3DUnit | DRUG DISCOVERY & DEVELOPMENT RESEARCH UNIT
Molecular Pharmacology and Cancer Therapeutics

OVERVIEW


The main research focus at 3DUnit is the identification of pharmacological modulators of human cancer-related proteins, including PKC family, p53 family, caspase family, and BRCAs, through an approach that combines yeast, human cell lines and animal models.

The research activities of the group are mainly focused on:
• Development of yeast models for functional and molecular studies of human disease-related proteins: yeast targeted screening assays
• Molecular and pharmacological studies in human tumor cell lines
• In vitro drug-protein binding assays
• Pharmacological studies in human tumor xenografts mice models