GBD_ICE_Day1

GBD-ICE Injury Meetings Day 1

Focus on GBD Injury

When: Oct 8 2009

Where: Harvard University, Cambridge, MA, USA

Agenda: Agenda.doc

Attended by: Kunuz Abdela, Jerry Abraham, J. Lee Annest, Deb Azrael, Cathy Barber, Kidist Bartolomeos, Kavi Bhalla, Colin Cryer, Nicole DeSantis, Vanessa Fawcett, Lois Fingerhut, Belinda Gabbe, Sue Gallagher, Rolf Gedeborg, Juanita Haagsma, James Harrison, David Hemenway, Yvette Holder, John Langley, Ronan Lyons, Alison MacPherson, Richard Matzopoulous, Kirsten McKenzie, Matt Miller, Ted Miller, Robert Mtonga, Takashi Nagata, Ian Pike, Megan Prinsloo, Fred Rivara, Yvonne Robatille, Maria Segui-Gomez, Saeid Shahraz, Gordon Smith, Jennifer Taylor, Maria Valenti, Margaret Warner, Pon-Hsiu Yeh, Diego Zavala

Presentations

Introduction (Speaker: Kavi Bhalla)

Purpose: Members of the GBD-Injury expert group met to report on progress, get feedback, and plan for future directions for various aspects of ongoing research related with the GBD-2005 project.

Meeting Notes:

After brief introductions, Kavi Bhalla provided a briefing on the history and recent activities of the GBD Injury expert group. The primary purpose of the expert group is to ensure that the best methods and data sources on injuries flow into the GBD study and sensible estimates of the burden of injuries flow out. Thus the work of the group is divided into the theoretical-side being done as discussion papers led by various established researchers in the injury community and an aggressive hunt for data sources lead by the group at Harvard University. At this stage in the GBD-2005 project, it is important for the Injury expert group to push ahead on the following topics: compilation of evidence reported in the academic literature about the incidence, and disability consequences of injuries (Session 1); methods for estimating in regions that are particularly information-poor (Session 2); methods for dealing with poor data quality and filling information gaps (Session 3 and 4).

1.Kavi_GBD_day_Introduction.ppt

Literature Reviews - overview (Speaker: James Harrison)

Session 1 focused on literature reviews. James Harrison started the session by explaining the need for GBD-2005 to summarize the literature for estimating the incidence and prevalence of injuries and the progression and duration of the injury. James described a standardized systematic literature review methodology that is being used by the group. There is only a small window of opportunity to get this work included in the GBD-2005 study. The literature reviews have a current deadline of the end of this year (2009) to report data back to the GBD-Central team.

Saeid Shahraz described the process of conducting a literature review for transport injuries and showed preliminary results. The transport literature review has focused heavily on identifying population-based measurements (usually surveys) of non-fatal injuries. He described the search strategy, the inclusion/exclusion criteria and what data was extracted. The discussion focused on some key methodological issues related with surveys (in particular definition of injury, and potential recall biases).

Fred Rivara described the current status for estimating the incidence, prevalence, and disability from burns. Their systematic review found 11 articles. However, the majority of the articles were hospital case series, without a defined catchment area. There were a few studies on the population level incidence of burns, although no studies provided the data needed for the GBD calculations. Analysis of available data from select countries will be conducted and will be used to make projections of the burned of injury form burns.

Call for volunteers for literature reviews: Several literature reviews still don’t have leaders. There is an urgent need for volunteers who can make substantial progress by the current deadline of the end of 2009. All interested researchers should contact Claire Bryan-Hancock (claire.bryanhancock@flinders.edu.au).

2_James-GBD Literature Re...ws on Injury2009Oct08.ppt

Literature Review: Transport (Speaker: Saeid Shahraz)

It should be noted that during these meetings the issue of potential underestimation of suicides and homicides by GBD due to misclassification of intentional injuries to unintentional injuries in death registration data was highlighted. Literature reviews for suicide and homicide could be important mechanisms for addressing these issues for the project.

In Session II, Kavi Bhalla briefed the group about the new project being undertaken by his group for estimating the burden of injuries in Sub-Saharan Africa with funding from the World Bank Global Road Safety Facility. The project aims to develop methods for estimating the burden of injuries that can be applied in regions that are particularly information poor. The project has duration of one year starting Oct 1 2009. Kavi provided a briefing on the outcome of the planning meeting with key collaborators that was held a day earlier (Oct 7).

Session III focused on methods for handling partially-specified causes. Kavi provided a brief overview of the issue as it relates with GBD-2005. In particular, GBD-2005 will rely heavily on mortality data. The Injury Expert group has recently completed an evaluation of the quality of global injury mortality data and found that the quality of data is poor, with more than 20% deaths in various partially-specified causes, even in many high income countries. This creates a substantial risk of biased estimates. The GBD-Central team is developing panel data methods to reassign deaths coded to partially-specified categories that exist across all diseases and injuries. The injury expert group can add value to this process by testing the validity of these results wherever other data sources permit better estimation methods.

Belinda Gabbe described results using multiple cause of death data from the death register in Wales (UK) and linking the death registration data to hospital admission data to estimate what external causes get coded to unintentional injuries from unspecified causes (ICD10:X59). The results showed that most cases coded to X59 are among the elderly and are likely falls.

3_Saeid RTI systematic review.ppt

Literature Review : TBI (Speaker: James Harrison)

Lois Fingerhut described results from using multiple causes of deaths data in the US to investigate cases coded to X59. Lois compared the effect of redistributing X59 cases proportionally based on diagnosis with the default age-sex- proportional redistribution methods that have been used in the past by GBD. The results showed that the age-sex- proportional redistribution leads to higher estimates of road injuries and lower estimates of falls especially among the elderly.

The final session, Session IV, of the day focused on extrapolation methods for filling information gaps. Pon-Hsiu Yeh provided a summary of the information gaps – focusing on what types of data sources are available to the project in different regions of the world. She proposed the development of three analytical tools that could be used to fill information gaps: (1) Injury pyramids, i.e. the ratio of number of deaths to the number of non-fatal injuries. These will need to be age, sex, external-cause and region specific. (2) E=>N mappings or external cause to nature of injury mappings. These provide a description of health states resulting from each external cause. These would have to be age-sex- specific. (3) Probability of admission: This allows mapping between incidence of injury hospitalization to incidence of all injuries. These would need to be age-sex- and region specific. Discussions focused on the suitability/reliability of making extrapolations using such tools.

While the main focus of the remaining two days of the joint GBD-ICE Injury meetings was on Injury ICE related work, there were several presentations of interest to the GBD-2005 Injury work. These included:

4_James-GBD-LitRevTBI2009Oct08.ppt

Literature Review : Burns (Speaker: Fred Rivara)

    • Kavi launched the Global Injury Mortality Database, which is a public repository of mortality data being collected for the GBD-2005 project. A few presentations focused on using data from this database (Lois Fingerhut: Suicides, Jennifer Taylor: Adverse medical effects and Kavi Bhalla: Road Injuries)
    • The strategic planning session on Day 3 discussed the future of the expert group beyond the lifespan of the GBD-2005 project. Various models were proposed. In particular, continuing to pursue the work under the banner of the Global Burden of Injuries (see www.globalburdenofinjuries.org) was discussed. This would be a loose alliance of projects that focus on global injury metrics work.
    • On Day 3, Ronan Lyons discussed the preliminary plans for a cluster of meetings related with burden of injuries to be held in Swansea in conjunction with the Safety 2010 conference in London (21-24 Sept 2010), where we expect there would be various opportunities to discuss GBD-Injury related work.
5_RIVARA gbd burns.ppt

The presentations that go along with these last three items can be found on the webpages related with Day 2 and Day 3 of the joint GBD-ICE Injury meetings.

Burden of Injuries in Africa (Speaker: Kavi Bhalla)

6_Kavi_Africa.ppt

Dealing with partially specified causes (Speaker: Kavi Bhalla)

7_Kavi_Unspecifieds.ppt

Unspecifieds in Wales (Speaker: Belinda Gabbe)

8_Belinda_Cymru_Deaths_GBD2009.ppt

Unspecifieds in the US (Speaker: Lois Fingerhut)

9_Lois_Unspecified in the US ‎(GBD talk)‎.ppt

Filling information gaps (Speaker: Pon-Pon Yeh)

10_PonPres.ppt