Delays in PKPD

ACoP9 2018, San Diego, CA, USA

Summary

A one day workshop on Modeling Delays in Pharmacokinetics and Pharmacodynamics will be presented by Wojciech Krzyzanski (University at Buffalo), Gilbert Koch (University of Basel, Children’s Hospital) and Johannes Schropp (University of Konstanz) on Sunday 7th October 2018. The course will provide an overview of biological systems exhibiting delays, concepts of lifespan driven pharmacodynamic response, modeling of cell maturation, and nonlinear mixed effect lifespan models. Delay differential equations (DDEs) will be introduced and implemented in R. The course will consist of both lectures and hands-on computer exercises. Source codes for DDE based PK/PD models and data will be provided to the participants. Contact wk@buffalo.edu for more information.

Location

To be announced.

Registration

Please register at the ACoP9 website.

Registration fee:

$175 Students

$350 Academia/Government

$700 Regular fee

Instructors

Instructors are members of Pharmacodynamic Systems with Delays Research Group

Wojciech Krzyzanski, PhD, MA. Associate Professor at Department of Pharmaceutical Sciences, University at Buffalo. Holds PhD in applied mathematics and MA in pharmacology. Research focus on pharmacokinetics and pharmacodynamics of hematopoietic growth factors and pharmacometrics.

Gilbert Koch, PhD. Gilbert Koch holds a PhD in applied mathematics. He worked as Postdoctoral Associate at the Department of Pharmaceutical Sciences, University at Buffalo and recently joined the Pediatric Pharmacology Group at the University Children´s Hospital in Basel as Senior Research Fellow. His research focus is on delay/lifespan modeling, anti-cancer effects in combination therapy, modeling in pediatric drug development and rare diseases, and target mediated drug disposition with drug-drug interaction.

Johannes Schropp, PhD. Professor at Department of Mathematics and Statistics, University of Konstanz. Research focus on PK/PD modeling and numerics of dynamical systems.

Agenda

8:00am - 8:10am Introduction

Krzyzanski

8:10am - 8:50am Biological systems exhibiting delays

Krzyzanski

Hematopoietic cascade
Immune system response
Apoptotic cancer cells

8:50am - 9:20 am Concept of lifespan driven pharmacodynamic response

Koch

Lifespan controlled cell loss
Point distributed lifespans
Lifespan PD models with delays

9:20am - 10:00am Introduction to delay differential equations in PK/PD

Schropp

Overview of DDE systems
Categories of DDE models

10:00am - 10:20am Coffee break

10:20am - 11:10am Hands-on I

Koch

Introduction to R for simulations of PKPD models
Implementation of DDEs in R
Estimation of parameters in PKPD models with delays

11:10am - 11:50am Basic lifespan based indirect response models

Krzyzanski

Drug effect on response production
Drug effect on lifespan distribution

11:50am - 1:00pm Lunch break

1:00pm - 1:50pm Hands-on II

Krzyzanski, Koch

Coding basic lifespan indirect model III
Simulation of repsones for varying dose and TR
Estimation of parameters for escalating single dose data

1:50pm - 2:20pm Transit compartment models

Koch

Transit compartment model properties
Signal transduction
Cell maturation and senscence

2:20pm - 3:10 pm Hands-on III

Koch

Rheumatoid arthritis model

3:10pm - 3:30pm Coffee break

3:30pm - 4:10pm Lifespan models of hematopoietic systems

Krzyzanski

PD models for rHuEPO, PegTPO
Hematological toxicities and rHu-G-CSF

4:10pm - 5:00pm Hands-on IV

Krzyzanski, Koch

Population model of rHuEPO effect on hemoglobin
Simulation of hemoglobin response in individual patients
Assessment of hemoglobin between subject variability

5:00pm - 5:10pm Closing remarks

Krzyzanski

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