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Modeling Delays in Pharmacokinetics and Pharmacodynamics
Modeling Delays in Pharmacokinetics and Pharmacodynamics
ICON will present a one-day workshop on Modeling Delays in Pharmacokinetics and Pharmacodynamics using NONMEM on Friday the 17th of October. The course will provide an overview of biological systems exhibiting delays, concepts of lifespan driven pharmacodynamic response, modeling of cell maturation, transduction delays, and nonlinear mixed effect lifespan models. Delay differential equations (DDEs) and distributed delay differential equations (DDDEs) will be introduced and implemented in NONMEM 7.5. The course will consist of both lectures and hands-on computer exercises. Temporary licenses for accessing NONMEM in cloud will be provided. Source codes for DDE and DDDE based PK/PD models and data will be available for downloading to the participants. For more information contact wk@buffalo.edu.
Location
Location
Red Rock 3
Red Rock 3
Gaylord Rockies, Aurora, Colorado, USA
Registration
Registration
Registration is open only for people who registered for ACoP 2025 annual meeting. To register please visit ACoP2025 event site.
Fees
Registration fees are Member: $600, Non-Member: $800, Student/Trainee: $300. This includes course documentation, mid-session refreshments and lunch.
Instructors
Instructors
Wojciech Krzyzanski, PhD, MA. Associate Professor at Department of Pharmaceutical Sciences, University at Buffalo. Holds PhD in applied mathematics and MA in pharmacology. Research focus on pharmacokinetics and pharmacodynamics of hematopoietic growth factors and pharmacometrics.
Johannes Schropp, PhD. Professor at Department of Mathematics and Statistics, University of Konstanz. Research focus on PK/PD modeling and numerics of dynamical systems.
Agenda
Agenda
8:00am - 8:10am Introduction
8:00am - 8:10am Introduction
8:10am - 8:55am Biological systems exhibiting delays
8:10am - 8:55am Biological systems exhibiting delays
Hematopoietic cascade
Immune system response
Apoptotic cancer cells
8:55am - 9:40am Introduction to delay differential equations in PK/PD
8:55am - 9:40am Introduction to delay differential equations in PK/PD
Overview of DDE systems
Examples of DDE PK/PD models
Categories of DDE models
9:40am - 10:00am Coffee break
9:40am - 10:00am Coffee break
10:00am - 11:10am Hands-on I
10:00am - 11:10am Hands-on I
Introduction to ADVAN16 for solving DDEs
Implementation in NONMEM of PKPD models with DDEs
Simulation and estimation of parameters in PKPD models with delays
11:10am - 11:55am Lifespan driven PD models
11:10am - 11:55am Lifespan driven PD models
Lifespan driven PD response
Drug effect on response production
Drug effect on lifespan distribution
11:55am - 12:55pm Lunch break
11:55am - 12:55pm Lunch break
12:55pm - 1:40pm Hands-on II
12:55pm - 1:40pm Hands-on II
Coding basic lifespan indirect model
Simulation of responses for varying dose and lifespan
Estimation of parameters for escalating single dose data
1:40pm - 2:25pm Transit compartment models
1:40pm - 2:25pm Transit compartment models
Transit compartment model properties
Signal transduction
Cell maturation and senescence
2:25pm - 3:10 pm Introduction to distributed delay differential equations in PK-PD
2:25pm - 3:10 pm Introduction to distributed delay differential equations in PK-PD
Overview of DDDE systems
Examples of DDDE PK/PD models
Numerical methods of solving DDDEs
3:10pm - 3:30pm Coffee break
3:10pm - 3:30pm Coffee break
3:30pm - 4:40pm Hands-on III
3:30pm - 4:40pm Hands-on III
Implementation in NONMEM of PKPD models with DDDEs
Population estimation of PKPD parameters: gamma DDDE model of myelosuppressive effects of anticancer agents
4:40pm - 4:50pm Final comments and remarks
4:40pm - 4:50pm Final comments and remarks
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