Delays in PKPD

PAGE June 25, 2024, Rome,  Italy

Modeling Delays in Pharmacokinetics and Pharmacodynamics

Mathematical and Computational Sciences Special Interest Group of International Society of Pharmacometrics will present a one day workshop on Modeling Delays in Pharmacokinetics and Pharmacodynamics using NONMEM on Tuesday the 25th of June. The course will provide an overview of biological systems exhibiting delays, concepts of lifespan driven pharmacodynamic response, modeling of cell maturation, transduction delays, and nonlinear mixed effect lifespan models. Delay differential equations (DDEs) will be introduced and implemented in NONMEM pre-release version 7.5. The course will consist of both lectures and hands-on computer exercises. Source code for DDE based PK/PD models and data will be provided to the participants. For more information contact  


Ergife Palace Hotel

Largo Lorenzo Mossa, 8, 00165 Roma RM, Italy


For registration please visit  ISoP registration site  


Registration fees are $80 for students, $160 for ISoP members, and  $320 for a regular registration. This includes course documentation, mid-session refreshments and lunch. 


Cancellations with a full refund may be made until May 14th, 2024. No refund is possible on cancellations received after this date. 


Instructors are members of MCS SIG Modeling Delays in PK/PD Working Group

Wojciech Krzyzanski, PhD, MA. Associate Professor at Department of Pharmaceutical Sciences, University at Buffalo. Holds PhD in applied mathematics and MA in pharmacology. Research focus on pharmacokinetics and pharmacodynamics of hematopoietic growth factors and pharmacometrics.

Robert J. Bauer, PhD.  Robert Bauer holds a PhD. in Pharmacology.  He heads the Pharmacometrics R&D department at ICON Plc, Gaithersburg, MD., where he and his group maintain the population analysis software NONMEM®, incorporating leading edge algorithms in pharmacometrics.  Dr. Bauer’s focus is on developing and implementing mathematical and statistical algorithms for biomedical problems.

Johannes Schropp, PhD. Professor at Department of Mathematics and Statistics, University of Konstanz. Research focus on PK/PD modeling and numerics of dynamical systems. 


8:00am - 8:10am        Introduction 

8:10am - 8:40am        Biological systems exhibiting delays 

8:40am - 9:20am       Introduction to delay differential equations in PK/PD

9:20am - 9:35am    Coffee break

9:35am - 10:35am     Hands-on I

10:35am - 11:15am   Lifespan driven PD models

11:15am - 12:15pm      Hands-on II

12:15pm - 1:15pm        Lunch break 

 1:15pm - 1:55pm       Transit compartment models

1:55pm - 2:10pm        Coffee break

2:10pm - 2:50 pm       Introduction to distributed delay differential equations in PK-PD

2:50pm - 3:50pm        Hands-on III

3:50pm - 4:00pm       Final comments and remarks