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Modeling Delays in Pharmacokinetics and Pharmacodynamics
Modeling Delays in Pharmacokinetics and Pharmacodynamics
Pharmacodynamic Systems with Delays Research Group will present a one day workshop on Modeling Delays in Pharmacokinetics and Pharmacodynamics using NONMEM on Sunday the 20th of October. The course will provide an overview of biological systems exhibiting delays, concepts of lifespan driven pharmacodynamic response, modeling of cell maturation, transduction delays, and nonlinear mixed effect lifespan models. Delay differential equations (DDEs) will be introduced and implemented in NONMEM pre-release version 7.5. The course will consist of both lectures and hands-on computer exercises. Source code for DDE based PK/PD models and data will be provided to the participants. For more information contact wk@buffalo.edu.
Location
Location
Rosen Shingle Creek Hotel
Orlando, FL, USA
Room Wekiwa 1
Registration
Registration
Registration can be made via the ACoP10 website https://www.go-acop.org/workshops-at-acop . Please register ASAP in view of the limited course capacity of 30 participants. Confirmation of registration will be returned upon receipt, together with an invoice for the course fee. Registration will not be final until payment is received.
Fees
Registration fees are 175 USD for students, 350 USD for academia/government, and 700 USD for a regular registration. This includes course documentation, mid-session refreshments and lunch.
Cancellations
Cancellations with a full refund may be made until September 30, 2019. No refund is possible on cancellations received after this date. Substitutions may be made at any time.
Instructors
Instructors
Instructors are members of Pharmacodynamic Systems with Delays Research Group
Wojciech Krzyzanski, PhD, MA. Associate Professor at Department of Pharmaceutical Sciences, University at Buffalo. Holds PhD in applied mathematics and MA in pharmacology. Research focus on pharmacokinetics and pharmacodynamics of hematopoietic growth factors and pharmacometrics.
Robert J. Bauer, PhD. Robert Bauer holds a PhD. in Pharmacology. He heads the Pharmacometrics R&D department at ICON Plc, Gaithersburg, MD., where he and his group maintain the population analysis software NONMEM®, incorporating leading edge algorithms in pharmacometrics. Dr. Bauer’s focus is on developing and implementing mathematical and statistical algorithms for biomedical problems.
Johannes Schropp, PhD. Professor at Department of Mathematics and Statistics, University of Konstanz. Research focus on PK/PD modeling and numerics of dynamical systems.
Agenda
Agenda
9:00am - 9:10am Introduction
9:00am - 9:10am Introduction
9:10am - 9:50am Biological systems exhibiting delays
9:10am - 9:50am Biological systems exhibiting delays
- Hematopoietic cascade
- Immune system response
- Apoptotic cancer cells
9:50am - 10:30am Concept of lifespan driven pharmacodynamic response
9:50am - 10:30am Concept of lifespan driven pharmacodynamic response
- Lifespan controlled cell loss
- Point distributed lifespans
- Lifespan PD models with delays
10:30am - 10:50am Coffee break
10:30am - 10:50am Coffee break
10:50am - 11:30am Introduction to delay differential equations in PK/PD
10:50am - 11:30am Introduction to delay differential equations in PK/PD
- Overview of DDE systems
- Categories of DDE models
11:30am - 12:30am Hands-on I
11:30am - 12:30am Hands-on I
- Introduction to ADVAN16 for solving DDEs
- Implementation in NONMEM of PKPD models with DDEs
- Simulation and estimation of parameters in PKPD models with delays
12:30am - 1:30pm Lunch break
12:30am - 1:30pm Lunch break
1:30am - 2:10pm Basic lifespan based indirect response models
1:30am - 2:10pm Basic lifespan based indirect response models
- Drug effect on response production
- Drug effect on lifespan distribution
2:10pm - 2:50pm Hands-on II
2:10pm - 2:50pm Hands-on II
- Coding basic lifespan indirect model III
- Simulation of repsones for varying dose and TR
- Estimation of parameters for escalating single dose data
2:50pm - 3:20pm Transit compartment models
2:50pm - 3:20pm Transit compartment models
- Transit compartment model properties
- Signal transduction
- Cell maturation and senscence
3:20pm - 3:40pm Coffee break
3:20pm - 3:40pm Coffee break
3:40pm - 4:20 pm Hands-on III
3:40pm - 4:20 pm Hands-on III
- Rheumatoid arthritis model
- Estimation of parameters for escalating single dose data
4:20pm - 5:00pm Lifespan models of hematopoietic systems
4:20pm - 5:00pm Lifespan models of hematopoietic systems
- PD models for rHuEPO, PegTPO
- Hematological toxicities and rHu-G-CSF
5:00pm - 5:05pm Final comments and remarks
5:00pm - 5:05pm Final comments and remarks
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