Professor
Ken Sato
Department of Cell Structure, Biological Information Division, Institute for Biological Regulation, Institute for Molecular and Cellular Regulation
You may have heard the name "mitochondria" at least once. They are tiny organelles found within the cells of our bodies, ranging from several tens to thousands in number. However, these organelles are more than just ordinary. They play a crucial role in all vital activities, such as movement, thinking, and digestion, by generating the energy necessary for these functions. Additionally, they have their own unique set of genes called mitochondrial DNA, which is known to be inherited exclusively from the mother (maternal inheritance). Professor Ken Sato and Associate Professor Miyuki Sato from the Institute for Biological Information Signal Research have been fascinated by the mysteries of mitochondria and have made significant contributions to their research.
Atsushi Shibata, a research lecturer, focuses on DNA damage and its repair reactions during cancer treatment. In genetics, DNA serves as the blueprint for constructing our bodies. Traditional cancer treatments aim to damage the DNA of cancer cells; however, it is known that DNA can repair itself. Recent research has made significant progress in the study of DNA repair. In recent years, immunotherapy using "anti-PD-1 antibodies" has garnered attention in cancer treatment, and it has been reported that combining this with radiation therapy enhances treatment efficacy. The reason for this enhanced effect and its mechanism were previously unknown. However, the team led by Research Lecturer Shibata made a significant discovery from the perspective of DNA repair reactions following radiation exposure, which contributes to unravelling the underlying mechanism. His finding is the world's first research achievement demonstrating the involvement of DNA repair in cutting-edge immunotherapy.
Research Lecturer Atsushi Shibata
Center for Graduate Education and Research Support, Graduate School of Medicine
Associate Professor Kiyohito Nagano
Faculty of Social and Information Studies
Associate Professor Kiyohito Nagano specializes in mathematical optimization, particularly algorithmic research in discrete optimization targeting structures like networks. The concept of "submodularity," which abstracts networks, is also a central research theme. He is actively involved in research in artificial intelligence fields such as machine learning, a significant application area for discrete algorithms. He has published a book titled "Submodular Optimization and Machine Learning".
Cancer tissues are in low oxygen conditions due to abnormal cell proliferation. Cancer and many other diseases are deeply associated with oxygen deficiency (hypoxia). If we can image and visualize oxygen distribution in the body through luminescence, it can contribute to understanding the mechanisms underlying disease development. One of the research themes in Professor Seiji Tobita's laboratory is the design, synthesis, and evaluation of molecules (luminescent probes) that can detect specific biomolecules through luminescence. They have succeeded in imaging oxygen distribution in organ tissues, including cancer tissues, at a cellular level with high resolution and have made significant advances in this field.
Professor
Seiji Tobita
Professor
Toshitada Yoshihara
Division of Molecular Science, Graduate School of Science and Technology