The starting dose of DMF is 120 mg twice a day for 7 days and if you are tolerating DMF the dose should be increased to the recommended maintenance dose of 240 mg twice a day. If you miss a dose, a double dose should not be taken. You may take a missed dose late if it leaves at least 4 hours before the next dose otherwise you should wait until the next scheduled dose.
Dose reduction: We have found that a temporary dose reduction to 120 mg twice a day may reduce the occurrence of flushing and gastrointestinal symptoms. However, the recommended maintenance dose of 240 mg twice a day should be resumed within the next 4 weeks. DMF should ideally be taken with food. Fatty foods, in particular, improve the tolerability of DMF.