Research

Neuronal networks, diversity, and specificity of function are important to both physiological processes and neurological disorders, including epilepsy and essential tremor. The K-M lab seeks to improve our understanding of how cells interact within a network, how networks interact with each other, and the physiological roles of neuronal populations. In this regard, key questions remain in epilepsy research, including what are the principal networks, conditions, and cell types involved in initiating, sustaining, propagating, terminating, and potentially suppressing, seizures. By improving our understanding of these, we improve the prospects of someday reaching the goal of no seizures, no side effects, for all epilepsy patients. Similarly, basic questions regarding the development and expression of essential tremor remain.

The K-M lab uses rodent models of neurological disorders, including temporal lobe epilepsy and essential tremor, and techniques including electrophysiology, optogenetics, immunocytochemistry, transgenic animals, and behavioral experiments to address these fundamental questions.

Check out the Publications tab to learn more.

Funding Sources

Current

  • National Institute of Health, R01-NS112518

"Hippobellum: Cerebellar influence on the hippocampus and temporal lobe seizures"

03/01/2020 – 11/30/2024

  • National Institute of Health, R01-NS104071

"A novel inhibitory target for temporal lobe epilepsy"

12/01/2017-11/30/2022

  • University of Minnesota's Academic Investment Research Program (AIRP)
    Center for Cerebellar Network Structure/Function in Health and Disease

  • University of Minnesota’s MnDRIVE (Minnesota’s Discovery, Research and Innovation Economy) Initiative

  • University of Minnesota’s Center for Neural Circuits in Addiction pilot funding , Co-Investigator (PI: Patrick Rothwell)

  • National Institute of Health, R01-MH111413 , Co-Investigator (PI: Wei Chen)

07/01/2016 – 06/30/2021


Past

  • University of Minnesota McKnight Land-Grant Professorship
    7/1/2018 – 6/30/2020

  • National Institute of Health, R03-NS098015
    07/01/2016 – 06/30/2018

  • National Institute of Health, NINDS, R00-NS087110
    05/1/2015 - 04/30/2018

  • Winston and Maxine Wallin Neuroscience Discovery Fund Award
    "Refocusing : Targeting the Cerebellum for Temporal Lobe Epilepsy"
    01/01/2018 - 12/31/2018

  • Institute for Engineering in Medicine (IEM) Seed Grant
    01/12/2017– 01/11/2018

  • Citizens United for Research in Epilepsy (CURE), Taking Flight Award
    "On-demand restoration of the dentate gate for temporal lobe epilepsy"
    01/01/2014 - 12/31/2014

  • National Institute of Health, NINDS, K99 NS087110
    "On-demand optogenetic cerebellar intervention for temporal lobe epilepsy"
    09/01/2014 - 12/15/2015

  • International Essential Tremor Foundation (IETF)
    07/01/2016 - 06/30/2017