Cerebral Blood Flow (CBF)

• CBF depends on cerebral perfusion pressure (CPP) and cerebral vascular resistance (CVR)

normal CPP >50 mmHg in adults

• cerebral autoregulation maintains constant CBF by compensating for changes in CPP, unless:

  • high ICP such that CPP <60 mmHg

  • MAP >150 mmHg or MAP <50 mmHg

  • brain injury: e.g. SAH, severe trauma