Research

Neuronal networks, diversity, and specificity of function are important to both physiological processes and neurological disorders, including epilepsy and essential tremor.  The K-M lab seeks to improve our understanding of how cells interact within a network, how networks interact with each other, and the physiological roles of neuronal populations.  In this regard, key questions remain in epilepsy research, including what are the principal networks, conditions, and cell types involved in initiating, sustaining, propagating, terminating, and potentially suppressing, seizures.  By improving our understanding of these, we improve the prospects of someday reaching the goal of no seizures, no side effects, for all epilepsy patients.  Similarly, basic questions regarding the development and expression of essential tremor remain.  
The K-M lab uses rodent models of neurological disorders, including temporal lobe epilepsy and essential tremor, and techniques including electrophysiology, optogenetics, immunocytochemistry, transgenic animals, and behavioral experiments to address these fundamental questions.

Check out the Publications tab to learn more.


Funding Sources
Current
  • National Institute of Health, R03-NS098015-01 
  • 07/01/2016 – 06/30/2018

  • National Institute of Health, NINDS, R00 NS087110
    05/1/2015 - 04/30/2018

  • University of Minnesota’s MnDRIVE (Minnesota’s Discovery, Research and Innovation Economy) initiative
  • International Essential Tremor Foundation (IETF)
    07/01/2016 - 06/30/2017

  • National Institute of Health, R01-MH111413 , Co-Investigator (PI: Wei Chen)            
    07/01/2016 – 06/30/2021


Past
  • Citizens United for Research in Epilepsy (CURE), Taking Flight Award 2014
    On-demand restoration of the dentate gate for temporal lobe epilepsy
    01/01/2014 - 12/31/2014

  • National Institute of Health, NINDS, K99 NS087110
    On-demand optogenetic cerebellar intervention for temporal lobe epilepsy
    09/01/2014 - 12/15/2015