Delays in PKPD
PAGE June 25, 2024, Rome, Italy
Modeling Delays in Pharmacokinetics and Pharmacodynamics
Mathematical and Computational Sciences Special Interest Group of International Society of Pharmacometrics will present a one day workshop on Modeling Delays in Pharmacokinetics and Pharmacodynamics using NONMEM on Tuesday the 25th of June. The course will provide an overview of biological systems exhibiting delays, concepts of lifespan driven pharmacodynamic response, modeling of cell maturation, transduction delays, and nonlinear mixed effect lifespan models. Delay differential equations (DDEs) will be introduced and implemented in NONMEM pre-release version 7.5. The course will consist of both lectures and hands-on computer exercises. Source code for DDE based PK/PD models and data will be provided to the participants. For more information contact wk@buffalo.edu.
Location
Ergife Palace Hotel
Largo Lorenzo Mossa, 8, 00165 Roma RM, Italy
Registration
For registration please visit ISoP registration site
Fees
Registration fees are $80 for students, $160 for ISoP members, and $320 for a regular registration. This includes course documentation, mid-session refreshments and lunch.
Cancellations
Cancellations with a full refund may be made until May 14th, 2024. No refund is possible on cancellations received after this date.
Instructors
Instructors are members of MCS SIG Modeling Delays in PK/PD Working Group
Wojciech Krzyzanski, PhD, MA. Associate Professor at Department of Pharmaceutical Sciences, University at Buffalo. Holds PhD in applied mathematics and MA in pharmacology. Research focus on pharmacokinetics and pharmacodynamics of hematopoietic growth factors and pharmacometrics.
Robert J. Bauer, PhD. Robert Bauer holds a PhD. in Pharmacology. He heads the Pharmacometrics R&D department at ICON Plc, Gaithersburg, MD., where he and his group maintain the population analysis software NONMEM®, incorporating leading edge algorithms in pharmacometrics. Dr. Bauer’s focus is on developing and implementing mathematical and statistical algorithms for biomedical problems.
Johannes Schropp, PhD. Professor at Department of Mathematics and Statistics, University of Konstanz. Research focus on PK/PD modeling and numerics of dynamical systems.
Agenda
8:00am - 8:10am Introduction
8:10am - 8:40am Biological systems exhibiting delays
Hematopoietic cascade
Immune system response
Apoptotic cancer cells
8:40am - 9:20am Introduction to delay differential equations in PK/PD
Overview of DDE systems
Examples of DDE PK/PD models
Categories of DDE models
9:20am - 9:35am Coffee break
9:35am - 10:35am Hands-on I
Introduction to ADVAN16 for solving DDEs
Implementation in NONMEM of PKPD models with DDEs
Simulation and estimation of parameters in PKPD models with delays
10:35am - 11:15am Lifespan driven PD models
Lifespan driven PD response
Drug effect on response production
Drug effect on lifespan distribution
11:15am - 12:15pm Hands-on II
Coding basic lifespan indirect model
Simulation of responses for varying dose and lifespan
Estimation of parameters for escalating single dose data
12:15pm - 1:15pm Lunch break
1:15pm - 1:55pm Transit compartment models
Transit compartment model properties
Signal transduction
Cell maturation and senescence
1:55pm - 2:10pm Coffee break
2:10pm - 2:50 pm Introduction to distributed delay differential equations in PK-PD
Overview of DDDE systems
Examples of DDDE PK/PD models
Numerical methods of solving DDDEs
2:50pm - 3:50pm Hands-on III
Implementation in NONMEM of PKPD models with DDDEs
Population estimation of PKPD parameters: gamma DDDE model of myelosuppressive effects of anticancer agents