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Modeling Delays in Pharmacokinetics and Pharmacodynamics
Modeling Delays in Pharmacokinetics and Pharmacodynamics
Mathematical and Computational Sciences Special Interest Group of International Society of Pharmacometrics will present a one day workshop on Modeling Delays in Pharmacokinetics and Pharmacodynamics using NONMEM on Tuesday the 27th of June. The course will provide an overview of biological systems exhibiting delays, concepts of lifespan driven pharmacodynamic response, modeling of cell maturation, transduction delays, and nonlinear mixed effect lifespan models. Delay differential equations (DDEs) will be introduced and implemented in NONMEM pre-release version 7.5. The course will consist of both lectures and hands-on computer exercises. Source code for DDE based PK/PD models and data will be provided to the participants. For more information contact wk@buffalo.edu.
Location
Location
Eurostars Atlántico hotel, 350 m away from Palexco Convention and Exhibition Centre
A Coruña, Spain
A Coruña, Spain
Registration
Registration
Registration is closed.
Fees
Registration fees are 75 USD for students, 150 USD for academia/government, and 300 USD for a regular registration. This includes course documentation, mid-session refreshments and lunch.
Cancellations
Cancellations with a full refund may be made until May 24th, 2023. No refund is possible on cancellations received after this date.
Instructors
Instructors
Instructors are members of MCS SIG Modeling Delays in PK/PD Working Group
Wojciech Krzyzanski, PhD, MA. Associate Professor at Department of Pharmaceutical Sciences, University at Buffalo. Holds PhD in applied mathematics and MA in pharmacology. Research focus on pharmacokinetics and pharmacodynamics of hematopoietic growth factors and pharmacometrics.
Gilbert Koch holds a PhD in applied mathematics and is a senior research fellow in modeling and simulation at the University Children’s Hospital Basel, Switzerland. He has more than 12 years of experience in pharmacokinetic and pharmacodynamic modeling. His research topics are modeling in (preterm) neonates and infants, computation of optimal dosing schedules, machine learning approaches, drug-drug interaction modeling, and the development of app-based solutions for clinicians.
Robert J. Bauer, PhD. Robert Bauer holds a PhD. in Pharmacology. He heads the Pharmacometrics R&D department at ICON Plc, Gaithersburg, MD., where he and his group maintain the population analysis software NONMEM®, incorporating leading edge algorithms in pharmacometrics. Dr. Bauer’s focus is on developing and implementing mathematical and statistical algorithms for biomedical problems.
Johannes Schropp, PhD. Professor at Department of Mathematics and Statistics, University of Konstanz. Research focus on PK/PD modeling and numerics of dynamical systems.
Agenda
Agenda
9:00am - 9:10am Introduction
9:00am - 9:10am Introduction
9:10am - 9:50am Biological systems exhibiting delays
9:10am - 9:50am Biological systems exhibiting delays
Hematopoietic cascade
Immune system response
Apoptotic cancer cells
9:50am - 10:30am Concept of lifespan driven pharmacodynamic response
9:50am - 10:30am Concept of lifespan driven pharmacodynamic response
Lifespan controlled cell loss
Point distributed lifespans
Lifespan PD models with delays
10:30am - 10:50am Coffee break
10:30am - 10:50am Coffee break
10:50am - 11:30am Introduction to delay differential equations in PK/PD
10:50am - 11:30am Introduction to delay differential equations in PK/PD
Overview of DDE systems
Categories of DDE models
11:30am - 12:30am Hands-on I
11:30am - 12:30am Hands-on I
Introduction to ADVAN16 for solving DDEs
Implementation in NONMEM of PKPD models with DDEs
Simulation and estimation of parameters in PKPD models with delays
12:30am - 1:30pm Lunch break
12:30am - 1:30pm Lunch break
1:30am - 2:10pm Basic lifespan based indirect response models
1:30am - 2:10pm Basic lifespan based indirect response models
Drug effect on response production
Drug effect on lifespan distribution
2:10pm - 2:50pm Hands-on II
2:10pm - 2:50pm Hands-on II
Coding basic lifespan indirect model III
Simulation of repsones for varying dose and TR
Estimation of parameters for escalating single dose data
2:50pm - 3:20pm Transit compartment models
2:50pm - 3:20pm Transit compartment models
Transit compartment model properties
Signal transduction
Cell maturation and senscence
3:20pm - 3:40pm Coffee break
3:20pm - 3:40pm Coffee break
3:40pm - 4:20 pm Introduction to distributed delay differential equations in PK-PD
3:40pm - 4:20 pm Introduction to distributed delay differential equations in PK-PD
Overview of DDDE systems
Numerical methods of solving DDDEs
4:20pm - 5:00pm Hands-on III
4:20pm - 5:00pm Hands-on III
Implementation in NONMEM of PKPD models with DDDEs
Population estimation of PKPD parameters: gamma DDDE model of myelosuppressive effects of anticancer agents
5:00pm - 5:05pm Final comments and remarks
5:00pm - 5:05pm Final comments and remarks
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