Gonadal development and gene expression in the leopard gecko during temperature-dependent sex determination
Okano S, Yoshizawa Y, Nobuchi S, Takeda Y, Miyazaki K, Akashi H, Toyota K, Yamagishi G, Miyagawa S.
Dev Biol 533:121–132, 2026（→解説ページ）
Functional phytochemicals cooperatively suppress inflammation in RAW264.7 cells
Terashita K, Kohakura M, Sugawara K, Miyagawa S, Arimrua GI.
Nutrients 18:376, 2026
Seasonal dynamics of gammarid assemblages associated with Sargassum macrocarpum and S. patens beds in Tsukumo Bay, Noto Peninsula, Sea of Japan
Tsunoda K, Kodama M, Higashide Y, Ogiso S, Matsubara H, Suzuki N, Miyagawa S, Toyota K.
Plankton Benthos Res 21:44–51, 2026
Identification of the estrogen receptor subtypes associated with testis-ova induction in the medaka
Murota S, Sato K, Nakashima H, Shimizu S, Enomoto S, Tambo R, Yamazaki S, Ogino Y, Lange A, Tyler CR, Iguchi T, Miyagawa S.
Sci Total Environ 1003:180773, 2025（→解説ページ）
Androgen-regulated gene expression of developing external genitalia in mice
Hasegawa M, Mizoguchi H, Ishikawa M, Tanaka K, Korenaga Y, Hatsuki S, Takahashi H, Yamada G, Akashi H, Toyota K, Miyagawa S.
Gene 965:149669, 2025（→解説ページ）
Deficiency of estrogen receptor 2 expression enhances disorganization of the mouse uterus with age
Nakajima T, Arakawa R, Nose S, Matsuda N, Tsuge A, Ishii M, Ishikawa T, Tsurugai Y, Miyagawa S, Iguchi T, Sato T.
Endocrinology 166:bqaf103, 2025
The powerful potential of amino acid menthyl esters for anti-inflammatory and anti-obesity therapies
Takasawa S, Kimura K, Miyanaga M, Uemura T, Hachisu M, Miyagawa S, Ramadan A, Sukegawa S, Kobayashi M, Kimura S, Matsui K, Shiroishi M, Terashita K, Nishiyama C, Yashiro T, Nagata K, Higami Y, Arimura GI.
Immunology 173:76–92, 2024
Neuroendocrinology of reproduction and social behaviors in reptiles: advances made in the last decade (review)
Yamagishi G, Miyagawa S.
Zoolog Sci. 41:87–96, 2024
Understanding the role of environmental temperature on sex determination through comparative studies in reptiles and amphibians (review)
Akashi H, Hasui D, Ueda K, Ishikawa M, Takeda M, Miyagawa S.
J Exp Zool A Ecol Integr Physiol. 341:48–59, 2024
Comparative analysis of gonadal transcriptomes between turtle and alligator identifies common molecular cues activated during the temperature-sensitive period for sex determination
Toyota K, Akashi H, Ishikawa M, Yamaguchi K, Shigenobu S, Sato T, Lange A, Tyler CR, Iguchi T, Miyagawa S.
Gene 888:147763, 2023（→解説ページ）
Sexual dimorphic eyestalk transcriptome of kuruma prawn Marsupenaeus japonicus
Toyota K, Mekuchi M, Akashi H, Miyagawa S, Ohira T.
Gene 885:147700, 2023
The role of mesenchymal estrogen receptor 1 in mouse uterus in response to estrogen
Furuminato K, Minatoya S, Seno E, Goto T, Yamazaki S, Sakaguchi M, Toyota K, Iguchi T, Miyagawa S.
Sci Rep. 13:12293, 2023（→解説ページ）
Müllerian duct development and regression in the Reeves’ turtle, Mauremys reevesii, under female and male producing temperatures
Akashi H, Yamamoto H, Miyagawa S.
J Herpetol. 57:270–273, 2023
Eyestalk transcriptome and methyl farnesoate titers provide insight into the physiological changes in male snow crab, Chionoecetes opilio, after the terminal molt
Toyota K, Yamamoto T, Mori T, Mekuchi M, Miyagawa S, Ihara M, Shigenobu S, Ohira T.
Sci Rep. 13:7204, 2023
Evolutionary differentiation of androgen receptor is responsible for sexual characteristic development in a teleost fish
Ogino Y, Ansai S, Watanabe E, Yasugi M, Katayama Y, Sakamoto H, Okamoto K, Okubo K, Yamamoto Y, Hara I, Yamazaki T, Kato A, Kamei Y, Naruse K, Ohta K, Ogino H, Sakamoto T, Miyagawa S, Sato T, Yamada G, Baker ME, Iguchi T.
Nat Commun. 14:1428, 2023
The role of p63 in embryonic external genitalia outgrowth in mice
Tanaka K, Matsumaru D, Suzuki K, Yamada G, Miyagawa S.
Dev Growth Differ. 65:132–140, 2023
Adverse effects of thyroid-hormone-disrupting chemicals 6-propyl-2-thiouracil and tetrabromobisphenol A on Japanese medaka (Oryzias latipes)
Horie Y, Yamagishi T, Yamamoto J, Suzuki M, Onishi Y, Chiba T, Miyagawa S, Lange A, Tyler CR, Okamura H, Iguchi T.
Comp Biochem Physiol C Toxicol Pharmacol. 263:109502, 2023
Chronology of embryonic and gonadal development in the Reeves’ turtle, Mauremys Reevesii
Akashi H, Kubota M, Yamamoto H, Miyaoku K, Yamagishi G, Miyagawa S.
Sci Rep. 12:11619, 2022
Evolution of g6pc1 paralogs in sarcopterygian lineages: multiple origins and functional divergence among ectotherms
Yamagishi G, Park MK, Miyagawa S.
Zool Sci. 39:419–430, 2022
Preself-feeding medaka fry provides a suitable screening system for in vivo assessment of thyroid hormone-disrupting potential
Myosho T, Ishibashi A, Fujimoto S, Miyagawa S, Iguchi T, Kobayashi T.
Environ Sci Technol. 56:6479–6490, 2022
Effect of thyroid hormone–disrupting chemicals on swim bladder inflation and thyroid hormone–related gene expression in Japanese medaka and zebrafish
Horie Y, Okamoto K, Yamamoto M, Takahashi C, Sato T, Miyagawa S, Okamura H, Iguchi T.
J Appl Toxicol. 42:1385–1395, 2022
Juvenile hormone synthesis and signaling disruption triggering male offspring induction and population decline in cladocerans (water flea) : Review and adverse outcome pathway development (review)
Toyota K, Watanabe H, Hirano M, Abe R, Miyakawa H, Song Y, Sato T, Miyagawa S, Tollefsen KE, Tatarazako N, Iguchi T.
Aquat Toxicol. 243:106058, 2022
Sexual fate of murine external genitalia development: conserved transcriptional competency for male-biased genes in both sexes
Kajioka D, Suzuki K, Matsushita S, Hino S, Sato T, Takada S, Isono K, Takeo T, Kajimoto M, Nakagata N, Nakao M, Suyama M, DeFalco T, Miyagawa S, Yamada G.
Proc Natl Acad Sci USA. 118:e2024067118, 2021
Novel validating indices to indicate sexual differences in the horsehair crab Erimacrus isenbeckii (Brandt, 1848)
Toyota K, Arai Y, Miyagawa S, Kogo Y, Takeuchi K.
Aquat Anim. AA2021, 1–8, 2021
Characterization of G protein-coupled estrogen receptors in Japanese medaka, Oryzias latipes
Miyaoku K, Ogino Y, Lange A, Ono A, Kobayashi T, Ihara M, Tanaka H, Toyota K Akashi H, Yamagishi G, Sato T, Tyler CR, Iguchi T, Miyagawa S.
J Appl Toxicol. 41:1390–1399, 2021
New frontiers of developmental endocrinology opened by researchers connecting irreversible effects of sex hormones on developing organs (review)
Iguchi T, Sato T, Nakajima T, Miyagawa S, Takasugi N.
Differentiation 18:4–23, 2021
Estrogen receptor 1 (ESR1) agonist induces ovarian differentiation and aberrant Müllerian duct development in Chinese soft-shelled turtle, Pelodiscus sinensis
Toyota K, Masuda S, Sugita S, Miyaoku K, Yamagishi G, Akashi H, Miyagawa S.
Zool Stud. 59:54, 2020
Expression dynamics of genes in the hypothalamic-pituitary-thyroid (HPT) cascade and their responses to 3,5,3’-tri-iodothyronine highlights potential vulnerability to thyroid-disrupting chemicals in zebrafish (Danio rerio) embryo-larvae
Parsons A, Lange A, Kudoh T, Hutchinson T, Miyagawa S, Iguchi T, Tyler CR.
Aquat Toxicol. 225:105547, 2020
Hedgehog signaling regulates the basement membrane remodeling during folliculogenesis in the neonatal mouse ovary
Terauchi KJ, Miyagawa S, Iguchi T, Sato T.
Cell Tissue Res. 381:555–567, 2020
A newly developed genetic sex marker and its application to understanding chemically induced feminisation in roach (Rutilus rutilus)
Lange A, Paris J, Gharbi K, Cezard T, Miyagawa S, Iguchi T, Studholme D, Tyler CR.
Mol Ecol Resour. 20:1007–1022, 2020
Bmp4 is an essential growth factor for the initiation of genital tubercle (GT) outgrowth
Kajioka D, Suzuki K, Nakada S, Matsushita S, Miyagawa S, Takeo T, Nakagata N, Yamada G.
Congenit Anom (Kyoto). 60:15–21, 2020
Hedgehog signaling for urogenital organogenesis and prostate cancer: an implication for the epithelial-mesenchyme interaction (EMI) (review)
Hyuga T, Alcantara M, Kajioka D, Haraguchi R, Suzuki K, Miyagawa S, Kojima Y, Hayashi Y, Yamada G.
Int J Mol Sci. 21:58, 2019
Regulatory roles of epithelial-mesenchymal interaction (EMI) during early and androgen dependent external genitalia development (review)
Hyuga T, Suzuki K, Acebedo AR, Hashimoto D, Kajimoto M, Miyagawa S, Enmi J, Yoshioka Y, Yamada G.
Differentiation 110:29–35, 2019
The role of Fgf signaling on epithelial cell differentiation in mouse vagina
Hirano Y, Suzuki K, Iguchi T, Yamada G, Miyagawa S.
In Vivo 33:1499–1505, 2019
Diethylstilbestrol alters the expression of activins in the neonatal mouse ovary in vitro
Oikawa S, Kobayashi S, Miyagawa S, Iguchi T, Sato T.
In Vivo 33:1095–1102, 2019
Molecular mechanisms and tissue targets of brominated flame retardants, BDE-47 and TBBPA, in embryo-larval life stages of zebrafish (Danio rerio)
Parsons A, Lange A, Hutchinson TH, Miyagawa S, Iguchi T, Kudoh T, Tyler CR.
Aquat Toxicol. 209:99–112, 2019
Mesenchymal actomyosin contractility is required for androgen-driven urethral masculinization in mice
Acebedo AR, Suzuki K, Hino S, Alcantara, MC, Haga H, Matsumoto KI, Nakao M, Shimamura K, Takeo T, Nakagata N, Miyagawa S, Nishinakamura R, Adelstein, RS, Yamada G.
Commun Biol. 8:95, 2019
Single nucleotide polymorphisms of HAAO and IRX6 genes as risk factors for hypospadias
Kojima Y, Koguchi T, Mizuno K, Sato Y, Hoshi S, Hata J, Nishio H, Hashimoto D, Matsushita S, Suzuki K, Miyagawa S, Hui CC, Tanikawa C, Murakami Y, Yamada G, Hayashi Y, Matsuda K.
J Urol. 201:386–392, 2019
Functional distinctions associated with the diversity of sex steroid hormone receptors ESR and AR.(review)
Ogino Y, Tohyama S, Kohno S, Toyota K, Yamada G, Yatsu R, Kobayashi T, Tatarazako N, Sato T, Matsubara H, Lange A, Tyler CR, Katsu Y, Iguchi T, Miyagawa S.
J Steroid Biochem Mol Biol. 184:38–46, 2018
Regulation of masculinization: androgen signalling for external genitalia development (review)
Matsushita S, Suzuki K, Murashima A, Kajioka D, Acebedo AR, Miyagawa S, Haraguchi R, Ogino Y, Yamada G.
Nat Rev Urol. 15:358–368, 2018
Identification of hepatic thyroid hormone-responsive genes in neonatal rats: potential targets for thyroid hormone-disrupting chemicals
Fujimoto N, Kitamura S, Uramaru N, Miyagawa S, Iguchi T.
Toxicol Lett. 286:48–53, 2018
Divergent responsiveness of two isoforms of the estrogen receptor to mixtures of contaminants of emerging concern in four vertebrates
Kohno S, Katsu Y, Cipoletti N, Wang LC, Jorgenson ZG, Miyagawa S, Schoenfuss HL.
J Appl Toxicol. 38:705–713, 2018
Establishment of estrogen receptor 1 (ESR1)-knockout medaka; ESR1 is dispensable for sexual development and reproduction in medaka, Oryzias latipes
Tohyama S, Ogino Y, Lange A, Myosho T, Kobayashi T, Hirano Y, Yamada G, Sato T, Tatarazako N, Tyler CR, Iguchi T, Miyagawa S.
Dev Growth Diff. 59:552–561, 2017
Altered expression of Olr59, Ethe1, and Slc10a2 genes in the liver of F344 rats by neonatal thyroid hormone disruption
Matsubara K, Nakamura N, Sanoh S, Ohta S, Kitamura S, Uramaru N, Miyagawa S, Iguchi T, Fujimoto N.
J Appl Toxicol. 37:1030–1035, 2017
Development of a common carp (Cyprinus carpio) pregnane X receptor (cPXR) transactivation reporter assay and its activation by azole fungicides and pharmaceutical chemicals
Lange A, Corcorana J, Miyagawa S, Iguchi T, Winter MJ, Tyler CR.
Toxicol In Vitro 41:114–122, 2017
Metabolomics reveals an involvement of pantothenate for male production responding to the short-day stimulus in the water flea, Daphnia pulex
Toyota K, Gavin A, Miyagawa S, Viant MR, Iguchi T.
Sci Rep. 6:25125, 2016
Characterization of evolutionary trend in squamate estrogen receptor sensitivity
Yatsu R, Katsu Y, Kohno S, Mizutani T, Ogino Y, Ohta Y, Myburgh J, van Wyk JH, Guillette Jr LJ, Miyagawa S#, Iguchi T.
Gen Comp Endocrinol. 238:88–95, 2016
Neverland regulates embryonic molts through the regulation of ecdysteroids synthesis in the water flea Daphnia magna
Sumiya E, Ogino Y, Toyota K, Miyakawa H, Miyagawa S, Iguchi T.
J Appl Toxicol. 36:1476–1485, 2016
Comparative developmental staging of the female and male water fleas Daphnia pulex and Daphnia magna dring embryogenesis
Toyota K, Hiruta C, Ogino Y, Miyagawa S, Okamura T, Onishi Y, Tatarazako N, Iguchi T.
Zool Sci. 33:31–37, 2016
RNA-seq analysis of the gonadal transcriptome during Alligator mississippiensis temperature- dependent sex determination and differentiation
Yatsu R, Miyagawa S, Kohno S, Parrott BB, Yamaguchi K, Ogino Y, Miyakawa H, Lowers RH, Shigenobu S, Guillette Jr LJ, Iguchi T.
BMC Genomics 17:77, 2016
Evolution of estrogen receptors in ray-finned fish and their comparative responses to estrogenic substances
Tohyama S*, Miyagawa S*#, Lange A, Ogino Y, Mizutani T, Ihara M, Tanaka H, Tatarazako N, Kobayashi T, Tyler CR, Iguchi T.
J Steroid Biochem Mol Biol. 158:189–197, 2016
Neofunctionalization of androgen receptor by gain-of-function mutations in teleost fish lineage
Ogino Y, Kuraku S, Ishibashi H, Miyakawa H, Sumiya E, Miyagawa S, Matsubara H, Yamada G, Baker ME, Iguchi T.
Mol Biol Evol. 33:228–244, 2016
TRPV4 associates environmental temperature and sex determination in the American alligator
Yatsu R*, Miyagawa S*, Kohno S, Saito S, Ogino Y, Katsu Y, Ohta Y, Tominaga M, Guillette Jr LJ, Iguchi T.
Sci Rep. 5:18581, 2015
Environmental chemicals active as human antiandrogens do not activate a stickleback androgen receptor but enhance a feminising effect of oestrogen in roach
Lange A, Sebirea M, Rostkowski P, Mizutani T, Miyagawa S, Iguchi T, Hill EM, Tyler CR.
Aquat Toxicol. 168:48–59, 2015
Epithelial estrogen receptor 1 intrinsically mediates squamous differentiation in the mouse vagina
Miyagawa S, Iguchi T.
Proc Natl Acad Sci USA. 112:12986–12991, 2015
Understanding the molecular basis for differences in responses of fish estrogen receptor subtypes to environmental estrogens
Tohyama S*, Miyagawa S*#, Lange A, Ogino Y, Mizutani T, Tatarazako N, Katsu Y, Ihara M, Tanaka H, Ishibashi H, Tatarazako N, Kobayashi T, Tyler CR, Iguchi T.
Environ Sci Technol. 49:7439–7447, 2015
Identification and characterization of the androgen receptor from the American alligator, Alligator mississippiensis
Miyagawa S, Yatsu R, Kohno S, Doheny BM, Ogino Y, Ishibashi H, Katsu Y, Ohta Y, Guillette Jr LJ, Iguchi T.
Endocrinology 156:2795–2806, 2015
Evaluation of estrogenic activity of wastewater: comparison among in vitro ERa reporter gene assay, in vivo vitellogenin induction, and chemical analysis
Ihara M, Kitamura T, Kumar V, Park C, Ihara MO, Lee S, Yamashita N, Miyagawa S, Iguchi T, Okamoto S, Suzuki Y, Tanaka H.
Environ Sci Technol. 49:6319–6326, 2015
NMDA receptor activation on the upstream of methyl farnesoate signaling for short-day induced male offspring production in water flea Daphnia pulex
Toyota K, Miyakawa H, Yamaguchi K, Shigenobu S, Ogino Y, Tatarazako N, Miyagawa S, Iguchi T.
BMC Genomics 16:1392, 2015
Methyl farnesoate synthesis is necessary for the environmental sex determination in the water flea Daphnia pulex
Toyota K, Miyakawa H, Hiruta C, Furuta K, Ogino Y, Shinoda T, Tatarazako N, Miyagawa S, Shaw JR, Iguchi T.
J Insect Physiol. 80:22–30, 2015
Differential ligand selectivity of androgen receptors α and β from Murray-Darling rainbowfish (Melanotaenia fluviatilis)
Bain PA, Ogino Y, Miyagawa S, Iguchi T, Kumar A.
Gen Comp Endocrinol. 212C:84–91, 2015
Unique roles of estrogen-dependent Pten control in epithelial cell homeostasis of mouse vagina
Miyagawa S, Sato M, Sudo T, Yamada G, Iguchi T.
Oncogene 34:1035–1043, 2015
Diofenolan induces male offspring production through binding to the juvenile hormone receptor in Daphnia magna
Abe R, Toyota K, Miyakawa H, Watanabe H, Oka T, Miyagawa S, Nishide H, Uchiyama I, Tollefsen KE, Iguchi T, Tatarazako N.
Aquat Toxicol. 159:44–51, 2015
Steroid responsive regulation of IFNg2 alternative splicing and its possible role in germ cell proliferation in medaka
Mohapatra S, Chakraborty T, Miyagawa S, Zhou L, Ohta K, Iguchi T, Nagahama Y.
Mol Cell Endocrinol. 400:61–70, 2015
Characterization of Oryzias latipes glucocorticoid receptors and their unique response to progestins
Miyagawa S, Lange A, Tohyama S, Ogino Y, Mizutani T, Kobayashi T, Tatarazako N, Tyler CR, Iguchi T.
J Appl Toxicol. 35: 302–309, 2015
Targeted gene disruption by use of transcription activator-like effector nuclease (TALEN) in the water flea Daphnia pulex
Hiruta C, Ogino Y, Sakuma T, Toyota K, Miyagawa S, Yamamoto T, Iguchi T.
BMC Biotechnol. 14:95, 2014
Rapid fluorescent detection of (anti)androgens with spiggin-gfp medaka
Sébillot A, Damdimopoulou P, Ogino Y, Spirhanzlova P, Miyagawa S, Du Pasquier D, Mouatassim N, Iguchi T, Lemkine GF, Demeneix BA, Tindall AJ.
Environ Sci Technol. 48:10919–10928, 2014
Co-occurrence of estrogenic and antiestrogenic activities in wastewater: quantitative evaluation of balance by in vitro ERa reporter gene assay and chemical analysis
Ihara M, Ihara MO, Kumar V, Narumiya M, Hanamoto S, Nakada N, Yamashita N, Miyagawa S, Iguchi T, Tanaka H.
Environ Sci Technol. 48:6366–6373, 2014
Essential roles of epithelial bone morphogenetic protein signaling during prostatic development
Omori A, Miyagawa S, Ogino Y, Harada M, Ishii K, Sugimura Y, Ogino H, Nakagata N, Yamada G.
Endocrinology 155:2534–2544, 2014
Differing species responsiveness of estrogenic contaminants in fish is conferred by the ligand binding domain of the estrogen receptor
Miyagawa S, Lange A, Hirakawa I, Tohyama S, Ogino Y, Mizutani T, Kagami Y, Kusano T, Ihara M, Tanaka H, Tatarazako N, Ohta Y, Katsu Y, Tyler CR, Iguchi T.
Environ Sci Technol. 48:5254–5263, 2014
Gonadal differentiation in reptiles exhibiting environmental sex determination
Kohno S, Parrott BB, Yatsu R, Miyagawa S, Moore BC, Iguchi T, Guillette Jr LJ.
Sex Dev. 8:208–226, 2014
The reproductive hormone cycle of adult female American alligators from a barrier island population
Hamlin HJ, Lowers RH, Kohno S, Mitsui-Watanabe N, Amano H, Hara A, Ohta Y, Miyagawa S, Iguchi T, Guillette LJ.
Reproduction 147:855–863, 2014
Disruption of the temporally regulated cloaca endodermal b-catenin signaling causes anorectal malformations
Miyagawa S, Harada M, Matsumaru D, Tanaka K, Inoue C, Nakahara C, Haraguchi R, Matsushita S, Suzuki K, Nakagata N, Ng RC, Akita K, Lui VC, Yamada G.
Cell Death Differ. 21: 990–997, 2014
Molecular impact of juvenile hormone agonists on neonatal Daphnia magna
Toyota K, Kato Y, Miyakawa H, Yatsu R, Mizutani T, Ogino Y, Miyagawa S, Watanabe H, Nishide H, Uchiyama I, Tatarazako N, Iguchi T.
J Appl Toxicol. 34, 537–544, 2014
Bmp7 and Lef1 are the downstream effectors of androgen signaling in androgen-induced sex characteristics development in medaka
Ogino Y, Hirakawa I, Miyakawa H, Inohaya K, Sumiya E, Miyagawa S, Denslow N, Yamada G, Tatarazako N, Iguchi T.
Endocrinology 155:449–462, 2014
Roles of ecdysteroids for progression of reproductive cycle in the fresh water crustacean Daphnia magna
Sumiya E, Ogino Y, Hirakawa I, Hiruta C, Toyota K, Miyagawa S, Iguchi T.
Front Zool. 11:60, 2014
Development of a microinjection system for RNA interference in the water flea Daphnia pulex
Hiruta C, Toyota K, Miyakawa H, Ogino Y, Miyagawa S, Tatarazako N, Shaw J, Iguchi T.
BMC Biotechnol. 13:96, 2013
A mutation in the receptor Methoprene-tolerant alters juvenile hormone response in insects and crustaceans
Miyakawa H, Toyota K, Hirakawa I, Ogino Y, Miyagawa S, Oda S, Tatarazako N, Miura T, Colbourne JK, Iguchi T.
Nat Commun. 4:1856, 2013
Molecular cloning of doublesex genes of four cladocera (water flea) species
Toyota K, Kato Y, Sato M, Sugiura N, Miyagawa S, Miyakawa H, Watanabe H, Oda S, Ogino Y, Hiruta C, Mizutani T, Tatarazako N, Paland S, Jackson C, Colbourne JK, Iguchi T.
BMC Genomics 14:239, 2013
b-Catenin signaling regulates Foxa2 expression during endometrial hyperplasia formation
Villacorte M, Suzuki K, Hirasawa A, Ohkawa Y, Suyama M, Maruyama M, Aoki D, Ogino Y, Miyagawa S, Terabayashi T, Tomooka Y, Nakagata N and Yamada G.
Oncogene 32:3477–3482, 2013
Developmental disorders and altered gene expression in the tropical clawed frog (Silurana tropicalis) exposed to 17a-ethinylestradiol
Hirakawa I*, Miyagawa S*, Mitsui N, Miyahara M, Onishi Y, Kagami Y, Kusano T, Takeuchi T, Ohta Y, Iguchi T.
J Appl Toxicol. 33:1001–1010, 2013
Establishment of transactivation assay systems using fish, amphibian, reptilian and human thyroid hormone receptors
Oka T, Mitsui-Watanabe N, Tatarazako N, Onishi Y, Katsu Y, Miyagawa S, Ogino Y, Yatsu R, Kohno S, Takase M, Kawashima Y, Ohta Y, Aoki Y, Guillette LJ Jr, Iguchi T.
J Appl Toxicol. 33:991–1000, 2013
Cloning, expression and functional characterization of carp, Cyprinus carpio, estrogen receptors and their differential activations by estrogens
Katsu Y, Lange A, Miyagawa S, Urushitani H, Tatarazako N, Kawashima Y, Tyler CR, Iguchi T.
J Appl Toxicol. 33:41–49, 2013
Sequential changes in the expression of Wnt- and Notch-related genes in the vagina and uterus of ovariectomized mice after estrogen exposure
Nakamura T, Miyagawa S, Katsu Y, Sato T, Iguchi T, Ohta Y.
In Vivo 26:899–906, 2012
The hedgehog signal induced modulation of bone morphogenetic protein signaling: an essential signaling relay for urinary tract morphogenesis
Haraguchi R, Matsumaru D, Nakagata N, Miyagawa S, Suzuki K, Kitazawa S, Yamada G.
PLoS One 7:e42245, 2012
P21 and Notch signalings in the persistently altered vagina induced by neonatal diethylstilbestrol exposure in mice
Nakamura T, Miyagawa S, Katsu Y, Mizutani T, Sato T, Takeuchi T, Iguchi T, Ohta Y.
J Vet Med Sci. 74:1589–1595, 2012
WNT family genes and their modulation in the ovary-independent and persistent vaginal epithelial cell proliferation and keratinization induced by neonatal diethylstilbestrol exposure in mice
Nakamura T, Miyagawa S, Katsu Y, Watanabe H, Mizutani T, Sato T, Morohashi KI, Takeuchi T, Iguchi T, Ohta Y.
Toxicology 296:13–19, 2012
Gene expression profiles in the testis associated with testis-ova in adult Japanese medaka (Oryzias latipes) exposed to 17alpha-ethinylestradiol
Hirakawa I*, Miyagawa S*, Katsu Y, Kagami Y, Tatarazako N, Kobayashi T, Kusano T, Mizutani T, Ogino Y, Takeuchi T, Ohta Y, Iguchi T.
Chemosphere 87:668–674, 2012
Comparative responsiveness to natural and synthetic estrogens of fish species commonly used in the laboratory and field monitoring
Lange A, Katsu Y, Miyagawa S, Ogino Y, Urushitani H, Kobayashi T, Hirai T, Shears JA, Nagae M, Yamamoto J, Ohnishi Y, Oka T, Tatarazako N, Ohta Y, Tyler CR, Iguchi T.
Aquat Toxicol. 109:250–258, 2012
The role of sonic hedgehog-gli2 pathway in the masculinization of external genitalia
Miyagawa S, Matsumaru D, Murashima A, Omori A, Satoh Y, Haraguchi R, Motoyama J, Iguchi T, Nakagata N, Hui CC, Yamada G.
Endocrinology 152:2894–2903, 2011
Molecular mechanisms of induction of persistent changes by estrogenic chemicals on female reproductive tracts and external genitalia (review)
Miyagawa S, Sato M, Iguchi T.
J Steroid Biochem Mol Biol. 127:51–57, 2011
Essential functions of androgen signaling emerged through the developmental analysis of vertebrate sex characteristics
Ogino Y, Miyagawa S, Katoh H, Prins GS, Iguchi T, Yamada G.
Evol Dev. 13:315–325, 2011
Essential roles of androgen signaling in Wolffian duct stabilization and epididymal cell differentiation
Murashima A, Miyagawa S, Ogino Y, Nishida-Fukuda H, Araki K, Matsumoto T, Kaneko T, Yoshinaga K, Yamamura KI, Kurita T, Kato S, Moon AM, Yamada G.
Endocrinology 152:1640–1651, 2011
Genetic analysis of hedgehog signaling in ventral body wall development and the onset of omphalocele formation
Matsumaru D, Haraguchi R, Miyagawa S, Motoyama J, Nakagata N, Meijlink F, Yamada G.
PLoS One 20:e16260, 2011
Molecular cloning of anti-Müllerian hormone from the American alligator; Alligator mississippiensis
Urushitani H, Katsu Y, Miyagawa S, Kohno S, Ohta Y, Guillette LJ Jr, Iguchi T.
Mol Cell Endocrinol. 333:190–199, 2011
Estrogen receptors in medaka (Oryzias latipes) and estrogenic environmental contaminants: An in vitro-in vivo correlation
Chakraborty T, Katsu Y, Zhou LY, Miyagawa S, Nagahama Y, Iguchi T.
J Steroid Biochem Mol Biol. 123:115–121, 2011
Cloning and functional characterization of Chondrichthyes, cloudy catshark, Scyliorhinus torazame and whale shark, Rhincodon typus estrogen receptors
Katsu Y, Kohno S, Narita H, Urushitani H, Yamane K, Hara A, Clauss TM, Walsh MT, Miyagawa S, Guillette Jr LJ, Iguchi T.
Gen Comp Endocrinol. 168:496–504, 2010
Progenitor cell expansion and organ size of mouse adrenal is regulated by sonic hedgehog
Huang CC, Miyagawa S, Matsumaru D, Parker KL, Yao HH.
Endocrinology 151:1119–1128, 2010
Molecular cloning and characterization of ligand- and species-specificity of amphibian estrogen receptors
Katsu Y, Taniguchi E, Urushitani H, Miyagawa S, Takase M, Kubokawa K, Tooi O, Oka T, Santo N, Myburgh J, Matsuno A, Iguchi T.
Gen Comp Endocrinol. 168:220–230, 2010
Estrogen receptor ESR1 is indispensable for the induction of persistent vaginal change by neonatal 5alpha-dihydrotestosterone exposure in mice
Miyagawa S, Katsu Y, Ohta Y, Sudo T, Lubahn DB, Iguchi T.
Biol Reprod. 82:497–503, 2010
Dosage dependent hedgehog signals integrated with Wnt/b-catenin regulate embryonic external genitalia formation as an appendicular program
Miyagawa S, Moon A, Haraguchi R, Inoue C, Harada M, Nakahara C, Suzuki K, Matsumaru D, Kaneko T, Matsuo, I, Yang L, Taketo MM, Iguchi T, Evans SM, Yamada G.
Development 136:3969–3978, 2009
Genetic integrations of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia
Miyagawa S, Satoh Y, Haraguchi R, Suzuki K, Iguchi T, Taketo MM, Nakagata N, Matsumoto T, Takeyama K, Kato S, Yamada G.
Mol Endcrinol. 23:871–880, 2009
Gene transduction by sonoporation
Ohta S, Suzuki K, Ogino Y, Miyagawa S, Murashima A, Matsumaru D, Yamada G.
Dev Growth Differ. 50: 517–520, 2008
Gene expression analyses on embryonic external genitalia: identification of regulatory genes possibly involved in masculinization processes
Nishida H*, Miyagawa S*, Matsumaru D, Wada Y, Satoh Y, Ogino Y, Fukuda S, Iguchi T, Yamada G.
Congenit Anom (Kyoto). 48:63–67, 2008
Positive regulation of steroidogenic acute regulatory protein (StAR) gene expression through the interaction between Dlx and GATA-4 for testicular steroidogenesis
Nishida H, Miyagawa S, Vieux-Rochas M, Morini M, Ogino Y, Suzuki K, Nakagata N, Choi HS, Levi G, Yamada G.
Endocrinology 149:2090–2097, 2008
Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling
Haraguchi R, Motoyama J, Sasaki H, Satoh Y, Miyagawa S, Nakagata N, Moon A, Yamada G.
Development 134:525–533, 2007
Cloning and differential expression of estrogen receptor and aromatase genes in the self-fertilizing hermaphrodite and male mangrove rivulus, Kryptolebias marmoratus
Orlando EF, Katsu Y, Miyagawa S, Iguchi T.
J Mol Endocrinol. 37:353–365, 2006
Chromatin immunoprecipitation-mediated target identification proved aquaporin 5 is regulated directly by estrogen in the uterus
Kobayashi M, Takahashi E, Miyagawa S, Watanabe H, Iguchi T.
Genes Cells. 11:1133–1143, 2006
Molecular genetic cascades for external genitalia formation: An emerging organogenesis program (review)
Yamada G, Suzuki K, Haraguchi R, Miyagawa S, Satoh Y, Kamimura M, Nakagata N, Kataoka H, Kuroiwa A, Chen Y.
Dev Dyn. 235:1738–1752, 2006
Persistent gene expression in mouse vagina exposed neonatally to diethylstilbestrol
Miyagawa S, Suzuki A, Katsu Y, Kobayashi M, Goto M, Handa H, Watanabe H, Iguchi T.
J Mol Endocrinol. 32:663–677, 2004
Molecular cloning of the estrogen and progesterone receptors of the American alligator
Katsu Y, Bermudez DS, Braun EL, Helbing C, Miyagawa S, Gunderson MP, Kohno S, Bryan TA, Guillette LJ Jr, Iguchi T.
Gen Comp Endocrinol. 136:122–133, 2004
Estrogen-independent activation of erbBs signaling and estrogen receptor alpha in the mouse vagina exposed neonatally to diethylstilbestrol
Miyagawa S, Katsu Y, Watanabe H, Iguchi T.
Oncogene 23:340–349, 2004
Developmental toxicity of estrogenic chemicals on rodents and other species (review)
Iguchi T, Watanabe H, Katsu Y, Mizutani T, Miyagawa S, Suzuki A, Kohno S, Sone K, Kato H.
Congenit Anom (Kyoto). 42:94–105, 2002
Characterization of diethylstilbestrol-induced hypospadias in female mice
Miyagawa S, Buchanan DL, Sato T, Ohta Y, Nishina Y, Iguchi T.
Anat Rec. 266:43–50, 2002