Florence attended Kingswood School for Girls (1932-1934), part of the
Cranbrook Educational Community in
Bloomfield Hills, Michigan. While Florence was in Cranbrook, she was mentored by Rachel de Wolfe Raseman (the art director at Kingswood). Together, they designed a home which integrated interior and exterior (at time Florence was 14). That work brought her to the attention of
Eliel Saarinen (President of
Cranbrook Art Academy). Eliel and his wife (Loja) practically adopted Knoll such that she spent summers with their family in Finland while she was in Cranbrook. Florence and Eero (Eliel's son) quickly became friends and Eero gave Florence impromptu architectural history lessons. Florence took architectural courses at Cranbook Academy during 1934–35. In 1935, she started town planning studies at the School of Architecture at
Columbia University. However due to health issues, she returned to Michigan in 1936 and enrolled in Cranbrook's architectural coursese , again. During this time (1936-1937), she explored furniture-making with
Eero Saarinen and
Charles Eames. In the summer of 1938 she met
Alvar Aalto, who praised the
Architectural Association in London a "terrific school". Knoll decided to attended that school from 1938-1939. There she enjoyed the focus on studio work and was influenced by
Le Corbusier's International style.