Not one, but TWO new KMLab BioRxiv preprints:
1) Streng, Tetzlaff, Krook-Magnuson
Distinct fastigial output channels and their impact on temporal lobe seizures
2) Stieve, Richner, Krook-Magnuson, Netoff, Krook-Magnuson
Optimization of closed-loop electrical stimulation enables robust cerebellar-directed seizure control
That's a lot of cool stuff...
Posted Sept 2021.
Sad to say goodbye...
We are super sad to have had to say goodbye to two great lab members -- Isaac Hoff and Madi Tetzlaff -- but our load is lightened by knowing they are on to great next things in their lives.
Also, the lab surprised me by secretly making lab shirts...
Posted July 2021.
Excitatory and Inhibitory Neurons' Responses to Transcranial Focus Ultrasound
Congratulations to our collaborators Kai Yu, Xiaodan Niu, and Bin He on the publication of their work looking at the impact of transcranial focused ultrasound (tFUS) on excitatory and inhibitory neuronal populations: Yu and Niu et al, Nature Communications, 2021
Posted May 2021.
Oh, the places they're going!
Madeline Marker, Yaro Pochinka, and Julia Klein will all be starting medical school at the University of Minnesota this coming year, and Katerina Hoffman will be starting at Rocky Vista University Physician Assistant program in Denver CO. Madi Tetzlaff will be starting the MSTProgram at UCI. Congratulations to all!!
Posted April 2021.
Kayla Togneri awarded Fullbright
Kayla Togneri will be completing a Fullbright at Universidad Peruana Cayetano Heredia (UPCH) in Lima, Peru directly with Dr. Hector H. Garcia and with support from Dr. Javier Bustos and Dr. Gianfranco Arroyo. The title of her project is "Hippocampal sclerosis as a clinical correlate of neurocysticercosis in endemic populations". Congratulations Kayla!
Posted April 2021.
Congratulations to Lauren Glassburn on receiving an MnDRIVE Fellowship!
Lauren has been awarded an MnDRIVE Brain Conditions fellowship for 2021-2022 to study long-range inhibitory projections from the hippocampus. Congratulations Lauren!!
Posted April 2021.
Update: We have finally gotten to celebrate this in person! Check out Lauren popping the champagne here.
Congratulations to our collaborators on these exciting publications!
Ritchie Chen, Felicity Gore, Quynh-Anh Nguyen, Charu Ramakrishnan, Sneha Patel, Soo Hyun Kim, Misha Raffiee, Yoon Seok Kim, Brian Hsueh, Esther Krook-Magnusson, Ivan Soltesz & Karl Deisseroth
Nature Biotechnology (2020) Published: 05 October 2020
Francesca Billwiller, Laura Castillo, Heba Elseedy, Anton Ivanovich Ivanov, Jennyfer Scapula, Antoine Ghestem, Julien Carponcy, Paul Antoine Libourel, Hélène Bras, Nabila ElSayed Abdelmeguid, Esther Krook-Magnuson, Ivan Soltesz, Christophe Bernard, Pierre-Hervé Luppi, Monique Esclapez
Brain Struct Funct (2020). Published: 24 Sep 2020
Happy (Socially Distanced) October from the KM Lab!
Congratulations to Dr. Angela Nietz and all the authors on the publication of
"Selective loss of the GABA Aα1 subunit from Purkinje cells is sufficient to induce a tremor phenotype" in Journal of Neurophysiology.
Congratulations to Jessica Froula on receiving an MnDRIVE Brain Conditions Fellowship for 2020-2021!
We're a little late announcing this one thanks to COVID, but no less excited about it.
Well done Jessica!
Stay tuned for all the exciting science Jessica is working on.
Update: A much belated celebration finally happened. Watch Jessica pop the champagne bottle here.
Congratulations to Bethany on being awarded an MnDRIVE Informatics Fellowship!
Find out more about the fellowship program here.
Watch Bethany pop the champagne bottle here.
Martha's paper has been published (available now in pretty pdf form!) in JPhysiol. Key take away in brief:
On-demand excitation of excitatory neurons in the cerebellar fastigial nucleus provides robust inhibition of hippocampal seizures in the IHKA mouse model. Inhibition of the same cells does nothing.
For a plain English version, check out EpilepsyInEnglish's write up of Martha's work here!
Sinem's Visit Comes to an end -- Nov 30, 2019
It was great havin Muhsine Sinem Ethemoglu Sari in the lab the past few weeks. Her enthusiasm for science was terrific and will be missed. Best wishes!
Zoe's paper accepted & published at eLIFE. -- Oct 14, 2019
The hippocampus, a brain region important for spatial navigation and episodic memory, benefits from a rich diversity of neuronal cell-types. Through the use of an intersectional genetic viral vector approach in mice, we report novel hippocampal neurons which we refer to as LINCs, as they are long-range inhibitory neuronal nitric oxide synthase (nNOS)-expressing cells. LINCs project to several extrahippocampal regions including the tenia tecta, diagonal band, and retromammillary nucleus, but also broadly target local CA1 cells. LINCs are thus both interneurons and projection neurons. LINCs display regular spiking non-pyramidal firing patterns, are primarily located in the stratum oriens or pyramidale, have sparsely spiny dendrites, and do not typically express somatostatin, VIP, or the muscarinic acetylcholine receptor M2. We further demonstrate that LINCs can strongly influence hippocampal function and oscillations, including interregional coherence. Identification and characterization of these novel cells advances our basic understanding of both hippocampal circuitry and neuronal diversity.
Dr. Christenson Wick — Aug 5, 2019 2:54:21 PM
A great big congratulations to Dr. Zoe Christenson Wick on successfully defending her dissertation! She's off to do a postdoc in the lab of Tristan Shuman at Mt. Sinai, and will be missed.
Thank you to all her family and friends for coming out to support her, and thank you to all of her committee members that helped guide us through the process.
Congratulations to UROP Awardees Madison Tetzlaff & Jane Yap — Jul 31, 2019
Madison Tetzlaff and Jane Yap were both (!) awarded UROP Awards for their proposed Fall 2019 studies in the KM lab. Way to go!
Madi Poster Presentation — May 14, 2019
Madison Tetzlaff presented her poster and braved hard to identify veggies at the U's Undergraduate Research Symposium, April 25th.
Epilepsy & Gene Therapy — Dec 12, 2018 7:41:52 PM
Purple — Nov 6, 2018 2:28:29 AM
Congratulations, Bethany!! — Oct 26, 2018 5:57:23 PM
Accepted for publication — Jun 29, 2018 5:59:41 PM
Poster Prizes — May 24, 2018 4:28:45 PM
Accepted for publication! — May 16, 2018 8:48:39 PM
Congrats to Zach, aka "President's Student Leadership and Service Awardee" — Mar 29, 2018 3:54:17 PM
Congratulations, Zoe! — Mar 19, 2018 7:41:31 PM
Did you know? — Feb 19, 2018 11:32:39 PM
International Epilepsy Day — Feb 12, 2018 4:08:01 PM
McKnight Land-Grant Professorship — Jan 31, 2018 3:46:39 PM
Another big congrats to Zach! He's going to get his NRSA! — Jan 22, 2018 9:43:05 PM
Congratulations to Zach on being awarded an UMII MnDRIVE Graduate Assistantship — Dec 18, 2017 11:14:24 PM
Congratulations to Mikaela Brandt-Fontaine on receiving an UROP award! — Dec 15, 2017 5:03:34 AM
Epilepsy Awareness Month — Nov 1, 2017 7:44:49 PM
Zoé Christenson Wick's Image selected for the cover of the November 2017 JNR — Oct 30, 2017 6:26:58 PM
Rise Above Seizures Walk 2017 — Sep 12, 2017 3:40:49 AM
Zoé Christenson Wick is awarded a Hello Bio Travel Award — Jun 13, 2017 4:32:20 PM
The IWSP8 will be held in Minneapolis this August! — May 15, 2017 12:55:57 AM
Job Opening - 317038 - Position has been filled — Apr 24, 2017 8:37:34 PM
Senator Franken came to the U to discuss NIH Funding — Apr 19, 2017 3:03:13 AM
Welcome to the world Alister! — Mar 7, 2017 4:01:30 AM
Best Undergraduate Research Mentor — Mar 7, 2017 3:58:37 AM
Congrats to Martha Streng on receiving a Milne & Brandenburg Research Award — Mar 7, 2017 3:55:01 AM
Congratulations to Zoé on receiving a Stark Award — Mar 1, 2017 2:58:54 AM
Congratulations to Zoé, Caara, Casey, and Bin! — Feb 16, 2017 2:27:55 AM
Zoé Christenson Wick is awarded the Spring and Ying Ngoh Lin award — Feb 16, 2017 2:21:48 AM
Zach Zeidler's Epilepsy Currents Commentary — Jul 7, 2016 7:08:27 PM
We are hiring! — Jul 7, 2016 6:54:18 PM
Wilson Yu's Frontiers Review paper — Dec 10, 2015 9:09:40 PM
KM-lab featured in Health Talk — Nov 11, 2015 7:37:01 PM
Zach Zeidler is awarded the 2015 Morris Smithberg Award — Oct 14, 2015 9:40:30 PM
Wilson Yu receives the MNDrive Post-Doctoral Fellowship — Apr 29, 2015 1:03:25 AM
Optogenetics in the spotlight — Apr 29, 2015 1:02:06 AM
Esther's latest article is out in the Journal of Physiology. — Apr 10, 2015 3:28:44 PM
Nature Neuroscience Review — Apr 10, 2015 3:26:13 PM
Cure Conversations — Apr 10, 2015 3:24:53 PM