Latest News

Thank you to UMD Biomedical Sciences for hosting this year's Neurosciences retreat

and

congratulations to Shayne Hastings on wining first prize for her poster presentation!

Posted June 2024

Congratulations to Jacob Weiner on being accepted into medical school at the U of M! We're super happy you'll be around for a few more years!

Posted June 2024

Thank you to all the undergraduates that contributed to the science in the KMLab this past semester. And congratulations to all on their end of the semester presentations.

Huge shout out to Molly for winning Best Presentation (two time champ!).

Posted May 2024

The Krook-Magnuson Lab has two new BioRxiv preprints! Check them out to see what we've been up to lately (and to have your mind blown).

Froula J, Rose J, Krook-Magnuson C, Krook-Magnuson E.
"Distinct functional classes of CA1 hippocampal interneurons are modulated by cerebellar stimulation in a coordinated manner"
BioRxiv 2024
https://doi.org/10.1101/2024.05.14.594213

Streng M, Kottke B, Wasserman E, Zecker L, Luong L, Ebner T, Krook-Magnuson E
"Early and widespread engagement of the cerebellum during hippocampal epileptiform activity"
bioRxiv 2024
https://doi.org/10.1101/2024.05.14.593969

Posted May 2024

Congratulations to DOCTOR Jessica Froula on the successful defense of her thesis! :)

Check out the full bottle opening video here

posted April 2024

Congratulations to Jacob Weiner on winning a poster prize at the 2024 Neuromodulation Symposium!

posted April 2024

Undergraduates Kat Paige, Adam Weiner, Molly Kimball, Aidan Holovnia, and Alex Ismail gave their end-of-the-semester presentations this week (in matching outfits...) and did a great job! Special congratulations to Molly on taking home the Best Presentation trophy (and shout-out to Chris Dulla for the trophy motivation).

posted December 2023

Farewell to Martha and Annual Pumpkin Carving Party

Boo!

Posted Oct 2023

Congratulations to soon-to-be-Assistant Professor Martha Streng!

A gigantic congratulations to Dr. Streng as she is about to embark on her independent career as an Assistant Professor, starting in November 2023.
ps- She's hiring!

Posted Oct 2023

Congratulations to KM Lab Undergraduates on a successful year!

Special congratulations to graduating seniors: Laurel Schuck, Jacob Weiner, Jarrett Rose, and Sam Phillip.

Thank you for all of your contributions to the KMLab.

Posted May 2023

Congratulations to Shayne Hastings for winning a poster presentation award at UMN's Neuromodulation Symposium!

Every year the University of Minnesota hosts a Neuromodulation Symposium. Check it out and attend in 2024 to learn more about all sorts of cutting edge neuromodulation-related research.

Posted 2023

Martha Streng awarded a K99!

It's official -- Martha has been awarded a K99 award from NIH! Congratulations Martha!

Posted July 2022

Congratulations to Ben Kottke!

Congratulations to Ben on receiving a poster award at the first annual Post Bacc Research Poster session, hosted by the MINDS program. It was great to see the wonderful turnout for this event. Thank you to Ben Saunders and the MINDS program for putting this event together!

Posted June 2022

Congratulations to Doctor Stieve!

Congratulations to Bethany Stieve, PhD on the successful defense of her dissertation! (And opening a champagne bottle like a pro.)

A job well done!

Posted May 2022

Many humble thanks to the CBS student body, for awarding me The Golden Pipettes "Most Passionate Professor Award" for exceptional enthusiasm for sharing knowledge. It was great to hear that I've inspired some of you to pursue Neuroscience!

I'm happy that even having to do lectures over zoom can't hide how truly awesome neuroscience is.

Posted April 2022

Congratulations to Bethany Stieve and thank you to the Institute for Engineering in Medicine.

Bethany has been awarded an IEM Walter Barnes Lang Travel Award, which she will use to attend the ICTALs conference this summer. Congratulations Bethany!

Posted April 2022

Congratulations to Shayne Hastings on receiving an MnDRIVE Neuromodulation Fellowship!

This award will allow Shayne to further investigate the anatomical underpinnings and functional consequences of the hippobellum. Congratlations Shayne!

March 2022

Congratulations to Bethany Stieve and Tom Richner for their joint first author publication in Brain: "Optimization of closed-loop electrical stimulation enables robust cerebellar-directed seizure control"

This work couldn't have been done with the amazing support and effort of our collaborator Tay Netoff.

Stieve B, Richner T, Krook-Magnuson C, Netoff T, Krook-Magnuson E
Optimization of closed-loop electrical stimulation enables robust cerebellar-directed seizure control
Brain. 08 February 2022; https://doi.org/10.1093/brain/awac051

Congratulations to Lauren Glassburn on her amazing F31 NRSA score!

Well done Lauren!

Also note those bottle opening skills!

https://photos.app.goo.gl/fagwVvK63Rw2nDfcA

4/12/22 update: NOA received!

Martha and Madi's beautiful paper is now out!

Streng M, Tetzlaff M, Krook-Magnuson E. "Distinct fastigial output channels and their impact on temporal lobe seizures". Journal of Neuroscience. 29 October 2021
https://doi.org/10.1523/JNEUROSCI.0683-21.2021

Not one, but TWO new KMLab BioRxiv preprints:

1) Streng, Tetzlaff, Krook-Magnuson
https://www.biorxiv.org/content/10.1101/2021.08.18.456836v1
Distinct fastigial output channels and their impact on temporal lobe seizures

2) Stieve, Richner, Krook-Magnuson, Netoff, Krook-Magnuson
https://www.biorxiv.org/content/10.1101/2021.09.03.458908v1
Optimization of closed-loop electrical stimulation enables robust cerebellar-directed seizure control

That's a lot of cool stuff...

Posted Sept 2021.

Sad to say goodbye...

We are super sad to have had to say goodbye to two great lab members -- Isaac Hoff and Madi Tetzlaff -- but our load is lightened by knowing they are on to great next things in their lives.

Also, the lab surprised me by secretly making lab shirts...

Posted July 2021.

Finally got to get together!

It was great to get together and decorate some mugs! Check out the gems here.

Posted June 2021.

Excitatory and Inhibitory Neurons' Responses to Transcranial Focus Ultrasound

Congratulations to our collaborators Kai Yu, Xiaodan Niu, and Bin He on the publication of their work looking at the impact of transcranial focused ultrasound (tFUS) on excitatory and inhibitory neuronal populations: Yu and Niu et al, Nature Communications, 2021

Posted May 2021.

Oh, the places they're going!

Madeline Marker, Yaro Pochinka, and Julia Klein will all be starting medical school at the University of Minnesota this coming year, and Katerina Hoffman will be starting at Rocky Vista University Physician Assistant program in Denver CO. Madi Tetzlaff will be starting the MSTProgram at UCI. Congratulations to all!!

Posted April 2021.

Kayla Togneri awarded Fullbright

Kayla Togneri will be completing a Fullbright at Universidad Peruana Cayetano Heredia (UPCH) in Lima, Peru directly with Dr. Hector H. Garcia and with support from Dr. Javier Bustos and Dr. Gianfranco Arroyo. The title of her project is "Hippocampal sclerosis as a clinical correlate of neurocysticercosis in endemic populations". Congratulations Kayla!

Posted April 2021.

Congratulations to Lauren Glassburn on receiving an MnDRIVE Fellowship!

Lauren has been awarded an MnDRIVE Brain Conditions fellowship for 2021-2022 to study long-range inhibitory projections from the hippocampus. Congratulations Lauren!!

Posted April 2021.

Update: We have finally gotten to celebrate this in person! Check out Lauren popping the champagne here.

Congratulations to our collaborators on these exciting publications!

Deep brain optogenetics without intracranial surgery

Ritchie Chen, Felicity Gore, Quynh-Anh Nguyen, Charu Ramakrishnan, Sneha Patel, Soo Hyun Kim, Misha Raffiee, Yoon Seok Kim, Brian Hsueh, Esther Krook-Magnusson, Ivan Soltesz & Karl Deisseroth

Nature Biotechnology (2020) Published: 05 October 2020

GABA-glutamate supramammillary neurons control theta and gamma oscillations in the dentate gyrus during paradoxical (REM) sleep

Francesca Billwiller, Laura Castillo, Heba Elseedy, Anton Ivanovich Ivanov, Jennyfer Scapula, Antoine Ghestem, Julien Carponcy, Paul Antoine Libourel, Hélène Bras, Nabila ElSayed Abdelmeguid, Esther Krook-Magnuson, Ivan Soltesz, Christophe Bernard, Pierre-Hervé Luppi, Monique Esclapez

Brain Struct Funct (2020). Published: 24 Sep 2020

Happy (Socially Distanced) October from the KM Lab!

Congratulations to Dr. Angela Nietz and all the authors on the publication of

"Selective loss of the GABA Aα1 subunit from Purkinje cells is sufficient to induce a tremor phenotype" in Journal of Neurophysiology.

Congratulations to Dr. Zachary Zeidler on the successful defense of his thesis.

Sad to see him go, but happy to announce that Zach is now Dr. Zeidler!

The final portion of his thesis just came out in Journal of Neuroscience.

Zach is off to UCLA to do a postdoc in the lab of Laura DeNardo.

Congratulations to Jessica Froula on receiving an MnDRIVE Brain Conditions Fellowship for 2020-2021!

We're a little late announcing this one thanks to COVID, but no less excited about it.

Well done Jessica!

Stay tuned for all the exciting science Jessica is working on.

Update: A much belated celebration finally happened. Watch Jessica pop the champagne bottle here.

Bethany Stieve awarded MnDRIVE Informatics Fellowship -- Dec, 2019

Congratulations to Bethany on being awarded an MnDRIVE Informatics Fellowship!

Find out more about the fellowship program here.

Watch Bethany pop the champagne bottle here.

Even a single 50ms light pulse to excite excitatory fastigial neurons can stop seizures! (aka: Martha's paper is published!) -- Dec, 2019

Martha's paper has been published (available now in pretty pdf form!) in JPhysiol. Key take away in brief:

On-demand excitation of excitatory neurons in the cerebellar fastigial nucleus provides robust inhibition of hippocampal seizures in the IHKA mouse model. Inhibition of the same cells does nothing.

For a plain English version, check out EpilepsyInEnglish's write up of Martha's work here!

Sinem's Visit Comes to an end -- Nov 30, 2019

It was great havin Muhsine Sinem Ethemoglu Sari in the lab the past few weeks. Her enthusiasm for science was terrific and will be missed. Best wishes!

Zoe's paper accepted & published at eLIFE. -- Oct 14, 2019

Abstract

The hippocampus, a brain region important for spatial navigation and episodic memory, benefits from a rich diversity of neuronal cell-types. Through the use of an intersectional genetic viral vector approach in mice, we report novel hippocampal neurons which we refer to as LINCs, as they are long-range inhibitory neuronal nitric oxide synthase (nNOS)-expressing cells. LINCs project to several extrahippocampal regions including the tenia tecta, diagonal band, and retromammillary nucleus, but also broadly target local CA1 cells. LINCs are thus both interneurons and projection neurons. LINCs display regular spiking non-pyramidal firing patterns, are primarily located in the stratum oriens or pyramidale, have sparsely spiny dendrites, and do not typically express somatostatin, VIP, or the muscarinic acetylcholine receptor M2. We further demonstrate that LINCs can strongly influence hippocampal function and oscillations, including interregional coherence. Identification and characterization of these novel cells advances our basic understanding of both hippocampal circuitry and neuronal diversity.

Get the full manuscript here!

Park City, here we come! — Aug 19, 2019 9:52:40 PM

Congratulations to Martha & Bethany on getting travel awards to attend the Park City Epilepsy meeting!

You can come too! Information and register here: http://www.parkcityepilepsymeeting.com/

Dr. Christenson Wick — Aug 5, 2019 2:54:21 PM

A great big congratulations to Dr. Zoe Christenson Wick on successfully defending her dissertation! She's off to do a postdoc in the lab of Tristan Shuman at Mt. Sinai, and will be missed.

Thank you to all her family and friends for coming out to support her, and thank you to all of her committee members that helped guide us through the process.