIH T32 predoctoral fellowship (T32 GM068411 PI: Lynne Maquat and Jeffery Hayes) to support his research in the 5' uORF project.
Dr. Jiangbin Wu joined the Cardiovascular Disease Research Institute of Soochow University as a professor in June 2023 to establish his independent lab.
During 7/1/2024 – 6/30/2025, Lindsey Wainwright was awarded an NIH T32 predoctoral fellowship (T32 GM068411 PI: Lynne Maquat and Jeffery Hayes) to support her research in the RNA aptamer project.
During 1/1/2025 – 12/31/2026, Dr. Debojyoti Das was awarded AHA postdoctoral fellowship (percentile: 23.57%) based on his research project on eIF4G2 function and mechanism in cardiac fibrosis.
In 10/2024, Dr. Debojyoti Das received the 2024 Postdoc Association Career Enhancement Award.
On 10/15/2024, Dr. Debojyoti Das received the Research Excellence of Poster Presentation Award and gave his lightning talk at the 2024 New York RNA Symposium in the Finger Lakes.
Teaching Activities for Graduate and/or Undergraduate Students
10/22, 24-25/2024 Lecturer (two lectures and one workshop) (8-10 hours per year)
Heart
PTH509 (Pathology) “Cell Biology of Disease” course
9/30, 10/2, 10/16, 12/9/2024 Co-director (with Dr. Douglas Anderson) and lecturer (8-10 hours per year)
CVS401 (Cardiovascular Biology and Disease) course
02/23, 02/26/2024 Lecturer (two lectures and one workshop) (8-10 hours per year)
Translational Control Mechanisms in Heart Health and Disease
BCH412 (Biochemistry) “Advanced Biochemistry of Macromolecules” course and lead a student workshop separately.
10/24, 26-27/2023 Lecturer (two lectures and one workshop) (8-10 hours per year)
Heart
PTH509 (Pathology) “Cell Biology of Disease” course
10/2, 10/18, 12/11, 12/13/2023 Co-director (with Dr. Douglas Anderson) and lecturer (8-10 hours per year)
CVS401 (Cardiovascular Biology and Disease) course
04/04/2023 Lecturer
Translational Control of Heart Health and Disease
Tribeta Sprining 2023 seminar series in Daemen University
02/17, 02/20/2023 Lecturer (two lectures and one workshop) (8-10 hours per year)
Translational Control Mechanisms in Heart Health and Disease
BCH412 (Biochemistry) “Advanced Biochemistry of Macromolecules” course and lead a student workshop separately.
10/31/2022 Lecturer (one lecture) (4-5 hours per year)
Heart
IND484 (Bioinformatics) “Current Topics in Bioinformatics”
11/9, 11-12/2022 Lecturer (two lectures and one workshop) (8-10 hours per year)
Heart
PTH509 (Pathology) “Cell Biology of Disease” course
10/31/2022 Lecturer (one research lecture) (5-6 hours per year)
Heart
PTH509 (Pathology) “Cell Biology of Disease” course
10/3, 10/19, 11/9, 12/14/2022 Co-director (with Dr. Douglas Anderson) and lecturer (8-10 hours per year)
CVS401 (Cardiovascular Biology and Disease) course
9/27, 10/6, 11/1, 12/8/2021 Co-director (with Dr. Douglas Anderson) and lecturer (8-10 hours per year)
CVS401 (Cardiovascular Biology and Disease) course
11/9, 11-12/2021 Lecturer (two lectures and one workshop) (8-10 hours per year)
Heart
PTH509 (Pathology) “Cell Biology of Disease” course
02/19, 02/22/2021 Lecturer
Translational Control Mechanisms in Heart Health and Disease
BCH412 (Biochemistry) “Advanced Biochemistry of Macromolecules” course and lead a student workshop separately.
11/10, 12-13/2020 Lecturer (two lectures and one workshop) (8-10 hours per year)
Heart
PTH509 (Pathology) “Cell Biology of Disease” course
9/28, 10/7, 12/9/2020 Co-director (with Dr. Douglas Anderson) and lecturer (8-10 hours per year)
CVS401 (Cardiovascular Biology and Disease) course
2/26, 3/24, 3/31/2020 Co-director (with Mitchell O’Connell) (6-8 hours per year)
Lead four BCH517 (Biochemistry) “Cellular & Molecular Sciences” journal clubs
3/16/2020 Lecturer (6-8 hours per year)
Translational Control Mechanisms in Heart Health and Disease
BCH412 (Biochemistry) “Advanced Biochemistry of Macromolecules” course and lead a student workshop separately (scheduled but canceled due to COVID-19)
11/22/2019 Lecturer (2 hours per year)
BCH515 (Biochemistry) “Critical Thinking” course
11/12, 14-15/2019 Lecturer (two lectures and one workshop) (8-10 hours per year)
Heart
PTH509/510 (Pathology) “Cell Biology of Disease” course
9/25, 10/9, 12/9, 12/11/2019 (8-10 hours per year)
Co-director (with Dr. Douglas Anderson) and lecturer
CVS401 (Cardiovascular Biology and Disease) course
9/10, 9/24, 10/29, 11/19/2019
Co-director (with Mitchell O’Connell) (6-8 hours per year)
Lead four BCH517 (Biochemistry) “Cellular & Molecular Sciences” journal clubs
3/18/2019 Lecturer (6-8 hours per year)
Cracking Translational Control Mechanisms in Heart Health and Disease
BCH412 (Biochemistry) “Advanced Biochemistry of Macromolecules” course and lead a student workshop separately.
11/27, 29-30/2018 Lecturer (two lectures and one workshop) (6-8 hours per year)
Heart
PTH509/510 (Pathology) “Cell Biology of Disease” course
3/9/2018 Lecturer (6-8 hours per year)
Cracking Translational Control Mechanisms in the Powerhouse of Life
BCH412 (Biochemistry) “Advanced Biochemistry of Macromolecules” course
10/25/2017 Lecturer (6-8 hours per year)
Translational Control Mechanisms in the Powerhouse of Life
MBI588 (Microbiology & Immunology) “Virology Seminar Series” course
10/10/2017 Lecturer (6-8 hours per year)
Translational Control in Development and Disease
GEN508 (Genetics) “Genomics and Systems Biology” course
4/28/2017 Lecturer (6-8 hours per year)
Stress responsive RNA switch in mammalian system
BCH412 (Biochemistry) “Advanced Biochemistry of Macromolecules” course
12/2014 – 8/2016 Lecturer (8-10 hours per year)
Amino Acid and Nucleotide Metabolism
MMED412: “Metabolism and Pharmacology” Course
Molecular Medicine Ph.D. Program, LRI, Cleveland Clinic
COMMUNITY ACTIVITIES
Local community engagement or service
03/2019 – Present Co-Chair (with Dr. Dmitri Ermolenko), the Translation Club (Cluster)
3/1/2018 – 12/2022 Member, Institutional Biosafety Committee (IBC)
10/23/2024 Host, the CVRI seminar for Dr. Clara L. Kielkopf (Professor of Dept. of B&B in URMC)
6/26/2024 Host, the CVRI seminar for Dr. Lei Yang (Professor, Dept. of Pediatrics Indiana University School of Medicine)
6/5/2024 Host, the CVRI seminar for Dr. Jay (Jianyi) Zhang (Chair, Dept. of Biomedical Engineering at the University of Alabama at Birmingham)
4/10/2024 Host, the CVRI seminar for Dr. George Porter (Professor of Dept. of Pediatrics, Cardiology in URMC)
3/13/2024 Host, the CVRI seminar for Dr. Yan Sun (Assistant Professor of Dept. of M&I in URMC)
3/6/2024 Host, the CVRI seminar for Dr. Patrick Murphy (Associate Professor of Dept. of BG in URMC)
1/17/2024 Host, the CVRI seminar for Dr. Marlies Rossmann (Assistant Professor of Dept. of BG in URMC)
12/20/2023 Host, the CVRI seminar for Dr. Paul Brookes (Professor of Dept. of P&P in URMC)
3/12/2023 Host, the CVRI seminar for Dr. Yongho Bae (Assistant Professor of Dept. of Pathology and Anatomical Sciences at SUNY Buffalo)
2/8/2023 Host, the CVRI seminar for Dr. Ju Chen (Director of Basic Cardiac Research and Co-Director of Molecular Cardiology Program in UCSD; Professor of the Department of Med., and American Heart Association Endowed Chair for Cardiovascular Research)
10/5/2022 Host, the CVRI seminar for Dr. Dmitri Ermolenko (Associate Professor of Dept. of B&B in URMC)
9/28/2022 Host, the Dept. of B&B seminar for Dr. Thomas Cooper (R. Clarence and Irene H. Fulbright Chair in Pathology and S. Donald Greenberg Chair in Pathology; Professor, Depts. of Molecular and Cellular Biology, Pathology & Immunology, and Molecular Physiology and Biophysics, Baylor College of Medicine)
3/9/2022 Host, the Dept. of B&B seminar for Dr. Eckhard Jankowsky (Director, Center for RNA Science and Therapeutics; Professor, Dept. of Biochemistry, Case Western Reserve University)
3/2/2022 Host, the CVRI seminar for Dr. Yiping Zhu (Dept. of M&I, URMC)
12/15/2021 Host, the CVRI seminar for Dr. Patrick Murphy (Dept. of BG, URMC)
12/8/2021 Host, the CVRI seminar for Dr. Rong Tian (Dept. of Anesthesiology & Pain Medicine, and Bioengineering, University of Washington)
9/15/2021 Host, the CVRI seminar for Dr. Eric Wagner (Dept. of B&B, URMC)
7/7/2021 Host, the ACRE-CAAC Joint Seminar Series for Dr. Zhong Wang (Associate Professor, Department of Cardiac Surgery, Cardiovascular Research Center, University of Michigan)
5/12/2021 Host, the CVRI seminar for Dr. Juilee Thacker (Dept. of M&I, URMC)
5/5/2021 Host, the CVRI seminar for Dr. Lilei Zhang (Dept. of MHG in Baylor College of Medicine)
11/11/2020 Host, the CVRI seminar for Dr. John Lueck (Dept. of P&P, URMC)
9/18/2019 Host, the CVRI seminar for Dr. Li Qian (Associate Director, Associate Professor, Dept. of Pathology and Laboratory Medicine, McAllister Heart Institute, University of North Carolina, Chapel Hill)
4/4/2019 Host, the Dept. of B&B seminar for Dr. Xiangdong Fu (Distinguished Professor, Dept. of Cellular & Molecular Medicine, UCSD School of Medicine)
12/5/2018 Host and organizer, the CVRI seminar for invited speaker Dr. Maria Kontaridis and her 2-day visit (Chair of Masonic Medical Research Institute)
10/24/2018 Host, the Dept. of B&B seminar for Dr. Nicholas Conrad (Dept. of Microbiology, UT Southwestern Medical Center, Dallas, TX)
6/6/2018 Host, the CVRI seminar for Dr. Lynne Maquat (Chair of RNA Center, Dept. of B&B, URMC)
1/24/2018 Host, the CVRI seminar for Dr. Xin Li (Dept. of B&B, URMC)
10/3/2017 Host and organizer, the CVRI seminar for invited speaker Dr. William Pu and his 2-day visit (Director, Basic and Translational Cardiovascular Research, Harvard Medical School)
2013 – 2016 Member, CMM Visiting Professorship Committee, Department of CMM, LRI, Cleveland Clinic. I hosted the 2-day visit for Dr. Ira Tabas (Columbia University) in 07/2015, and organized the 2-day visit for Dr. Cathryn J. Moore (NYU School of Medicine) in 2014.
EQUITY, DIVERSITY & INCLUSION ACTIVITIES
Efforts related to equity, diversity, or inclusion:
I am hiring an African American lab research assistant or technician, Matthew Auguste, who has worked in my lab for three years, from 2021 to 2024. I have recruited Japanese lab technician Yui Kawakami (female); Chinese American lab tech Virginia Aswad (female), American white lab technician Jared Hollinger (male), and Chinese research specialist Jiali He (female); Chinese graduate student Feng Jiang (male); Egyptian American graduate student Omar Hedaya (male); American White graduate students Lindsey Wainwright (female; BMB Program Ph.D. student), Jack Schwartz (male; BMB Program Ph.D. student), and Kevin Lei Pan (Chinese male; Biology Program Ph.D. student); Chinese postdoctoral fellow Jiangbin Wu (male) and Liuqing Yang (female), Indian American postdoctoral fellow Dr. Uday Bagali (from UR Pathology Ph.D. Program); India postdoctoral fellow Drs. Venkata Kadiam (male), Madhuparna Pandit (female), Debojyoti Das (male); Malaysia postdoctoral fellow EngSoon Khor (male); Russian postdoctoral fellow Dr. Aleksandr Ivanov. I also recruited multiple undergraduate students as intern research assistants in the lab, including African American lab research assistant Matthew Auguste, American undergraduate students Emily Bonanno (female) and Joseph DeTraglia (male), and Taiwanese undergraduate student Alexander Chen (male). We have a great diversity of different races and genders in my lab. I will continue hiring more lab persons from various races and countries in the future to maintain and enhance the diversity in our laboratory.
INTERNAL FELLOWSHIP REVIEW PANELS
2021 University Research Award Review Panel, University of Rochester
2022 Rubens Discovery Award Review Panel, Aab Cardiovascular Research Institute, University of Rochester Medical Center
2024 2024 Provost’s Fellowships Faculty Review Panel, University Fellowships Faculty Review Panel, University of Rochester Medical Center
2024 2024 Robert L. and Mary L. Sproull University Fellowships, Faculty Review Panel, University of Rochester Medical Center
EXTERNAL ADVISORY / HEALTH COUNCILS & RESEARCH REVIEW COMMITTEES
2018 – 2024 Grant reviewer for AHA Innovative Project Award
2020 Ad hoc reviewer, Cardiac Contractility, Hypertrophy, and Failure Study Section, NIH
2021 Ad hoc reviewer (invited), British Heart Foundation, UK
2021 – 2024 Ad hoc reviewer, Integrative Myocardial Physiology/Pathophysiology A Study Section, NIH
2024 – 2028 Standing Member, Integrative Myocardial Physiology/Pathophysiology A Study Section, NIH
(recommended by the Program Officer Dr. Abdelouahab Aitouche and approved by NIH to serve as a Standing Member of the MPPA study section for the next 4 years)
EDITORIAL ASSIGNMENTS IN PROFESSIONAL JOURNALS Ad hoc reviews for:
Science Advances, Nature Communications, European Heart Journal, Signal Transduction and Targeted Therapy, Circulation, Circulation Research, Nucleic Acids Research, Advanced Science, Theranostics, RNA, Vascular Pharmacology, Oncotarget, PLOS One, Molecular and Cellular Biochemistry, Cellular Signaling, Frontiers in Neuroscience, and International Journal of Molecular Sciences
2018 Guest Editor board member, Journal of Cardiology Research and Practice
Title: Posttranscriptional regulation in cardiomyopathies
2022 – Present Review Editor, member of the Editorial Board of RNP, Frontiers in RNA Research
2024 – Present Lead Guest Editor (co-Guest Editor: Dr. Wei Guo), Biomolecules
Title: Recent advances in the role of translation machinery and translational control in the cardiovascular system
PATENTS & INVENTIONS
Peng Yao; Omar Hedaya. GATA4-targeted therapeutics for treatment of cardiac hypertrophy. The provisional application (Serial No. 63/263,852) was filed on 11/10/2021 (U.S. Patent and Trademark Office).
Peng Yao; Omar Hedaya. Antisense oligonucleotides for modifying protein expression. The provisional application (Serial No. 63/263,853) was filed on 11/10/2021 (U.S. Patent and Trademark Office).
Peng Yao; Omar Hedaya. Antisense oligonucleotide-based anti-fibrotic therapeutics. The provisional application was filed in 9/2022 (U.S. Patent and Trademark Office).
Wei Guo; Yanghai Zhang; Peng Yao; Feng Jiang. Gene therapy for diastolic dysfunction using ASOs. The provisional application was filed in 9/2023 (U.S. Patent and Trademark Office).
Peng Yao; Omar Hedaya; Lindsey Wainwright. Method and compositions for aptamer mediated delivery of therapeutics. The provisional application (DOCKET NO: 1134-194 PROV) was filed on 5/30/2024 (U.S. Patent and Trademark Office).
Contributed Rodent Lines
1. microRNA-574 global knockout mice at JAX Laboratory (B6J.B6N-Mir574tm1.1Wtsi/PyaoMmjax)
2. Eprs global knockout mice at JAX Laboratory (C57BL/6-Eprs1em1Pyao/Mmjax)
3. Several mouse strains, including Eprs-PostnMCM, Eprs-Myh6MCM, Eif4g2-PostnMCM, Eif4g2-Myh6MCM, Fam210a-Myh6MCM, Fam210a-Itga8-CreERT2, Gata4 uORF-inactivating knock-in, Prrc2b tm1b global knockout, and Prrc2b global knock-in.
GRANTS & CONTRACTS
As Principal Investigator / Co-Principal Investigator
National Institute of Health R01HL164584 PI: Peng Yao 4-year
Score: 35 Percentile: 14% Funding period: 04/01/2023-03/31/2027
Role: Principal Investigator (20% effort)
Project Title: uORF-mediated Translational Control of Cardiac Transcription Factor Expression
This study aims to determine the function and mechanism of cardiac transcription factor uORF in non-ischemic hypertensive cardiomyopathy.
Direct costs: $329,637 Total amount of award: $507,641
National Institute of Health R01HL169432 PI: Peng Yao 4-year
Score: 25 Percentile: 5% Funding period: 08/01/2023-07/31/2027
Role: Principal Investigator (20% effort)
Project Title: Deciphering the role of FAM210A in cardiac physiopathology
This study aims to decipher the role and mechanism of the mitochondrial protein FAM210A in cardiac physiology and heart disease via regulating mitochondrial Ca2+ transportation and mitochondrial translation.
Direct costs: $315,372 Total amount of award: $485,673
AHA Established Investigator Award 24EIA1255341 PI: Peng Yao 5-year
Score: 1.05 Percentile: 2.56% Funding period: 04/01/2024-03/31/2029
Role: Principal Investigator (10% effort)
Project Title: Interplay between translational control and alternative splicing of mRNAs in cardiac pathological remodeling
Direct costs: $72,000 Total amount of award: $80,000
Harold S. Geneen Charitable Trust Award Peng Yao 2-year
Funding period: 01/01/23 – 12/31/24
Role: Principal Investigator (10% effort)
Project Title: Deciphering function of GATA4 uORF in myocardial infarction
This study aims to develop GATA4-ASO-based therapeutics to treat myocardial infarction.
Total amount of award: $250,000 / 2 year
LeapRx Program Award Peng Yao 1-year
Funding period: 12/01/22 – 3/31/24
Role: Principal Investigator (10% effort)
Project Title: Development of a novel RNA therapeutic platform for increasing expression of beneficial intracellular proteins
This study aims to apply a novel mRNA translation-activating technology to develop RNA-based therapeutics and treat organ fibrosis.
Total amount of award: $138,051 / 1 year
National Institute of Health R01HL147954 PI: Peng Yao 5-year (NCE)
Score: 33 Percentile: 14% Funding period: 08/1/2019-07/31/2024
Role: Principal Investigator (25% effort)
Project Title: Translational control of cardiac fibrosis
This study aims to determine the pathophysiological function and molecular mechanism of EPRS and eIF5A and their upstream activators and downstream mRNA targets in cardiac fibrosis and heart failure.
Direct costs: $250,000 Total amount of award: $383,849
National Institute of Health R01HL132899 PI: Peng Yao 5-year (NCE)
Score: 20 Percentile: 3% Funding period: 09/01/2018-08/31/2023
Role: Principal Investigator (25% effort)
Project Title: Role of miR-574-Fam210a axis in cardiac hypertrophy and remodeling
This study aims to determine the pathophysiological function and molecular mechanism of the guide and passenger strands of miR-574 and their common target gene, Fam210a, in cardiac hypertrophy and heart failure.
Direct costs: $250,000 Total amount of award: $383,849
Rubens Discovery Award PI: Peng Yao 1-year
Funding period: 09/01/21 – 08/31/22
Award Description: The Helen and Jack Rubens family kindly donated to accelerate discovery-based research in the CVRI and push our research in new, groundbreaking directions.
Role: Principal Investigator
Project Title: Development of novel RNA-based therapeutics for heart disease
This pilot study aims to prepare preliminary data for applying for an NIH R01 grant to support a research program for developing translation-manipulating antisense oligonucleotides as novel RNA-based therapeutics for the treatment of pathological cardiac hypertrophy.
Direct costs: $15,000
University Research Award Peng Yao 1-year
Funding period: 07/01/22 – 06/30/23
Role: Principal Investigator
Project Title: Development of Novel RNA-based Therapeutics for Heart Disease
This study aims to apply a novel mRNA translation-silencing technology to develop RNA-based therapeutics and treat heart disease.
Total amount of award: $75,000 / 1 year
URMC Interim Fund Peng Yao 1-year
Funding period: 11/01/2022-10/30/2023
Role: Principal Investigator
This study aims to support our research program on both FAM210A and uORF to obtain extramural NIH funding.
Total amount of award: $75,000 / 1 year
University of Rochester CTSI Incubator Program Peng Yao 2-year
(CTSI: Clinical & Translational Science Institute)
Submitted to CTSI by Drs. Chen Yan and Eric Small (Co-PIs) on 12/4/2017. Funding period: 06/01/18 – 05/31/20
Role: Co-Investigator (Co-I with Dr. Chen Yan, and together with other Co-PIs: Drs. Craig Morrell, Eric Small and Charles Lowenstein)
Project Title: Mechanisms of intercellular signaling in cardiac fibrosis (sub-aim: Novel mechanism for cardiac myocyte to regulate cardiac fibroblast function)
The goal of this study is to identify and characterize cardiomyocyte-derived positive and negative regulators that modulate cardiac fibroblast function and fibrosis and prepare for submission of a PPG application in the future.
Total amount of award: $50,000 / 2 years
National Institute of Health R56 1R56HL132899 Peng Yao 09/19/16 – 08/31/18
Role: Principal Investigator (35% effort)
Project Title: Role of miR-574 driver and passenger strands in cardiac hypertrophy
The goal of this study is to determine the pathophysiological function and molecular mechanism of guide and passenger strands of miR-574 for cardiac protection in cardiac hypertrophy and heart failure.
Direct costs: $250,000 Total amount of award: $383,849
University of Rochester-University Research Award Peng Yao 06/01/17 – 12/31/18
Role: Co-Investigator (collaborate with Dr. Craig Morrell)
Project Title: Inflammatory protein translation in anucleate platelets
Total amount of award: $50,000/1 year
Scientist Development Grant 13SDG15970006 (American Heart Association, National Affiliate)
Peng Yao 07/01/13 – 06/30/17
Role: Principal Investigator (60% effort)
Project Title: Stress responsive VEGF-A RNA switch
Direct costs: $280,000
Total amount of award: $308,000
Clinical and Translational Science Collaborative (CTSC) Core Utilization Pilot Grant (from Case Western Reserve University Core Utilization pilot program) Peng Yao 09/01/16 – 03/01/17
Role: Principal Investigator
Project Title: Generation of miR-574 transgenic mice to study cardiac protective function
Total amount of award: $9,700 (Grant was declined due to inability of institutional transfer)
Postdoctoral Fellowship 10POST3770012 (American Heart Association)
Peng Yao 07/01/10 – 06/30/12
Role: Principal Investigator (100% effort)
Project Title: “Translational trickle” mechanism prevents total inhibition of inflammatory gene expression
Total amount of award: $88,000
UNFUNDED / OTHER RESEARCH PROJECTS
National Institute of Health PI: Craig Morrell 4-year
Role: Co-Investigator (5% effort) Under preparation and plan to be submitted by 2/19/2025
Project Title: Platelet Regulation of Monocyte Responses in Vascular Inflammation
Direct costs: $250,000 Total amount of award: $383,849
National Institute of Health R01 (reviewed & resubmitted) PI: Bradford Berk Co-I: Peng Yao 4-year
Submitted in 10/2020, 6/2022, 2/2023, and resubmitted in 2/2024
Role: Co-Investigator (5% effort)
Project Title: RpL17 is a stress-responsive ribosomal protein that regulates endothelial cell function and vascular remodeling
National Institute of Health P01HL147822 (Reviewed twice) Co-PI: Peng Yao 5-year
Submitted to NHLBI Program Project Grant special panel on 1/25/2019 and reviewed on 4/26/2019, and resubmitted on 1/25/2020 and reviewed on 5/11/2020 (percentile: 10-20%)
Role: Principal Investigator (20% effort)
Project Title: Translational control of cardiac fibrosis
The goal of this study is to determine the pathophysiological function and molecular mechanism of EPRS and eIF5A and their preferential mRNA targets in cardiac fibrosis and heart failure.
Direct costs: $240,000 Total amount of award: $360,000
PRESENTATIONS
Local, Regional, & State Conferences
10/14-15/2024 Peng Yao. Translational control of cardiomyocyte hypertrophy in heart disease and its therapeutic targeting. Poster presentation. 2024 New York RNA Symposium in the Finger Lakes. Canandaigua, NY
10/7-8/2024 Peng Yao. Fam210a regulates mitochondrial translation and maintains cardiac mitochondrial homeostasis. Poster presentation. 11th Annual Conference on Translational Research in Mitochondria, Aging & Disease (TriMAD 2024), University of Rochester, Rochester, NY
3/21/2024 Peng Yao. Development of novel RNA-based therapeutics for heart disease. Scientific presentation for LeapRx program. Invited talk by the Empire Discovery Institute and Novo Nordisk for the joint steering committee meeting (invited by Dr. Martin Graham, CEO of EDI, and Sebastian Beck Jorgensen, Novo Nordisk), Rochester, NY
5/12/2023 Peng Yao. Development of novel RNA-based therapeutics for heart disease. Scientific presentation for LeapRx program. Invited talk by the Empire Discovery Institute (invited by Dr. Martin Graham, CEO of EDI, and Sebastian Beck Jorgensen, Novo Nordisk), Rochester, NY
12/10/2021 Peng Yao. Development of novel RNA-based therapeutics for heart disease. Scientific presentation for the Medicines Discovery Award Program (MDAP). Invited talk by the Empire Discovery Institute (invited by Dr. Martin Graham, CEO of EDI, and EDI Scientific Advisory Board), Rochester, NY
10/21/2021 Peng Yao. uORF-mediated Translational Control of Cardiac Transcription Factor Expression and Cardiomyocyte Hypertrophy. RNA Cluster Seminar Series, The Center for RNA Biology, University of Rochester, Rochester, NY
7/23/2021 Peng Yao. Development of Novel RNA-based Therapeutics for Heart Disease. RNA Group Presentations, The Center for RNA Biology, University of Rochester, Rochester, NY (Invited talk by Drs. Steven Fox & Lynne Maquat; Dr. Steven Fox, the Chairman of AKELOS company, is screening for RNA therapeutics to invest)
1/21/2021 Peng Yao. FAM210A Deficiency Activates Integrated Stress Response and Causes Heart Failure. RNA Cluster Seminar Series, The Center for RNA Biology, University of Rochester, Rochester, NY
4/25/2019 Peng Yao. Translational control of cardiac fibrosis. Conference talk. Genetics Day 2019, University of Rochester, Rochester, NY (Invited talk by Drs. Dirk Bohmann & Xin Li)
10/14-15/2016 Peng Yao. miR-574-5p plays a cardioprotective role in heart failure. Conference talk. The 18th Annual Rustbelt RNA Meeting, Cleveland, OH
9/12/2016 Peng Yao. Translational Control Mechanisms of VEGFA. Conference talk. Scientific Advisory Board (SAB) Meeting for Aab CVRI in URMC, Rochester, NY
5/18-20/2015 Qiuqing Wang*, Peng Yao. Synergistic regulatory function of driver and passenger strands in microRNA-574. Poster presentation. Great Lakes Bioinformatics Conference 2015, Purdue University, West Lafayette, IN
5/16-18/2014 Qiuqing Wang*, Peng Yao. Transcriptome-wide bioinformatics analysis reveals human oncogenic RNA switches. Poster presentation. Great Lakes Bioinformatics Conference 2014, Cincinnati Children’s Hospital, University of Cincinnati, Cincinnati, OH
10/18-19/2013 Peng Yao, Paul L. Fox. Mechanism and function of a 3-element mRNA switch in the VEGFA 3´UTR. Poster presentation. Rustbelt RNA Meeting, Cleveland, OH
10/22-23/2010 Peng Yao, Paul L. Fox. Alternative polyadenylation generates a truncated EPRS protein that maintains a “translational trickle” of expression from GAIT target mRNAs. Poster presentation. Rustbelt RNA Meeting, Cleveland, OH
National & International Conferences
10/17-20/2024 Peng Yao. Targeting mRNA translation for developing novel heart disease therapeutic strategies. Invited talk. CSC-AHA Joint Session, the 26th Scientific Sessions of the Chinese Society of Cardiology (CSC 2024), Changsha, China. (Invited by the AHA president, Dr. Joseph Wu from Stanford University and the CSC)
9/3-7/2024 Peng Yao. Loss-of-function of RNA-binding protein PRRC2B causes translational defects and congenital malformations in hearts. Poster presentation. eIF4G2-dependent translation of pro-fibrotic mRNAs is essential for cardiac fibroblast activation. Conference talk. Cold Spring Harbor Translational Control meeting 2024, New York, NY
8/19-23/2024 Peng Yao. Loss-of-function of RNA-binding protein PRRC2B causes translational defects and congenital malformations in hearts. Invited conference talk. The 43rd North American Society Annual Meeting of the IHSR, ACRE-SAHR @ ISHR-NAS Pre-Conference Symposium, Long Beach, LA
6/11-14/2024 Peng Yao. Secondary structures regulate uORF-mORF translation balance and provide targets for ASO-mediated modulation of cardiac hypertrophy. Poster presentation. 38th Meeting of the European Section of the ISHR, Toulouse, France
5/28-6/1/2024 Peng Yao. Secondary structures regulate uORF-mORF translation balance and provide targets for ASO-mediated modulation of cardiac hypertrophy. Poster presentation. The 29th Annual Meeting of the RNA Society, Edinburgh, United Kingdom
11/12/2023 Peng Yao. FAM210A regulates mitochondrial translation and maintains cardiac mitochondrial homeostasis. Conference talk. AHA Scientific Session 2023, Philadelphia, PA
6/28/2023 Peng Yao. Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophy. Conference talk. The 42nd International Society for Heart Research-North American (ISHR-NAS) Section, Madison, WI
6/26/2023 Peng Yao. Translational control of cardiac pathophysiology: when mRNA meets the heart. Invited featured lecture. ACRE@ ISHR-NAS Pre-Conference Symposium, University of Wisconsin, Madison, WI
9/9/2022 Peng Yao. Translational control of cardiomyocyte hypertrophy in heart disease and its therapeutic targeting. Poster presentation. The 2022 Cold Spring Harbor Translational Control Meeting, New York, NY
7/26/2022 Peng Yao. Secondary structure and antisense oligonucleotides regulate cardiac messenger RNA translation and modulates cardiomyocyte hypertrophy. Poster presentation (ranked among top 10% of all the abstracts). Basic Cardiovascular Sciences (BCVS) Scientific Sessions and associated 4th ACRE-APS Symposium 2022, Chicago, IL
2/23/2022 Peng Yao. Hyperactive translation programs during cardiac remodeling. RNA Collaborative Seminar Series, (25 attending institutions across multiple countries including US, Canada, UK, Germany, France, Italy, China, Singapore, etc.; Invited talk via Zoom meeting by Dr. Lynne Maquat, J. Lowell Orbison Endowed Chair and Professor, Department of Biochemistry & Biophysics, Director of the Center for RNA Biology, URMC)
11/14/2021 Peng Yao. FAM210A maintains cardiac mitochondrial homeostasis by promoting Ca2+ efflux. Poster presentation. AHA Scientific Sessions 2019, virtual meeting.
5/31/2021 Peng Yao. uORF control of cardiac transcription factor expression and heart pathophysiology. Poster presentation. The 26th Annual Meeting of the RNA Society, virtual meeting.
11/16-18/2019 Peng Yao. EPRS promotes cardiac fibrosis by regulating proline-rich pro-fibrotic protein synthesis. Conference talk. AHA Scientific Sessions 2019, Philadelphia, PA
9/4-7/2019 Peng Yao. MicroRNA-574-FAM210A axis maintains mitochondrial translational homeostasis and antagonizes pathological cardiac remodeling. Conference talk. Protein Synthesis and Translational Control–EMBO Workshop 2019, EMBL Heidelberg, Germany
7/28-8/1/2019 Peng Yao. MicroRNA-574-FAM210A axis maintains mitochondrial translational homeostasis and influences pathological cardiac remodeling. Invited talk for receiving the ACRE-APS Junior Faculty Award, 1st place. Basic Cardiovascular Sciences (BCVS) Scientific Sessions 2019 and associated Asian Cardiovascular Symposium, Boston, MA
5/29-6/3/2018 Peng Yao. Cardioprotective microRNA-574-Fam210a axis maintains mitochondrial translational homeostasis. Conference talk. The 23rd Annual Meeting of the RNA Society, UC Berkeley, San Francisco, CA
6/28-7/2/2016 Peng Yao, Paul Fox. Mechanism, function and regulation of human HILDA-directed RNA switches. Poster presentation. The RNA Society of Japan 18th Annual Meeting and the 21st Annual Meeting of the RNA Society, Kyoto, Japan
2/22-27/2015 Peng Yao, Daniel Lindner, Paul L. Fox. Interplay between miR-574-3p and hnRNP L regulates VEGFA mRNA translation and tumorigenesis. Poster presentation. The 1st Gordon Research Conference of Translation Machinery in Health & Disease, Ventura, CA
6/3-8/2014 Peng Yao, Alka A. Potdar, Paul L. Fox. Hypoxia-induced polysome dissociation of miR-574-3p promotes oncogenesis. Poster presentation. The 19th Annual Meeting of the RNA Society, Quebec, Canada
9/4-8/2012 Peng Yao, Paul L. Fox. Hypoxia-induced HILDA complex directs human stress-responsive RNA switch. Conference talk. The 2012 Cold Spring Harbor Translational Control Meeting, New York, NY
9/25-30/2011 Peng Yao, Paul L. Fox. Alternative polyadenylation generates a truncated EPRS protein that maintains a “translational trickle” of expression from GAIT target mRNAs. Conference talk. The 2011 International Symposium on Aminoacyl-tRNA Synthetases, Salt Lake City, UT
9/13-17/2010 Peng Yao, Paul L. Fox. Alternative polyadenylation in the EPRS coding region generates a truncated, RNA-binding competitor that maintains a “translational trickle” from GAIT target mRNAs. Conference talk. The 2010 Cold Spring Harbor Translational Control Meeting, New York, NY
11/15-17/2007 Peng Yao, En-Duo Wang. Recognition of tRNALeu by Aquifex aeolicus leucyl-tRNA synthetase. Conference talk. The 5th National Nucleic Acids Workshop, Shanghai, China
11/1-6/2007 Peng Yao, Xiao-Long Zhou, Ran He, Mo-Fang Liu, En-Duo Wang. Declined cell viability led by genetic code ambiguity due to editing-defective eukaryotic leucyl-tRNA synthetase. Poster presentation. Sweden 22nd tRNA Workshop, Uppsala University, Sweden
Invited Presentations: Local, Regional, & State
10/25/2023 Peng Yao. Translational control of cardiac pathophysiology: when mRNA meets the heart. Invited talk for Aab Cardiovascular Research Institute seminar series at the University of Rochester Medical Center (invited by Dr. Zhenggen Jin, Professor of Aab CVRI), Rochester, NY
10/25/2023 Peng Yao. Development of novel RNA-based therapeutics for heart disease. Invited talk for Cardiology Grand Rounds seminar series at University of Rochester Medical Center (invited by Dr. Craig Morrell, Chair of Aab CVRI), Rochester, NY
9/30/2021 Peng Yao. Development of Novel RNA-based Therapeutics to Treat Heart Disease. CCRC (Clinical Cardiovascular Research Center)/CVRI (Cardiovascular Research Institute) collaboration seminar series, University of Rochester, Rochester, NY (Invited talk by Drs. Craig Morrell (Chair of Aab CVRI) and Valentina Kutyifa [Director of Clinical Trials])
8/4/2020 Peng Yao. Translational control of cardiac disease. Department of Medicine, University of Rochester, Rochester, NY (Invited talk by Dr. Stephen R Hammes, Chief of Division of Endocrinology and Metabolism and Vice Chair for Research and Academic Affairs)
7/29-31/2019, 2nd Conference on Biomotors, Virus Assembly, and Nanobiotechnology Applications in 2019, Fawcett Center, Columbus, OH, (Invited talk by Drs. Mario Vieweger and Peixuan Guo, ExoNanoRNA, LLC and Ohio State University; not attending due to a time conflict)
10/18-19/2018 Peng Yao. MicroRNA-574-FAM210A axis maintains mitochondrial translational homeostasis and antagonizes pathological cardiac remodeling. Upstate New York Cardiac Electrophysiology Society 2018 Annual Meeting (held by Masonic Medical Research Institute), Utica, NY (Invited talk by Dr. Maria Kontaridis)
Invited Presentations: National & International
3/6/2025 Peng Yao. Translational control in cardiac pathophysiology and medicine: when mRNA meets the heart. Yale University School of Medicine, Section of Cardiovascular Medicine, Yale Stem Cell Center, New Haven, CT (Invited talk by Dr. Yibing Qyang, Associate Professor of Medicine (Cardiology), of Biomedical Engineering, and of Pathology, Director of Yale Stem Cell Research Forum)
1/22-24/2025 Peng Yao. Translational control in cardiac pathophysiology and medicine: when mRNA meets the heart. University of Wisconsin Madison Cardiovascular Research Center, Madison, WI, January 23, 2025 (Invited talk by Dr. Guo Wei, Assistant Professor of Meat Science & Muscle Biology)
10/17-20/2024 Peng Yao. Targeting mRNA translation for developing novel heart disease therapeutic strategies. 26th Scientific Sessions of the Chinese Society of Cardiology (CSC 2024) (Selected speaker as representative of American Heart Association by the AHA President Dr. Joseph Wu and invited talk by Chinese Society of Cardiology)
9/11/2024 Peng Yao. Translational control of cardiac pathophysiology: when mRNA meets the heart. Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH (Invited talk by Dr. Hua Lou, Associate Professor, Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University)
5/20/2024 Peng Yao. Translational control of cardiac pathophysiology: when mRNA meets the heart. Heart Institute, University of South Florida, Tampa, FL (Invited talk by Dr. Dazhi Wang, Professor & Director, Heart Institute, College of Medicine Internal Medicine)
3/25/2024 Peng Yao. Translational control of cardiac pathophysiology: when mRNA meets the heart. Department of Surgery, College of Pharmacology and Physiology, USF Health Heart Institute, University of South Florida, Tampa, FL (Invited talk by Dr. Matthias Majetschak, Professor, College of Medicine Molecular Pharmacology & Physiology and College of Medicine Surgery)
3/20/2024 Peng Yao. Translational control of cardiac pathophysiology: when mRNA meets the heart. Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA (Invited by Dr. Joseph Miano, Professor of Medicine, and Dr. Huabo Su, Professor of Medicine, Director, VBC Seminar Program)
2/8/2024 Peng Yao. Translational control of cardiac pathophysiology: when mRNA meets the heart. Department of Pathology and Anatomical Sciences, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY (Grand Rounds seminar series; Invited talk by Dr. John E. Tomaszewski, SUNY Distinguished Professor and Peter A. Nickerson, PhD Professor and Chair of Pathology and Anatomical Sciences)
1/22/2024 Peng Yao. Translational control of cardiac pathophysiology: when mRNA meets the heart. The School of Medicine and the Graduate School of Biomedical Sciences, New York Medical College School of Medicine, Valhalla, NY (Deans’ Seminar Series; Invited talk by Dr. Marcello Rota, Associate Professor of Physiology)
4/28/2023 Peng Yao. Translational control of cardiac disease and beyond. Division of Cardiovascular Medicine, Department of Medicine, UC San Diego, CA (Invited talk by Dr. Yoshitake (Yoshi) Cho and Dr. Ju Chen, Director of Basic Cardiac Research and Co-Director of Molecular Cardiology Program in UCSD; Professor of the Department of Med., and American Heart Association Endowed Chair for Cardiovascular Research)
11/5/2022 Peng Yao. Secondary structure and antisense oligonucleotides regulate cardiac messenger RNA translation and modulate cardiomyocyte hypertrophy. Invited Poster presentation (ranked among top 10% of all the abstracts). AHA Scientific Sessions 2022, Chicago, IL
9/1/2022 Peng Yao. Translational control of cardiac disease. Department of Physiology, University of Tennessee Health Science Center, Memphis, TN (Invited talk by Dr. Zhongjie Sun, Professor and Chair of Thomas A. Gerwin Chair of Excellence in Physiology; Co-Director, UT Methodist Cardiovascular Institute)
2/23/2022 Peng Yao. Hyperactive translation programs during cardiac remodeling. RNA Collaborative Seminar Series (25 attending institutions across multiple countries including US, Canada, UK, Germany, France, Italy, China, Singapore, etc.; Invited talk via Zoom meeting by Dr. Lynne Maquat, J. Lowell Orbison Endowed Chair and Professor, Department of Biochemistry & Biophysics, Director of the Center for RNA Biology, URMC)
11/19/2021 Peng Yao. Translational control of cardiac disease and beyond. Department of Biological Sciences, Mississippi State University, Mississippi State, MS (Invited talk via Zoom meeting by Dr. Bin Liu, Assistant Professor)
3/10/2021 Peng Yao. Translational control of cardiac disease. Baylor College of Medicine Cardiovascular Research Institute (CVRI), Houston, DX (Invited talk via Zoom meeting by Dr. Xander H.T. Wehrens, Director of BCM CVRI and Dr. Lilei Zhang, Chief of Cardiovascular Genetics Clinic)
4/27-28/2020 Peng Yao. Translational control of cardiac disease. Department of Physiology & Cell Biology, The Ohio State University, Columbus, OH (Invited talk by Dr. Isabelle Deschenes, Department Chair of Physiology & Cell Biology)
1/29-30/2020 Peng Yao. Translational control of cardiac disease. Department of Integrative Biology & Physiology, UCLA, CA (Invited talk by Dr. Rachelle H. Crosbie, Department Chair of Integrative Biology & Physiology)
10/14-15/2019 Peng Yao. Translational control of cardiac disease. Fralin Biomedical Research Institute, Virginia Tech, Roanoke, VA (Invited talk by Dr. Michael Friedlander, Vice President for Health Sciences & Technology)
1/2016 Peng Yao. Talk invitation received. Department of Health Sciences, Boston University, College of Health & Rehabilitation Sciences: Sargent College, Boston, MA
1/5-7/2016 Peng Yao. Translational control mechanisms of VEGFA. Department of Biochemistry, University at Buffalo, Buffalo, NY
12/2-4/2015 Peng Yao. Translational control mechanisms of VEGFA. Department of Biochemistry & Molecular Biology, Michigan Technological University, Houton, MI
11/11-13/2015 Peng Yao. Translational control mechanisms of VEGFA. Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester Medical Center, Rochester, NY
10/13-14/2015 Peng Yao. Translational control mechanisms of VEGFA. Department of Biochemistry & Molecular Biology, Wright State University, Dayton, OH
5/4-5/2015 Peng Yao. Translational control mechanisms of VEGFA. Department of Biological Sciences, Oakland University, Rochester, MI
PUBLICATIONS
Peer-Reviewed Journal Articles
Bat-Ider Tumenbayar, Vincent M. Tutino, Joseph A. Brazzo III, Peng Yao, Yongho Bae. FAK and p130Cas modulate stiffness-mediated early transcription and cellular metabolism. Online published in Cytoskeleton (https://doi.org/10.1002/cm.21971)
Jiangbin Wu, Jared Hollinger, Emily Bonanno, Feng Jiang, Peng Yao. (2024) Cardiomyocyte-specific loss of glutamyl-prolyl-tRNA synthetase leads to disturbed protein homeostasis and dilated cardiomyopathy. Cells 13:35
Omar M. Hedaya, Kadiam C Venkata Subbaiah, Feng Jiang, Li Huitong Xie, Jiangbin Wu, Eng-Soon Khor, Mingyi Zhu, David H. Mathews, Chris Proschel, Peng Yao. Secondary structures that regulate mRNA translation provide insights for ASO-mediated inhibition of cardiac hypertrophy. Nature Communications 2023 14:6166
Jared Hollinger, Jiangbin Wu, Kamel M. Awayda, Mitchell R. O’Connell, Peng Yao. Expression and purification of the mitochondrial transmembrane protein FAM210A in Escherichia coli. Protein Expression & Purification 2023 210:106322
Jiangbin Wu, Kadiam C Venkata Subbaiah, Omar Hedaya, Si Chen, Chen Yan, Peng Yao. FAM210A regulates mitochondrial translation and maintains cardiac mitochondrial homeostasis. Cardiovascular Research 2023 119: 2441-2457
Feng Jiang, Omar M. Hedaya, EngSoon Khor, Jiangbin Wu, Matthew Auguste, Peng Yao. RNA binding protein PRRC2B mediates translation of specific proteins and regulates cell cycle progression. Nucleic Acids Research 2023 51:5831-5846
Kadiam C. Venkata Subbaiah, Jiangbin Wu, Wai Hong Wilson Tang, Peng Yao. Ciclopirox inhibition of eIF5A hypusination attenuates fibroblast activation and cardiac fibrosis. Journal of Cardiovascular Development and Disease 2023 10:52
Kadiam C Venkata Subbaiah, Jiangbin Wu, Wai Hong Wilson Tang, and Peng Yao. FAM114A1 influences cardiac pathological remodeling by regulating angiotensin II signaling. JCI Insight 2022 7:e152783 (featured article)
Qing Lyu, Peng Yao, Joseph M Miano. Generating a CRISPR knock-out mouse through a strong premature termination codon: a cautionary tale. Journal of Biomedical Research 2020 35:174-178
Jiangbin Wu, Kadiam C Venkata Subbaiah, Feng Jiang, Omar Hedaya, Amy Mohan, Tingting Yang, Kevin Welle, Sina Ghaemmaghami, Wai Hong Wilson Tang, Eric Small, Chen Yan, and Peng Yao. MicroRNA-574 regulates FAM210A expression and influences pathological cardiac remodeling. EMBO Molecular Medicine 2021 13:e12710
Jiangbin Wu, Kadiam C Venkata Subbaiah, Li Huitong Xie, Feng Jiang, Eng-Soon Khor, Deanne Mickelsen, Jason R. Myers, Wai Hong Wilson Tang, and Peng Yao. Glutamyl-prolyl-tRNA synthetase regulates proline-rich pro-fibrotic protein synthesis during cardiac fibrosis. Circulation Research 2020 127:827–846
Shuai Zhao, Dina Dejanovic, Peng Yao, Shardul Bhilocha, Tammy Sadler, Anja Schirbel, Gail West, Genevieve Doyon, Rocio Lopez, Ren Mao, Satya Kurada, Guntram Grassl, Paul Fox, Michael Cruise, Daniel L. Worthley, Christine McDonald, Carol de la Motte, Eleni Stylianou, Claudio Fiocchi, and Florian Rieder. Selective deletion of MyD88 signaling in a-SMA positive cells ameliorates experimental intestinal fibrosis via post-transcriptional regulation. Mucosal Immunology 2020 13:665–678
Si Chen, Yishuai Zhang, Jiangbin Wu, Janet K. Lighthouse, Deanne M. Mickelsen, Xuan Li, Thomas Rousselle, Peng Yao, Eric M. Small, Ji Li, and Chen Yan. Role of cyclic nucleotide phosphodiesterase 10A in pathological cardiac remodeling and dysfunction. Circulation 2019 141:217–233
Changyi Ji, Yao Li, Alec Kittredge, Austin Hopiavuori, Nancy Ward, Peng Yao, Yohta Fukuda, Yu Zhang, Stephen H. Tsang, and Tingting Yang. Investigation and restoration of BEST1 activity in patient-derived RPEs with dominant mutations. Scientific Reports 2019 9: 19026
Kadiam C Venkata Subbaiah, Jiangbin Wu, Alka Potdar, and Peng Yao. HnRNP L-mediated RNA switches function as a hypoxia-induced translational regulon. Biochemical and Biophysical Research Communications 2019 516: 753-759
Dalia Halawani, Valentin Gogonea, Joseph A. DiDonato, Vitaliy Pipich, Peng Yao, Arnab China, Celalettin Topbas, Kommireddy Vasu, Abul Arif, Stanley L. Hazen, and Paul L. Fox. Structural control of caspase-generated glutamyl-tRNA synthetase by appended noncatalytic WHEP domains. Journal of Biological Chemistry 2018 293: 8843-8860
Peng Yao#, Jiangbin Wu, Daniel Lindner, and Paul L. Fox. Interplay between miR-574-3p and hnRNP L regulates VEGFA mRNA translation and tumorigenesis. Nucleic Acids Research 2017 45: 7950–7964 (#: sole corresponding author)
Patsharaporn Techasintana, Jason S. Ellis, Jacqueline Glascock, Matthew M. Gubin, Suzanne E. Ridenhour, Joseph D. Magee, Marcia L. Hart, Peng Yao, Hao Zhou, Maryln S. Whitney, Craig L. Franklin, Jennifer L. Martindale, Myriam Gorospe, Wade J. Davis, Paul L. Fox, Xiaoxia Li, and Ulus Atasoy. The RNA-binding protein HuR posttranscriptionally regulates IL-2 homeostasis and CD4+ Th2 differentiation. ImmunoHorizons 2017 1: 109-123
Qian Huang, Xiao-Long Zhou, Qing-Hua Hu, Hui-Yan Lei, Zhi-Peng Fang, Peng Yao, and En-Duo Wang. A bridge between the aminoacylation and editing domains of leucyl-tRNA synthetase is crucial for its synthetic activity. RNA 2014 20: 1440-1450
Peng Yao, Alka A. Potdar, Partho Sarothi Ray, Sandeepa M. Eswarappa, Andrew C. Flagg, Belinda Willard, and Paul L. Fox. The HILDA complex coordinates a conditional switch in the 3´-untranslated region of the VEGFA mRNA. Plos Biology 2013 11: e1001635
Hao Zhou, Minjia Yu, Koichi Fukuda, Jinteak Im, Peng Yao, Wei Cui, Katarzyna Bulek, Jarod Zepp, Youzhong Wan, Tae Whan Kim, Weiguo Yin, Victoria Ma, James Thomas, Jun Gu, Jian-an Wang, Paul E DiCorleto, Paul L Fox, Jun Qin, and Xiaoxia Li. IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine production. EMBO Journal 2013 32: 583-596
Tomasz Herjan, Peng Yao, Wen Qian, Xiao Li, Caini Liu, Katarzyna Bulek, Dongxu Sun, Wen-Pin Yang, Jun Zhu, Aiqing He, Julie A. Carman, Serpil C. Erzurum, Howard D. Lipshitz, Paul L. Fox, Thomas A. Hamilton, and Xiaoxia Li. HuR is required for IL-17-induced Act1-mediated CXCL1 and CXCL5 mRNA stabilization. Journal of Immunology 2013 191: 640-649
Peng Yao, Alka A. Potdar, Abul Arif, Partho Sarothi Ray, Rupak Mukhopadhyay, Belinda Willard, Yichi Xu, Jun Yan, Gerald M. Saidel, and Paul L. Fox. Coding region polyadenylation generates a truncated tRNA synthetase that counters translation repression. Cell 2012 149: 88-100 Previewed by Matthew Brook, Richard W.P. Smith, and Nicola K. Gray. A molecular doorstop ensures a trickle through translational repression. Cell 2012 149: 13-15 Leading Edge Preview
Qian Huang, Peng Yao, Gilbert Eriani, and En-Duo Wang. In vivo identification of essential nucleotides in tRNALeu to its functions by using a constructed yeast tRNALeu knockout strain. Nucleic Acids Research 2012 40: 10463-10477
Faegheh Jafarifar, Peng Yao, Sandeepa M Eswarappa, and Paul L Fox. Repression of VEGFA by CA-rich element-binding microRNAs is modulated by hnRNP L. EMBO Journal 2011 30: 1324-1334
Xin Chen, Jing-Jing Ma, Min Tan, Peng Yao, Qing-Hua Hu, Gilbert Eriani, and En-Duo Wang. Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase. Nucleic Acids Research 2011 39: 235-247
Weiguo Yin, Youzhong Wan, Tae Whan Kim, Peng Yao, Hui Xiao, Hao Zhou, Jianhua Xiao, Paul Fox, and Xiaoxia Li. The kinase activity of interleukin-1 receptor-associated kinase 2 is essential for lipopolysaccharide-mediated cytokine and chemokine mRNA stability and translation. J Interferon Cytokine Research 2011 31: 415-422
Bin Zhu*, Peng Yao*, Min Tan*, Gilbert Eriani, and En-Duo Wang. trNA-independent pre-transfer editing by class I leucyl-tRNA synthetase. Journal of Biological Chemistry 2009 284: 3418-3424 (*: co-author)
Ran He, Li-Dong Zu, Peng Yao, Xin Chen, and En-Duo Wang. Two non-redundant fragments in the N-terminal peptide of human cytosolic methionyl-tRNA synthetase were indispensable for the multi-synthetase complex incorporation and enzyme activity. Biochimica et Biophysica Acta 2009 1794: 347-354
Xiao-Long Zhou, Peng Yao, Bin Zhu, Liang-Liang Ruan, and En-Duo Wang. A unique insertion in the CP1 domain of Giardia lamblia leucyl-tRNA synthetase. Biochemistry 2009 48: 1340-1347
Partho Sarothi Ray, Jie Jia, Peng Yao, Mithu Majumder, Maria Hatzoglou, and Paul L. Fox. A stress-responsive RNA switch regulates VEGFA expression. Nature 2008 457: 915-919
Peng Yao, Xiao-Long Zhou, Ran He, Mei-Qin Xue, Yong-Gang Zheng, Yue-Fei Wang, and En-Duo Wang. Unique residues crucial for optimal editing in the yeast cytoplasmic leucyl-tRNA synthetase revealed by a novel knockout yeast strain. Journal of Biological Chemistry 2008 283: 22591-22600
Peng Yao, Bin Zhu, Sophie Jaeger, Gilbert Eriani, and En-Duo Wang. Recognition of tRNALeu by Aquifex aeolicus leucyl-tRNA synthetase during aminoacylation and editing steps. Nucleic Acids Research 2008 36: 2728-2738
Manuscripts under preparation for submission
Kaili Hao+, Thanh Nguyen+, Yuji Nakada, Gregory Walcott, Yuhua Wei, Yalin Wu, Daniel J. Garry, Peng Yao#, Jianyi Zhang#. RNA Binding Protein Signature in Proliferative Cardiomyocyte: A Cross-species Meta-analysis from Mouse, Pig, and Human Transcriptomic Profiling Data. Under review in Stem Cells since 11/21/2024 (# : corresponding author)
Kaili Hao+, Thanh Nguyen+, Yuji Nakada, Gregory Walcott, Yuhua Wei, Yalin Wu, Daniel J. Garry, Peng Yao#, Jianyi Zhang#. New born apical resection preserves the proliferative capacity of cardiomyocytes located throughout the left ventricle. Under review in Biomolecules since 12/15/2024 (# : corresponding author)
Debojyoti Das*, EngSoon Khor*, Feng Jiang*, Jiali He, Joshua Geiger, Huan Liu, Fanju Meng, George Porter, Zhenggen Jin, Patrick Murphy, Peng Yao. Loss-of-function of RNA-binding protein PRRC2B causes congenital cardiovascular malformations. Uploaded to MedRxiv (doi: https://doi.org/10.1101/2024.09.26.24313895); In preparation for submission
Debojyoti Das*, Eng-Soon Khor*, Feng Jiang, Omar M. Hedaya, Matthew Auguste, Jiangbin Wu, Waihong Wilson Tang, Peng Yao. eIF4G2-dependent translation of pro-fibrotic mRNAs is essential for cardiac fibroblast activation. Reviewed by Nature Communications in August 2023; Under revision for new submission
Omar M. Hedaya*, Feng Jiang*, Uday Baliga*, Si Chen, Yui Kawakami, Chen Yan, Peng Yao. Upstream open reading frame inactivation augments GATA4 translation and cardiomyocyte hypertrophy in mice. In preparation for submission
Uday Baliga, Debojyoti Das, Feng Jiang, EngSoon Khor, Peng Yao. Translational control in cardiac pathophysiology and therapeutic development. In preparation for submission (an invited review article as part of the Special Issue “Recent advances in the role of translation machinery and translational control in the cardiovascular system”)
Uday Baliga*, Jiangbin Wu*, Yui Kawakami, Peng Yao. FAM210A maintains vascular smooth muscle cell mitochondrial homeostasis and blood vessel integrity. In preparation.
Aleksandr Ivanov*, Liuqing Yang*, Debojyoti Das*, EngSoon Khor, Feng Jiang, Peng Yao. Integrated multi-omics analyses of neurohumoral stimulated mouse hearts reveal interplay between alternative splicing and translational control. In preparation.
Books, Monographs, Chapters, & Reviews
Peng Yao*, Paul L. Fox*. Aminoacyl-tRNA synthetases in cell signaling. Volume title: “The biology of aminoacyl-tRNA synthetase” in the highly regarded and long-standing Series. The Enzymes (Series Editor, Laurie S. Kaguni; Elsevier, Publisher) 2020 48: 243-275 (Book chapter; *: co-corresponding author)
Kadiam C Venkata Subbaiah, Omar Hedaya, Jiangbin Wu, Feng Jiang, and Peng Yao. Mammalian RNA switches: molecular rheostat in gene regulation, disease, and medicine. Computational and Structural Biotechnology Journal 2019 17: 1326-1338 (invited by chief editor Dr. Gianni Panagiotou; selected as a special collection on celebrating the success of CSBJ 2019)
Abul Arif, Peng Yao, FulviaTerenz, Jie Jia, Partho Sarothi Ray, and Paul L. Fox. The GAIT translational control system. Wiley Interdiscip Rev RNA 2017 e1441
Peng Yao, Sandeepa M. Eswarappa, and Paul L. Fox. Translational control mechanisms in angiogenesis and vascular biology. Current Atherosclerosis Reports 2015 17: 30
Peng Yao, Kiran Poruri, Susan A. Martinis, and Paul L. Fox. Non-catalytic regulation of gene expression by aminoacyl-tRNA synthetases. Topics in Current Chemistry (Springer; Editor: Kim Sunghoon, Professor, Seoul National University) 2013 344: 167-187 (Book chapter)
Peng Yao, Paul L. Fox. Aminoacyl-tRNA synthetases in medicine and disease. EMBO Molecular Medicine 2013 5: 332-343
Jie Jia, Peng Yao, Abul Arif, and Paul L. Fox. Regulation and dysregulation of 3´UTR mediated translational control. Current Opinion in Genetics & Development 2013 23: 29-34
Peng Yao and Paul L. Fox. A truncated tRNA synthetase directs a “translational trickle” of gene expression. Cell Cycle 2012 11: 10
Peng Yao and Paul L. Fox. Sex lethal and upstream ORFs: a bait-and-trap system for ribosomes. Genome Biology 2011 12: 12
Other Media
2/23/2022 Peng Yao. Webinar presented by Zoom, recorded, and posted on YouTube.
Hyperactive translation programs during cardiac remodeling. RNA Collaborative Seminar Series, (25 attending institutions across multiple countries including US, Canada, UK, Germany, France, Italy, China, Singapore, etc.; Invited talk via Zoom meeting by Dr. Lynne Maquat, J. Lowell Orbison Endowed Chair and Professor, Department of Biochemistry & Biophysics, Director of the Center for RNA Biology, URMC)
Web link for the webinar (880 views to date): https://www.youtube.com/watch?v=Keidcup5VMU
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