Publications

Recent Updates from the KM Lab

Jessica's research paper is now available at J Neuroscience:


Research & Protocol Publications

"Distinct functional classes of CA1 hippocampal interneurons are modulated by cerebellar stimulation in a coordinated manner"

Journal of Neuroscience.   Oct 2024

https://doi.org/10.1523/JNEUROSCI.0887-24.2024 


"LINCs Are Vulnerable to Epileptic Insult and Fail to Provide Seizure Control via On-Demand Activation"

eNeuro.  February 2023

https://doi.org/10.1523/ENEURO.0195-22.2022


"Optimization of closed-loop electrical stimulation enables robust cerebellar-directed seizure control"

Brain.  08 February 2022

https://doi.org/10.1093/brain/awac051


"Distinct fastigial output channels and their impact on temporal lobe seizures"

Journal of Neuroscience.   29 October 2021

https://doi.org/10.1523/JNEUROSCI.0683-21.2021

See also Trends in Neurosciences writeup:  "The cerebellum on the epilepsy frontline", Rondi-Reig, 2022
and Epilepsy Currents commentary: "Not All Paths are Equal: Stimulating Specific Cerebellar Outputs Inhibits Hippocampal Seizures", Buchanan 2022


"Selective loss of the GABAAα1 subunit from Purkinje cells is sufficient to induce a tremor phenotype"

Journal of Neurophysiology

09 SEP 2020 https://doi.org/10.1152/jn.00100.2020


"HippoBellum: acute cerebellar modulation alters hippocampal dynamics and function"

Journal of Neuroscience.  2 September 2020, 40 (36) 6910-6926 

https://doi.org/10.1523/JNEUROSCI.0763-20.2020

Check out a brief summary in This Week in the Journal. (scroll down)


"Excitation, but not inhibition of the fastigial nucleus provides powerful control over temporal lobe seizures"

J Physiol (2020) 598(1): 171-187 [Epub ahead of print: Nov 4, 2019.  doi: 10.1113/JP278747 ]

For a plain English explanation of Martha's paper,  check out EpilepsyInEnglish's write up of Martha's work here.

To see associated cover art, click here.


"Novel long-range inhibitory nNOS-expressing hippocampal cells"

eLIFE (2019) Oct 14;8. pii: e46816. doi: 10.7554/eLife.46816 

Find associated BrdU protocol published in bio-101 here.


"Targeting the Mouse Ventral Hippocampus in the Intrahippocampal Kainic Acid Model of Temporal Lobe Epilepsy"

eNeuro (2018) 0158-18.2018; doi: 10.1523/ENEURO.0158-18.2018


"Axonal sprouting in commissurally projecting parvalbumin-expressing interneurons"

Journal of Neuroscience Research. (2017) doi: 10.1002/jnr.24011

To see associated cover art, click here.


"In Vivo Evaluation of the Dentate Gate Theory in Epilepsy. "

Journal of Physiology. (2015)   doi: 10.1113/JP270056


"Cerebellar Directed Optogenetic Intervention Inhibits Spontaneous Hippocampal Seizures in a Mouse Model of Temporal Lobe Epilepsy"

eNeuro 2014. DOI: 10.1523/ENEURO.0005-14.2014

See also Epilepsy Currents writeup:  "Illuminating the Cerebellum as a Potential Target for Treating Epilepsy: Targeting the Cerebellum in Epilepsy", Wong & Escayg, 2015

And Nature's summary: https://www.nature.com/articles/515469d


"Closed-loop optogenetic intervention in mice."

Nature Protocol. 2013 Aug;8(8):1475-93. doi: 10.1038/nprot.2013.080. Epub 2013 Jul 11.


"On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy."

Nature Communications. 2013;4:1376. doi: 10.1038/ncomms2376.


"Ivy and neurogliaform interneurons are a major target of μ-opioid receptor modulation."

J Neurosci. 2011 Oct 19;31(42):14861-70. doi: 10.1523/JNEUROSCI.2269-11.2011.


"Tonically active inhibition selectively controls feedforward circuits in mouse barrel cortex."

J Neurophysiol. 2008 Aug;100(2):932-44. doi: 10.1152/jn.01360.2007. Epub 2008 May 28.


"Excitability of cortical neurons depends upon a powerful tonic conductance in inhibitory networks."

Thalamus Relat Syst. 2005 Jun;3(2):115-120.

Pre-prints not yet out in final form



In Collaboration...

Levetiracetam prevents neurophysiological changes and preserves cognitive function in the HIV-1 TAT transgenic mouse model of HIV-associated neurocognitive disorder

J Pharmacol Exp Ther (2024)


TRPM7 kinase mediates hypomagnesemia-induced seizure-related death

Scientific Reports (2023).


Intrinsic functional neuron-type selectivity of transcranial focused ultrasound neuromodulation

Nature Communications (2021).  


GABA-glutamate supramammillary neurons control theta and gamma oscillations in the dentate gyrus during paradoxical (REM) sleep

Brain Struct Funct (2020).  


Deep brain optogenetics without intracranial surgery

Nature Biotechnology (2020).


Reviews & Book Chapters

"The cerebellum's understated role and influences in the epilepsies"

Neurobiology of Disease (2023) ; doi: 10.1016/j.nbd.2023.106160


"The little brain and the seahorse: cerebellar-hippocampal interactions"

Frontiers in Systems Neuroscience (2023) ; https://doi.org/10.3389/fnsys.2023.1158492 


"Stimulating Solutions for Intractable Epilepsy"

Epilepsy Currents  (2021) ; https://doi.org/10.1177/15357597211012466


"The cerebellum and epilepsy"

Epilepsy & Behavior (2021) ; https://doi.org/10.1016/j.yebeh.2020.106909 


"Specificity, Versatility, and Continual Development: The Power of Optogenetics for Epilepsy Research"

Front. Cell. Neurosci. (2018) doi: 10.3389/fncel.2018.00151


"Cognitive collaborations: bidirectional functional connectivity between the cerebellum and the hippocampus"

Frontiers in Systems Neuroscience. (2015)  doi: 10.3389/fnsys.2015.00177


"Beyond the hammer and the scalpel: selective circuit control for the epilepsies."

Nature Neuroscience 18, 331–338 (2015) doi:10.1038/nn.3943


"Neuroelectronics and bio-optics: Closed-loop technologies in neurological disorders."

 JAMA Neurology (2015) doi:10.1001/jamaneurol.2015.0608


"Future of Seizure Prediction and Intervention: Closing the loop."

Journal of Clinical Neurophysiology. (2015) doi: 10.1097/WNP.0000000000000139 


"How might novel technologies such as optogenetics lead to better treatments in epilepsy?"

Adv Exp Med Biol. 2014;813:319-36. doi: 10.1007/978-94-017-8914-1_26. 


"Neurogliaform and Ivy Cells: A Major Family of nNOS Expressing GABAergic Neurons."

Front Neural Circuits. 2012 May 16;6:23. doi: 10.3389/fncir.2012.00023. eCollection 2012.


"New dimensions of interneuronal specialization unmasked by principal cell heterogeneity."

Trends Neurosci. 2012 Mar;35(3):175-84. doi: 10.1016/j.tins.2011.10.005. Epub 2011 Nov 24. 


"The transience of interneuron circuit diversity just "sped" up."

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16723-4. Epub 2007 Oct 15. 

Commentaries

The Devil’s in the Details: How to Harness Inhibition for Seizure Control

Epilepsy Currents (first published Feb 2020); Vol 20, Issue 2, 2020


From Point A to Point B, and What it Means for Epilepsy.

Epilepsy Currents (first published Dec 2019); Vol 20, Issue 1, 2020


Seizing Sequencing Data to Consider Cell and Circuity Complexity

Epilepsy Currents March/April 2019, Vol 19, No. 2, pp. 124-125.


"Progress Toward Precise Genetic Repair in Neurons"

Epilepsy Currents March/April 2018, Vol 18, No. 2, pp. 121-122.


"Back to the Dentate: Network Changes of Early- and Late-Born Dentate Granule Cells"

Epilepsy Currents Jan/Feb 2018, Vol. 18, No. 1, pp. 49-50


"Targeting Newly Generated Granule Cells: A Double-Edged Sword"

Epilepsy Currents: March/April, Vol. 17, No. 2, pp. 121-123. (2017)


"The Gate and the Source? The Dentate Gyrus Takes Central Stage in Temporal Lobe Epilepsy" 

Epilepsy Currents: January/February, Vol. 17, No. 1, pp. 48-49. (2017)


"Downsides and Downstream Effects of Interictal Epileptiform Discharges"

Epilepsy Currents: September/October, Vol. 16, No. 5, pp. 325-326. (2016)


"One Site to Rule Them All: Toward a Master Regulator of Ictal Activity"

Epilepsy Currents. (2016) doi: 10.5698/1535-7511-16.3.170


The transience of interneuron circuit diversity just "sped" up.

PNAS (2007); 104(43):16723-4.  doi: 10.1073/pnas.0708149104


Edited Publications

"Illuminating seizures: optogenetic approaches to studying networks in epilepsy"