Associate Professor
Naoki Asakawa
Division of Molecular Science, Graduate School of Science and Technology
Professor Asakawa is researching intelligent artificial machines (sensors, signal processing devices, etc.) that mimic the information processing mechanisms of living organisms through a materials science approach. After obtaining his doctorate in 1996, he conducted research and development on the methodology of examining the solid structure and molecular motion of polymers. He was fascinated by the unique properties of polymers and one of their fundamental aspects, molecular motion. Around 2006, he considered whether this molecular motion could be applied to electronics. At that time, organic electronics devices were gaining attention, but their performance was significantly lower than silicon and compound semiconductors. He came to believe that for organic electronic devices to survive, it is necessary to pioneer new areas and harness the inherent characteristics of polymers. That's the direction of utilizing the features of polymers as they are, prompting him to focus his attention on the human brain.
Systemic sclerosis is a disease characterized by skin and internal organ hardening, vascular disorders, and immune abnormalities. It is a systemic condition with an unknown mechanism of onset. Patients often suffer from symptoms such as Raynaud's phenomenon and finger ulcers. A few years ago, we came across reports of symptom improvement through local injection of type A botulinum toxin in Europe and the United States. In collaboration with our Clinical Trials Department, we initiated a clinical study to develop the practical application (expansion of indications) of botulinum toxin injection therapy for Raynaud's phenomenon in systemic sclerosis. We conducted the world's first randomized blind trial of this therapy, which demonstrated improvement in the severity of Raynaud's symptoms and pain and reduction and healing of ulcers. We are currently in the process of the patent application. With valuable advice and guidance from the Pharmaceuticals and Medical Devices Agency (PMDA), we initiated our hospital's first physician-led clinical trial, starting in 2016.
In the basic research, we use cultured fibroblasts and systemic sclerosis mouse models to advance the understanding of skin fibrosis and peripheral vascular disorders' onset mechanisms, obtaining new insights. These achievements led us to receive the prestigious 2017 Japanese Society for Investigative Dermatology Award (JSID Award).
Associate Professor
Seiichiro Motegi
Department of Dermatology, Graduate School of Medicine
Associate Professor
Rie Sano
Department of Legal Medicine, Graduate School of Medicine
Associate Professor Sano is involved in forensic autopsy work as a physician and researches ABO blood type. Forensic medicine is a discipline that deals with legal issues based on medicine and natural sciences and provides expert opinions on them. ABO blood type is inherited, and in 1990, a Japanese research group elucidated the structure of the ABO gene in the Japanese population. For approximately 10 years, she has been researching the "gene expression mechanism" of how the ABO gene is regulated and contributes to the production of ABO blood-type substances. One of her focuses is studying the Bm type, which accounts for approximately half of the subtypes and variants in the Japanese population. In individuals with the Bm type, although the genetic structure is B type and the saliva is also B type, they are classified as O type in blood cell tests. Her research found that only the region responsible for activating gene expression in red blood cells was genetically missing in the Bm type.
On the other hand, the region involved in gene expression in epithelial cells remained intact, leading to the understanding of this phenomenon. In transplant medicine, incompatible blood types can cause rejection reactions. In addition, diseases associated with ABO blood types, such as the severity of thrombosis, have been identified. These findings indicate that A/B type substances can pose risks in transplantation medicine and disease development. She believes that by utilizing their research, it will be possible to develop methods to decrease the levels of blood-type substances. Furthermore, the association between ABO blood type and susceptibility to cancer has been reported worldwide, and she aims to elucidate the mechanism behind it from their perspective.
Assistant Professor Yuya Tachibana has been actively working on the development of new materials and plastics using furfural derived from biomass resources. In 2013, he served as a PRESTO researcher under the Japan Science and Technology Agency (JST). Since 2016, he has received support from the JST's Advanced Low Carbon Technology Research and Development (ALCA) project, focusing on developing plastics from furfural produced from food waste. One of his achievements includes synthesizing terephthalic acid, one of the raw materials for polyethylene terephthalate (PET) resin, from furfural. He has also succeeded in creating biodegradable plastics from furfural that can be decomposed by microorganisms in the natural environment without causing environmental pollution.
Assistant Professor
Yuya Tachibana
Division of Molecular Science, Graduate School of Science and Technology