Mathematical and Computational Sciences Special Interest Group of International Society of Pharmacometrics will present a one day workshop on Modeling Delays in Pharmacokinetics and Pharmacodynamics using NONMEM on Tuesday the 27th of June. The course will provide an overview of biological systems exhibiting delays, concepts of lifespan driven pharmacodynamic response, modeling of cell maturation, transduction delays, and nonlinear mixed effect lifespan models. Delay differential equations (DDEs) will be introduced and implemented in NONMEM pre-release version 7.5. The course will consist of both lectures and hands-on computer exercises. Source code for DDE based PK/PD models and data will be provided to the participants. For more information contact wk@buffalo.edu.
Eurostars Atlántico hotel, 350 m away from Palexco Convention and Exhibition Centre
Registration is closed.
Fees
Registration fees are 75 USD for students, 150 USD for academia/government, and 300 USD for a regular registration. This includes course documentation, mid-session refreshments and lunch.
Cancellations
Cancellations with a full refund may be made until May 24th, 2023. No refund is possible on cancellations received after this date.
Instructors are members of MCS SIG Modeling Delays in PK/PD Working Group
Wojciech Krzyzanski, PhD, MA. Associate Professor at Department of Pharmaceutical Sciences, University at Buffalo. Holds PhD in applied mathematics and MA in pharmacology. Research focus on pharmacokinetics and pharmacodynamics of hematopoietic growth factors and pharmacometrics.
Gilbert Koch holds a PhD in applied mathematics and is a senior research fellow in modeling and simulation at the University Children’s Hospital Basel, Switzerland. He has more than 12 years of experience in pharmacokinetic and pharmacodynamic modeling. His research topics are modeling in (preterm) neonates and infants, computation of optimal dosing schedules, machine learning approaches, drug-drug interaction modeling, and the development of app-based solutions for clinicians.
Robert J. Bauer, PhD. Robert Bauer holds a PhD. in Pharmacology. He heads the Pharmacometrics R&D department at ICON Plc, Gaithersburg, MD., where he and his group maintain the population analysis software NONMEM®, incorporating leading edge algorithms in pharmacometrics. Dr. Bauer’s focus is on developing and implementing mathematical and statistical algorithms for biomedical problems.
Johannes Schropp, PhD. Professor at Department of Mathematics and Statistics, University of Konstanz. Research focus on PK/PD modeling and numerics of dynamical systems.
Hematopoietic cascade
Immune system response
Apoptotic cancer cells
Lifespan controlled cell loss
Point distributed lifespans
Lifespan PD models with delays
Overview of DDE systems
Categories of DDE models
Introduction to ADVAN16 for solving DDEs
Implementation in NONMEM of PKPD models with DDEs
Simulation and estimation of parameters in PKPD models with delays
Drug effect on response production
Drug effect on lifespan distribution
Coding basic lifespan indirect model III
Simulation of repsones for varying dose and TR
Estimation of parameters for escalating single dose data
Transit compartment model properties
Signal transduction
Cell maturation and senscence
Overview of DDDE systems
Numerical methods of solving DDDEs
Implementation in NONMEM of PKPD models with DDDEs
Population estimation of PKPD parameters: gamma DDDE model of myelosuppressive effects of anticancer agents