Tsunoda K, Kodama M, Higashide Y, Ogiso S, Matsubara H, Suzuki N, Miyagawa S, Toyota K.
Seasonal dynamics of gammarid assemblages associated with Sargassum macrocarpum and S. patens beds in Tsukumo Bay, Noto Peninsula, Sea of Japan.
Plankton Benthos Res 2026, in press
Murota S, Sato K, Nakashima H, Shimizu S, Enomoto S, Tambo R, Yamazaki S, Ogino Y, Lange A, Tyler CR, Iguchi T, Miyagawa S.
Identification of the estrogen receptor subtypes associated with testis-ova induction in the medaka.
Sci Total Environ 1003:180773, 2025
Hasegawa M, Mizoguchi H, Ishikawa M, Tanaka K, Korenaga Y, Hatsuki S, Takahashi H, Yamada G, Akashi H, Toyota K, Miyagawa S.
Androgen-regulated gene expression of developing external genitalia in mice.
Gene 965:149669, 2025
Nakajima T, Arakawa R, Nose S, Matsuda N, Tsuge A, Ishii M, Ishikawa T, Tsurugai Y, Miyagawa S, Iguchi T, Sato T.
Deficiency of estrogen receptor 2 expression enhances disorganization of the mouse uterus with age.
Endocrinology 166:bqaf103, 2025
Takasawa S, Kimura K, Miyanaga M, Uemura T, Hachisu M, Miyagawa S, Ramadan A, Sukegawa S, Kobayashi M, Kimura S, Matsui K, Shiroishi M, Terashita K, Nishiyama C, Yashiro T, Nagata K, Higami Y, Arimura GI.
The powerful potential of amino acid menthyl esters for anti-inflammatory and anti-obesity therapies.
Immunology 173:76–92, 2024
Yamagishi G, Miyagawa S.
Neuroendocrinology of reproduction and social behaviors in reptiles: advances made in the last decade. (review)
Zoolog Sci. 41:87–96, 2024
Akashi H, Hasui D, Ueda K, Ishikawa M, Takeda M, Miyagawa S.
Understanding the role of environmental temperature on sex determination through comparative studies in reptiles and amphibians. (review)
J Exp Zool A Ecol Integr Physiol. 341:48–59, 2024
Toyota K, Akashi H, Ishikawa M, Yamaguchi K, Shigenobu S, Sato T, Lange A, Tyler CR, Iguchi T, Miyagawa S.
Comparative analysis of gonadal transcriptomes between turtle and alligator identifies common molecular cues activated during the temperature-sensitive period for sex determination.
Gene 888:147763, 2023
Toyota K, Mekuchi M, Akashi H, Miyagawa S, Ohira T.
Sexual dimorphic eyestalk transcriptome of kuruma prawn Marsupenaeus japonicus.
Gene 885:147700, 2023
Furuminato K, Minatoya S, Seno E, Goto T, Yamazaki S, Sakaguchi M, Toyota K, Iguchi T, Miyagawa S.
The role of mesenchymal estrogen receptor 1 in mouse uterus in response to estrogen.
Sci Rep. 13:12293, 2023
Akashi H, Yamamoto H, Miyagawa S.
Müllerian duct development and regression in the Reeves’ turtle, Mauremys reevesii, under female and male producing temperatures.
J Herpetol. 57:270–273, 2023
Toyota K, Yamamoto T, Mori T, Mekuchi M, Miyagawa S, Ihara M, Shigenobu S, Ohira T.
Eyestalk transcriptome and methyl farnesoate titers provide insight into the physiological changes in male snow crab, Chionoecetes opilio, after the terminal molt.
Sci Rep. 13:7204, 2023
Ogino Y, Ansai S, Watanabe E, Yasugi M, Katayama Y, Sakamoto H, Okamoto K, Okubo K, Yamamoto Y, Hara I, Yamazaki T, Kato A, Kamei Y, Naruse K, Ohta K, Ogino H, Sakamoto T, Miyagawa S, Sato T, Yamada G, Baker ME, Iguchi T.
Evolutionary differentiation of androgen receptor is responsible for sexual characteristic development in a teleost fish.
Nat Commun. 14:1428, 2023
Tanaka K, Matsumaru D, Suzuki K, Yamada G, Miyagawa S.
The role of p63 on embryonic external genitalia outgrowth in mice.
Dev Growth Differ. 65:132–140, 2023
Horie Y, Yamagishi T, Yamamoto J, Suzuki M, Onishi Y, Chiba T, Miyagawa S, Lange A, Tyler CR, Okamura H, Iguchi T.
Adverse effects of thyroid-hormone-disrupting chemicals 6-propyl-2-thiouracil and tetrabromobisphenol A on Japanese medaka (Oryzias latipes).
Comp Biochem Physiol C Toxicol Pharmacol. 263:109502, 2023
Akashi H, Kubota M, Yamamoto H, Miyaoku K, Yamagishi G, Miyagawa S.
Chronology of embryonic and gonadal development in the Reeves’ turtle, Mauremys Reevesii.
Sci Rep. 12:11619, 2022
Yamagishi G, Park MK, Miyagawa S.
Evolution of g6pc1 paralogs in sarcopterygian lineages: multiple origins and functional divergence among ectotherms.
Zool Sci. 39:419–430, 2022
Myosho T, Ishibashi A, Fujimoto S, Miyagawa S, Iguchi T, Kobayashi T.
Pre-self-feeding medaka fry provides a suitable screening system for in vivo assessment of thyroid hormone-disrupting potential.
Environ Sci Technol. 56:6479–6490, 2022
Horie Y, Okamoto K, Yamamoto M, Takahashi C, Sato T, Miyagawa S, Okamura H, Iguchi T.
Effect of thyroid hormone–disrupting chemicals on swim bladder inflation and thyroid hormone–related gene expression in Japanese medaka and zebrafish.
J Appl Toxicol. 42:1385–1395, 2022
Toyota K, Watanabe H, Hirano M, Abe R, Miyakawa H, Song Y, Sato T, Miyagawa S, Tollefsen KE, Tatarazako N, Iguchi T.
Juvenile hormone synthesis and signaling disruption triggering male offspring induction and population decline in cladocerans: Review and adverse outcome pathway development. (review)
Aquat Toxicol. 243:106058, 2022
Kajioka S, Suzuki K, Matsushita S, Hino S, Sato T, Takada S, Isono K, Takeo T, Kajimoto M, Nakagata N, Nakao M, Suyama M, DeFalco T, Miyagawa S, Yamada G.
Sexual fate of murine external genitalia development: conserved transcriptional competency for male-biased genes in both sexes.
Proc Natl Acad Sci USA. 118:e2024067118, 2021
Toyota K, Arai Y, Miyagawa S, Kogo Y, Takeuchi K.
Novel validating indices to indicate sexual differences in the horsehair crab Erimacrus isenbeckii (Brandt, 1848).
Aquat Anim. AA2021, 1–8, 2021
Miyaoku K, Ogino Y, Lange A, Ono A, Kobayashi T, Ihara M, Tanaka H, Toyota K Akashi H, Yamagishi G, Sato T, Tyler CR, Iguchi T, Miyagawa S.
Characterization of G protein-coupled estrogen receptors in Japanese medaka, Oryzias latipes.
J Appl Toxicol. 41:1390–1399, 2021
Iguchi T, Sato T, Nakajima T, Miyagawa S, Takasugi N.
New frontiers of developmental endocrinology opened by researchers connecting irreversible effects of sex hormones on developing organs. (review)
Differentiation 18:4–23, 2021
Toyota K, Masuda S, Sugita S, Miyaoku K, Yamagishi G, Akashi H, Miyagawa S.
Estrogen receptor 1 (ESR1) agonist induces ovarian differentiation and aberrant Müllerian duct development in Chinese soft-shelled turtle, Pelodiscus sinensis.
Zool Stud. 59:54, 2020
Parsons A, Lange A, Kudoh T, Hutchinson T, Miyagawa S, Iguchi T, Tyler CR.
Expression dynamics of genes in the hypothalamic-pituitary-thyroid (HPT) cascade and their responses to 3,5,3’-tri-iodothyronine highlights potential vulnerability to thyroid-disrupting chemicals in zebrafish (Danio rerio) embryo-larvae.
Aquat Toxicol. 225:105547, 2020
Terauchi KJ, Miyagawa S, Iguchi T, Sato T.
Hedgehog signaling regulates the basement membrane remodeling during folliculogenesis in the neonatal mouse ovary.
Cell Tissue Res. 381:555–567, 2020
Lange A, Paris J, Gharbi K, Cezard T, Miyagawa S, Iguchi T, Studholme D, Tyler CR.
A newly developed genetic sex marker and its application to understanding chemically induced feminisation in roach (Rutilus rutilus).
Mol Ecol Resour. 20:1007–1022, 2020
Kajioka D, Suzuki K, Nakada S, Matsushita S, Miyagawa S, Takeo T, Nakagata N, Yamada G.
Bmp4 is an essential growth factor for the initiation of genital tubercle (GT) outgrowth.
Congenit Anom (Kyoto). 60:15–21, 2020
Hyuga T, Alcantara M, Kajioka D, Haraguchi R, Suzuki K, Miyagawa S, Kojima Y, Hayashi Y, Yamada G.
Hedgehog signaling for urogenital organogenesis and prostate cancer: an implication for the epithelial-mesenchyme interaction (EMI). (review)
Int J Mol Sci. 21:58, 2019
Hyuga T, Suzuki K, Acebedo AR, Hashimoto D, Kajimoto M, Miyagawa S, Enmi J, Yoshioka Y, Yamada G.
Regulatory roles of epithelial-mesenchymal interaction (EMI) during early and androgen dependent external genitalia development. (review)
Differentiation 110:29–35, 2019
Hirano Y, Suzuki K, Iguchi T, Yamada G, Miyagawa S.
The role of Fgf signaling on epithelial cell differentiation in mouse vagina.
In Vivo 33:1499–1505, 2019
Oikawa S, Kobayashi S, Miyagawa S, Iguchi T, Sato T.
Diethylstilbestrol alters the expression of activins in the neonatal mouse ovary in vitro.
In Vivo 33:1095–1102, 2019
Parsons A, Lange A, Hutchinson TH, Miyagawa S, Iguchi T, Kudoh T, Tyler CR.
Molecular mechanisms and tissue targets of brominated flame retardants, BDE-47 and TBBPA, in embryo-larval life stages of zebrafish (Danio rerio).
Aquat Toxicol. 209:99–112, 2019
Acebedo AR, Suzuki K, Hino S, Alcantara, MC, Haga H, Matsumoto KI, Nakao M, Shimamura K, Takeo T, Nakagata N, Miyagawa S, Nishinakamura R, Adelstein, RS, Yamada G.
Mesenchymal actomyosin contractility is required for androgen-driven urethral masculinization in mice.
Commun Biol. 8:95, 2019
Kojima Y, Koguchi T, Mizuno K, Sato Y, Hoshi S, Hata J, Nishio H, Hashimoto D, Matsushita S, Suzuki K, Miyagawa S, Hui CC, Tanikawa C, Murakami Y, Yamada G, Hayashi Y, Matsuda K.
Single nucleotide polymorphisms of HAAO and IRX6 genes as risk factors for hypospadias
J Urol. 201:386–392, 2019
Ogino Y, Tohyama S, Kohno S, Toyota K, Yamada G, Yatsu R, Kobayashi T, Tatarazako N, Sato T, Matsubara H, Lange A, Tyler CR, Katsu Y, Iguchi T, Miyagawa S.
Functional distinctions associated with the diversity of sex steroid hormone receptors ESR and AR. (review)
J Steroid Biochem Mol Biol. 184:38–46, 2018
Matsushita S, Suzuki K, Murashima A, Kajioka D, Acebedo AR, Miyagawa S, Haraguchi R, Ogino Y, Yamada G.
Regulation of masculinization: androgen signalling for external genitalia development. (review)
Nat Rev Urol. 15:358–368, 2018
Fujimoto N, Kitamura S, Uramaru N, Miyagawa S, Iguchi T.
Identification of hepatic thyroid hormone-responsive genes in neonatal rats: potential targets for thyroid hormone-disrupting chemicals.
Toxicol Lett. 286:48–53, 2018
Kohno S, Katsu Y, Cipoletti N, Wang LC, Jorgenson ZG, Miyagawa S, Schoenfuss HL.
Divergent responsiveness of two isoforms of the estrogen receptor to mixtures of contaminants of emerging concern in four vertebrates.
J Appl Toxicol. 38:705–713, 2018
Tohyama S, Ogino Y, Lange A, Myosho T, Kobayashi T, Hirano Y, Yamada G, Sato T, Tatarazako N, Tyler CR, Iguchi T, Miyagawa S.
Establishment of estrogen receptor 1 (ESR1)-knockout medaka; ESR1 is dispensable for sexual development and reproduction in medaka, Oryzias latipes.
Dev Growth Diff. 59:552–561, 2017
Matsubara K, Nakamura N, Sanoh S, Ohta S, Kitamura S, Uramaru N, Miyagawa S, Iguchi T, Fujimoto N.
Altered expression of Olr59, Ethe1, and Slc10a2 genes in the liver of F344 rats by neonatal thyroid hormone disruption.
J Appl Toxicol. 37:1030–1035, 2017
Lange A, Corcorana J, Miyagawa S, Iguchi T, Winter MJ, Tyler CR.
Development of a common carp (Cyprinus carpio) pregnane X receptor (cPXR) transactivation reporter assay and its activation by azole fungicides and pharmaceutical chemicals.
Toxicol In Vitro 41:114–122, 2017
Toyota K, Gavin A, Miyagawa S, Viant MR, Iguchi T.
Metabolomics reveals an involvement of pantothenate for male production responding to the short-day stimulus in the water flea, Daphnia pulex.
Sci Rep. 6:25125, 2016
Yatsu R, Katsu Y, Kohno S, Mizutani T, Ogino Y, Ohta Y, Myburgh J, van Wyk JH, Guillette Jr LJ, Miyagawa S#, Iguchi T.
Characterization of evolutionary trend in squamate estrogen receptor sensitivity.
Gen Comp Endocrinol. 238:88–95, 2016
Sumiya E, Ogino Y, Toyota K, Miyakawa H, Miyagawa S, Iguchi T.
Neverland regulates embryonic molts through the regulation of ecdysteroids synthesis in the water flea Daphnia magna.
J Appl Toxicol. 36:1476–1485, 2016
Toyota K, Hiruta C, Ogino Y, Miyagawa S, Okamura T, Onishi Y, Tatarazako N, Iguchi T.
Comparative developmental staging of the female and male water fleas Daphnia pulex and Daphnia magna during embryogenesis.
Zool Sci. 33:31–37, 2016
Yatsu R, Miyagawa S, Kohno S, Parrott BB, Yamaguchi K, Ogino Y, Miyakawa H, Lowers RH, Shigenobu S, Guillette Jr LJ, Iguchi T.
RNA-seq analysis of the gonadal transcriptome during Alligator mississippiensis temperature- dependent sex determination and differentiation.
BMC Genomics 17:77, 2016
Tohyama S*, Miyagawa S*#, Lange A, Ogino Y, Mizutani T, Ihara M, Tanaka H, Tatarazako N, Kobayashi T, Tyler CR, Iguchi T.
Evolution of estrogen receptors in ray-finned fish and their comparative responses to estrogenic substances.
J Steroid Biochem Mol Biol. 158:189–197, 2016
Ogino Y, Kuraku S, Ishibashi H, Miyakawa H, Sumiya E, Miyagawa S, Matsubara H, Yamada G, Baker ME, Iguchi T.
Neofunctionalization of androgen receptor by gain-of-function mutations in teleost fish lineage.
Mol Biol Evol. 33:228–244, 2016
Yatsu R*, Miyagawa S*, Kohno S, Saito S, Ogino Y, Katsu Y, Ohta Y, Tominaga M, Guillette Jr LJ, Iguchi T.
TRPV4 associates environmental temperature and sex determination in the American alligator.
Sci Rep. 5:18581, 2015
Lange A, Sebirea M, Rostkowski P, Mizutani T, Miyagawa S, Iguchi T, Hill EM, Tyler CR.
Environmental chemicals active as human antiandrogens do not activate a stickleback androgen receptor but enhance a feminising effect of oestrogen in roach.
Aquat Toxicol. 168:48–59, 2015
Miyagawa S, Iguchi T.
Epithelial estrogen receptor 1 intrinsically mediates squamous differentiation in the mouse vagina.
Proc Natl Acad Sci USA. 112:12986–12991, 2015
Tohyama S*, Miyagawa S*#, Lange A, Ogino Y, Mizutani T, Tatarazako N, Katsu Y, Ihara M, Tanaka H, Ishibashi H, Tatarazako N, Kobayashi T, Tyler CR, Iguchi T.
Understanding the molecular basis for differences in responses of fish estrogen receptor subtypes to environmental estrogens.
Environ Sci Technol. 49:7439–7447, 2015
Miyagawa S, Yatsu R, Kohno S, Doheny BM, Ogino Y, Ishibashi H, Katsu Y, Ohta Y, Guillette Jr LJ, Iguchi T.
Identification and characterization of the androgen receptor from the American alligator, Alligator mississippiensis.
Endocrinology 156:2795–2806, 2015
Ihara M, Kitamura T, Kumar V, Park C, Ihara MO, Lee S, Yamashita N, Miyagawa S, Iguchi T, Okamoto S, Suzuki Y, Tanaka H.
Evaluation of estrogenic activity of wastewater: comparison among in vitro ERa reporter gene assay, in vivo vitellogenin induction, and chemical analysis.
Environ Sci Technol. 49:6319–6326, 2015
Toyota K, Miyakawa H, Yamaguchi K, Shigenobu S, Ogino Y, Tatarazako N, Miyagawa S, Iguchi T.
NMDA receptor activation on the upstream of methyl farnesoate signaling for short-day induced male offspring production in water flea Daphnia pulex.
BMC Genomics 16:1392, 2015
Toyota K, Miyakawa H, Hiruta C, Furuta K, Ogino Y, Shinoda T, Tatarazako N, Miyagawa S, Shaw JR, Iguchi T.
Methyl farnesoate synthesis is necessary for the environmental sex determination in the water flea Daphnia pulex.
J Insect Physiol. 80:22–30, 2015
Bain PA, Ogino Y, Miyagawa S, Iguchi T, Kumar A.
Differential ligand selectivity of androgen receptors α and β from Murray-Darling rainbowfish (Melanotaenia fluviatilis).
Gen Comp Endocrinol. 212C:84–91, 2015
Miyagawa S, Sato M, Sudo T, Yamada G, Iguchi T.
Unique roles of estrogen-dependent Pten control in epithelial cell homeostasis of mouse vagina.
Oncogene 34:1035–1043, 2015
Abe R, Toyota K, Miyakawa H, Watanabe H, Oka T, Miyagawa S, Nishide H, Uchiyama I, Tollefsen KE, Iguchi T, Tatarazako N.
Diofenolan induces male offspring production through binding to the juvenile hormone receptor in Daphnia magna.
Aquat Toxicol. 159:44–51, 2015
Mohapatra S, Chakraborty T, Miyagawa S, Zhou L, Ohta K, Iguchi T, Nagahama Y.
Steroid responsive regulation of IFNg2 alternative splicing and its possible role in germ cell proliferation in medaka.
Mol Cell Endocrinol. 400:61–70, 2015
Miyagawa S, Lange A, Tohyama S, Ogino Y, Mizutani T, Kobayashi T, Tatarazako N, Tyler CR, Iguchi T.
Characterization of Oryzias latipes glucocorticoid receptors and their unique response to progestins.
J Appl Toxicol. 35: 302–309, 2015
Hiruta C, Ogino Y, Sakuma T, Toyota K, Miyagawa S, Yamamoto T, Iguchi T.
Targeted gene disruption by use of transcription activator-like effector nuclease (TALEN) in the water flea Daphnia pulex.
BMC Biotechnol. 14:95, 2014
Sébillot A, Damdimopoulou P, Ogino Y, Spirhanzlova P, Miyagawa S, Du Pasquier D, Mouatassim N, Iguchi T, Lemkine GF, Demeneix BA, Tindall AJ.
Rapid fluorescent detection of (anti)androgens with spiggin-gfp medaka.
Environ Sci Technol. 48:10919–10928, 2014
Ihara M, Ihara MO, Kumar V, Narumiya M, Hanamoto S, Nakada N, Yamashita N, Miyagawa S, Iguchi T, Tanaka H.
Co-occurrence of estrogenic and antiestrogenic activities in wastewater: quantitative evaluation of balance by in vitro ERa reporter gene assay and chemical analysis.
Environ Sci Technol. 48:6366–6373, 2014
Omori A, Miyagawa S, Ogino Y, Harada M, Ishii K, Sugimura Y, Ogino H, Nakagata N, Yamada G.
Essential roles of epithelial bone morphogenetic protein signaling during prostatic development.
Endocrinology 155:2534–2544, 2014
Miyagawa S, Lange A, Hirakawa I, Tohyama S, Ogino Y, Mizutani T, Kagami Y, Kusano T, Ihara M, Tanaka H, Tatarazako N, Ohta Y, Katsu Y, Tyler CR, Iguchi T.
Differing species responsiveness of estrogenic contaminants in fish is conferred by the ligand binding domain of the estrogen receptor.
Environ Sci Technol. 48:5254–5263, 2014
Kohno S, Parrott BB, Yatsu R, Miyagawa S, Moore BC, Iguchi T, Guillette Jr LJ.
Gonadal differentiation in reptiles exhibiting environmental sex determination.
Sex Dev. 8:208–226, 2014
Hamlin HJ, Lowers RH, Kohno S, Mitsui-Watanabe N, Amano H, Hara A, Ohta Y, Miyagawa S, Iguchi T, Guillette LJ.
The reproductive hormone cycle of adult female American alligators from a barrier island population.
Reproduction 147:855–863, 2014
Miyagawa S, Harada M, Matsumaru D, Tanaka K, Inoue C, Nakahara C, Haraguchi R, Matsushita S, Suzuki K, Nakagata N, Ng RC, Akita K, Lui VC, Yamada G.
Disruption of the temporally regulated cloaca endodermal b-catenin signaling causes anorectal malformations.
Cell Death Differ. 21: 990–997, 2014
Toyota K, Kato Y, Miyakawa H, Yatsu R, Mizutani T, Ogino Y, Miyagawa S, Watanabe H, Nishide H, Uchiyama I, Tatarazako N, Iguchi T.
Molecular impact of juvenile hormone agonists on neonatal Daphnia magna.
J Appl Toxicol. 34, 537–544, 2014
Ogino Y, Hirakawa I, Miyakawa H, Inohaya K, Sumiya E, Miyagawa S, Denslow N, Yamada G, Tatarazako N, Iguchi T.
Bmp7 and Lef1 are the downstream effectors of androgen signaling in androgen-induced sex characteristics development in medaka.
Endocrinology 155:449–462, 2014
Sumiya E, Ogino Y, Hirakawa I, Hiruta C, Toyota K, Miyagawa S, Iguchi T.
Roles of ecdysteroids for progression of reproductive cycle in the fresh water crustacean Daphnia magna.
Front Zool. 11:60, 2014
Hiruta C, Toyota K, Miyakawa H, Ogino Y, Miyagawa S, Tatarazako N, Shaw J, Iguchi T.
Development of a microinjection system for RNA interference in the water flea Daphnia pulex.
BMC Biotechnol. 13:96, 2013
Miyakawa H, Toyota K, Hirakawa I, Ogino Y, Miyagawa S, Oda S, Tatarazako N, Miura T, Colbourne JK, Iguchi T.
A mutation in the receptor Methoprene-tolerant alters juvenile hormone response in insects and crustaceans.
Nat Commun. 4:1856, 2013
Toyota K, Kato Y, Sato M, Sugiura N, Miyagawa S, Miyakawa H, Watanabe H, Oda S, Ogino Y, Hiruta C, Mizutani T, Tatarazako N, Paland S, Jackson C, Colbourne JK, Iguchi T.
Molecular cloning of doublesex genes of four cladocera (water flea) species.
BMC Genomics 14:239, 2013
Villacorte M, Suzuki K, Hirasawa A, Ohkawa Y, Suyama M, Maruyama M, Aoki D, Ogino Y, Miyagawa S, Terabayashi T, Tomooka Y, Nakagata N and Yamada G.
b-Catenin signaling regulates Foxa2 expression during endometrial hyperplasia formation.
Oncogene 32:3477–3482, 2013
Hirakawa I*, Miyagawa S*, Mitsui N, Miyahara M, Onishi Y, Kagami Y, Kusano T, Takeuchi T, Ohta Y, Iguchi T.
Developmental disorders and altered gene expression in the tropical clawed frog (Silurana tropicalis) exposed to 17a-ethinylestradiol.
J Appl Toxicol. 33:1001–1010, 2013
Oka T, Mitsui-Watanabe N, Tatarazako N, Onishi Y, Katsu Y, Miyagawa S, Ogino Y, Yatsu R, Kohno S, Takase M, Kawashima Y, Ohta Y, Aoki Y, Guillette LJ Jr, Iguchi T.
Establishment of transactivation assay systems using fish, amphibian, reptilian and human thyroid hormone receptors.
J Appl Toxicol. 33:991–1000, 2013
Katsu Y, Lange A, Miyagawa S, Urushitani H, Tatarazako N, Kawashima Y, Tyler CR, Iguchi T.
Cloning, expression and functional characterization of carp, Cyprinus carpio, estrogen receptors and their differential activations by estrogens.
J Appl Toxicol. 33:41–49, 2013
Nakamura T, Miyagawa S, Katsu Y, Sato T, Iguchi T, Ohta Y.
Sequential changes in the expression of Wnt- and Notch-related genes in the vagina and uterus of ovariectomized mice after estrogen exposure.
In Vivo 26:899–906, 2012
Haraguchi R, Matsumaru D, Nakagata N, Miyagawa S, Suzuki K, Kitazawa S, Yamada G.
The hedgehog signal induced modulation of bone morphogenetic protein signaling: an essential signaling relay for urinary tract morphogenesis.
PLoS One 7:e42245, 2012
Nakamura T, Miyagawa S, Katsu Y, Mizutani T, Sato T, Takeuchi T, Iguchi T, Ohta Y.
P21 and Notch signalings in the persistently altered vagina induced by neonatal diethylstilbestrol exposure in mice.
J Vet Med Sci. 74:1589–1595, 2012
Nakamura T, Miyagawa S, Katsu Y, Watanabe H, Mizutani T, Sato T, Morohashi KI, Takeuchi T, Iguchi T, Ohta Y.
WNT family genes and their modulation in the ovary-independent and persistent vaginal epithelial cell proliferation and keratinization induced by neonatal diethylstilbestrol exposure in mice.
Toxicology 296:13–19, 2012
Hirakawa I*, Miyagawa S*, Katsu Y, Kagami Y, Tatarazako N, Kobayashi T, Kusano T, Mizutani T, Ogino Y, Takeuchi T, Ohta Y, Iguchi T.
Gene expression profiles in the testis associated with testis-ova in adult Japanese medaka (Oryzias latipes) exposed to 17alpha-ethinylestradiol.
Chemosphere 87:668–674, 2012
Lange A, Katsu Y, Miyagawa S, Ogino Y, Urushitani H, Kobayashi T, Hirai T, Shears JA, Nagae M, Yamamoto J, Ohnishi Y, Oka T, Tatarazako N, Ohta Y, Tyler CR, Iguchi T.
Comparative responsiveness to natural and synthetic estrogens of fish species commonly used in the laboratory and field monitoring.
Aquat Toxicol. 109:250–258, 2012
Miyagawa S, Matsumaru D, Murashima A, Omori A, Satoh Y, Haraguchi R, Motoyama J, Iguchi T, Nakagata N, Hui CC, Yamada G.
The role of sonic hedgehog-gli2 pathway in the masculinization of external genitalia.
Endocrinology 152:2894–2903, 2011
Miyagawa S, Sato M, Iguchi T.
Molecular mechanisms of induction of persistent changes by estrogenic chemicals on female reproductive tracts and external genitalia.
J Steroid Biochem Mol Biol. 127:51–57, 2011 (Review)
Ogino Y, Miyagawa S, Katoh H, Prins GS, Iguchi T, Yamada G.
Essential functions of androgen signaling emerged through the developmental analysis of vertebrate sex characteristics.
Evol Dev. 13:315–325, 2011
Murashima A, Miyagawa S, Ogino Y, Nishida-Fukuda H, Araki K, Matsumoto T, Kaneko T, Yoshinaga K, Yamamura KI, Kurita T, Kato S, Moon AM, Yamada G.
Essential roles of androgen signaling in Wolffian duct stabilization and epididymal cell differentiation.
Endocrinology 152:1640–1651, 2011
Matsumaru D, Haraguchi R, Miyagawa S, Motoyama J, Nakagata N, Meijlink F, Yamada G.
Genetic analysis of hedgehog signaling in ventral body wall development and the onset of omphalocele formation.
PLoS One 20:e16260, 2011
Urushitani H, Katsu Y, Miyagawa S, Kohno S, Ohta Y, Guillette LJ Jr, Iguchi T.
Molecular cloning of anti-Müllerian hormone from the American alligator; Alligator mississippiensis.
Mol Cell Endocrinol. 333:190–199, 2011
Chakraborty T, Katsu Y, Zhou LY, Miyagawa S, Nagahama Y, Iguchi T.
Estrogen receptors in medaka (Oryzias latipes) and estrogenic environmental contaminants: An in vitro-in vivo correlation.
J Steroid Biochem Mol Biol. 123:115–121, 2011
Katsu Y, Kohno S, Narita H, Urushitani H, Yamane K, Hara A, Clauss TM, Walsh MT, Miyagawa S, Guillette Jr LJ, Iguchi T.
Cloning and functional characterization of Chondrichthyes, cloudy catshark, Scyliorhinus torazame and whale shark, Rhincodon typus estrogen receptors.
Gen Comp Endocrinol. 168:496–504, 2010
Huang CC, Miyagawa S, Matsumaru D, Parker KL, Yao HH.
Progenitor cell expansion and organ size of mouse adrenal is regulated by sonic hedgehog.
Endocrinology 151:1119–1128, 2010
Katsu Y, Taniguchi E, Urushitani H, Miyagawa S, Takase M, Kubokawa K, Tooi O, Oka T, Santo N, Myburgh J, Matsuno A, Iguchi T.
Molecular cloning and characterization of ligand- and species-specificity of amphibian estrogen receptors.
Gen Comp Endocrinol. 168:220–230, 2010
Miyagawa S, Katsu Y, Ohta Y, Sudo T, Lubahn DB, Iguchi T.
Estrogen receptor ESR1 is indispensable for the induction of persistent vaginal change by neonatal 5alpha-dihydrotestosterone exposure in mice.
Biol Reprod. 82:497–503, 2010
Miyagawa S, Moon A, Haraguchi R, Inoue C, Harada M, Nakahara C, Suzuki K, Matsumaru D, Kaneko T, Matsuo, I, Yang L, Taketo MM, Iguchi T, Evans SM, Yamada G.
Dosage dependent hedgehog signals integrated with Wnt/b-catenin regulate embryonic external genitalia formation as an appendicular program.
Development 136:3969–3978, 2009
Miyagawa S, Satoh Y, Haraguchi R, Suzuki K, Iguchi T, Taketo MM, Nakagata N, Matsumoto T, Takeyama K, Kato S, Yamada G.
Genetic integrations of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia.
Mol Endcrinol. 23:871–880, 2009
Ohta S, Suzuki K, Ogino Y, Miyagawa S, Murashima A, Matsumaru D, Yamada G.
Gene transduction by sonoporation.
Dev Growth Differ. 50: 517–520, 2008
Nishida H*, Miyagawa S*, Matsumaru D, Wada Y, Satoh Y, Ogino Y, Fukuda S, Iguchi T, Yamada G.
Gene expression analyses on embryonic external genitalia: identification of regulatory genes possibly involved in masculinization processes.
Congenit Anom (Kyoto). 48:63–67, 2008
Nishida H, Miyagawa S, Vieux-Rochas M, Morini M, Ogino Y, Suzuki K, Nakagata N, Choi HS, Levi G, Yamada G.
Positive regulation of steroidogenic acute regulatory protein (StAR) gene expression through the interaction between Dlx and GATA-4 for testicular steroidogenesis.
Endocrinology 149:2090–2097, 2008
Haraguchi R, Motoyama J, Sasaki H, Satoh Y, Miyagawa S, Nakagata N, Moon A, Yamada G.
Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling.
Development 134:525–533, 2007
Orlando EF, Katsu Y, Miyagawa S, Iguchi T.
Cloning and differential expression of estrogen receptor and aromatase genes in the self-fertilizing hermaphrodite and male mangrove rivulus, Kryptolebias marmoratus.
J Mol Endocrinol. 37:353–365, 2006
Kobayashi M, Takahashi E, Miyagawa S, Watanabe H, Iguchi T.
Chromatin immunoprecipitation-mediated target identification proved aquaporin 5 is regulated directly by estrogen in the uterus.
Genes Cells. 11:1133–1143, 2006
Yamada G, Suzuki K, Haraguchi R, Miyagawa S, Satoh Y, Kamimura M, Nakagata N, Kataoka H, Kuroiwa A, Chen Y.
Molecular genetic cascades for external genitalia formation: An emerging organogenesis program.
Dev Dyn. 235:1738–1752, 2006 (review)
Miyagawa S, Suzuki A, Katsu Y, Kobayashi M, Goto M, Handa H, Watanabe H, Iguchi T.
Persistent gene expression in mouse vagina exposed neonatally to diethylstilbestrol.
J Mol Endocrinol. 32:663–677, 2004
Katsu Y, Bermudez DS, Braun EL, Helbing C, Miyagawa S, Gunderson MP, Kohno S, Bryan TA, Guillette LJ Jr, Iguchi T.
Molecular cloning of the estrogen and progesterone receptors of the American alligator.
Gen Comp Endocrinol. 136:122–133, 2004
Miyagawa S, Katsu Y, Watanabe H, Iguchi T.
Estrogen-independent activation of erbBs signaling and estrogen receptor alpha in the mouse vagina exposed neonatally to diethylstilbestrol.
Oncogene 23:340–349, 2004
Iguchi T, Watanabe H, Katsu Y, Mizutani T, Miyagawa S, Suzuki A, Kohno S, Sone K, Kato H.
Developmental toxicity of estrogenic chemicals on rodents and other species.
Congenit Anom (Kyoto). 42:94–105, 2002 (review)
Miyagawa S, Buchanan DL, Sato T, Ohta Y, Nishina Y, Iguchi T.
Characterization of diethylstilbestrol-induced hypospadias in female mice.
Anat Rec. 266:43–50, 2002