Summary
A one day workshop on Modeling Delays in Pharmacokinetics and Pharmacodynamics will be presented by Wojciech Krzyzanski (University at Buffalo), Gilbert Koch (University of Basel, Children’s Hospital), Johannes Schropp (University of Konstanz), Juan Jose Perez-Ruixo (Janssen Research & Development) and Matthias Machacek (Lixoft Inc.) on Tuesday 7th of June 2016. The course will provide an overview of biological systems exhibiting delays, concepts of lifespan driven pharmacodynamic response, modeling of cell maturation, and nonlinear mixed effect lifespan models. Delay differential equations (DDEs) will be introduced and implemented in Monolix and Simulix. The course will consist of both lectures and hands-on computer exercises. Source codes for DDE based PK/PD models and data will be provided to the participants. Contact wk@buffalo.edu for more information.
Location
The workshop will take place at VIP Grand Lisboa.
Registration
Please register ASAP in view of the limited course capacity of 20 participants. The regular fee is $660 USD (~ €600). People affiliated with academia can register at $330 USD (~ €300). The registration fee for students is $165 USD (~ €150). The registration includes course documentation, midsession refreshments and lunch. The preferable form of payment is credit card using following links. We also accept bank transfers. The payment will be made to University at Buffalo Foundation Inc. Proof of payment will be e-mailed upon completion of registration. Cancellations with a full refund may be made until May 15, 2016. No refund is possible on cancellations received after this date. Substitutions may be made at any time.
Instructors
Wojciech Krzyzanski, PhD, MA. Associate Professor at Department of Pharmaceutical Sciences, University at Buffalo. Holds PhD in applied mathematics and MA in pharmacology. Research focus on pharmacokinetics and pharmacodynamics of hematopoietic growth factors and pharmacometrics.
Gilbert Koch, PhD. Gilbert Koch holds a PhD in applied mathematics. He worked as Postdoctoral Associate at the Department of Pharmaceutical Sciences, University at Buffalo and recently joined the Pediatric Pharmacology Group at the University Children´s Hospital in Basel as Senior Research Fellow. His research focus is on delay/lifespan modeling, anti-cancer effects in combination therapy, modeling in pediatric drug development and rare diseases, and target mediated drug disposition with drug-drug interaction.
Johannes Schropp, PhD. Professor at Department of Mathematics and Statistics, University of Konstanz. Research focus on PK/PD modeling and numerics of dynamical systems.
Matthias Machacek, PhD. Matthias Machacek studied mechanical engineering and obtained his PhD from ETH Zurich for his research on fluid dynamics and computer vision. During his postdoc at Scripps he applied computer vision to monitor molecules inside live cells at nanometer scale. His research was published in both Nature and Science. After, Matthias established the Medical Engineering Group at Novartis, dedicated to the systems pharmacology support for the preclinical and translational development of biotherapeutics.Today, Machacek applies systems pharmacology
for the development of biologics and cell based therapeutics. He is Managing Director of LYO-X and contributes to compound design, format selection, candidate selection, PK/PD and toxicology study design, first in human dose selection, optimal dose-regimen finding and pediatric development. He also works with Lixoft as a pharmacometrics expert developing and promoting the Monolix software suite.
Juan Jose Perez-Ruixo, PharmD, PhD. Senior Scientific Director, Model Based Drug Development, Quantitative Sciences at Janssen Research Foundations. Holds PhD in pharmaceutical sciences. Research focus on quantitative pharmacology of growth factors, oncology and bone therapeutics.
Agenda