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Summary
A one day workshop on Modeling Delays in Pharmacokinetics and Pharmacodynamics will be presented by
Wojciech Krzyzanski (University at Buffalo), Gilbert Koch (University of Basel, Children’s Hospital), Johannes
Schropp (University of Konstanz), Mélanie Wilbaux (University of Basel, Children's Hospital), and Juan Jose Perez-
Ruixo (Janssen Research & Development) on Saturday 3rd of October 2015. The course will provide an overview
of biological systems exhibiting delays, concepts of lifespan driven pharmacodynamic response, modeling of cell
maturation, and nonlinear mixed effect lifespan models. Delay differential equations (DDEs) will be introduced and
implemented in R. The course will consist of both lectures and hands-on computer exercises. Source codes for
DDE based PK/PD models and data will be provided to the participants. Contact wk@buffalo.edu for more
information.
Location
The meeting will take place at the Hyatt Regency Crystal City, on the outskirts of Washington D.C., which offers beautiful
accommodations, a convenient location for transportation for attendees, and state-of-the-art facility.
Wojciech Krzyzanski, PhD, MA. Associate Professor at Department of Pharmaceutical Sciences,
University at Buffalo. Holds PhD in applied mathematics and MA in pharmacology. Research focus
on pharmacokinetics and pharmacodynamics of hematopoietic growth factors and pharmacometrics.
Gilbert Koch, PhD. Gilbert Koch holds a PhD in applied mathematics. He worked as Postdoctoral
Associate at the Department of Pharmaceutical Sciences, University at Buffalo and recently joined the
Pediatric Pharmacology Group at the University Children´s Hospital in Basel as Research Assistant.
His research focus is on delay/lifespan modeling, anti-cancer effects in combination therapy and
modeling in pediatric drug development and rare diseases.
Johannes Schropp, PhD. Professor at Department of Mathematics and Statistics, University of
Konstanz. Research focus on PK/PD modeling and numerics of dynamical systems.
Mélanie Wilbaux, PhD. After biological and biostatistics studies she obtained her PhD in pharmacometrics
from the University of Lyon. Her research interest focused on mathematical modeling of tumor marker kinetics
to predict clinical outcomes and treatment effects. Recently she joined the Pediatric Pharmacology group at
the University Children’s Hospital in Basel as a postdoctoral fellow where she develops semi-mechanistic
models in pediatrics.
Juan Jose Perez-Ruixo, PharmD, PhD. Senior Scientific Director, Model Based Drug Development, Quantitative Sciences at Janssen Research Foundations. Holds PhD in pharmaceutical sciences. Research focus on quantitative pharmacology of growth factors, oncology and bone therapeutics.
Agenda
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