Publications
Research Articles
Bat-Ider Tumenbayar, Vincent M. Tutino, Joseph A. Brazzo III, Peng Yao, Yongho Bae. FAK and p130Cas modulate stiffness-mediated early transcription and cellular metabolism. BioRxiv January 2024 (doi: https://doi.org/10.1101/2024.01.15.575789)
Jiangbin Wu, Jared Hollinger, Emily Bonanno, Feng Jiang, Peng Yao. (2024) Cardiomyocyte-specific loss of glutamyl-prolyl-tRNA synthetase leads to disturbed protein homeostasis and dilated cardiomyopathy. Cells 13:35
Feng Jiang, Omar M. Hedaya, EngSoon Khor, Jiangbin Wu, Matthew Auguste, Peng Yao. RNA binding protein PRRC2B mediates translation of specific proteins and regulates cell cycle progression. Nucleic Acids Research 2023 51:5831-5846
Omar Hedaya, Feng Jiang, Kadiam C Venkata Subbaiah, Jiangbin Wu, Eng Soon Khor, Peng Yao. Secondary structures that regulate mRNA translation provide insights for ASO-mediated inhibition of cardiac hypertrophy. Nature Communications 2023 14:6166
Jiangbin Wu, Kadiam C Venkata Subbaiah, Omar Hedaya, Si Chen, Chen Yan, Peng Yao. FAM210A regulates mitochondrial translation and maintains cardiac mitochondrial homeostasis. Cardiovascular Research 2023 119: 2441-2457
Jared Hollinger, Jiangbin Wu, Kamel M. Awayda, Mitchell R. O’Connell, Peng Yao. Expression and purification of the mitochondrial transmembrane protein FAM210A in Escherichia coli. Protein Expression & Purification 2023 210:106322
Kadiam C. Venkata Subbaiah, Jiangbin Wu, Wai Hong Wilson Tang, Peng Yao. Ciclopirox inhibition of eIF5A hypusination attenuates fibroblast activation and cardiac fibrosis. J. Cardiovasc. Dev. Dis. 2023, 10:52
Kadiam C Venkata Subbaiah, Jiangbin Wu, Wai Hong Wilson Tang, and Peng Yao. FAM114A1 influences cardiac fibrosis by regulating angiotensin II signaling in cardiac fibroblasts. JCI Insight 2022 7:e152783 (featured article)
Qing Lyu, Peng Yao, Joseph M Miano. Generating a CRISPR knock-out mouse through a strong premature termination codon: a cautionary tale. Journal of Biomedical Research 2020 35:174-178
Jiangbin Wu*, Kadiam C Venkata Subbaiah*, Feng Jiang, Omar Hedaya, Amy Mohan, Tingting Yang, Kevin Welle, Sina Ghaemmaghami, Wai Hong Wilson Tang, Eric Small, Chen Yan, and Peng Yao. MicroRNA-574 regulates FAM210A expression and influences pathological cardiac remodeling. EMBO Molecular Medicine 2021 13:e12710 (*: co-first author)
Jiangbin Wu, Kadiam C Venkata Subbaiah, Li Huitong Xie, Feng Jiang, Eng-Soon Khor, Deanne Mickelsen, Jason R. Myers, Wai Hong Wilson Tang, and Peng Yao. Glutamyl-prolyl-tRNA synthetase regulates proline-rich pro-fibrotic protein synthesis during cardiac fibrosis. Circulation Research 2020 127:827–846
Peng Yao, Paul L. Fox. Aminoacyl-tRNA synthetases in cell signaling. Volume title: “The biology of aminoacyl-tRNA synthetase” in the highly regarded and long-standing Series The Enzymes (Series Editor, Laurie S. Kaguni; Elsevier, Publisher) 2020 Volume 48: 243-275
Si Chen, Yishuai Zhang, Jiangbin Wu, Janet K. Lighthouse, Deanne M. Mickelsen, Xuan Li, Thomas Rousselle, Peng Yao, Eric M. Small, Ji Li, and Chen Yan. Role of cyclic nucleotide phosphodiesterase 10A in pathological cardiac remodeling and dysfunction. Circulation 2020 141:217–233
Changyi Ji, Yao Li, Alec Kittredge, Austin Hopiavuori, Nancy Ward, Peng Yao, Yohta Fukuda, Yu Zhang, Stephen H. Tsang, and Tingting Yang. Investigation and restoration of BEST1 activity in patient-derived RPEs with dominant mutations. Scientific Reports 2019 9: 19026
Kadiam C Venkata Subbaiah, Omar Hedaya, Jiangbin Wu, Feng Jiang, and Peng Yao*. Mammalian RNA switches: molecular rheostat in gene regulation, disease, and medicine. Computational and Structural Biotechnology Journal 2019 17: 1326-1338 (invited by chief editor Dr. Gianni Panagiotou)
Kadiam C. Venkata Subbaiah, Jiangbin Wu, Alka Potdar, Peng Yao* HnRNP L-mediated RNA switches function as a hypoxia-induced translational regulon. Biochemical and Biophysical Research Communications 2019 516: 753-759
Peng Yao*, Jiangbin Wu, Daniel Lindner, Paul L. Fox. Interplay between miR-574-3p and hnRNP L regulates VEGFA mRNA translation and tumorigenesis. Nucleic Acids Research 2017 45: 7950–7964 (*: corresponding author)
Qian Huang, Xiao-Long Zhou, Qing-Hua Hu, Hui-Yan Lei, Zhi-Peng Fang, Peng Yao, and En-Duo Wang. A bridge between the aminoacylation and editing domains of leucyl-tRNA synthetase is crucial for its synthetic activity. RNA 2014 20: 1440-1450
Peng Yao, Alka A. Potdar, Partho Sarothi Ray, Sandeepa M. Eswarappa, Andrew C. Flagg, Belinda Willard, and Paul L. Fox. The HILDA complex coordinates a conditional switch in the 3´-untranslated region of the VEGFA mRNA. Plos Biology 2013 11: e1001635
Hao Zhou, Minjia Yu, Koichi Fukuda, Jinteak Im, Peng Yao, Wei Cui, Katarzyna Bulek, Jarod Zepp, Youzhong Wan, Tae Whan Kim, Weiguo Yin, Victoria Ma, James Thomas, Jun Gu, Jian-an Wang, Paul E DiCorleto, Paul L Fox, Jun Qin and Xiaoxia Li. IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine production. EMBO Journal 2013 32: 583-596
Tomasz Herjan, Peng Yao, Wen Qian, Xiao Li, Caini Liu, Katarzyna Bulek, Dongxu Sun, Wen-Pin Yang, Jun Zhu, Aiqing He, Julie A. Carman, Serpil C. Erzurum, Howard D. Lipshitz, Paul L. Fox, Thomas A. Hamilton and Xiaoxia Li. HuR is required for IL-17-induced Act1-mediated CXCL1 and CXCL5 mRNA stabilization. Journal of Immunology 2013 191: 640-649
Peng Yao, Alka A. Potdar, Abul Arif, Partho Sarothi Ray, Rupak Mukhopadhyay, Belinda Willard, Yichi Xu, Jun Yan, Gerald M. Saidel, and Paul L. Fox. Coding region polyadenylation generates a truncated tRNA synthetase that counters translation repression. Cell 2012 149: 88-100
Previewed by Matthew Brook, Richard W.P. Smith, and Nicola K. Gray. A molecular doorstop ensures a trickle through translational repression. Cell 2012 149: 13-15 Leading Edge Preview
Qian Huang, Peng Yao, Gilbert Eriani, En-Duo Wang. In vivo identification of essential nucleotides in tRNALeu to its functions by using a constructed yeast tRNALeu knockout strain. Nucleic Acids Research 2012 40: 10463-10477
Faegheh Jafarifar, Peng Yao, Sandeepa M Eswarappa, Paul L Fox. Repression of VEGFA by CA-rich element-binding microRNAs is modulated by hnRNP L. EMBO Journal 2011 30: 1324-1334
Xin Chen, Jing-Jing Ma, Min Tan, Peng Yao, Qing-Hua Hu, Gilbert Eriani, En-Duo Wang. Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase.Nucleic Acids Research 2011 39: 235-247
Weiguo Yin, Youzhong Wan, Tae Whan Kim, Peng Yao, Hui Xiao, Hao Zhou, Jianhua Xiao, Paul Fox, Xiaoxia Li. The kinase activity of interleukin-1 receptor-associated kinase 2 is essential for lipopolysaccharide-mediated cytokine and chemokine mRNA stability and translation. J Interferon Cytokine Research 2011 31: 415-422
Bin Zhu*, Peng Yao*, Min Tan*, Gilbert Eriani, En-Duo Wang. tRNA-independent pre-transfer editing by class I leucyl-tRNA synthetase. Journal of Biological Chemistry 2009 284: 3418-3424 (*: co-author)
Ran He, Li-Dong Zu, Peng Yao, Xin Chen, En-Duo Wang. Two non-redundant fragments in the N-terminal peptide of human cytosolic methionyl-tRNA synthetase were indispensable for the multi-synthetase complex incorporation and enzyme activity. Biochimica et Biophysica Acta 2009 1794: 347-354
Xiao-Long Zhou, Peng Yao, Bin Zhu, Liang-Liang Ruan and En-Duo Wang. A unique insertion in the CP1 domain of Giardia lamblia leucyl-tRNA synthetase. Biochemistry 2009 48: 1340-1347
Partho Sarothi Ray, Jie Jia, Peng Yao, Mithu Majumder, Maria Hatzoglou and Paul L. Fox. A stress-responsive RNA switch regulates VEGFA expression. Nature 2008 457: 915-919
Peng Yao, Xiao-Long Zhou, Ran He, Mei-Qin Xue, Yong-Gang Zheng, Yue-Fei Wang, En-Duo Wang. Unique residues crucial for optimal editing in the yeast cytoplasmic leucyl-tRNA synthetase revealed by a novel knockout yeast strain. Journal of Biological Chemistry 2008 283: 22591-22600
Peng Yao, Bin Zhu, Sophie Jaeger, Gilbert Eriani, En-Duo Wang. Recognition of tRNALeu by Aquifex aeolicus leucyl-tRNA synthetase during aminoacylation and editing steps. Nucleic Acids Research 2008 36: 2728-2738
Invited Reviews
Abul Arif, Peng Yao, FulviaTerenz, Jie Jia, Partho Sarothi Ray, Paul L. Fox. The GAIT translational control system. Wiley Interdiscip Rev RNA 2017 e1441
Peng Yao, Sandeepa M. Eswarappa, Paul L. Fox. Translational control mechanisms in angiogenesis and vascular biology. Current Atherosclerosis Reports 2015 17: 30
Peng Yao, Paul L. Fox. Aminoacyl-tRNA synthetases in medicine and disease. EMBO Molecular Medicine 2013 5: 332-343
Jie Jia, Peng Yao, Abul Arif, and Paul L. Fox. Regulation and dysregulation of 3´UTR mediated translational control. Current Opinion in Genetics & Development 2013 23: 29-34
Peng Yao, Paul L. Fox. A truncated tRNA synthetase directs a “translational trickle” of gene expression. Cell Cycle 2012 11: 10
Peng Yao, Paul L. Fox. Sex lethal and upstream ORFs: a bait-and-trap system for ribosomes. Genome Biology 2011 12: 12
Book Chapter
Peng Yao, Kiran Poruri, Susan A. Martinis, Paul L. Fox. Non-catalytic regulation of gene expression by aminoacyl-tRNA synthetases. Topics in Current Chemistry 2013 344: 167-187 (Springer; Editor: Kim Sunghoon, Professor, Seoul National University)