The 458 Italia has slightly better nitro efficiency values (9/14/19) than the Mazda Furai, which is also slower and much more expensive. The 458 Italia is also faster than the Nissan GT-R (R35), although, it has a shorter-lasting nitro boost. The Ford Shelby GT500 is both faster and more nitro-efficient than the 458 Italia, but only slightly.

Other nearby cars outperform the 458 Italia because of superior nitro efficiencies paired with similar or higher total top speeds, however, they are far more expensive. The Mercedes-Benz Biome is notably much faster than the 458 Italia in both raw and total top speeds, while possessing a far more efficient nitro, stronger handling, and a faster acceleration, making it better for both Time-Limited Events and Multiplayer. The Mercedes-Benz Biome could be considered a straight upgrade to the 458 Italia, other than the fact that it has a purchase price of 450,000.

The 458 Italia's handling is good and it possesses a fairly strong drifting statistic. The 458 Italia has most of its speed in raw top speed, which is fortunate, since it has moderately short nitro durations. The 458 Italia has good acceleration.