References
Acid
[a-i] “I have observed that when the use of fat or oily food has been persevered in for some time, there is generally the presence of bile in the gastric fluids.” Experiments and Observations on the Gastric Juice, and the Physiology of Digestion by William Beaumont, 1833
Experiments and Observations on the Gastric Juice, and the Physiology of ... - William Beaumont, Alexis St. Martin - Google Books
https://books.google.co.uk/books?id=LOwqAAAAYAAJ&source=gbs_book_other_versions
[a-ii] Dramatic diurnal variation in the concentration of the human trefoil peptide TFF2 in gastric juice -- Semple et al. 48 (5): 648 -- Gut
http://gut.bmj.com/content/48/5/648.short
[a-iii] Host-Bacterial Interactions in Helicobacter pylori Infection - Gastroenterology
http://www.gastrojournal.org/article/S0016-5085(07)02016-1/abstract?
[a-iv] Results - Drug Class Review: Proton Pump Inhibitors - NCBI Bookshelf
http://www.ncbi.nlm.nih.gov/books/NBK47258/
[a-v] Systematic review of PPI and H2A in Reflux oesophagitis
http://www.medicine.ox.ac.uk/bandolier/bandopubs/gordf/gord.html
[a-vi] Esomeprazole provides improved acid control vs. omeprazole In patients with symptoms of gastro-oesophageal reflux disease. - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/10886041
[a-vii] Management of reflux esophagitis: does the choice of proton pump inhibitor matter? - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/25721889
[a-viii] BMC Gastroenterology | Full text | Gaviscon(R) vs. Omeprazole in symptomatic treatment of moderate gastroesophageal reflux. A direct comparative randomised tria...
http://www.biomedcentral.com/1471-230X/12/18
[a-ix] Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population - PLoS one
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124653
[a-x] Risk of acute myocardial infarction in patients with gastroesophageal reflux disease: A nationwide population-based study - PLoS one]
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173899#sec015
[a-xi] Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease | Acute Kidney Injury | JAMA Internal Medicine | The JAMA Network
http://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2481157
[a-xii] Proton Pump Inhibitors and Risk of Dementia | Dementia and Cognitive Impairment | JAMA Neurology | The JAMA Network
http://jamanetwork.com/journals/jamaneurology/fullarticle/2487379
[a-xiii] Doctors: Be wary of new PPI studies linking drug to health problems | The Brattleboro Reformer | Brattleboro Breaking News, Sports, Weather, Traffic
[a-xiv] Proton Pump Inhibitors and Risk of Mild Cognitive Impairment and Dementia - Goldstein - 2017 - Journal of the American Geriatrics Society - Wiley Online Library
http://onlinelibrary.wiley.com/doi/10.1111/jgs.14956/abstract
[a-xv] Proton pump inhibitor use may not prevent high-grade dysplasia and oesophageal adenocarcinoma in Barrett’s oesophagus: a nationwide study of 9883 patients - Alimentary Pharmacology & Therapeutics
www.voiceinstituteofnewyork.com/wp-content/uploads/2011/01/PPIs-Dont-Prevent-Cancer.pdf
[a-xvi] Letter: proton pump inhibitor usage still seems to reduce the risk of high-grade dysplasia and/or oesophageal adenocarcinoma in Barrett's oesophagus - Aydin - 2014 - Alimentary Pharmacology & Therapeutics - Wiley Online Library
http://onlinelibrary.wiley.com/doi/10.1111/apt.12892/full
[a-xvii] Proton pump inhibitor use may not prevent high-grade dysplasia and oesophageal adenocarcinoma in Barrett's oesophagus: a nationwide study of 9883 patients - PubMed ...
http://www.ncbi.nlm.nih.gov/pubmed/24617286
[a-xviii] Acid-suppressive medications and risk of oesophageal adenocarcinoma in patients with Barrett's oesophagus: a systematic review and meta-analysis -- Singh et al....
http://gut.bmj.com/content/early/2013/11/12/gutjnl-2013-305997
[a-xix] PPIs Protective for Esophageal Cancer
[a-xx] Acid-suppressive medications and risk of oesophageal adenocarcinoma in patients with Barrett’s oesophagus: a systematic review and meta-analysis - Gut
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199831/
[a-xxi] Proton Pump Inhibitors Display Antitumor Effects in Barrett's Adenocarcinoma Cells - Frontiers in Pharmacology
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122752/
[a-xxii] Dyspepsia and gastro‑oesophageal reflux disease | 1-recommendations | Guidance and guidelines | NICE
[a-xxiii] Is Apple Cider Vinegar Effective for Reducing Heartburn Symptoms Related to Gastroesophageal Reflux Disease? 2015 Thesis
https://repository.asu.edu/attachments/166181/content/Yeh_asu_0010N_15671.pdf
[a-xxiv] Consuming Too Much Apple Cider Vinegar: Here are 5 Side Effects - Foods 4 Better Health
http://www.foods4betterhealth.com/apple-cider-vinegar-side-effects-30850
Bile
[b-i] Chronic diarrhea caused by idiopathic bile acid malabsorption: an explanation at last, Expert Review of Gastroenterology & Hepatology, Informa Healthcare
http://informahealthcare.com/doi/abs/10.1586/egh.09.49
[b-ii] Acute Cholecystitis associated with pancreatic reflux
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1390992/
[b-iii] American Journal of Gastroenterology - Abstract of article: No association between gallstones and gastroesophageal reflux disease
http://www.nature.com/ajg/journal/v96/n10/abs/ajg2001715a.html
Reflux
[f-i] Heller Myotomy Versus Heller Myotomy With Dor Fundoplication for Achalasia
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1448931/
[f-ii] Laparoscopic Nissen fundoplication in the treatment of Barrett's esophagus - 10 years of experience.
http://www.ncbi.nlm.nih.gov/pubmed/23837098
[f-iii] 20 years later: laparoscopic fundoplication durability.
http://www.ncbi.nlm.nih.gov/pubmed/25487547
[f-iv] Laparoscopic Nissen-Rossetti fundoplication is effective to control gastro-oesophageal and pharyngeal reflux
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639973/
[f-v] Laparoscopic Toupet versus Nissen fundoplication for the treatment of gastroesophageal reflux disease.
http://www.ncbi.nlm.nih.gov/pubmed/14717528
[f-vi] Laparoscopic Nissen Fundoplication
http://emedicine.medscape.com/article/1892517-overview
[r-i] LPR - Aspiration of Upper Oesophageal Reflux (August 2014)
https://sites.google.com/site/robichris/barretts/lpr
[r-ii] Prevalence of Extra-Oesophageal Reflux symptoms amongst acid refluxers and perceived efficacy of regular medication and reflux reduction intervention. (CR 2017)
[r-iii] Nissen fundoplication vs proton pump inhibitors for laryngopharyngeal reflux - World Journal of Gastroenterology
https://www.wjgnet.com/1007-9327/full/v23/i19/3546.htm
[r-iv] Heartburn Hell on the NBC Today Show: omitting things consumers might want to know about a $14K device - HealthNewsReview.org
[r-v] One Hundred Consecutive Patients Treated with Magnetic Sphincter Augmentation for Gastroesophageal Reflux Disease: 6 Years of Clinical Experience from a Single ...
http://www.journalacs.org/article/S1072-7515(13)00356-6/abstract
[r-vi] Device for acid reflux approved by FDA, but not by insurers - StarTribune.com
http://www.startribune.com/device-for-acid-reflux-approved-by-fda-but-not-by-insurers/303946711/
[r-vii] LINX Procedure for GERD: Risks and Benefits
http://www.surgery.usc.edu/uppergi-general/gastroesophagealrefluxdisease-linx-risksbenefits.html
[r-viii] Laparoscopic insertion of a magnetic bead band for gastro-oesophageal reflux disease | Guidance and guidelines | NICE
http://www.nice.org.uk/guidance/ipg431
[r-ix] Removal of the Magnetic Sphincter Augmentation Device: Surgical Technique and Results - Europe PMC
http://europepmc.org/abstract/med/27163959
[r-x] Esophageal Penetration of the Magnetic Sphincter Augmentation Device: History Repeats Itself. - Journal of Laparoendoscopic and Advanced Surgical techniques
https://www.ncbi.nlm.nih.gov/pubmed/28586287
[r-xi] Linx more effective than PPIs for treating regurgitation in GERD - Gastroenterology
[r-xii] Long-term maintenance effect of radiofrequency energy delivery for refractory GERD: a decade later - Springer
http://link.springer.com/article/10.1007%2Fs00464-014-3461-6
[r-xiii] Endoluminal Treatments for Gastroesophageal Reflux Disease (GERD) - A SAGES Guideline
[r-xiv] Antireflux Transoral Incisionless Fundoplication Using EsophyX: 12-Month Results of a Prospective Multicenter Study - Springer
http://link.springer.com/article/10.1007/s00268-008-9594-9/fulltext.html
[r-xv] Two-year results of a feasibility study on antireflux transoral incisionless fundoplication using EsophyX - Springer
http://link.springer.com/article/10.1007/s00464-009-0384-8/fulltext.html
[r-xvi] Clinical and pH-metric outcomes of transoral esophagogastric fundoplication for the treatment of gastroesophageal reflux disease - Springer
http://link.springer.com/article/10.1007/s00464-010-1497-9/fulltext.html
[r-xvii] EsophyX for Transoral Incisionless Fundoplication (TIF) Proves Itself in Trial (w/video)
http://www.medgadget.com/2013/05/esophyx-for-transoral-incisionless-fundoplication-tif.html
[r-xviii] TIF Underperforming as Long-Term GERD Treatment
http://www.medscape.com/viewarticle/842806?src=wnl_edit_tpal&uac=121783PV
[r-xix] Medigus Announces Completion of First Commercial Procedures in Turkey in GERD Patients Using New Generation of MUSE™ System
[r-xx] First MUSE procedures for GERD performed in Italy
[r-xxi] Endoscopic anterior fundoplication with the Medigus Ultrasonic Surgical Endostapler (MUSE™) for gastroesophageal reflux disease: 6-month results from a multi-center prospective trial
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293474/
[r-xxii] Endoluminal gastroplication for gastro-oesophageal reflux disease | 1-guidance | Guidance and guidelines | NICE
http://www.nice.org.uk/guidance/IPG404/chapter/1-guidance
[r-xxiii] Endocinch therapy for gastro-oesophageal reflux disease: a one year prospective follow up
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1773510/
[r-xxiv] Long term failure of endoscopic gastroplication (EndoCinch)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774515/
[r-xxv] EndoCinch Procedure: Success Rates
http://www.healthline.com/health/gerd/endocinch-procedure#2
[r-xxvi] StomaphyX Gastric Bypass Revision Surgery
http://bariatric.stopobesityforlife.com/obesity-surgery/correcting-obesity/procedures/stomaphyx/
[r-xxvii] Endoluminal gastroplication for gastro-oesophageal reflux disease
http://www.nice.org.uk/guidance/ipg404
[r-xxviii] Short-term electrical stimulation of the lower esophageal sphincter increases sphincter pressure in patients with gastroesophageal reflux disease
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2982.2012.01878.x/full
[r-xxix] Electrical stimulation therapy of the lower esophageal sphincter is successful in treating GERD: final results of open-label prospective trial - Springer
http://link.springer.com/article/10.1007/s00464-012-2561-4/fulltext.html
[r-xxx] EndoStim Treats First Patient with Severe Acid Reflux... -- THE HAGUE, Netherlands and ST. LOUIS, Feb. 19, 2013 /PRNewswire/ --
[r-xxxi] Long-term results of electrical stimulation of the lower esophageal sphincter for the treatment of gastroesophageal reflux disease
https://www.thieme-connect.com/DOI/DOI?10.1055/s-0033-1344213
[r-xxxii] Two-year results of intermittent electrical stimulation of the lower esophageal sphincter treatment of gastroesophageal reflux disease - Surgery
http://www.surgjournal.com/article/S0039-6060(14)00708-9/fulltext
[r-xxxiii] EndoStim Launches Second Generation Neurostimulation Device for GERD -- NIJMEGEN, Netherlands and ST. LOUIS, May 18, 2015 /PRNewswire/ --
[r-xxxiv] Electrical stimulation of the lower oesophageal sphincter for treating gastro-oesophageal reflux disease | Guidance and guidelines | NICE
http://www.nice.org.uk/guidance/indevelopment/gid-ip1244
[r-xxxv] Endoscopic implantation of enteryx for treatment of GERD: 12-month results of a prospective, multicenter trial. - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/14499767
[r-xxxvi] Enteryx implantation for GERD: expanded multicenter trial results and interim postapproval follow-up to 24 months
http://www.rima.org/web/medline_pdf/GastrointestEndosc_650-8.pdf
[r-xxxvii] Complications involving the mediastinum after injection of Enteryx for GERD - Gastrointestinal Endoscopy
http://www.giejournal.org/article/S0016-5107(04)02645-8/abstract
[r-xxxviii] Public Health Notifications (Medical Devices) > FDA Preliminary Public Health Notification*: Recall of Boston Scientific ENTERYX® Procedure Kits.
http://www.fda.gov/MedicalDevices/Safety/AlertsandNotices/PublicHealthNotifications/ucm064523.htm
[r-xxxix] Visceral artery embolization after endoscopic injection of Enteryx for gastroesophageal reflux disease
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242123/
[r-xl] Endoscopic augmentation of the lower oesophageal sphincter using hydrogel implants for the treatment of gastro-oesophageal reflux disease
http://www.nice.org.uk/guidance/IPG222/chapter/1-guidance
[r-xli] A now rarely seen anti-reflux device: The Angelchik prosthesis - International Journal of Case Reports and Images (IJCRI)
[r-xlii] Dysphagia Secondary to an Angelchik Prosthesis Insertion: the Role of Laparoscopic Management - SAGES Abstract Archives
[r-xliii] Complications of the Angelchik Antireflux Prosthesis | Annals of Internal Medicine
http://annals.org/article.aspx?articleid=698225
[r-xliv]
Efficacy of a Novel “UES Assist Device” in Management of Supraesophageal Complications of Reflux Disease: the Results of a Limited Clinical Trial
http://www.gastrojournal.org/article/S0016-5085(12)60385-0/pdf
[r-xlv] Use of a Sleep Positioning Device Significantly Improves Nocturnal Gastroesophageal Reflux Symptoms
[r-xlvi] A Novel Sleep Assist Device Prevents Gastroesophageal Reflux: A Randomized Controlled Trial
[r-xlvii] Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer
http://clincancerres.aacrjournals.org/content/14/14/4491.full
[r-xlviii] Japanese apricot improves symptoms of gastrointestinal dysmotility associated with gastroesophageal reflux disease.
http://www.ncbi.nlm.nih.gov/pubmed/26185391
Food
[fd-i] No Association of Coffee Consumption with Gastric Ulcer, Duodenal Ulcer, Reflux Esophagitis, and Non-Erosive Reflux Disease: A Cross-Sectional Study of 8,013 Healthy Subjects in Japan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680393/
[fd-ii] Coffee or Tea, Hot or Cold, Are Not Associated With Risk of Barrett’s Esophagus - Clinical Gastroenterology and Hepatology
http://www.cghjournal.org/article/S1542-3565%2815%2901616-X/fulltext
[fd-iii] Effects of Alcohol on Barrett's oesophagus
[fd-iv] Potential Benefits of pH 8.8 Alkaline Drinking Water as an Adjunct in the Treatment of Reflux DiseaseAnnals of Otology, Rhinology & Laryngology - Jamie A. Koufman, Nikki Johnston, 2012
http://journals.sagepub.com/doi/abs/10.1177/000348941212100702
[fd-v] Alkaline Water Hoax - It is Simple Science
https://www.apswater.com/article.asp?id=198&title=Alkaline_Water_Hoax_-_It_Is_Simple_Science.
[fd-vi] Alkaline Water Helps Neutralize Heartburn Symptoms? Doctors Debunk Claims : SCIENCE : Design & Trend
[fd-vii] The Doctor is In: Water, water everywhere — which drop should we drink?
[fd-viii] American Journal of Gastroenterology - Abstract of article: The role of diet and lifestyle measures in the pathogenesis and treatment of gastroesophageal reflux disease
http://www.nature.com/ajg/journal/v95/n10/abs/ajg20001421a.html
[fd-ix] Diet and GERD: Role in Pathogenesis and Management
http://www.medscape.com/viewarticle/875920
[fd-x] Diet and GERD: Role in Pathogenesis and Management
http://www.medscape.com/viewarticle/875920
Complications
[c-i] Barrett’s Stem Cells as a Unique and Targetable Entity - Cellular and Molecular Gastroenterology and Hepatology
http://www.cmghjournal.org/article/S2352-345X(17)30079-6/fulltext
[c-ii] UK tops WHO gullet cancer table and obesity may be factor - BBC News
http://www.bbc.co.uk/news/health-29634263
[c-iii] Controversies in Barrett Esophagus - Mayo Clinic Proceedings
http://www.mayoclinicproceedings.org/article/S0025-6196(14)00107-4/fulltext
[c-iv] [Esophageal complications of gastroesophageal reflux disease: consequences or defensive reactions?] - PubMed - NCBI
https://www.ncbi.nlm.nih.gov/pubmed/28502210
[c-v] Long-term Consequences of Chronic Proton Pump Inhibitor Use
http://www.medscape.com/viewarticle/820136_print
[c-vi] Consumer Use of Over-the-Counter PPIs in Patients With GERD
http://www.medscape.com/viewarticle/826831?src=wnl_edit_tpal&uac=121783PV
[c-vii] The Risks and Benefits of Long-term Use of Proton Pump Inhibitors: Expert Review and Best Practice Advice From the American Gastroenterological Association - Gastroenterology
http://www.gastrojournal.org/article/S0016-5085(17)30091-4/fulltext
[c-viii] Proton pump inhibitor use and the risk of small intestinal bacterial overgrowth: a meta-analysis. - PubMed - NCBI
https://www.ncbi.nlm.nih.gov/pubmed/23270866
Tests and diagnosis
[t-i] Systematic Four-Quadrant Biopsy Detects Barrett's Dysplasia
http://www.medscape.com/viewarticle/572642
[t-ii] The Seattle protocol does not more reliably predict the detection of cancer at the time of esophagectomy than a less intensive surveillance protocol. - PubMed -...
http://www.ncbi.nlm.nih.gov/pubmed/19264576
[t-iii] Diagnosis of extraesophageal reflux in children with chronic otitis media with effusion using Peptest.
http://www.ncbi.nlm.nih.gov/pubmed/25736547
[t-iv] Gastroenterology & Endoscopy News - U.K. Study Finds No Need for Diagnostic Barium Test
Treatments
[tr-i] New British Society of Gastroenterology (BSG) guidelines for the diagnosis and management of Barrett's oesophagus
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1856188/
[tr-ii] Revised British Society of Gastroenterology recommendation on the diagnosis and management of Barrett's oesophagus with low-grade dysplasia | Gut
http://gut.bmj.com/content/early/2017/04/07/gutjnl-2017-314135
[tr-iii] Radiofrequency Ablation in Barrett's Esophagus with Dysplasia — NEJM
http://www.nejm.org/doi/full/10.1056/NEJMoa0808145
[tr-iv] Comparing outcome of radiofrequency ablation in Barrett's with high grade dysplasia and intramucosal carcinoma: a prospective multicenter UK registry... - Abstract - Europe PubMed Central
http://europepmc.org/abstract/med/26126159
[tr-v] Cryotherapy for Barrett's esophagus and esophageal cancer. - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/21597370
[tr-vi] Horizon Scanning in Surgery: Application to Surgical Education and Practice - Cryotherapy for Esophageal Cancer
https://www.facs.org/~/media/files/education/ceste/cryotherapy%20for%20esophageal%20cancer.ashx
[tr-vii] Photodynamic therapy vs radiofrequency ablation for Barrett’s dysplasia: Efficacy, safety and cost-comparison
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819546/
[tr-viii] Randomized trial of argon plasma coagulation vs. multipolar electrocoagulation for ablation of Barrett's esophagus.
http://www.ncbi.nlm.nih.gov/pubmed/15729231
[tr-ix] A prospective comparison of totally minimally invasive versus open Ivor Lewis esophagectomy
http://onlinelibrary.wiley.com/doi/10.1111/j.1442-2050.2012.01356.x/abstract
Other
[o-i] The effects of concomitant GERD, dyspepsia, and rhinosinusitis on asthma symptoms
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161609/
[o-ii] Gastroesophageal reflux as a cause of chronic cough, severe asthma, and migratory pulmonary infiltrates
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184716/#b5
[o-iii] Chronic Asthma and Gastro-Esophageal Reflux Disease: The Treatment Plans
http://jctm.mums.ac.ir/article_4751_0.html
[o-iv] CORE Dumping Syndrome factsheet
http://www.corecharity.org.uk/assets/files/information_pdfs/DumpingSyndrome.pdf
[o-v] Closer to a treatment for the 'asthma of the esophagus' | EurekAlert! Science News
http://www.eurekalert.org/pub_releases/2015-08/difr-cta082815.php
Myths and Misconceptions
[m-i] Negative Effects of Alkaline Water | eHow
http://www.ehow.com/list_7609516_negative-effects-alkaline-water.html
[m-ii] What You Need to Know When You Prescribe a PPI: Cancer
http://www.medscape.com/viewarticle/753221_5
[m-iii] Don’t believe the hype – 10 persistent cancer myths debunked - Cancer Research UK - Science blog