Research Topics

本實驗室致力於開發 MXene 前瞻奈米材料，結合綠色基材（如宣紙、竹纖維）、與微針技術 ，打造具備高導電性、生物相容性且透氣的多功能感測電極 。這些感測器能精準偵測肌肉收縮（EMG） 、眼動電訊號（EOG） 、以及透過深度學習輔助的吞嚥功能監測 ，並廣泛應用於外骨骼精準控制 、臨床吞嚥障礙復健 與智慧抗菌傷口修復 等次世代穿戴式醫療與綠色電子系統。
The Tzu-En Lin Laboratory (TEL Lab) is a premier hub for the development of high-performance, next-generation sensors. The lab’s research centers on the architectural engineering of two-dimensional MXene-based nanomaterials to create sensors with unprecedented sensitivity and mechanical resilience. By leveraging the high metallic conductivity and hydrophilic surface of MXenes, the lab fabricates specialized structures including MXene nano-cellulose fiber membranes, conductive aerogels, and 3D-printed hydrogels.

The TEL Lab excels in developing multi-modal sensors capable of detecting subtle physiological signals and large-scale human motions via advanced pressure and strain sensing mechanisms. To address the global challenge of e-waste, the lab prioritizes sustainable electronics, utilizing biodegradable substrates like bamboo-derived cellulose. This ensures that the lab's cutting-edge wearable devices remain eco-friendly while providing continuous, real-time health monitoring.

Selected Publications:

• 3D-Printed Auxetic Hydrogel Dressings Reinforced with MXene and Carbonized Polymer Dots for Cascaded Antibacterial and Pro-Regenerative Effects in Wound Healing. Chen-Yu Lee, Ya-Ting Hsu, Qian-Ci Huang, Pulikkutty Subramaniyan, Akhil K. Paulose, Chih-Ching Huang,* Tzu-En Lin* Small 2026 e08633. (IF 12.1)

• Biodegradable MXene-bamboo cellulose paper electrodes for green wearable sensing and exoskeleton control. Tung-Li Hung, Chien-Yu Huang, Chun-Ho Lin, Yu-Chen Wei, Yung-Jung Hsu, Jr-Hau He, Yun-Ting Kuo, An-Yu Huang, You-Yin Chen, You-Rong Lin, Clemens M. Franz, Chia-Hao Kuo, Pulikkutty Subramaniyan, Shan-Chu Yu, Xinwei Guan*, Tzu-En Lin*, Advanced Science, 2025, 12, e09554 (IF 14.1)

• Deep Learning-Enabled Swallowing Monitoring and Postoperative Recovery Biosensing System. Chih-Ning Tsai, Pei-Wen Yang, Tzu-Yen Huang, Jung-Chih Chen, Hsin-Yi Tseng, Che-Wei Wu, Amrit Sarmah, Pulikkutty Subramaniyan, Tzu-En Lin*. IEEE Sensors Journal, 2025, 25, 1, 108-116. (Instruments & Instrumentation: 15/76)

• MXene Nanosheets Decorated Paper as a Green Electronics Material for Biosensing. Tzu-En Lin*, Shan-Chu Yu, Tzu-Yen Huang. ACS Measurement Science Au, 2024, 4 (1), 81-91. (Invited, Rising star special issue)

• MXene nanosheet-based microneedles for monitoring muscle contraction and electrostimulation treatment. Yen-Chang Yang, Yen-Tzu Lin, Jiashing Yu, Huan-Tsung Chang, Ting-Yu Lu, Tzu-Yen Huang, Anant Preet, Ya-Ju Hsu, Ligang Wang, Tzu-En Lin*. ACS Applied Nano Materials 2021, 4, 8, 7917. (2025 Google Scholar Citation:44)

本實驗室致力於開發各種導電材料，作為感測電極，感測器可以偵測人體的肌肉收縮、特定的癌症相關蛋白質、電訊號等，並可運用於穿戴式裝置。

Selected Publications:

• 3D-Printed Auxetic Hydrogel Dressings Reinforced with MXene and Carbonized Polymer Dots for Cascaded Antibacterial and Pro-Regenerative Effects in Wound Healing. Chen-Yu Lee, Ya-Ting Hsu, Qian-Ci Huang, Pulikkutty Subramaniyan, Akhil K. Paulose, Chih-Ching Huang,* Tzu-En Lin* Small 2026 e08633. (IF 12.1)

• Deep Learning-Enabled Swallowing Monitoring and Postoperative Recovery Biosensing System. Chih-Ning Tsai, Pei-Wen Yang, Tzu-Yen Huang, Jung-Chih Chen, Hsin-Yi Tseng, Che-Wei Wu, Amrit Sarmah, Pulikkutty Subramaniyan, Tzu-En Lin*. IEEE Sensors Journal, 2025, 25, 1, 108-116. (Instruments & Instrumentation: 15/76)

• MXene nanosheet-based microneedles for monitoring muscle contraction and electrostimulation treatment. Yen-Chang Yang, Yen-Tzu Lin, Jiashing Yu, Huan-Tsung Chang, Ting-Yu Lu, Tzu-Yen Huang, Anant Preet, Ya-Ju Hsu, Ligang Wang, Tzu-En Lin*. ACS Applied Nano Materials 2021, 4, 8, 7917. (2025 Google Scholar Citation:44)

掃描式探針(scanning probe)是利用物理探針，對物體表面進行掃描的一種系統，最著名的包含了原子力顯微鏡(AFM)，以及掃描式電化學顯微鏡(SECM)等。台灣學界專注在掃描探針系統的學者們相當優秀也很辛苦，因為此類系統儀器價格相當昂貴，通常為上百萬甚至千萬，技術操作門檻相當高，探針又為昂貴消耗品，每年儀器維護費至少要十幾萬以上，林子恩老師亦是台灣少數鑽研此類系統的學者之一。就SECM而言，傳統的探針有許多缺點，例如易碎且為微米等級，操作極為困難，如何控制樣品與探針的距離，更是難上加難。因此，要應用到現實世界中，就更加困難了，更遑論進行藥物釋放、掃描真實世界的樣品。為了克服此問題，林子恩老師在國外與指導教授針對儀器改良與偵測樣品的部分做了許多研究，也有相當的成果。回台灣後，有鑑於台灣的AI人才相當優秀且數量多，林老師和學生們開發出可以利用AI來優化成項系統的方法。另外，林老師和同學們也在探針上進行改良，讓探針可以進行藥物遞送，並和台大醫院、清大合作，對真實世界的病人樣品進行細菌偵測與藥物遞送，並可在豬眼球上進行細菌偵測與藥物遞送。此研究已發表在Sensors and Actuators B: Chemical上，此期刊在儀器領域排名第一(INSTRUMENTS & INSTRUMENTATION 1/76 )。Crossref.

Selected Publications:

• Microelectrode and Microchannel Integrated Micro-Robotic Arm for Bacteria Sensing and on-Demand Drug Delivery. Tzu-En Lin*, Yi-Hong Lin, Yu-Jie Lin, Ya-Ting Hsu, Yu-Feng Wu, Chia-Ying Tsai, Pulikkutty Subramaniyan, Chao-Min Cheng. Sensors and Actuators B: Chemical, 2025, 425, 136970. (Instruments & Instrumentation: 1/76)

• In situ detection of multitarget impurities on contact lens by electrochemical scanning probe. Tzu-En Lin*, Yingdi Zhu, Yueh-Tien Hsu, Fang-Yu Liu, Yen-Pin Lin, Chao-Min Cheng. Sensors and Actuators B: Chemical, 2023, 374, 132855. (Instruments & Instrumentation: 1/76)

• AI-Assisted fusion of scanning electrochemical microscopy images using novel soft probe. Yi-Hong Lin, Chih-Ning Tsai, Po-Feng Chen, Yen-Tzu Lin, Sorour Darvishi, Hubert H. Girault, Tung-Yi Lin, Mei-Yi Liao, Tzu-En Lin*. ACS Measurement Science Au, 2022 , 2, 6, 576–583. (Journal Cover, IF 9.0, Chemistry Analytical 5/111)

• Soft electrochemical probes for mapping the distribution of biomarkers and injected nanomaterials in animal and human tissues. Tzu‐En Lin, Yu‐Jen Lu, Chia‐Liang Sun, Horst Pick, Jyh‐Ping Chen, Andreas Lesch, Hubert H. Girault. Angewandte Chemie International Edition 2017, 56, 16498–16502. (Reported by EPFL news press and media worldwide)

•  Monitoring tyrosinase expression in non-metastatic and metastatic melanoma tissues by scanning electrochemical microscopy. Tzu-En Lin, Alexandra Bondarenko, Andreas Lesch, Horst Pick, Fernando Cortés-Salazar, Hubert H Girault. Angewandte Chemie International Edition 2016, 55, 3813–3816. (reported by EPFL news press and media worldwide, 2025 google scholar citation:81)