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What is the Mallory Stain?
What is the Mallory Stain?
The Mallory stain (also known as Mallory's trichrome stain) is a polychromatic connective tissue stain. The Mallory stain is known for its ability to stain collagen and its ability to highlight the effects of cytomegalovirus (human herpesvirus 5), including cytomegaly and nuclear inclusion.
The Mallory stain (also known as Mallory's trichrome stain) is a polychromatic connective tissue stain. The Mallory stain is known for its ability to stain collagen and its ability to highlight the effects of cytomegalovirus (human herpesvirus 5), including cytomegaly and nuclear inclusion.
What are cytomegaly and nuclear inclusion?
What are cytomegaly and nuclear inclusion?
Cytomegaly is the enlargement of the cytoplasm and in this case, is caused by cytomegalovirus.
Nuclear inclusion is the growth of unusual proteins/nucleic acids that aggregate around the nucleus.
Intranuclear Inclusions. (2023). MyPathologyReport, https://www.mypathologyreport.ca/pathology-dictionary/intranuclear-inclusions/
Cedeno-Mendoza, R. et al. (2024). Cytomegalovirus (CMV). MedScape, https://emedicine.medscape.com/article/215702-overview?form=fpf
Intranuclear Inclusions. (2023). MyPathologyReport, https://www.mypathologyreport.ca/pathology-dictionary/intranuclear-inclusions/
Mallory's Trichrome Stain. (n.d.) Taylor & Francis, https://taylorandfrancis.com/knowledge/Medicine_and_healthcare/Anatomy/Mallory%27s_trichrome_stain/
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ISBN 9780124171442, https://doi.org/10.1016/B978-0-12-417144-2.00010-X. (https://www.sciencedirect.com/science/article/pii/B978012417144200010X)
Safety:
Safety:
The potential hazards of the Mallory stain are dependent on which dyes are used to make up the stain. It is advisable to read the safety data sheets (SDS) of each reagent you are using. Reasonable lab safety is encouraged- wear lab goggles, gloves, and appropriate clothing.
Staining Analysis:
Staining Analysis:
Red:
Nuclei
Muscle
Orange:
Erythrocytes (red blood cells)
Blue:
Collagen
Bergman, R. A. et al. (n.d.) Plate 3.35: Elastic Membranes; Collagenous Fibers. https://www.anatomyatlases.org/MicroscopicAnatomy/Section03/Plate0335.shtml
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Krušlin, Božo & Ulamec, Monika & Tomas, Davor. (2015). Prostate cancer stroma: An important factor in cancer growth and progression. Bosnian Journal of Basic Medical Sciences. 15. 10.17305/bjbms.2015.449.
Elmelegy, Manal & El-Melegy, & Ghoneim, Nagwa & Mohamed, Nermeen & El-Dien, Noor & Rizk, Mohamed. (2019). Silver Nano Particles Improve the Therapeutic Effect of Mebendazole Treatment during the Muscular Phase of Experimental Trichinellosis. 10.7537/marsjas150519.06.
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